A native of Cleveland Ohio, Doctor Kelly graduated with a BA in Chemistry from Cornell University in 1995. She attended the Ohio State University College of Medicine and completed internship/residency at Boston University Medical Center. She came to Providence, Rhode Island to complete a fellowship in Gastroenterology at the Brown program, where she has remained as a faculty member since 2006. She is a member of the Lifespan Physician Group Gastroenterology practice and her clinical and research interests include inflammatory bowel disease, C difficile infections and fecal microbiota transplantation. She lives with her husband and 3 children in Providence.
| Haifer C, Kelly CR, Paramsothy S, Andresen D, Papanicolas LE, McKew GL, Borody TJ, Kamm M, Costello SP, Andrews JM, Begun J, Chan HT, Connor S, Ghaly S, Johnson PD, Lemberg DA, Paramsothy R, Redmond A, Sheorey H, van der Poorten D, Leong RW. "Australian consensus statements for the regulation, production and use of faecal microbiota transplantation in clinical practice." Gut, vol. 69, no. 5, 2020, pp. 801-810. |
| Perler BK, Chen B, Phelps E, Allegretti JR, Fischer M, Ganapini V, Krajiceck E, Kumar V, Marcus J, Nativ L, Kelly CR. "Long-Term Efficacy and Safety of Fecal Microbiota Transplantation for Treatment of Recurrent Clostridioides difficile Infection." Journal of clinical gastroenterology, 2020. |
| Kelly CR, Fischer M, Grinspan A, Allegretti JR. "Patients Eligible for Trials of Microbe-Based Therapeutics Do Not Represent the Population With Recurrent Clostridioides difficile Infection." Clinical Gastroenterology and Hepatology, vol. 18, no. 5, 2020, pp. 1099-1101. |
| Allegretti JR, Mehta SR, Kassam Z, Kelly CR, Kao D, Xu H, Fischer M. "Risk Factors that Predict the Failure of Multiple Fecal Microbiota Transplantations for Clostridioides difficile Infection." Digestive Diseases and Sciences, 2020. |
| Ekekezie C, Perler BK, Wexler A, Duff C, Lillis CJ, Kelly CR. "Understanding the Scope of Do-It-Yourself Fecal Microbiota Transplant." American Journal of Gastroenterology, vol. 115, no. 4, 2020, pp. 603-607. |
| Cammarota G, Ianiro G, Kelly CR, Mullish BH, Allegretti JR, Kassam Z, Putignani L, Fischer M, Keller JJ, Costello SP, Sokol H, Kump P, Satokari R, Kahn SA, Kao D, Arkkila P, Kuijper EJ, Vehreschild MJG, Pintus C, Lopetuso L, Masucci L, Scaldaferri F, Terveer EM, Nieuwdorp M, López-Sanromán A, Kupcinskas J, Hart A, Tilg H, Gasbarrini A. "International consensus conference on stool banking for faecal microbiota transplantation in clinical practice." Gut, vol. 68, no. 12, 2019, pp. 2111-2121. |
| Kelly, Colleen R., Ananthakrishnan, Ashwin N. "Manipulating the Microbiome With Fecal Transplantation to Treat Ulcerative Colitis." JAMA, vol. 321, no. 2, 2019, pp. 151. |
| Krajicek, Edward, Fischer, Monika, Allegretti, Jessica R., Kelly, Colleen R. "Nuts and Bolts of Fecal Microbiota Transplantation." Clinical Gastroenterology and Hepatology, vol. 17, no. 2, 2019, pp. 345-352. |
| Browne, Alexander S., Kelly, Colleen R. "Fecal Transplant in Inflammatory Bowel Disease." Gastroenterology Clinics of North America, vol. 46, no. 4, 2017, pp. 825-837. |
| Rebello, Dionne. "Hair Growth in Two Alopecia Patients after Fecal Microbiota Transplant." ACG Case Reports Journal, vol. 4, 2017. |
| Jackson M, Olefson S, Machan JT, Kelly CR. "A High Rate of Alternative Diagnoses in Patients Referred for Presumed Clostridium difficile Infection." Journal of clinical gastroenterology, vol. 50, no. 9, 2016, pp. 742-6. |
| Khanna S, Pardi DS, Kelly CR, Kraft CS, Dhere T, Henn MR, Lombardo MJ, Vulic M, Ohsumi T, Winkler J, Pindar C, McGovern BH, Pomerantz RJ, Aunins JG, Cook DN, Hohmann EL. "A Novel Microbiome Therapeutic Increases Gut Microbial Diversity and Prevents Recurrent Clostridium difficile Infection." The Journal of Infectious Diseases, vol. 214, no. 2, 2016, pp. 173-81. |
| Staley, Christopher, Kelly, Colleen R., Brandt, Lawrence J., Khoruts, Alexander, Sadowsky, Michael J. "Complete Microbiota Engraftment Is Not Essential for Recovery from RecurrentClostridium difficileInfection following Fecal Microbiota Transplantation." mBio, vol. 7, no. 6, 2016, pp. e01965-16. |
| Kelly CR, Khoruts A, Staley C, Sadowsky MJ, Abd M, Alani M, Bakow B, Curran P, McKenney J, Tisch A, Reinert SE, Machan JT, Brandt LJ. "Effect of Fecal Microbiota Transplantation on Recurrence in Multiply Recurrent Clostridium difficile Infection: A Randomized Trial." Annals of Internal Medicine, vol. 165, no. 9, 2016, pp. 609-616. |
| Fischer M, Kao D, Kelly C, Kuchipudi A, Jafri SM, Blumenkehl M, Rex D, Mellow M, Kaur N, Sokol H, Cook G, Hamilton MJ, Phelps E, Sipe B, Xu H, Allegretti JR. "Fecal Microbiota Transplantation is Safe and Efficacious for Recurrent or Refractory Clostridium difficile Infection in Patients with Inflammatory Bowel Disease." Inflammatory Bowel Diseases, vol. 22, no. 10, 2016, pp. 2402-9. |
| Fischer M, Kao D, Mehta SR, Martin T, Dimitry J, Keshteli AH, Cook GK, Phelps E, Sipe BW, Xu H, Kelly CR. "Predictors of Early Failure After Fecal Microbiota Transplantation for the Therapy of Clostridium Difficile Infection: A Multicenter Study." American Journal of Gastroenterology, vol. 111, no. 7, 2016, pp. 1024-31. |
| Kelly, C. R. "Editorial: a simple faecal preparation protocol for faecal microbiota transplantation." Aliment Pharmacol Ther, vol. 41, no. 3, 2015, pp. 320-320. |
| Grinspan, Ari M., Kelly, Colleen R. "Fecal Microbiota Transplantation for Ulcerative Colitis: Not Just Yet." Gastroenterology, vol. 149, no. 1, 2015, pp. 15-18. |
| Mao EJ, Kelly CR, Machan JT. "Racial Differences in Clostridium difficile Infection Rates Are Attributable to Disparities in Health Care Access." Antimicrobial Agents and Chemotherapy, vol. 59, no. 10, 2015, pp. AAC.00795-15. |
| Kelly CR, Kahn S, Kashyap P, Laine L, Rubin D, Atreja A, Moore T, Wu G. "Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook." Gastroenterology, vol. 149, no. 1, 2015, pp. 223-237. |
| Alang N, Kelly CR. "Weight gain after fecal microbiota transplantation." Open Forum Infectious Diseases, vol. 2, no. 1, 2015, pp. ofv004. |
| Kelly CR, Ihunnah C, Fischer M, Khoruts A, Surawicz C, Afzali A, Aroniadis O, Barto A, Borody T, Giovanelli A, Gordon S, Gluck M, Hohmann EL, Kao D, Kao JY, McQuillen DP, Mellow M, Rank KM, Rao K, Ray A, Schwartz MA, Singh N, Stollman N, Suskind DL, Vindigni SM, Youngster I, Brandt L. "Fecal microbiota transplant for treatment of Clostridium difficile infection in immunocompromised patients." American Journal of Gastroenterology, vol. 109, no. 7, 2014, pp. 1065-71. |
| Kelly CR, Kunde SS, Khoruts A. "Guidance on preparing an investigational new drug application for fecal microbiota transplantation studies." Clinical Gastroenterology and Hepatology, vol. 12, no. 2, 2014, pp. 283-8. |
| Smith MB, Kelly C, Alm EJ. "Policy: How to regulate faecal transplants." J. Geophys. Res., vol. 506, no. 7488, 2014, pp. 290-1. |
| De Leon LM, Watson JB, Kelly CR. "Transient flare of ulcerative colitis after fecal microbiota transplantation for recurrent Clostridium difficile infection." Clinical Gastroenterology and Hepatology, vol. 11, no. 8, 2013, pp. 1036-8. |
| Kelly CR, de Leon L, Jasutkar N. "Fecal microbiota transplantation for relapsing Clostridium difficile infection in 26 patients: methodology and results." Journal of clinical gastroenterology, vol. 46, no. 2, 2012, pp. 145-9. |
| Brandt LJ, Aroniadis OC, Mellow M, Kanatzar A, Kelly C, Park T, Stollman N, Rohlke F, Surawicz C. "Long-term follow-up of colonoscopic fecal microbiota transplant for recurrent Clostridium difficile infection." American Journal of Gastroenterology, vol. 107, no. 7, 2012, pp. 1079-87. |
| Bakken JS, Borody T, Brandt LJ, Brill JV, Demarco DC, Franzos MA, Kelly C, Khoruts A, Louie T, Martinelli LP, Moore TA, Russell G, Surawicz C, Fecal Microbiota Transplantation Workgroup. "Treating Clostridium difficile infection with fecal microbiota transplantation." Clinical Gastroenterology and Hepatology, vol. 9, no. 12, 2011, pp. 1044-9. |
The focus of Dr. Kelly’s research and clinical practice is Clostridium difficile infection (CDI) and fecal microbiota transplantation (FMT). She was the principal investigator (PI) for a first placebo-controlled trial of FMT for treatment of recurrent CDI and one of the first investigators to sponsor of an investigational new drug (IND) application for FMT with the Food and Drug Administration. She has since served on several working groups focusing on regulatory issues related to FMT. Dr. Kelly is currently site PI for an industry funded trial of live microbiota for treatment of recurrent CDI as well as investigator-initiated clinical trials assessing conventional FMT for CDI treatment. Dr. Kelly is interested in the long-term effects around manipulation of gut microbiota and serves as one of the PIs for an NIH-funded FMT National Registry which will answer important questions around the safety of FMT. She has collaborated on several studies investigating the impact of FMT on patients with Inflammatory Bowel Disease, Nonalcoholic Fatty Liver Disease and Alopecia Areata. In addition to coauthoring current FMT guidelines and participating in drafting the European Consensus Conference on Fecal Microbiota Transplant in Clinical Practice, she serves as the primary author for the forthcoming American College of Gastroenterology (ACG) 2019 C. difficile treatment guidelines. Dr. Kelly is past member of the scientific advisory board for Gut Microbiome Research and Education of the American Gastroenterological Association.
07/16-06/21 NIAID 1R24AI118629-01A1 Co-PI (Wu, Kelly, Laine)
Fecal Microbiome Transplant National Registry $2,778,96
| Year | Degree | Institution |
|---|---|---|
| 1999 | MD | Ohio State University |
| 1995 | BA | Cornell University |
2019 Beckwith Family Teaching Award; Warren Alpert Medical School of Brown University
2019 American Gastroenterological Association Fellow
2017 Rhode Island Monthly Magazine: Top Doctor
2014 American College of Gastroenterology Fellow
2010 Certificate of Recognition for Exemplary Teaching: BIOL 3673 IMS IV: Gastroenterology, The Warren Alpert Medical School of Brown University
Lifespan Physician Group Gastroenterology Practice
The Warren Alpert Medical School of Brown Univerisity
The Miriam Hospital
Rhode Island Hospital
| Member | 2006-2020 | #212933 | |
| Physician | 2006-2020 | #12090 |
| Physician. 2006-2020 |
| Physician. The Miriam Hospital, 2006-2020 |
2017-present Lecturer; Alpert Medical School of Brown University Gastroenterology Course
2016-present Noon conference lecturer; Rhode Island Hospital and Providence VA Medical Center
2009-2014, 2016-present Small group facilitator. Gastroenterology course; Brown University Alpert School of Medicine
2009-present Gastroenterology service attending. Rhode Island Hospital
