1 R21 AR077326-01 NIH/NIAMS Jayasuriya (PI) 4/01/20-3/31/22
National Institute of Arthritis and Musculoskeletal and Skin and Disease
Our long-term goal is to determine whether stimulating CXCR4 pathway signaling will stimulate fibrocartilage healing in a rabbit model of meniscus injury. The goal of this study is to evaluate the efficacy of meniscus repair resulting from CXCR4 overexpression in CPCs and BM-MSCs.
Role: Principal Investigator
OREF/MTF Research Grant Jayasuriya (PI) 05/01/19 - 04/31/21
Orthopaedic Research and Education Foundation, Rosemont, IL
There are two goals in this two-year project: The first is to quantify the number of viable cartilage progenitor cells that can be successfully extracted from donor cartilage graft tissue for the purpose of cell-mediated meniscus tissue repair. In this first part, we are identifying graft conditions that allow for optimal viable progenitor cell quantities to be extracted from donor tissues. The second goal is to use these donor cells to repair meniscal defects using an immunocompetent rodent model of knee injury.
Role: Principle Investigator
IDeA-CTR Pilot Project (Parent Grant: U54GM115677) Jayasuriya (PI) 02/14/17 - 02/13/18
Advance-Clinical and Translational Research (Advance-CTR), Providence, RI
The goal of this one-year pilot project is to evaluate the clinical availability and reparative capacity of a newly identified human cartilage-derived mesenchymal stem cell population for the development of cell-based meniscus repair strategies.
Role: Principle Investigator
Biomedical Research Grant (#20154146) Jayasuriya (PI) 04/01/16 - 03/30/18
Rhode Island Foundation, Providence, RI
The goal of this one-year project is to elucidate the biological mechanism by which matrilin-3 prevents accelerated osteoarthritis.
Role: Principle Investigator
Jayasuriya Laboratory
Dr. Chathuraka T. Jayasuriya (ResearchGate Profile)
