Dr. Rice received his AB degree from Harvard College in 1977 and his MD from Columbia University College of Physicians and Surgeons in 1983. He trained in Internal Medicine at New York University and Bellevue Hospital Center from 1983-1986. After completing his residency, he trained in clinical infectious diseases at the New England Deaconess Hospital and Harvard Medical School, followed by three years working in the laboratories of Robert C. Moellering, Jr., M.D. at the Deaconess Hospital and George A. Jacoby, M.D. at Massachusetts General Hospital in Boston. In 1990, Dr. Rice moved to Cleveland, Ohio where he assumed a staff position in the Infectious Diseases Section at the Cleveland VA Medical Center. In 1996, Dr. Rice became Chief of the Infectious Diseases Section at the Cleveland VA Medical Center and Chairman of the VA Medical Center Infection Control Committee. In 1999, Dr. Rice became Chief of the Medical Service at the Cleveland VAMC and Vice Chairman of Medicine at University Hospitals of Cleveland. In 2010, Dr. Rice moved to his current position as Chair of the Department of Medicine at Warren Alpert Medical School of Brown University and Physician-in-Chief of Rhode Island Hospital and The Miriam Hospital in Providence, RI. Dr. Rice’s laboratory effort has been funded by the Department of Veterans Affairs and the National Institutes of Health, and he is an author of more than 180 original papers and invited reviews. He is a Fellow and former Director of the Infectious Diseases Society of America, and is currently Editor-in-Chief of the journal Antimicrobial Agents and Chemotherapy. He is a member of the American Society for Microbiology and a Fellow of the American College of Physicians. His research interests focus on the mechanisms of gene exchange and penicillin resistance in enterococci, the molecular epidemiology of resistant enterococcal infection, the molecular genetics of extended-spectrum b-lactamases in Gram-negative bacilli and the influence of antibiotic administration on the emergence of resistance in the clinical setting.
| García-Solache M, Rice LB. "The Enterococcus: a Model of Adaptability to Its Environment." Clinical microbiology reviews, vol. 32, no. 2, 2019. |
| Beganovic, Maya, Luther, Megan K, Rice, Louis B, Arias, Cesar A, Rybak, Michael J, LaPlante, Kerry L. "A Review of Combination Antimicrobial Therapy for Enterococcus faecalis Bloodstream Infections and Infective Endocarditis." Clinical Infectious Diseases, vol. 67, no. 2, 2018, pp. 303-309. |
| Beganovic M, Luther MK, Rice LB, Arias CA, Rybak MJ, LaPlante KL. "A Review of Combination Antimicrobial Therapy for Enterococcus faecalis Bloodstream Infections and Infective Endocarditis." Clinical Infectious Diseases, vol. 67, no. 2, 2018, pp. 303-309. |
| Rice LB. "Acknowledgment of <i>Ad Hoc</i> Reviewers." Antimicrobial Agents and Chemotherapy, vol. 62, no. 12, 2018. |
| Rice, Louis B., Desbonnet, Charlene, Tait-Kamradt, Amelia, Garcia-Solache, Monica, Lonks, John, Moon, Thomas M., D’Andréa, Éverton D., Page, Rebecca, Peti, Wolfgang. "Structural and Regulatory Changes in PBP4 Trigger Decreased β-Lactam Susceptibility in Enterococcus faecalis." mBio, vol. 9, no. 2, 2018, pp. e00361-18. |
| Guo, Yan, Tomich, Adam D., McElheny, Christi L., Cooper, Vaughn S., Tait-Kamradt, Amelia, Wang, Minggui, Hu, Fupin, Rice, Louis B., Sluis-Cremer, Nicolas, Doi, Yohei. "High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium." Emerging Infectious Diseases, vol. 23, no. 11, 2017, pp. 1902-1904. |
| García-Solache M, Rice LB. "Draft Genome Sequence of Vancomycin-Susceptible, Ampicillin-Intermediate Enterococcus faecium Strain D344RRF." Genome Announcements, vol. 4, no. 3, 2016, pp. e01720-15. |
| García-Solache M, Rice LB. "Genome Sequence of the Multiantibiotic-ResistantEnterococcus faeciumStrain C68 and Insights on the pLRM23 Colonization Plasmid." Genome Announcements, vol. 4, no. 3, 2016, pp. e01719-15. |
| García-Solache M, Lebreton F, McLaughlin RE, Whiteaker JD, Gilmore MS, Rice LB. "Homologous Recombination within Large Chromosomal Regions Facilitates Acquisition of β-Lactam and Vancomycin Resistance in Enterococcus faecium." Antimicrobial Agents and Chemotherapy, vol. 60, no. 10, 2016, pp. 5777-86. |
| Fuchs BB, RajaMuthiah R, Souza AC, Eatemadpour S, Rossoni RD, Santos DA, Junqueira JC, Rice LB, Mylonakis E. "Inhibition of bacterial and fungal pathogens by the orphaned drug auranofin." Future Medicinal Chemistry, vol. 8, no. 2, 2016, pp. 117-32. |
| Miller, William R., Murray, Barbara E., Rice, Louis B., Arias, Cesar A. "Vancomycin-Resistant Enterococci." Infectious Disease Clinics of North America, vol. 30, no. 2, 2016, pp. 415-439. |
| Arias, Cesar A., Rice, Louis B. "A New AAC Section: Translating Resistance to the Bedside." Antimicrobial Agents and Chemotherapy, vol. 59, no. 8, 2015, pp. 4365-4365. |
| Arias CA, Rice LB. "A New AAC Section: Translating Resistance to the Bedside." Antimicrobial Agents and Chemotherapy, vol. 59, no. 8, 2015, pp. 4365. |
| Sakoulas, George, Kumaraswamy, Monika, Nonejuie, Poochit, Werth, Brian J., Rybak, Micahel J., Pogliano, Joseph, Rice, Louis B., Nizet, Victor. "Differential Effects of Penicillin Binding Protein Deletion on the Susceptibility of Enterococcus faecium to Cationic Peptide Antibiotics." Antimicrobial Agents and Chemotherapy, vol. 59, no. 10, 2015, pp. 6132-6139. |
| Sakoulas G, Kumaraswamy M, Nonejuie P, Werth BJ, Rybak MJ, Pogliano J, Rice LB, Nizet V. "Differential Effects of Penicillin Binding Protein Deletion on the Susceptibility of Enterococcus faecium to Cationic Peptide Antibiotics." Antimicrobial Agents and Chemotherapy, vol. 59, no. 10, 2015, pp. 6132-9. |
| Sacco, Emmanuelle, Cortes, Mélanie, Josseaume, Nathalie, Bouchier, Christiane, Dubée, Vincent, Hugonnet, Jean-Emmanuel, Mainardi, Jean-Luc, Rice, Louis B., Arthur, Michel. "Mutation Landscape of Acquired Cross-Resistance to Glycopeptide and β-Lactam Antibiotics in Enterococcus faecium." Antimicrobial Agents and Chemotherapy, vol. 59, no. 9, 2015, pp. 5306-5315. |
| Sacco E, Cortes M, Josseaume N, Bouchier C, Dubée V, Hugonnet JE, Mainardi JL, Rice LB, Arthur M. "Mutation landscape of acquired cross-resistance to glycopeptide and β-lactam antibiotics in Enterococcus faecium." Antimicrobial Agents and Chemotherapy, vol. 59, no. 9, 2015, pp. 5306-15. |
| Zacharioudakis, Ioannis M., Zervou, Fainareti N., Ziakas, Panayiotis D., Rice, Louis B., Mylonakis, Eleftherios. "Vancomycin-Resistant Enterococci Colonization Among Dialysis Patients: A Meta-analysis of Prevalence, Risk Factors, and Significance." American Journal of Kidney Diseases, vol. 65, no. 1, 2015, pp. 88-97. |
| Rice, L. B. "Will use of combination cephalosporin/azithromycin therapy forestall resistance to cephalosporins in Neisseria gonorrhoeae?." Sexually Transmitted Infections, vol. 91, no. 4, 2015, pp. 238-240. |
| Perez F, Arias CA, Bush K, Drusano GL, Lolans K, Munoz-Price LS, Nicolau DP, Queenan AM, Rice LB, Segreti J, Shlaes DM, Weinstein RA, Bonomo RA. "In memoriam: John P. Quinn, MD." Clinical Infectious Diseases, vol. 58, no. 5, 2014, pp. 748-50. |
| Rice LB, Eliopoulos GM, Jacoby GA. "In memoriam: Robert C. Moellering, Jr." Antimicrobial Agents and Chemotherapy, vol. 58, no. 7, 2014, pp. 3583-4. |
| Ziakas PD, Pliakos EE, Zervou FN, Knoll BM, Rice LB, Mylonakis E. "MRSA and VRE colonization in solid organ transplantation: a meta-analysis of published studies." American Journal of Transplantation, vol. 14, no. 8, 2014, pp. 1887-94. |
| Hugonnet JE, Haddache N, Veckerlé C, Dubost L, Marie A, Shikura N, Mainardi JL, Rice LB, Arthur M. "Peptidoglycan cross-linking in glycopeptide-resistant Actinomycetales." Antimicrobial Agents and Chemotherapy, vol. 58, no. 3, 2014, pp. 1749-56. |
| Sacco, E., Cortes, M., Josseaume, N., Rice, L. B., Mainardi, J.-L., Arthur, M. "Serine/Threonine Protein Phosphatase-Mediated Control of the Peptidoglycan Cross-Linking L,D-Transpeptidase Pathway in Enterococcus faecium." mBio, vol. 5, no. 4, 2014, pp. e01446-14-e01446-14. |
| Rice LB, Tait-Kamradt A. "A novel genetic region flanks the plasmid-carried blaNDM-1 isolated from a patient in Rhode Island in 2012." Antimicrobial Agents and Chemotherapy, vol. 57, no. 8, 2013, pp. 4084-5. |
| Triboulet S, Dubée V, Lecoq L, Bougault C, Mainardi JL, Rice LB, Ethève-Quelquejeu M, Gutmann L, Marie A, Dubost L, Hugonnet JE, Simorre JP, Arthur M. "Kinetic features of L,D-transpeptidase inactivation critical for β-lactam antibacterial activity." PLoS ONE, vol. 8, no. 7, 2013, pp. e67831. |
| Chibebe Junior J, Fuchs BB, Sabino CP, Junqueira JC, Jorge AO, Ribeiro MS, Gilmore MS, Rice LB, Tegos GP, Hamblin MR, Mylonakis E. "Photodynamic and antibiotic therapy impair the pathogenesis of Enterococcus faecium in a whole animal insect model." PLoS ONE, vol. 8, no. 2, 2013, pp. e55926. |
| Rice LB. "The complex dynamics of antimicrobial activity in the human gastrointestinal tract." Transactions of the American Clinical and Climatological Association, vol. 124, 2013, pp. 123-32. |
| Ziakas PD, Thapa R, Rice LB, Mylonakis E. "Trends and significance of VRE colonization in the ICU: a meta-analysis of published studies." PLoS ONE, vol. 8, no. 9, 2013, pp. e75658. |
| Papp-Wallace KM, Senkfor B, Gatta J, Chai W, Taracila MA, Shanmugasundaram V, Han S, Zaniewski RP, Lacey BM, Tomaras AP, Skalweit MJ, Harris ME, Rice LB, Buynak JD, Bonomo RA. "Early insights into the interactions of different β-lactam antibiotics and β-lactamase inhibitors against soluble forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3." Antimicrobial Agents and Chemotherapy, vol. 56, no. 11, 2012, pp. 5687-92. |
| Rice LB. "Gastrointestinal bacteria will have its way." The Journal of Infectious Diseases, vol. 206, no. 9, 2012, pp. 1334-5. |
| Hollenbeck BL, Rice LB. "Intrinsic and acquired resistance mechanisms in enterococcus." Virulence, vol. 3, no. 5, 2012, pp. 421-33. |
| Dubée V, Arthur M, Fief H, Triboulet S, Mainardi JL, Gutmann L, Sollogoub M, Rice LB, Ethève-Quelquejeu M, Hugonnet JE. "Kinetic analysis of Enterococcus faecium L,D-transpeptidase inactivation by carbapenems." Antimicrobial Agents and Chemotherapy, vol. 56, no. 6, 2012, pp. 3409-12. |
| Rice LB. "Mechanisms of resistance and clinical relevance of resistance to β-lactams, glycopeptides, and fluoroquinolones." Mayo Clinic proceedings, vol. 87, no. 2, 2012, pp. 198-208. |
| Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, Harbarth S, Hindler JF, Kahlmeter G, Olsson-Liljequist B, Paterson DL, Rice LB, Stelling J, Struelens MJ, Vatopoulos A, Weber JT, Monnet DL. "Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance." Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, vol. 18, no. 3, 2012, pp. 268-81. |
| Galloway-Peña JR, Rice LB, Murray BE. "Analysis of PBP5 of early U.S. isolates of Enterococcus faecium: sequence variation alone does not explain increasing ampicillin resistance over time." Antimicrobial Agents and Chemotherapy, vol. 55, no. 7, 2011, pp. 3272-7. |
| Endimiani A, Blackford M, Dasenbrook EC, Reed MD, Bajaksouszian S, Hujer AM, Rudin SD, Hujer KM, Perreten V, Rice LB, Jacobs MR, Konstan MW, Bonomo RA. "Emergence of linezolid-resistant Staphylococcus aureus after prolonged treatment of cystic fibrosis patients in Cleveland, Ohio." Antimicrobial Agents and Chemotherapy, vol. 55, no. 4, 2011, pp. 1684-92. |
| Triboulet S, Arthur M, Mainardi JL, Veckerlé C, Dubée V, Nguekam-Moumi A, Gutmann L, Rice LB, Hugonnet JE. "Inactivation kinetics of a new target of beta-lactam antibiotics." Journal of Biological Chemistry, vol. 286, no. 26, 2011, pp. 22777-84. |
| Rice LB. "Rapid diagnostics and appropriate antibiotic use." Clinical Infectious Diseases, vol. 52 Suppl 4, 2011, pp. S357-60. |
| Panesso D, Montealegre MC, Rincón S, Mojica MF, Rice LB, Singh KV, Murray BE, Arias CA. "The hylEfm gene in pHylEfm of Enterococcus faecium is not required in pathogenesis of murine peritonitis." BMC microbiology, vol. 11, no. 1, 2011, pp. 20. |
| Sacco E, Hugonnet JE, Josseaume N, Cremniter J, Dubost L, Marie A, Patin D, Blanot D, Rice LB, Mainardi JL, Arthur M. "Activation of the L,D-transpeptidation peptidoglycan cross-linking pathway by a metallo-D,D-carboxypeptidase in Enterococcus faecium." Molecular Microbiology, vol. 75, no. 4, 2010, pp. 874-85. |
| Endimiani A, Hujer AM, Hujer KM, Gatta JA, Schriver AC, Jacobs MR, Rice LB, Bonomo RA. "Evaluation of a commercial microarray system for detection of SHV-, TEM-, CTX-M-, and KPC-type beta-lactamase genes in Gram-negative isolates." Journal of clinical microbiology, vol. 48, no. 7, 2010, pp. 2618-22. |
| Endimiani A, Patel G, Hujer KM, Swaminathan M, Perez F, Rice LB, Jacobs MR, Bonomo RA. "In vitro activity of fosfomycin against blaKPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistin." Antimicrobial Agents and Chemotherapy, vol. 54, no. 1, 2010, pp. 526-9. |
| Rice LB, Carias LL, Rudin S, Hutton RA, Marshall S. "Multiple copies of functional, Tet(M)-encoding Tn916-like elements in a clinical Enterococcus faecium isolate." Plasmid, vol. 64, no. 3, 2010, pp. 150-5. |
| Rice LB. "Progress and challenges in implementing the research on ESKAPE pathogens." Infection Control & Hospital Epidemiology, vol. 31 Suppl 1, 2010, pp. S7-10. |
| Boucher HW, Talbot GH, Bradley JS, Edwards JE, Gilbert D, Rice LB, Scheld M, Spellberg B, Bartlett J. "Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America." Clinical Infectious Diseases, vol. 48, no. 1, 2009, pp. 1-12. |
| Endimiani A, Hujer AM, Perez F, Bethel CR, Hujer KM, Kroeger J, Oethinger M, Paterson DL, Adams MD, Jacobs MR, Diekema DJ, Hall GS, Jenkins SG, Rice LB, Tenover FC, Bonomo RA. "Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the Eastern USA." Journal of Antimicrobial Chemotherapy, vol. 63, no. 3, 2009, pp. 427-37. |
| Arias CA, Panesso D, Singh KV, Rice LB, Murray BE. "Cotransfer of antibiotic resistance genes and a hylEfm-containing virulence plasmid in Enterococcus faecium." Antimicrobial Agents and Chemotherapy, vol. 53, no. 10, 2009, pp. 4240-6. |
| Rice LB. "Evidence-based evaluation of physician work hour regulations." JAMA, vol. 301, no. 5, 2009, pp. 484; author reply 484-5. |
| Drusano GL, Liu W, Brown DL, Rice LB, Louie A. "Impact of short-course quinolone therapy on susceptible and resistant populations of Staphylococcus aureus." The Journal of Infectious Diseases, vol. 199, no. 2, 2009, pp. 219-26. |
| Rice LB, Carias LL, Rudin S, Hutton R, Marshall S, Hassan M, Josseaume N, Dubost L, Marie A, Arthur M. "Role of class A penicillin-binding proteins in the expression of beta-lactam resistance in Enterococcus faecium." Journal of bacteriology, vol. 191, no. 11, 2009, pp. 3649-56. |
| Rice LB. "The clinical consequences of antimicrobial resistance." Current opinion in microbiology, vol. 12, no. 5, 2009, pp. 476-81. |
| Rice LB, Lakticová V, Carias LL, Rudin S, Hutton R, Marshall SH. "Transferable capacity for gastrointestinal colonization in Enterococcus faecium in a mouse model." The Journal of Infectious Diseases, vol. 199, no. 3, 2009, pp. 342-9. |
| Tabor E, Rice LB. "Bacteria by the book." Science, vol. 322, no. 5903, 2008, pp. 853-4. |
| Rice LB. "Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE." The Journal of Infectious Diseases, vol. 197, no. 8, 2008, pp. 1079-81. |
| Endimiani A, Carias LL, Hujer AM, Bethel CR, Hujer KM, Perez F, Hutton RA, Fox WR, Hall GS, Jacobs MR, Paterson DL, Rice LB, Jenkins SG, Tenover FC, Bonomo RA. "Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States." Antimicrobial Agents and Chemotherapy, vol. 52, no. 7, 2008, pp. 2680-2. |
| Rice LB, Carias LL, Hutton RA, Rudin SD, Endimiani A, Bonomo RA. "The KQ element, a complex genetic region conferring transferable resistance to carbapenems, aminoglycosides, and fluoroquinolones in Klebsiella pneumoniae." Antimicrobial Agents and Chemotherapy, vol. 52, no. 9, 2008, pp. 3427-9. |
| Rice LB. "The Maxwell Finland Lecture: for the duration-rational antibiotic administration in an era of antimicrobial resistance and clostridium difficile." Clinical Infectious Diseases, vol. 46, no. 4, 2008, pp. 491-6. |
| Rice LB, Carias LL, Marshall SH, Hutton-Thomas R, Rudin S. "Characterization of Tn5386, a Tn916-related mobile element." Plasmid, vol. 58, no. 1, 2007, pp. 61-7. |
| Rice LB. "Emerging issues in the management of infections caused by multidrug-resistant gram-negative bacteria." Cleveland Clinic Journal of Medicine, vol. 74 Suppl 4, 2007, pp. S12-20. |
| Rice LB, Carias LL, Hutton-Thomas R, Rudin S. "Interaction of related Tn916-like transposons: analysis of excision events promoted by Tn916 and Tn5386 integrases." Journal of bacteriology, vol. 189, no. 10, 2007, pp. 3909-17. |
| Magnet S, Arbeloa A, Mainardi JL, Hugonnet JE, Fourgeaud M, Dubost L, Marie A, Delfosse V, Mayer C, Rice LB, Arthur M. "Specificity of L,D-transpeptidases from gram-positive bacteria producing different peptidoglycan chemotypes." Journal of Biological Chemistry, vol. 282, no. 18, 2007, pp. 13151-9. |
| Mainardi JL, Hugonnet JE, Rusconi F, Fourgeaud M, Dubost L, Moumi AN, Delfosse V, Mayer C, Gutmann L, Rice LB, Arthur M. "Unexpected inhibition of peptidoglycan LD-transpeptidase from Enterococcus faecium by the beta-lactam imipenem." Journal of Biological Chemistry, vol. 282, no. 42, 2007, pp. 30414-22. |
| Lakticová V, Hutton-Thomas R, Meyer M, Gurkan E, Rice LB. "Antibiotic-induced enterococcal expansion in the mouse intestine occurs throughout the small bowel and correlates poorly with suppression of competing flora." Antimicrobial Agents and Chemotherapy, vol. 50, no. 9, 2006, pp. 3117-23. |
| Rice LB. "Antimicrobial resistance in gram-positive bacteria." The American Journal of Medicine, vol. 119, no. 6 Suppl 1, 2006, pp. S11-9; discussion S62-70. |
| Rice LB. "Antimicrobial resistance in gram-positive bacteria." American journal of infection control, vol. 34, no. 5 Suppl 1, 2006, pp. S11-9; discussion S64-73. |
| Rice LB. "Challenges in identifying new antimicrobial agents effective for treating infections with Acinetobacter baumannii and Pseudomonas aeruginosa." Clinical Infectious Diseases, vol. 43 Suppl 2, 2006, pp. S100-5. |
| Cremniter J, Mainardi JL, Josseaume N, Quincampoix JC, Dubost L, Hugonnet JE, Marie A, Gutmann L, Rice LB, Arthur M. "Novel mechanism of resistance to glycopeptide antibiotics in Enterococcus faecium." Journal of Biological Chemistry, vol. 281, no. 43, 2006, pp. 32254-62. |
| Rice LB. "Unmet medical needs in antibacterial therapy." Biochemical pharmacology, vol. 71, no. 7, 2006, pp. 991-5. |
| Mainardi JL, Fourgeaud M, Hugonnet JE, Dubost L, Brouard JP, Ouazzani J, Rice LB, Gutmann L, Arthur M. "A novel peptidoglycan cross-linking enzyme for a beta-lactam-resistant transpeptidation pathway." Journal of Biological Chemistry, vol. 280, no. 46, 2005, pp. 38146-52. |
| Rice LB. "Antibiotics and gastrointestinal colonization by vancomycin-resistant enterococci." European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, vol. 24, no. 12, 2005, pp. 804-14. |
| Rice LB. "Emerging issues in the management of infections caused by multi-drug-resistant, gram-negative bacilli." Surgical infections, vol. 6 Suppl 2, 2005, pp. S-37-47. |
| Rice LB, Carias LL, Rudin S, Lakticová V, Wood A, Hutton-Thomas R. "Enterococcus faecium low-affinity pbp5 is a transferable determinant." Antimicrobial Agents and Chemotherapy, vol. 49, no. 12, 2005, pp. 5007-12. |
| Hujer KM, Hamza NS, Hujer AM, Perez F, Helfand MS, Bethel CR, Thomson JM, Anderson VE, Barlow M, Rice LB, Tenover FC, Bonomo RA. "Identification of a new allelic variant of the Acinetobacter baumannii cephalosporinase, ADC-7 beta-lactamase: defining a unique family of class C enzymes." Antimicrobial Agents and Chemotherapy, vol. 49, no. 7, 2005, pp. 2941-8. |
| Hujer AM, Kania M, Gerken T, Anderson VE, Buynak JD, Ge X, Caspers P, Page MG, Rice LB, Bonomo RA. "Structure-activity relationships of different beta-lactam antibiotics against a soluble form of Enterococcus faecium PBP5, a type II bacterial transpeptidase." Antimicrobial Agents and Chemotherapy, vol. 49, no. 2, 2005, pp. 612-8. |
| Rice LB, Carias LL, Marshall S, Rudin SD, Hutton-Thomas R. "Tn5386, a novel Tn916-like mobile element in Enterococcus faecium D344R that interacts with Tn916 to yield a large genomic deletion." Journal of bacteriology, vol. 187, no. 19, 2005, pp. 6668-77. |
| Paterson DL, Ko WC, Von Gottberg A, Mohapatra S, Casellas JM, Goossens H, Mulazimoglu L, Trenholme G, Klugman KP, Bonomo RA, Rice LB, Wagener MM, McCormack JG, Yu VL. "Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases." Clinical Infectious Diseases, vol. 39, no. 1, 2004, pp. 31-7. |
| Rice LB, Hutton-Thomas R, Lakticova V, Helfand MS, Donskey CJ. "Beta-lactam antibiotics and gastrointestinal colonization with vancomycin-resistant enterococci." The Journal of Infectious Diseases, vol. 189, no. 6, 2004, pp. 1113-8. |
| Raad II, Hanna HA, Hachem RY, Dvorak T, Arbuckle RB, Chaiban G, Rice LB. "Clinical-use-associated decrease in susceptibility of vancomycin-resistant Enterococcus faecium to linezolid: a comparison with quinupristin-dalfopristin." Antimicrobial Agents and Chemotherapy, vol. 48, no. 9, 2004, pp. 3583-5. |
| Donskey CJ, Helfand MS, Pultz NJ, Rice LB. "Effect of parenteral fluoroquinolone administration on persistence of vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tract." Antimicrobial Agents and Chemotherapy, vol. 48, no. 1, 2004, pp. 326-8. |
| Rice LB, Bellais S, Carias LL, Hutton-Thomas R, Bonomo RA, Caspers P, Page MG, Gutmann L. "Impact of specific pbp5 mutations on expression of beta-lactam resistance in Enterococcus faecium." Antimicrobial Agents and Chemotherapy, vol. 48, no. 8, 2004, pp. 3028-32. |
| Rice LB, Lakticová V, Helfand MS, Hutton-Thomas R. "In vitro antienterococcal activity explains associations between exposures to antimicrobial agents and risk of colonization by multiresistant enterococci." The Journal of Infectious Diseases, vol. 190, no. 12, 2004, pp. 2162-6. |
| Paterson DL, Ko WC, Von Gottberg A, Mohapatra S, Casellas JM, Goossens H, Mulazimoglu L, Trenholme G, Klugman KP, Bonomo RA, Rice LB, Wagener MM, McCormack JG, Yu VL. "International prospective study of Klebsiella pneumoniae bacteremia: implications of extended-spectrum beta-lactamase production in nosocomial Infections." Annals of Internal Medicine, vol. 140, no. 1, 2004, pp. 26-32. |
| Rice LB, Carias L, Rudin S, Vael C, Goossens H, Konstabel C, Klare I, Nallapareddy SR, Huang W, Murray BE. "A potential virulence gene, hylEfm, predominates in Enterococcus faecium of clinical origin." The Journal of Infectious Diseases, vol. 187, no. 3, 2003, pp. 508-12. |
| Feucht CL, Rice LB. "An interventional program to improve antibiotic use." Annals of Pharmacotherapy, vol. 37, no. 5, 2003, pp. 646-51. |
| Rice LB. "Collateral damage." Annals of Internal Medicine, vol. 139, no. 6, 2003, pp. 523-4. |
| Rice LB. "Controlling antibiotic resistance in the ICU: different bacteria, different strategies." Cleveland Clinic Journal of Medicine, vol. 70, no. 9, 2003, pp. 793-800. |
| Rice LB. "Do we really need new anti-infective drugs?." Current opinion in pharmacology, vol. 3, no. 5, 2003, pp. 459-63. |
| Paterson DL, Rice LB. "Empirical antibiotic choice for the seriously ill patient: are minimization of selection of resistant organisms and maximization of individual outcome mutually exclusive?." Clinical Infectious Diseases, vol. 36, no. 8, 2003, pp. 1006-12. |
| Paterson DL, Hujer KM, Hujer AM, Yeiser B, Bonomo MD, Rice LB, Bonomo RA, International Klebsiella Study Group. "Extended-spectrum beta-lactamases in Klebsiella pneumoniae bloodstream isolates from seven countries: dominance and widespread prevalence of SHV- and CTX-M-type beta-lactamases." Antimicrobial Agents and Chemotherapy, vol. 47, no. 11, 2003, pp. 3554-60. |
| Lobritz M, Hutton-Thomas R, Marshall S, Rice LB. "Recombination proficiency influences frequency and locus of mutational resistance to linezolid in Enterococcus faecalis." Antimicrobial Agents and Chemotherapy, vol. 47, no. 10, 2003, pp. 3318-20. |
| Donskey CJ, Hujer AM, Das SM, Pultz NJ, Bonomo RA, Rice LB. "Use of denaturing gradient gel electrophoresis for analysis of the stool microbiota of hospitalized patients." Journal of microbiological methods, vol. 54, no. 2, 2003, pp. 249-56. |
| Hoyen CM, Hujer AM, Hujer KM, Marshall SH, Carias L, Toltzis P, Rice LB, Bonomo RA. "A clinical strain of Escherichia coli possessing CMY-2 plasmid-mediated amp C beta-lactamase: an emerging concern in pediatrics?." Microbial drug resistance (Larchmont, N.Y.), vol. 8, no. 4, 2002, pp. 329-33. |
| Lidsky K, Hoyen C, Salvator A, Rice LB, Toltzis P. "Antibiotic-resistant gram-negative organisms in pediatric chronic-care facilities." Clinical Infectious Diseases, vol. 34, no. 6, 2002, pp. 760-6. |
| Rice LB. "Association of different mobile elements to generate novel integrative elements." Cellular and molecular life sciences : CMLS, vol. 59, no. 12, 2002, pp. 2023-32. |
| Marshall SH, Donskey CJ, Hutton-Thomas R, Salata RA, Rice LB. "Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis." Antimicrobial Agents and Chemotherapy, vol. 46, no. 10, 2002, pp. 3334-6. |
| Rice LB. "Antimicrobial pressure and the emergence and spread of multiresistant enterococci." Postgraduate Medicine, vol. 109, no. 2 Suppl, 2001, pp. 22-31. |
| Rice LB. "Emergence of vancomycin-resistant enterococci." Emerging infectious diseases, vol. 7, no. 2, 2001, pp. 183-7. |
| Donskey CJ, Hume ME, Callaway TR, Das SM, Hoyen CK, Rice LB. "Inhibition of vancomycin-resistant enterococci by an in vitro continuous-flow competitive exclusion culture containing human stool flora." The Journal of Infectious Diseases, vol. 184, no. 12, 2001, pp. 1624-7. |
| Rice LB. "Mobilization of transposons : rationale and techniques for detection." Methods in molecular medicine, vol. 48, 2001, pp. 275-84. |
| Paterson DL, Ko WC, Von Gottberg A, Casellas JM, Mulazimoglu L, Klugman KP, Bonomo RA, Rice LB, McCormack JG, Yu VL. "Outcome of cephalosporin treatment for serious infections due to apparently susceptible organisms producing extended-spectrum beta-lactamases: implications for the clinical microbiology laboratory." Journal of clinical microbiology, vol. 39, no. 6, 2001, pp. 2206-12. |
| Rice LB, Carias LL, Hutton-Thomas R, Sifaoui F, Gutmann L, Rudin SD. "Penicillin-binding protein 5 and expression of ampicillin resistance in Enterococcus faecium." Antimicrobial Agents and Chemotherapy, vol. 45, no. 5, 2001, pp. 1480-6. |
| Paterson DL, Rice LB, Bonomo RA. "Rapid method of extraction and analysis of extended-spectrum beta-lactamases from clinical strains of Klebsiella pneumoniae." Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, vol. 7, no. 12, 2001, pp. 709-11. |
| Rice LB. "Bacterial monopolists: the bundling and dissemination of antimicrobial resistance genes in gram-positive bacteria." Clinical Infectious Diseases, vol. 31, no. 3, 2000, pp. 762-9. |
| Rice LB, Bonomo RA. "beta -Lactamases: which ones are clinically important?." Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, vol. 3, no. 3, 2000, pp. 178-189. |
| Donskey CJ, Chowdhry TK, Hecker MT, Hoyen CK, Hanrahan JA, Hujer AM, Hutton-Thomas RA, Whalen CC, Bonomo RA, Rice LB. "Effect of antibiotic therapy on the density of vancomycin-resistant enterococci in the stool of colonized patients." New England Journal of Medicine, vol. 343, no. 26, 2000, pp. 1925-32. |
| Donskey CJ, Hanrahan JA, Hutton RA, Rice LB. "Effect of parenteral antibiotic administration on the establishment of colonization with vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tract." The Journal of Infectious Diseases, vol. 181, no. 5, 2000, pp. 1830-3. |
| Hanrahan J, Hoyen C, Rice LB. "Geographic distribution of a large mobile element that transfers ampicillin and vancomycin resistance between Enterococcus faecium strains." Antimicrobial Agents and Chemotherapy, vol. 44, no. 5, 2000, pp. 1349-51. |
| Rice LB, Carias LL, Hujer AM, Bonafede M, Hutton R, Hoyen C, Bonomo RA. "High-level expression of chromosomally encoded SHV-1 beta-lactamase and an outer membrane protein change confer resistance to ceftazidime and piperacillin-tazobactam in a clinical isolate of Klebsiella pneumoniae." Antimicrobial Agents and Chemotherapy, vol. 44, no. 2, 2000, pp. 362-7. |
| Romeo JH, Rice LB, McQuarrie IG. "Hydrocephalus in coccidioidal meningitis: case report and review of the literature." Neurosurgery, vol. 47, no. 3, 2000, pp. 773-7. |
| John JF Jr, Rice LB. "The microbial genetics of antibiotic cycling." Infection Control & Hospital Epidemiology, vol. 21, no. 1 Suppl, 2000, pp. S22-31. |
| Rice LB. "Therapeutic considerations in the treatment of respiratory infections caused by ceftazidime-resistant Klebsiella pneumoniae." Seminars in Respiratory and Critical Care Medicine, vol. 21, no. 4, 2000, pp. 323-9. |
| Donskey CJ, Schreiber JR, Jacobs MR, Shekar R, Salata RA, Gordon S, Whalen CC, Smith F, Rice LB. "A polyclonal outbreak of predominantly VanB vancomycin-resistant enterococci in northeast Ohio. Northeast Ohio Vancomycin-Resistant Enterococcus Surveillance Program." Clinical Infectious Diseases, vol. 29, no. 3, 1999, pp. 573-9. |
| Rice LB. "A silver bullet for colonization and infection with methicillin-resistant Staphylococcus aureus still eludes us." Clinical Infectious Diseases, vol. 28, no. 5, 1999, pp. 1067-70. |
| Ghannoum MA, Rice LB. "Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance." Clinical microbiology reviews, vol. 12, no. 4, 1999, pp. 501-17. |
| Donskey CJ, Hanrahan JA, Hutton RA, Rice LB. "Effect of parenteral antibiotic administration on persistence of vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tract." The Journal of Infectious Diseases, vol. 180, no. 2, 1999, pp. 384-90. |
| Bonomo RA, Rice LB. "Emerging issues in antibiotic resistant infections in long-term care facilities." The Journals of Gerontology: Series A, vol. 54, no. 6, 1999, pp. B260-7. |
| Bonomo RA, Rice LB. "Inhibitor resistant class A beta-lactamases." Frontiers in Bioscience, vol. 4, 1999, pp. e34-41. |
| Rice LB. "Successful interventions for gram-negative resistance to extended-spectrum beta-lactam antiobiotics." Pharmacotherapy, vol. 19, no. 8 Pt 2, 1999, pp. 120S-128S; discussion 133S-137S. |
| Carias LL, Rudin SD, Donskey CJ, Rice LB. "Genetic linkage and cotransfer of a novel, vanB-containing transposon (Tn5382) and a low-affinity penicillin-binding protein 5 gene in a clinical vancomycin-resistant Enterococcus faecium isolate." Journal of bacteriology, vol. 180, no. 17, 1998, pp. 4426-34. |
| Rice LB. "Tn916 family conjugative transposons and dissemination of antimicrobial resistance determinants." Antimicrobial Agents and Chemotherapy, vol. 42, no. 8, 1998, pp. 1871-7. |
| Rice LB, Carias LL. "Transfer of Tn5385, a composite, multiresistance chromosomal element from Enterococcus faecalis." Journal of bacteriology, vol. 180, no. 3, 1998, pp. 714-21. |
| Rice LB, Carias LL, Donskey CL, Rudin SD. "Transferable, plasmid-mediated vanB-type glycopeptide resistance in Enterococcus faecium." Antimicrobial Agents and Chemotherapy, vol. 42, no. 4, 1998, pp. 963-4. |
| Bonafede M, Rice LB. "Emerging antibiotic resistance." The Journal of laboratory and clinical medicine, vol. 130, no. 6, 1997, pp. 558-66. |
| Bonafede ME, Carias LL, Rice LB. "Enterococcal transposon Tn5384: evolution of a composite transposon through cointegration of enterococcal and staphylococcal plasmids." Antimicrobial Agents and Chemotherapy, vol. 41, no. 9, 1997, pp. 1854-8. |
| Rice LB, Eckstein EC, DeVente J, Shlaes DM. "Ceftazidime-resistant Klebsiella pneumoniae isolates recovered at the Cleveland Department of Veterans Affairs Medical Center." Clinical Infectious Diseases, vol. 23, no. 1, 1996, pp. 118-24. |
| Rice LB, Carias LL, Bonomo RA, Shlaes DM. "Molecular genetics of resistance to both ceftazidime and beta-lactam-beta-lactamase inhibitor combinations in Klebsiella pneumoniae and in vivo response to beta-lactam therapy." The Journal of Infectious Diseases, vol. 173, no. 1, 1996, pp. 151-8. |
| Rice LB, Carias LL, Marshall SH, Bonafede ME. "Sequences found on staphylococcal beta-lactamase plasmids integrated into the chromosome of Enterococcus faecalis CH116." Plasmid, vol. 35, no. 2, 1996, pp. 81-90. |
| Rice LB, Murray BE. "Beta-lactamase-producing enterococci." Developments in biological standardization, vol. 85, 1995, pp. 107-14. |
| Boyce JM, Mermel LA, Zervos MJ, Rice LB, Potter-Bynoe G, Giorgio C, Medeiros AA. "Controlling vancomycin-resistant enterococci." Infection Control & Hospital Epidemiology, vol. 16, no. 11, 1995, pp. 634-7. |
| Rice LB, Carias LL, Marshall SH. "Tn5384, a composite enterococcal mobile element conferring resistance to erythromycin and gentamicin whose ends are directly repeated copies of IS256." Antimicrobial Agents and Chemotherapy, vol. 39, no. 5, 1995, pp. 1147-53. |
| Rice LB, Carias LL, Marshall SH. "Tn5384, an IS256-based composite mobile element in Enterococcus faecalis." Developments in biological standardization, vol. 85, 1995, pp. 71-5. |
| Rice LB, Shlaes DM. "Vancomycin resistance in the enterococcus. Relevance in pediatrics." Pediatric Clinics of North America, vol. 42, no. 3, 1995, pp. 601-18. |
| Shlaes DM, Rice LB. "Bacterial resistance to the cyclic glycopeptides." Trends in microbiology, vol. 2, no. 10, 1994, pp. 385-8. |
| Rice LB, Carias LL, Shlaes DM. "In vivo efficacies of beta-lactam-beta-lactamase inhibitor combinations against a TEM-26-producing strain of Klebsiella pneumoniae." Antimicrobial Agents and Chemotherapy, vol. 38, no. 11, 1994, pp. 2663-4. |
| Rice LB, Marshall SH. "Insertions of IS256-like element flanking the chromosomal beta-lactamase gene of Enterococcus faecalis CX19." Antimicrobial Agents and Chemotherapy, vol. 38, no. 4, 1994, pp. 693-701. |
| Rice LB, Carias LL. "Studies on excision of conjugative transposons in enterococci: evidence for joint sequences composed of strands with unequal numbers of nucleotides." Plasmid, vol. 31, no. 3, 1994, pp. 312-6. |
| Rice LB, Thorisdottir AS. "The prevalence of sequences homologous to IS256 in clinical enterococcal isolates." Plasmid, vol. 32, no. 3, 1994, pp. 344-9. |
| Rice LB, Carias LL, Shlaes DM. "Efficacy of ampicillin-sulbactam versus that of cefoxitin for treatment of Escherichia coli infections in a rat intra-abdominal abscess model." Antimicrobial Agents and Chemotherapy, vol. 37, no. 3, 1993, pp. 610-2. |
| Shlaes DM, Binczewski B, Rice LB. "Emerging antimicrobial resistance and the immunocompromised host." Clinical Infectious Diseases, vol. 17 Suppl 2, 1993, pp. S527-36. |
| Rice LB, Carias LL, Etter L, Shlaes DM. "Resistance to cefoperazone-sulbactam in Klebsiella pneumoniae: evidence for enhanced resistance resulting from the coexistence of two different resistance mechanisms." Antimicrobial Agents and Chemotherapy, vol. 37, no. 5, 1993, pp. 1061-4. |
| Rice LB, Marshall SH, Carias LL, Sutton L, Jacoby GA. "Sequences of MGH-1, YOU-1, and YOU-2 extended-spectrum beta-lactamase genes." Antimicrobial Agents and Chemotherapy, vol. 37, no. 12, 1993, pp. 2760-1. |
| Rice LB, Marshall SH. "Evidence of incorporation of the chromosomal beta-lactamase gene of Enterococcus faecalis CH19 into a transposon derived from staphylococci." Antimicrobial Agents and Chemotherapy, vol. 36, no. 9, 1992, pp. 1843-6. |
| Rice LB, Eliopoulos CT, Yao JD, Eliopoulos GM, Moellering RC Jr. "In vivo activity of the combination of daptomycin and fosfomycin compared with daptomycin alone against a strain of Enterococcus faecalis with high-level gentamicin resistance in the rat endocarditis model." Diagnostic microbiology and infectious disease, vol. 15, no. 2, 1992, pp. 173-6. |
| Rice LB, Marshall SH, Carias LL. "Tn5381, a conjugative transposon identifiable as a circular form in Enterococcus faecalis." Journal of bacteriology, vol. 174, no. 22, 1992, pp. 7308-15. |
| Rice LB, Eliopoulos GM, Wennersten C, Goldmann D, Jacoby GA, Moellering RC Jr. "Chromosomally mediated beta-lactamase production and gentamicin resistance in Enterococcus faecalis." Antimicrobial Agents and Chemotherapy, vol. 35, no. 2, 1991, pp. 272-6. |
| Rice LB, Yao JD, Klimm K, Eliopoulos GM, Moellering RC Jr. "Efficacy of different beta-lactams against an extended-spectrum beta-lactamase-producing Klebsiella pneumoniae strain in the rat intra-abdominal abscess model." Antimicrobial Agents and Chemotherapy, vol. 35, no. 6, 1991, pp. 1243-4. |
| Rice LB, Calderwood SB, Eliopoulos GM, Farber BF, Karchmer AW. "Enterococcal endocarditis: a comparison of prosthetic and native valve disease." Reviews of infectious diseases, vol. 13, no. 1, 1991, pp. 1-7. |
| Murray BE, Singh KV, Markowitz SM, Lopardo HA, Patterson JE, Zervos MJ, Rubeglio E, Eliopoulos GM, Rice LB, Goldstein FW. "Evidence for clonal spread of a single strain of beta-lactamase-producing Enterococcus (Streptococcus) faecalis to six hospitals in five states." The Journal of Infectious Diseases, vol. 163, no. 4, 1991, pp. 780-5. |
| Eliopoulos GM, Klimm K, Rice LB, Ferraro MJ, Moellering RC Jr. "Comparative in vitro activity of WIN 57273, a new fluoroquinolone antimicrobial agent." Antimicrobial Agents and Chemotherapy, vol. 34, no. 6, 1990, pp. 1154-9. |
| Thauvin-Eliopoulos C, Rice LB, Eliopoulos GM, Moellering RC Jr. "Efficacy of oxacillin and ampicillin-sulbactam combination in experimental endocarditis caused by beta-lactamase-hyperproducing Staphylococcus aureus." Antimicrobial Agents and Chemotherapy, vol. 34, no. 5, 1990, pp. 728-32. |
| Rice LB, Willey SH, Papanicolaou GA, Medeiros AA, Eliopoulos GM, Moellering RC Jr, Jacoby GA. "Outbreak of ceftazidime resistance caused by extended-spectrum beta-lactamases at a Massachusetts chronic-care facility." Antimicrobial Agents and Chemotherapy, vol. 34, no. 11, 1990, pp. 2193-9. |
| Rice LB, Eliopoulos GM. "Imipenem and aztreonam: current role in antimicrobial therapy." Current clinical topics in infectious diseases, vol. 10, 1989, pp. 109-39. |
| Rice LB, Eliopoulos GM, Moellering RC Jr. "In vitro synergism between daptomycin and fosfomycin against Enterococcus faecalis isolates with high-level gentamicin resistance." Antimicrobial Agents and Chemotherapy, vol. 33, no. 4, 1989, pp. 470-3. |
| Hindes RG, Willey SH, Eliopoulos GM, Rice LB, Eliopoulos CT, Murray BE, Moellering RC Jr. "Treatment of experimental endocarditis caused by a beta-lactamase-producing strain of Enterococcus faecalis with high-level resistance to gentamicin." Antimicrobial Agents and Chemotherapy, vol. 33, no. 7, 1989, pp. 1019-22. |
| Rice LB, Karchmer AW. "Artificial heart implantation: what limitations are imposed by infectious complications?." JAMA, vol. 259, no. 6, 1988, pp. 894-5. |
| Year | Degree | Institution |
|---|---|---|
| 1983 | MD | Columbia University |
| 1977 | AB | Harvard University |
Joseph Garrison Parker Award - Columbia University College of Physicians and Surgeons awarded by classmates to the student exemplifying through activities in art, music and literature, and the public interest the fact that living and learning go together, 1983
Selected as a speaker for the Foundation for Microbiology Lectures Program, 1998-2000
Federal Executive Board “Wings of Excellence” Award, 2000
Inpatient Teacher of the Year – Awarded by the University Hospitals Cleveland/Cleveland VA
Medical Center Medical House Staff, 2001-2002
Kaiser-Permanente Award for Teaching Excellence. Awarded by the Case Western Reserve University School of Medicine Class of 2003, 2002-2003
Keynote Speaker, 46th Interscience Conference on Antimicrobial Agents and Chemotherapy.
San Francisco, CA, September 17, 2006.
Maxwell Finland Lecture. Annual Meeting of the Infectious Diseases Society of America, 2007
Master of Arts ad eundem, Brown University, 2014
Dancing with the Doctors benefit for Leukemia and Lymphoma Society, People’s Choice Award, April, 2015.
Women’s Resource Center Men Who Make a Difference honoree. April 22, 2017.
Rhode Island Hospital
The Miriam Hospital
Women's and Infants Hospital
Memorial Hospital
Providence VA Medical Center
