1) Analysis of novel diagnostic and prognostic markers in gastrointestinal malignancies using molecular techniques;
2) Developing machine learning algorithms to assist pathologists and translational researchers. Focus areas include inflammatory bowel disease, Non-Alcoholic Steatohepatitis and immunoncology

Current:

COBRE Center for Cancer Research Development  

#5 P20 GM103421 Molecular Pathology CoreNational Institutes of Health/National Institute of General Medical Sciences  09/30/02 – 04/30/14 NCE            Role:  Co-Investigator

 A Phase III Trial Evaluating the Addition of Trastuzumab to Trimodality Treatment of HER2 Overexpressing Esophageal Adenocarcinoma                   

#RTOG-1010 National Institutes of Health NCI CTROC BIQSFP Radiation Therapy Oncology Group

01/01/10-12/31/14

Role:  Co-Principal Investigator

Single Agent Adjuvant Aflibercept for Patients with Resected or Ablated Metastatic Colorectal Cancer:  A Randomized Phase II Study         #BrUOG-261 SANOFI

12/01/12-11/31/13

Role:  Co-Investigator

 Lu S, Mukkada VA, Mangray S, Cleveland K, Shillingford N, et al (2012) MicroRNA profiling in mucosal biopsies of eosinophilic     esophagitis patients pre and post glucocorticoid steroid treatment and relationship with mRNA target expression. PLoS One 7:e40676

Cao W, Tian W, Hong J, Li D, Tavares R, et al (2013) Expression of bile acid receptor TGR5 in gastric adenocarcinoma. Am J Phys Gast and Liver 304:G322-27.

Lu S, Singh K, Magray S, Tavares R, Nobel L, et al (2013) Claudin expression in high grade invasive ductal carcinoma of the breast. Mod Pathol 26:485-95.

Matoso A, Mukkada V, Lu S Monahan R, Cleveland K, Noble L, Mangray S, Resnick MB. (2013) Expression microarray analysis identifies novel epithelial derived proteins in eosinophilic esophagitis. Mod Pathol  26:665-672.

Taliano RJ, Lu S, Singh K, Mangray S, Tavares R, Nobel L, et al (2013) Calretinin expression in high grade invasive ductal carcinoma of the breast is associated with basal-like subtype and unfavorable prognosis. Human Pathology 44:2743-50.

Matoso A, Allen D, Herzlinger M, Ferreira J, Chen S, Lu S, et al (2014) Correlation of ALOX15 expression with eosinophilic or reflux esophagitis in a cohort of pediatric patients with esophageal eosinophilia. Human Pathology (accepted for publication).

Sargent DJ, Shi Q, Gill S, Louvet C, Everson RB, Kellner U, et al (2014) Molecular testing for lymph node metastases as a determinant of colon cancer recurrence: results from a retrospective multicenter study. Clin Can Res (accepted for publication).

Ronald DeLellis Mentoring Award, Department of Pathology and Laboratory Medicine,

    Brown University Medical School 2012

Certificate of Recognition, Exemplary Teaching, Brown Medical School 2009-2010

Dean’s Teaching Excellence Award, Brown Medical School 2008-2009

Dean’s Teaching Excellence Award, Brown Medical School 2005-2006

Dean’s Teaching Excellence Award, Brown Medical School 2004-2005

Listed in Best Doctors in America 2007-present

Fulver Foundation Scholarship for excellence in studies, 1985

Foulkes Foundation Scholarship for excellence in studies, 1984-1987

ACADEMIC APPOINTMENTS

2005-present   Professor of Pathology Brown University Medical School, Providence, RI

2002-2005       Associate Professor of Pathology, Brown University Medical School, Providence, RI

1997-2002       Senior Lecturer Basic Sciences, Technion Medical School, Haifa, Israel

1990-1995       Clinical and Research Fellow, Harvard Medical School, Boston, MA

HOSPITAL APPOINTMENTS

2022-present   Pathologist-in-Chief, Lifespan Medical Center

2012-2019       Vice Chief of Pathology and Director of Anatomical Pathology, Rhode Island Hospital and The Miriam Hospital, Providence, RI

2010-2012       Interim Chief of Pathology, Rhode Island Hospital and The Miriam Hospital, Providence, RI

2003-present   Director of Surgical Pathology, Rhode Island Hospital and The Miriam Hospital, Providence, RI

2002-present   Director of Gastrointestinal Pathology, Rhode Island Hospital and The Miriam Hospital, Providence, RI

1999-2001       Consultant Pathologist, Brigham and Women’s Hospital and Childrens  Hospital, Boston, MA

1997-2002       Director, Department of Pathology, Carmel Medical Center, Haifa, Israel

1996-1997       Director of Gastrointestinal Pathology Unit, Carmel Medical Center, Haifa, Israel

1995-1996       Senior Pathologist, Sourasky Medical Center, Tel-Aviv, Israel

INDUSTRY EXPERIENCE

2019-2022       Chief of Pathology, PATH-AI, Boston, MA

1999-2002       Medical Advisor, Proteologics, Rehovot, Israel

Membership in Societies:

American Association of Directors of Surgical Pathologists

American Gastroenterological Association

United States and Canadian Academy of Pathology

Roger Haggitt Gastrointestinal Pathology Society

Arthur Purdy Stout Society of Pathology

American Association for Cancer Research

2003-present   Director, Gastrointestinal Pathology Fellowship Program, Rhode Island Hospital

2003-2009       Director Surgical Pathology Fellowship Program, Rhode Island Hospital

2002-present   Pathology Residents, Rhode Island Hospital, approx. five one-hour teaching sessions per year, 12 students

2002-present   Gastrointestinal (Medicine) Fellows, Rhode Island Hospital, one month tutorial per fellow, per year (2-3 fellows per year)

2002-present  Pathology Residents and Fellows, Rhode Island Hospital, approximately 250 hours of direct microscopy training sessions each year.