Attending Neurosurgeon Rhode Island Hospital, Providence RI
Director Pediatric Neurosurgery Division
Director Research Center and Clinic for Cerebrospinal Fluid Disorders
Co-Editor "Clinical Neurology and Neurosurgery"
Editor “Interdisciplinary Neurosurgery: Advanced Techniques and Case Management”
| Adam A, Robison J, Lu J, Jose R, Badran N, Vivas-Buitrago T, Rigamonti D, Sattar A, Omoush O, Hammad M, Dawood M, Maghaslah M, Belcher T, Carson K, Hoffberger J, Jusué Torres I, Foley S, Yasar S, Thai QA, Wemmer J, Klinge P, Al-Mutawa L, Al-Ghamdi H, Carson KA, Asgari M, de Zélicourt D, Kurtcuoglu V, Garnotel S, Salmon S, Balédent O, Lokossou A, Page G, Balardy L, Czosnyka Z, Payoux P, Schmidt EA, Zitoun M, Sevestre MA, Alperin N, Baudracco I, Craven C, Matloob S, Thompson S, Haylock Vize P, Thorne L, Watkins LD, Toma AK, Bechter K, Pong AC, Jugé L, Bilston LE, Cheng S, Bradley W, Hakim F, Ramón JF, Cárdenas MF, Davidson JS, García C, González D, Bermúdez S, Useche N, Mejía JA, Mayorga P, Cruz F, Martinez C, Matiz MC, Vallejo M, Ghotme K, Soto HA, Riveros D, Buitrago A, Mora M, Murcia L, Bermudez S, Cohen D, Dasgupta D, Curtis C, Domínguez L, Remolina AJ, Grijalba MA, Whitehouse KJ, Edwards RJ, Eleftheriou A, Lundin F, Fountas KN, Kapsalaki EZ, Smisson HF, Robinson JS, Fritsch MJ, Arouk W, Garzon M, Kang M, Sandhu K, Baghawatti D, Aquilina K, James G, Thompson D, Gehlen M, Schmid Daners M, Eklund A, Malm J, Gomez D, Guerra M, Jara M, Flores M, Vío K, Moreno I, Rodríguez S, Ortega E, Rodríguez EM, McAllister JP, Guerra MM, Morales DM, Sival D, Jimenez A, Limbrick DD, Ishikawa M, Yamada S, Yamamoto K, Junkkari A, Häyrinen A, Rauramaa T, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Luikku A, Jääskeläinen JE, Leinonen V, Kehler U, Lilja-Lund O, Kockum K, Larsson EM, Riklund K, Söderström L, Hellström P, Laurell K, Kojoukhova M, Sutela A, Vanninen R, Vanha KI, Timonen M, Rummukainen J, Korhonen V, Helisalmi S, Solje E, Remes AM, Huovinen J, Paananen J, Hiltunen M, Kurki M, Martin B, Loth F, Luciano M, Luikku AJ, Hall A, Herukka SK, Mattila J, Lötjönen J, Alafuzoff I, Jurjević I, Miyajima M, Nakajima M, Murai H, Shin T, Kawaguchi D, Akiba C, Ogino I, Karagiozov K, Arai H, Reis RC, Teixeira MJ, Valêncio CG, da Vigua D, Almeida-Lopes L, Mancini MW, Pinto FCG, Maykot RH, Calia G, Tornai J, Silvestre SSS, Mendes G, Sousa V, Bezerra B, Dutra P, Modesto P, Oliveira MF, Petitto CE, Pulhorn H, Chandran A, McMahon C, Rao AS, Jumaly M, Solomon D, Moghekar A, Relkin N, Hamilton M, Katzen H, Williams M, Bach T, Zuspan S, Holubkov R, Rigamonti A, Clemens G, Sharkey P, Sanyal A, Sankey E, Rigamonti K, Naqvi S, Hung A, Schmidt E, Ory-Magne F, Gantet P, Guenego A, Januel AC, Tall P, Fabre N, Mahieu L, Cognard C, Gray L, Buttner-Ennever JA, Takagi K, Onouchi K, Thompson SD, Thorne LD, Tully HM, Wenger TL, Kukull WA, Doherty D, Dobyns WB, Moran D, Vakili S, Patel MA, Elder B, Goodwin CR, Crawford JA, Pletnikov MV, Xu J, Blitz A, Herzka DA, Guerrero-Cazares H, Quiñones-Hinojosa A, Mori S, Saavedra P, Treviño H, Maitani K, Ziai WC, Eslami V, Nekoovaght-Tak S, Dlugash R, Yenokyan G, McBee N, Hanley DF. "Abstracts from Hydrocephalus 2016." Fluids and barriers of the CNS, vol. 14, no. Suppl 1, 2017, pp. 15. |
| Doberstein CA, Torabi R, Klinge PM. "Current Concepts in the Pathogenesis, Diagnosis, and Management of Type I Chiari Malformations." Rhode Island medical journal (2013), vol. 100, no. 6, 2017, pp. 47-49. |
| Henderson FC Sr, Austin C, Benzel E, Bolognese P, Ellenbogen R, Francomano CA, Ireton C, Klinge P, Koby M, Long D, Patel S, Singman EL, Voermans NC. "Neurological and spinal manifestations of the Ehlers-Danlos syndromes." American journal of medical genetics. Part C, Seminars in medical genetics, vol. 175, no. 1, 2017, pp. 195-211. |
| Carnevale JA, Ahmedli N, Morrison JF, Asaad WF, Klinge P, Telfeian A. "T-Connector Modification for Reducing Recurrent Distal Shunt Failure: Report of 2 Cases." Operative neurosurgery (Hagerstown, Md.), vol. 13, no. 6, 2017, pp. E33-E36. |
| Ha, Austin, Mangham, William, Frommer, Sarah, Choi, David, Klinge, Petra, Taylor, Helena, Oyelese, Adetokunbo, Sullivan, Stephen. "Interdisciplinary Management of Minimally Displaced Orbital Roof Fractures: Delayed Pulsatile Exophthalmos and Orbital Encephalocele." Craniomaxillofacial Trauma and Reconstruction, vol. 10, no. 01, 2016, pp. 11-15. |
| Iyengar, Rajiv J., Klinge, Petra M., Chen, Wendy S., Boxerman, Jerrold L., Sullivan, Stephen R., Taylor, Helena O. "Management of Craniosynostosis at an Advanced Age: Controversies, Clinical Findings, and Surgical Treatment." Journal of Craniofacial Surgery, vol. 27, no. 5, 2016, pp. e435-41. |
| Carnevale JA, Morrison JF, Choi DB, Klinge PM, Cosgrove GR, Oyelese AA. "Self-inflicted nail-gun injury with cranial penetration and use of intraoperative computed tomography." Surgical neurology international, vol. 7, no. Suppl 10, 2016, pp. S259-62. |
| Tracy, Aaron, Klinge, Petra, Morrison, John, Jayaraman, Mahesh V., Kriz, Peter K. "Traumatic Superficial Temporal Artery Pseudoaneurysm in a Helmeted Lacrosse Player." Current Sports Medicine Reports, vol. 15, no. 1, 2016, pp. 13-5. |
| Rossetti MA, Piryatinsky I, Ahmed FS, Klinge PM, Relkin NR, Salloway S, Ravdin LD, Brenner E, Malloy PF, Levin BE, Broggi M, Gavett R, Maniscalco JS, Katzen H. "Two Novel Psychomotor Tasks in Idiopathic Normal Pressure Hydrocephalus." Journal of the International Neuropsychological Society, vol. 22, no. 3, 2016, pp. 341-9. |
| Brinker T, Stopa E, Morrison J, Klinge P. "A new look at cerebrospinal fluid circulation." Fluids and barriers of the CNS, vol. 11, no. 1, 2014, pp. 10. |
| Phillips BZ, Taylor HO, Klinge PM, Sullivan SR. "Piezoelectric technology for pediatric autologous cranioplasty." The Cleft Palate-Craniofacial Journal, vol. 51, no. 3, 2014, pp. 361-4. |
| Fehnel CR, Wendell LC, Potter NS, Klinge P, Thompson BB. "Severe cerebral vasospasm after traumatic brain injury." Rhode Island medical journal (2013), vol. 97, no. 7, 2014, pp. 45-6. |
| Cossman JP, Morrison CS, Taylor HO, Salter AB, Klinge PM, Sullivan SR. "Traumatic orbital roof fractures: interdisciplinary evaluation and management." Plastic and Reconstructive Surgery, vol. 133, no. 3, 2014, pp. 335e-343e. |
| Klinge, Petra M. "Welcome to Interdisciplinary Neurosurgery." Interdisciplinary Neurosurgery, vol. 1, no. 1, 2014, pp. 1-2. |
| Taylor EM, Klinge PM, Sullivan SR, Taylor HO. "Cerebrospinal fluid leak masquerading as a decubitus ulcer in a patient with spina bifida." Eplasty, vol. 13, 2013, pp. ic62. |
| Klinge, Petra, Malloy, Paul, Salloway, Stephen, Blennow, Kaj. "Outcome of shunt surgery for normal pressure hydrocephalus in patients with and without comorbid Alzheimer's disease." Alzheimer's & Dementia, vol. 9, no. 4, 2013, pp. P850. |
| Swenson DW, Nickel BJ, Boxerman JL, Klinge PM, Rogg JM. "Prenatal MRI characterization of brainstem glioma." Pediatr Radiol, vol. 43, no. 10, 2013, pp. 1404-7. |
| Hellström, P., Klinge, P., Tans, J., Wikkelsø, C. "A new scale for assessment of severity and outcome in iNPH." Acta Neurologica Scandinavica, vol. 126, no. 4, 2012, pp. 229-237. |
| Klinge PM. "Idiopathic normal pressure hydrocephalus--neurosurgical management of dementia!." Medicine and health, Rhode Island, vol. 95, no. 3, 2012, pp. 86-7. |
| Mirzayan MJ, Klinge PM, Samii M, Goetz F, Krauss JK. "MRI safety of a programmable shunt assistant at 3 and 7 Tesla." British Journal of Neurosurgery, vol. 26, no. 3, 2012, pp. 397-400. |
| Klinge, P., Hellström, P., Tans, J., Wikkelsø, C. "One-year outcome in the European multicentre study on iNPH." Acta Neurologica Scandinavica, vol. 126, no. 3, 2012, pp. 145-153. |
| Karian LS, Phillips BZ, Morrison CS, Klinge PM, Sullivan SR, Taylor HO. "Technology to minimize the morbidity of Le Fort III osteotomies." Plastic and Reconstructive Surgery, vol. 130, no. 1, 2012, pp. 210e-212e. |
| Wikkelso, C., Hellstrom, P., Klinge, P. M., Tans, J. T. J. "The European iNPH Multicentre Study on the predictive values of resistance to CSF outflow and the CSF Tap Test in patients with idiopathic normal pressure hydrocephalus." Journal of Neurology, Neurosurgery & Psychiatry, vol. 84, no. 5, 2012, pp. 562-568. |
| Hellström, Per, Klinge, Petra, Tans, Jos, Wikkelsø, Carsten. "The neuropsychology of iNPH: Findings and evaluation of tests in the European multicentre study." Clinical Neurology and Neurosurgery, vol. 114, no. 2, 2012, pp. 130-134. |
| Kleinschmidt K, Klinge PM, Stopa E, Wallrapp C, Glage S, Geigle P, Brinker T. "Alginate encapsulated human mesenchymal stem cells suppress syngeneic glioma growth in the immunocompetent rat." Journal of Microencapsulation, vol. 28, no. 7, 2011, pp. 621-627. |
| Klinge, Petra M., Harmening, Kathrin, Miller, Miles C., Heile, Anna, Wallrapp, Christine, Geigle, Peter, Brinker, Thomas. "Encapsulated native and glucagon-like peptide-1 transfected human mesenchymal stem cells in a transgenic mouse model of Alzheimer's disease." Neuroscience Letters, vol. 497, no. 1, 2011, pp. 6-10. |
| Glage, Silke, Klinge, Petra M, Miller, Miles C, Wallrapp, Christine, Geigle, Peter, Hedrich, Hans J, Brinker, Thomas. "Therapeutic concentrations of glucagon-like peptide-1 in cerebrospinal fluid following cell-based delivery into the cerebral ventricles of cats." Fluids Barriers CNS, vol. 8, no. 1, 2011, pp. 18. |
| Silverberg GD, Miller MC, Machan JT, Johanson CE, Caralopoulos IN, Pascale CL, Heile A, Klinge PM. "Amyloid and Tau accumulate in the brains of aged hydrocephalic rats." Brain Research, vol. 1317, 2010, pp. 286-296. |
| Duncan, John, Caralopoulos, Ilias, Noren, Georg, Stopa, Edward, Silverberg, Gerald, Klinge, Petra, Donahue, John, Park, Michael, Miller, Miles, Johanson, Conrad. "A porcine model of hydrocephalus induced by gamma knife irradiation." Cerebrospinal Fluid Research, vol. 6, no. Suppl 2, 2009, pp. S40. |
| Heile, Anna M.B., Wallrapp, Christine, Klinge, Petra M., Samii, Amir, Kassem, Moustapha, Silverberg, Gerald, Brinker, Thomas. "Cerebral transplantation of encapsulated mesenchymal stem cells improves cellular pathology after experimental traumatic brain injury." Neuroscience Letters, vol. 463, no. 3, 2009, pp. 176-181. |
| Kelly, Kelley, Forsyth, Jennifer, Klinge, Petra, Silverberg, Gerald, Johanson, Conrad, McAllister, James P. "Clearance of amyloid-beta in experimental neonatal hydrocephalus." Cerebrospinal Fluid Research, vol. 6, no. Suppl 1, 2009, pp. S26. |
| Klinge, Petra M, Heile, Anna, Slone, Stephanie, Johanson, Conrad E, Miller, Miles, Duncan, John A, Brinker, Thomas, Silverberg, Gerald D. "Evidence of TAU pathology in kaolin-induced hydrocephalus model of the aged rat." Cerebrospinal Fluid Research, vol. 6, no. Suppl 1, 2009, pp. S37. |
| Deren, Kelley E, Forsyth, Jennifer, Abdullah, Osama, Hsu, Edward W, Klinge, Petra M, Silverberg, Gerald D, Johanson, Conrad E, McAllister, James P. "Low levels of amyloid-beta and its transporters in neonatal rats with and without hydrocephalus." Cerebrospinal Fluid Research, vol. 6, no. 1, 2009, pp. 4. |
| Harmening, Kathrin, Heile, Anna, Miller, Miles, Johanson, Conrad E, Wallrapp, Christine, Brinker, Thomas, Silverberg, Gerald D, Klinge, Petra M. "Microglial downregulation in a double transgenic mouse model associated with early-onset Alzheimer's disease (AD) after intraventricular implantation of alginate encapsulated Glukagon-like-peptide-1 (GLP-1) producing human mesenchymal stem-cells." Cerebrospinal Fluid Research, vol. 6, no. Suppl 2, 2009, pp. S15. |
| Johanson, Conrad, Messier, Arthur, Miller, Miles, Pascale, Crissey, Vasudevan, Kumar, Donahue, John, Stopa, Edward, Sabo, Ed, Caralopoulos, Ilias, Klinge, Petra, Brinker, Thomas, Silverberg, Gerald. "Periventricular destabilization and ventriculomegaly in aging rats: implications for reduced neurogenesis and cognition." Cerebrospinal Fluid Research, vol. 6, no. Suppl 2, 2009, pp. S16. |
| Gerganov VM, Klinge PM, Nouri M, Stieglitz L, Samii M, Samii A. "Prognostic clinical and radiological parameters for immediate facial nerve function following vestibular schwannoma surgery." Acta Neurochirurgica, vol. 151, no. 6, 2009, pp. 581-7; discussion 587. |
| Klinge, Petra M., Brooks, David J., Samii, Amir, Weckesser, Eva, van den Hoff, Jörg, Fricke, Harald, Brinker, Thomas, Knapp, Wolfram H., Berding, Georg. "Correlates of local cerebral blood flow (CBF) in normal pressure hydrocephalus patients before and after shunting—A retrospective analysis of [15O]H2O PET-CBF studies in 65 patients." Clinical Neurology and Neurosurgery, vol. 110, no. 4, 2008, pp. 369-375. |
| Jones, Hazel C, Klinge, Petra M. "Hydrocephalus 2008, 17–20th September, Hannover Germany: a conference report." Cerebrospinal Fluid Research, vol. 5, no. 1, 2008, pp. 19. |
| Mirzayan MJ, Klinge PM, Ude S, Hotop A, Samii M, Brinker T, Korkmaz Z, Meyer GJ, Knapp WH, Samii A. "Modified calcium accumulation after controlled cortical impact under cyclosporin A treatment: a 45Ca autoradiographic study." Neurological research, vol. 30, no. 5, 2008, pp. 476-9. |
| Johanson CE, Duncan JA 3rd, Klinge PM, Brinker T, Stopa EG, Silverberg GD. "Multiplicity of cerebrospinal fluid functions: New challenges in health and disease." Cerebrospinal fluid research, vol. 5, no. 1, 2008, pp. 10. |
| Silverberg, Gerald, Johanson, Conrad, Duncan, John, Brinker, Thomas, Slone, Stephanie, Messier, Arthur, Soltman, Sarah, Klinge, Petra. "Does NPH equal ischemia?." Cerebrospinal Fluid Research, vol. 4, no. Suppl 1, 2007, pp. S3. |
| Johanson, Conrad E, Klinge, Petra M, Soltman, Sarah, Flaherty, Stephanie, Messier, Arthur, Duncan, John A, Stopa, Edward G, Silverberg, Gerald D. "Enhanced expression of the LRP-1 transporter at the blood-CSF interface in chronic hydrocephalus." Cerebrospinal Fluid Research, vol. 4, no. Suppl 1, 2007, pp. S45. |
| Heile, Anna, Baltes, Steffen, Klinge, Petra M, Wallrapp, Christine, Brinker, Thomas. "GLP-1 secreting encapsulated human mesenchymal stem cells for neuroprotection." Cerebrospinal Fluid Research, vol. 4, no. Suppl 1, 2007, pp. S47. |
| Klinge, Petra M, Messier, Arthur, Heile, Anna, Nouri, Mohsen, Johanson, Conrad E, Duncan, John A, Brinker, Thomas, Silverberg, Gerald D. "Opposite changes in cerebellar vs. cortical blood brain barrier (BBB) expression in aged and hydrocephalic rats." Cerebrospinal Fluid Research, vol. 4, no. Suppl 1, 2007, pp. S4. |
| Klinge, Petra M., Samii, Amir, Niescken, Sabine, Brinker, Thomas, Silverberg, Gerald D. "Brain amyloid accumulates in aged rats with kaolin-induced hydrocephalus." Neuroreport, vol. 17, no. 6, 2006, pp. 657-660. |
| Klinge PM, Samii A, Niescken S, Brinker T, Silverberg GD. "Brain amyloid accumulates in aged rats with kaolin-induced hydrocephalus." Neuroreport, vol. 17, no. 6, 2006, pp. 657-60. |
| Gielow, P., Klinge, P., Knapp, W.H., Berding, G. "Synthesis and preliminary biological evaluation of [123I]Me2Pyr, a new potential ligand for imaging of central cannabinoid CB1 receptors." Applied Radiation and Isotopes, vol. 64, no. 7, 2006, pp. 763-768. |
| Marmarou, Anthony, Bergsneider, Marvin, Relkin, Norman, Klinge, Petra, Black, Peter McL. "Development of Guidelines for Idiopathic Normal-pressure Hydrocephalus: Introduction." Neurosurgery, 2005, pp. S2-1-S2-3. |
| Marmarou A, Bergsneider M, Relkin N, Klinge P, Black PM. "Development of guidelines for idiopathic normal-pressure hydrocephalus: introduction." Neurosurgery, vol. 57, no. 3 Suppl, 2005, pp. S1-3; discussion ii-v. |
| Relkin, Norman, Marmarou, Anthony, Klinge, Petra, Bergsneider, Marvin, Black, Peter McL. "Diagnosing Idiopathic Normal-pressure Hydrocephalus." Neurosurgery, 2005, pp. S2-4-S2-16. |
| Relkin N, Marmarou A, Klinge P, Bergsneider M, Black PM. "Diagnosing idiopathic normal-pressure hydrocephalus." Neurosurgery, vol. 57, no. 3 Suppl, 2005, pp. S4-16; discussion ii-v. |
| Marmarou A, Black P, Bergsneider M, Klinge P, Relkin N, International NPH Consultant Group. "Guidelines for management of idiopathic normal pressure hydrocephalus: progress to date." Acta Neurochirurgica Supplementum, vol. 95, 2005, pp. 237-40. |
| Klinge, Petra, Marmarou, Anthony, Bergsneider, Marvin, Relkin, Norman, Black, Peter McL. "Outcome of Shunting in Idiopathic Normal-pressure Hydrocephalus and the Value of Outcome Assessment in Shunted Patients." Neurosurgery, 2005, pp. S2-40-S2-52. |
| Klinge P, Marmarou A, Bergsneider M, Relkin N, Black PM. "Outcome of shunting in idiopathic normal-pressure hydrocephalus and the value of outcome assessment in shunted patients." Neurosurgery, vol. 57, no. 3 Suppl, 2005, pp. S40-52; discussion ii-v. |
| Bergsneider, Marvin, Black, Peter McL., Klinge, Petra, Marmarou, Anthony, Relkin, Norman. "Surgical Management of Idiopathic Normal-pressure Hydrocephalus." Neurosurgery, 2005, pp. S2-29-S2-39. |
| Bergsneider M, Black PM, Klinge P, Marmarou A, Relkin N. "Surgical management of idiopathic normal-pressure hydrocephalus." Neurosurgery, vol. 57, no. 3 Suppl, 2005, pp. S29-39; discussion ii-v. |
| Marmarou, Anthony, Bergsneider, Marvin, Klinge, Petra, Relkin, Norman, Black, Peter McL. "The Value of Supplemental Prognostic Tests for the Preoperative Assessment of Idiopathic Normal-pressure Hydrocephalus." Neurosurgery, 2005, pp. S2-17-S2-28. |
| Marmarou A, Bergsneider M, Klinge P, Relkin N, Black PM. "The value of supplemental prognostic tests for the preoperative assessment of idiopathic normal-pressure hydrocephalus." Neurosurgery, vol. 57, no. 3 Suppl, 2005, pp. S17-28; discussion ii-v. |
| Kaminsky J, Klinge P, Rodt T, Bokemeyer M, Luedemann W, Samii M. "Specially adapted interactive tools for an improved 3D-segmentation of the spine." Computerized Medical Imaging and Graphics, vol. 28, no. 3, 2004, pp. 119-27. |
| Klinge PM, Samii A, Mühlendyck A, Visnyei K, Meyer GJ, Walter GF, Silverberg GD, Brinker T. "Cerebral hypoperfusion and delayed hippocampal response after induction of adult kaolin hydrocephalus." Stroke, vol. 34, no. 1, 2003, pp. 193-9. |
| Schuhmann MU, Stiller D, Skardelly M, Bernarding J, Klinge PM, Samii A, Samii M, Brinker T. "Metabolic changes in the vicinity of brain contusions: a proton magnetic resonance spectroscopy and histology study." Journal of Neurotrauma, vol. 20, no. 8, 2003, pp. 725-43. |
| Schuhmann MU, Mokhtarzadeh M, Stichtenoth DO, Skardelly M, Klinge PM, Gutzki FM, Samii M, Brinker T. "Temporal profiles of cerebrospinal fluid leukotrienes, brain edema and inflammatory response following experimental brain injury." Neurological research, vol. 25, no. 5, 2003, pp. 481-91. |
| Schuhmann MU, Schneekloth CG, Klinge P, Engel M, Samii M, Brinker T. "Dynamic shunt testing applying short lasting pressure waves--inertia of shunt systems." Acta Neurochirurgica Supplementum, vol. 81, 2002, pp. 19-21. |
| Klinge P, Rückert N, Schuhmann M, Berding G, Brinker T, Knapp WH, Samii M. "Neuropsychological sequels to changes in global cerebral blood flow and cerebrovascular reserve capacity after shunt treatment in chronic hydrocephalus--a quantitative PET-study." Acta Neurochirurgica Supplementum, vol. 81, 2002, pp. 55-7. |
| Klinge P, Rückert N, Schuhmann M, Dörner L, Brinker T, Samii M. "Neuropsychological testing to improve surgical management of patients with chronic hydrocephalus after shunt treatment." Acta Neurochirurgica Supplementum, vol. 81, 2002, pp. 51-3. |
| Klinge P, Berding G, Brinker T, Schuhmann M, Knapp WH, Samii M. "PET-studies in idiopathic chronic hydrocephalus before and after shunt-treatment: the role of risk factors for cerebrovascular disease (CVD) on cerebral hemodynamics." Acta Neurochirurgica Supplementum, vol. 81, 2002, pp. 43-5. |
| Klinge P, Berding G, Brinker T, Weckesser E, Knapp WH, Samii M. "Regional cerebral blood flow profiles of shunt-responder in idiopathic chronic hydrocephalus--a 15-O-water PET-study." Acta Neurochirurgica Supplementum, vol. 81, 2002, pp. 47-9. |
| Luedemann W, Kondziella D, Tienken K, Klinge P, Brinker T, Berens von Rautenfeld D. "Spinal cerebrospinal fluid pathways and their significance for the compensation of kaolin-hydrocephalus." Acta Neurochirurgica Supplementum, vol. 81, 2002, pp. 271-3. |
| Klinge P, Mühlendyck A, Lee S, Lüdemann W, Groos S, Samii M, Brinker T. "Temporal and regional profile of neuronal and glial cellular injury after induction of kaolin hydrocephalus." Acta Neurochirurgica Supplementum, vol. 81, 2002, pp. 275-7. |
| Klinge P, Berding G, Brinker T, Schuhmann M, Weckesser E, Knapp WH, Samii M. "The role of cerebral blood flow and cerebrovascular reserve capacity in the diagnosis of chronic hydrocephalus--a PET-study on 60 patients." Acta Neurochirurgica Supplementum, vol. 81, 2002, pp. 39-41. |
| Klinge PM, Vafa MA, Brinker T, Brandis A, Walter GF, Stieglitz T, Samii M, Wewetzer K. "Immunohistochemical characterization of axonal sprouting and reactive tissue changes after long-term implantation of a polyimide sieve electrode to the transected adult rat sciatic nerve." Biomaterials, vol. 22, no. 17, 2001, pp. 2333-43. |
| Klinge PM, Groos S, Wewetzer K, Haastert K, Rosahl S, Vafa MA, Hosseini H, Samii M, Brinker T. "Regeneration of a transected peripheral nerve by transplantation of spinal cord encapsulated in a vein." Neuroreport, vol. 12, no. 6, 2001, pp. 1271-5. |
| Klinge PM, Berding G, Brinker T, Knapp WH, Samii M. "A positron emission tomography study of cerebrovascular reserve before and after shunt surgery in patients with idiopathic chronic hydrocephalus." Journal of Neurosurgery, vol. 91, no. 4, 1999, pp. 605-9. |
| Klinge PM, Beck H, Brinker T, Walter GF, Samii M. "Induction of heat shock protein 70 in the rat brain following intracisternal infusion of autologous blood: evaluation of acute neuronal damage." Journal of Neurosurgery, vol. 91, no. 5, 1999, pp. 843-50. |
| Klinge P, Fischer J, Brinker T, Heissler HE, Burchert W, Berding G, Knapp WH, Samii M. "PET and CBF studies of chronic hydrocephalus: a contribution to surgical indication and prognosis." Journal of Neuroimaging, vol. 8, no. 4, 1998, pp. 205-9. |
| Brinker T, Beck H, Klinge P, Kischnik B, Oi S, Samii M. "Sinusoidal intrathecal infusion for assessment of CSF dynamics in kaolin-induced hydrocephalus." Acta Neurochirurgica, vol. 140, no. 10, 1998, pp. 1069-75. |
| Schmidt D, Klinge P, Leuschner I, Harms D. "Infantile desmoid-type fibromatosis. Morphological features correlate with biological behaviour." The Journal of Pathology, vol. 164, no. 4, 1991, pp. 315-9. |
ONGOING RESEARCH
- Electrophysiological and optogenetic assessment of cognition in hydrocephalic rats
- Randomized multicenter trial on shunt treatment in NPH
PREVIOUS RESEARCH
Experimental and clinical studies on the pathophysiology of iNPH
I was lead investigator of experimental and clinical studies showing the impact of hydrocephalus on cerebral perfusion. Such studies demonstrated that hydrocephalus does not cause a cerebral blood flow impairment which is critical for the survival of neurons. Instead, my group demonstrated that a chronic “sublethal” impairment of cerebral perfusion causes permanent neuronal damage explaining the neurological deficits in hydrocephalic animals and patients.
1: Klinge PM, Samii A, Mühlendyck A, Visnyei K, Meyer GJ, Walter GF, Silverberg
GD, Brinker T. Cerebral hypoperfusion and delayed hippocampal response after
induction of adult kaolin hydrocephalus. Stroke. 2003 Jan;34(1):193-9. PubMed
PMID: 12511773.
2: Klinge PM, Berding G, Brinker T, Knapp WH, Samii M. A positron emission
tomography study of cerebrovascular reserve before and after shunt surgery in
patients with idiopathic chronic hydrocephalus. J Neurosurg. 1999
Oct;91(4):605-9. PubMed PMID: 10507382.
3: Klinge P, Fischer J, Brinker T, Heissler HE, Burchert W, Berding G, Knapp WH,
Samii M. PET and CBF studies of chronic hydrocephalus: a contribution to surgical
indication and prognosis. J Neuroimaging. 1998 Oct;8(4):205-9. PubMed PMID:
9780851.
International guidelines for diagnosis and treatment of iNPH
I served as co-author in a group of renowned experts in the field of hydrocephalus to conduct a comprehensive review of existing literature (meta-analysis) to summarize the existing knowledge on the pathophysiology of normal pressure hydrocephalus und to provide, for the first time, guidelines for the diagnosis and treatment of NPH.
1: Marmarou A, Black P, Bergsneider M, Klinge P, Relkin N; International NPH
Consultant Group. Guidelines for management of idiopathic normal pressure
hydrocephalus: progress to date. Acta Neurochir Suppl. 2005;95:237-40. PubMed
PMID: 16463856.
2: Klinge P, Marmarou A, Bergsneider M, Relkin N, Black PM. Outcome of shunting
in idiopathic normal-pressure hydrocephalus and the value of outcome assessment
in shunted patients. Neurosurgery. 2005 Sep;57(3 Suppl):S40-52; discussion ii-v.
Review. PubMed PMID: 16160428.
3: Bergsneider M, Black PM, Klinge P, Marmarou A, Relkin N. Surgical management
of idiopathic normal-pressure hydrocephalus. Neurosurgery. 2005 Sep;57(3
Suppl):S29-39; discussion ii-v. Review. PubMed PMID: 16160427.
4: Marmarou A, Bergsneider M, Klinge P, Relkin N, Black PM. The value of
supplemental prognostic tests for the preoperative assessment of idiopathic
normal-pressure hydrocephalus. Neurosurgery. 2005 Sep;57(3 Suppl):S17-28;
discussion ii-v. Review. PubMed PMID: 16160426.
5: Relkin N, Marmarou A, Klinge P, Bergsneider M, Black PM. Diagnosing idiopathic
normal-pressure hydrocephalus. Neurosurgery. 2005 Sep;57(3 Suppl):S4-16;
discussion ii-v. Review. PubMed PMID: 16160425.
6: Marmarou A, Bergsneider M, Relkin N, Klinge P, Black PM. Development of
guidelines for idiopathic normal-pressure hydrocephalus: introduction.
Neurosurgery. 2005 Sep;57(3 Suppl):S1-3; discussion ii-v. PubMed PMID: 16160424.
Prospective clinical trial to improve diagnosing and monitoring of iNPH
I was lead PI of the first prospective clinical trial aiming to find standards for clinical diagnosing of normal pressure hydrocephalus. The study included 16 European centers and demonstrated the lack of diagnostic tests to predict a positive outcome following shunting. It was the major conclusion of the trial to demonstrate that it is not justified to exclude patients from surgical shunting just because of existing co-morbidity, for example Alzheimer’s disease or cerebrovascular disease.
1: Wikkelsø C, Hellström P, Klinge PM, Tans JT; European iNPH Multicentre Study
Group. The European iNPH Multicentre Study on the predictive values of resistance
to CSF outflow and the CSF Tap Test in patients with idiopathic normal pressure
hydrocephalus. J Neurol Neurosurg Psychiatry. 2013 May;84(5):562-8. doi:
10.1136/jnnp-2012-303314. Epub 2012 Dec 18. PubMed PMID: 23250963.
2: Hellström P, Klinge P, Tans J, Wikkelsø C. A new scale for assessment of
severity and outcome in iNPH. Acta Neurol Scand. 2012 Oct;126(4):229-37. doi:
10.1111/j.1600-0404.2012.01677.x. Epub 2012 May 16. PubMed PMID: 22587624.
3: Klinge P, Hellström P, Tans J, Wikkelsø C; European iNPH Multicentre Study
Group. One-year outcome in the European multicentre study on iNPH. Acta Neurol
Scand. 2012 Sep;126(3):145-53. doi: 10.1111/j.1600-0404.2012.01676.x. Epub 2012
May 10. PubMed PMID: 22571428.
4: Hellström P, Klinge P, Tans J, Wikkelsø C. The neuropsychology of iNPH:
findings and evaluation of tests in the European multicentre study. Clin Neurol
Neurosurg. 2012 Feb;114(2):130-4. doi: 10.1016/j.clineuro.2011.09.014. Epub 2011
Oct 22. PubMed PMID: 22023722.
Neurotechnology in nervous system disorders
I had the opportunity to collaborate in a multidisciplinary project, aiming to develop an artificial structure to electrically contact severed peripheral nerves. I was responsible for the histological analysis of of nerve-implant specimens. We demonstrated, that neurons transplanted to severed nerve stumps may grow through interposed polyimide sieve implants (coated with strip conductors). Electrical stimulation via the implanted electrode results in muscle activity.
1: Klinge PM, Vafa MA, Brinker T, Brandis A, Walter GF, Stieglitz T, Samii M,
Wewetzer K. Immunohistochemical characterization of axonal sprouting and reactive
tissue changes after long-term implantation of a polyimide sieve electrode to the
transected adult rat sciatic nerve. Biomaterials. 2001 Sep;22(17):2333-43. PubMed
PMID: 11511030.
2: Klinge PM, Groos S, Wewetzer K, Haastert K, Rosahl S, Vafa MA, Hosseini H,
Samii M, Brinker T. Regeneration of a transected peripheral nerve by
transplantation of spinal cord encapsulated in a vein. Neuroreport. 2001 May
8;12(6):1271-5. PubMed PMID: 11338205.
Stem cell therapy of gliomas
I had the opportunity to collaborate in a multidisciplinary project, aiming to develop a stem cell therapy for gliomas: encapsulated mesenchymal stem cells (MSC’s) were implanted into the experimental glioma in rats. It was shown that the anti-inflammatory effects of transplanted MSC’s were effective to suppress the tumor growth in the rat model.
1: Kleinschmidt K, Klinge PM, Stopa E, Wallrapp C, Glage S, Geigle P, Brinker T.
Alginate encapsulated human mesenchymal stem cells suppress syngeneic glioma
growth in the immunocompetent rat. J Microencapsul. 2011;28(7):621-7. doi:
10.3109/02652048.2011.599441. Epub 2011 Jul 18. PubMed PMID: 21767114.
2: Heile AM, Wallrapp C, Klinge PM, Samii A, Kassem M, Silverberg G, Brinker T.
Cerebral transplantation of encapsulated mesenchymal stem cells improves cellular
pathology after experimental traumatic brain injury. Neurosci Lett. 2009 Oct
9;463(3):176-81. doi: 10.1016/j.neulet.2009.07.071. Epub 2009 Jul 26. PubMed
PMID: 19638295.
3: Klinge PM, Harmening K, Miller MC, Heile A, Wallrapp C, Geigle P, Brinker T.
Encapsulated native and glucagon-like peptide-1 transfected human mesenchymal
stem cells in a transgenic mouse model of Alzheimer's disease. Neurosci Lett.
2011 Jun 15;497(1):6-10. doi: 10.1016/j.neulet.2011.03.092. Epub 2011 Apr 12.
PubMed PMID: 21507341.
4: Glage S, Klinge PM, Miller MC, Wallrapp C, Geigle P, Hedrich HJ, Brinker T.
Therapeutic concentrations of glucagon-like peptide-1 in cerebrospinal fluid
following cell-based delivery into the cerebral ventricles of cats. Fluids
Barriers CNS. 2011 May 17;8:18. doi: 10.1186/2045-8118-8-18. PubMed PMID:
21575271; PubMed Central PMCID: PMC3114785.
| Year | Degree | Institution |
|---|---|---|
| 1993 | PhD | University of Kiel |
| 1993 | MD | University of Kiel |
Professor of Neurosurgery Alpert Medical School Brown University
Attending Neurosurgeon and Director Research Center and Clinic for Cerebrospinal Fluid Disorders Rhode Island Hospital, Providence RI
