B.S. 1986. Microbiology, University of Massachusetts, Amherst
Ph.D. 1991. Neurovirology, University of Massachusetts, Amherst
1991-94 Staff Fellow, Section on Molecular Virology and Genetics, Laboratory of Viral and Molecular Pathogenesis, NINDS, NIH, Bethesda, MD
1992-95 Adjunct Assistant Professor of Microbiology and Immunology, The George Washington University School of Medicine and Health Sciences, Washington, DC
1994-95 Senior Staff Fellow, Section of Molecular Medicine and Virology, Laboratory of Molecular Medicine and Neuroscience, NINDS, NIH, Bethesda, MD
1995-01 Assistant Professor of Medical Science, Department of Molecular Microbiology and Immunology, Brown University, Providence, RI
2001-05 Associate Professor of Medical Science (with Tenure), Department of Molecular Microbiology and Immunology, Brown University, Providence, RI
2005-06 Associate Professor of Medical Science (with Tenure), Department of Molecular Biology, Cell Biology Biochemistry, Brown University, Providence, RI
2006- Professor of Medical Science, Department of Molecular Biology, Cell Biology Biochemistry, Brown University, Providence, RI
| Kaiserman J, O'Hara BA, Haley SA, Atwood WJ. "An Elusive Target: Inhibitors of JC Polyomavirus Infection and Their Development as Therapeutics for the Treatment of Progressive Multifocal Leukoencephalopathy." International Journal of Molecular Sciences, vol. 24, no. 10, 2023. |
| Kaiserman J, O'Hara BA, Garabian K, Lukacher A, Haley SA, Atwood WJ. "The Oxindole GW-5074 Inhibits JC Polyomavirus Infection and Spread by Antagonizing the MAPK-ERK Signaling Pathway." mBio, vol. 14, no. 2, 2023, pp. e0358322. |
| Goodrum F, Lowen AC, Lakdawala S, Alwine J, Casadevall A, Imperiale MJ, Atwood W, Avgousti D, Baines J, Banfield B, Banks L, Bhaduri-McIntosh S, Bhattacharya D, Blanco-Melo D, Bloom D, Boon A, Boulant S, Brandt C, Broadbent A, Brooke C, Cameron C, Campos S, Caposio P, Chan G, Cliffe A, Coffin J, Collins K, Damania B, Daugherty M, Debbink K, DeCaprio J, Dermody T, Dikeakos J, DiMaio D, Dinglasan R, Duprex WP, Dutch R, Elde N, Emerman M, Enquist L, Fane B, Fernandez-Sesma A, Flenniken M, Frappier L, Frieman M, Frueh K, Gack M, Gaglia M, Gallagher T, Galloway D, García-Sastre A, Geballe A, Glaunsinger B, Goff S, Greninger A, Hancock M, Harris E, Heaton N, Heise M, Heldwein E, Hogue B, Horner S, Hutchinson E, Hyser J, Jackson W, Kalejta R, Kamil J, Karst S, Kirchhoff F, Knipe D, Kowalik T, Lagunoff M, Laimins L, Langlois R, Lauring A, Lee B, Leib D, Liu SL, Longnecker R, Lopez C, Luftig M, Lund J, Manicassamy B, McFadden G, McIntosh M, Mehle A, Miller WA, Mohr I, Moody C, Moorman N, Moscona A, Mounce B, Munger J, Münger K, Murphy E, Naghavi M, Nelson J, Neufeldt C, Nikolich J, O'Connor C, Ono A, Orenstein W, Ornelles D, Ou JH, Parker J, Parrish C, Pekosz A, Pellett P, Pfeiffer J, Plemper R, Polyak S, Purdy J, Pyeon D, Quinones-Mateu M, Renne R, Rice C, Schoggins J, Roller R, Russell C, Sandri-Goldin R, Sapp M, Schang L, Schmid S, Schultz-Cherry S, Semler B, Shenk T, Silvestri G, Simon V, Smith G, Smith J, Spindler K, Stanifer M, Subbarao K, Sundquist W, Suthar M, Sutton T, Tai A, Tarakanova V, tenOever B, Tibbetts S, Tompkins S, Toth Z, van Doorslaer K, Vignuzzi M, Wallace N, Walsh D, Weekes M, Weinberg J, Weitzman M, Weller S, Whelan S, White E, Williams B, Wobus C, Wong S, Yurochko A. "Virology under the Microscope-a Call for Rational Discourse." mBio, vol. 14, no. 1, 2023, pp. e0018823. |
| Goodrum F, Lowen AC, Lakdawala S, Alwine J, Casadevall A, Imperiale MJ, Atwood W, Avgousti D, Baines J, Banfield B, Banks L, Bhaduri-McIntosh S, Bhattacharya D, Blanco-Melo D, Bloom D, Boon A, Boulant S, Brandt C, Broadbent A, Brooke C, Cameron C, Campos S, Caposio P, Chan G, Cliffe A, Coffin J, Collins K, Damania B, Daugherty M, Debbink K, DeCaprio J, Dermody T, Dikeakos J, DiMaio D, Dinglasan R, Duprex WP, Dutch R, Elde N, Emerman M, Enquist L, Fane B, Fernandez-Sesma A, Flenniken M, Frappier L, Frieman M, Frueh K, Gack M, Gaglia M, Gallagher T, Galloway D, García-Sastre A, Geballe A, Glaunsinger B, Goff S, Greninger A, Hancock M, Harris E, Heaton N, Heise M, Heldwein E, Hogue B, Horner S, Hutchinson E, Hyser J, Jackson W, Kalejta R, Kamil J, Karst S, Kirchhoff F, Knipe D, Kowalik T, Lagunoff M, Laimins L, Langlois R, Lauring A, Lee B, Leib D, Liu SL, Longnecker R, Lopez C, Luftig M, Lund J, Manicassamy B, McFadden G, McIntosh M, Mehle A, Miller WA, Mohr I, Moody C, Moorman N, Moscona A, Mounce B, Munger J, Münger K, Murphy E, Naghavi M, Nelson J, Neufeldt C, Nikolich J, O'Connor C, Ono A, Orenstein W, Ornelles D, Ou JH, Parker J, Parrish C, Pekosz A, Pellett P, Pfeiffer J, Plemper R, Polyak S, Purdy J, Pyeon D, Quinones-Mateu M, Renne R, Rice C, Schoggins J, Roller R, Russell C, Sandri-Goldin R, Sapp M, Schang L, Schmid S, Schultz-Cherry S, Semler B, Shenk T, Silvestri G, Simon V, Smith G, Smith J, Spindler K, Stanifer M, Subbarao K, Sundquist W, Suthar M, Sutton T, Tai A, Tarakanova V, tenOever B, Tibbetts S, Tompkins S, Toth Z, van Doorslaer K, Vignuzzi M, Wallace N, Walsh D, Weekes M, Weinberg J, Weitzman M, Weller S, Whelan S, White E, Williams B, Wobus C, Wong S, Yurochko A. "Virology under the Microscope-a Call for Rational Discourse." Journal of Virology, vol. 97, no. 2, 2023, pp. e0008923. |
| Goodrum F, Lowen AC, Lakdawala S, Alwine J, Casadevall A, Imperiale MJ, Atwood W, Avgousti D, Baines J, Banfield B, Banks L, Bhaduri-McIntosh S, Bhattacharya D, Blanco-Melo D, Bloom D, Boon A, Boulant S, Brandt C, Broadbent A, Brooke C, Cameron C, Campos S, Caposio P, Chan G, Cliffe A, Coffin J, Collins K, Damania B, Daugherty M, Debbink K, DeCaprio J, Dermody T, Dikeakos J, DiMaio D, Dinglasan R, Duprex WP, Dutch R, Elde N, Emerman M, Enquist L, Fane B, Fernandez-Sesma A, Flenniken M, Frappier L, Frieman M, Frueh K, Gack M, Gaglia M, Gallagher T, Galloway D, García-Sastre A, Geballe A, Glaunsinger B, Goff S, Greninger A, Hancock M, Harris E, Heaton N, Heise M, Heldwein E, Hogue B, Horner S, Hutchinson E, Hyser J, Jackson W, Kalejta R, Kamil J, Karst S, Kirchhoff F, Knipe D, Kowalik T, Lagunoff M, Laimins L, Langlois R, Lauring A, Lee B, Leib D, Liu SL, Longnecker R, Lopez C, Luftig M, Lund J, Manicassamy B, McFadden G, McIntosh M, Mehle A, Miller WA, Mohr I, Moody C, Moorman N, Moscona A, Mounce B, Munger J, Münger K, Murphy E, Naghavi M, Nelson J, Neufeldt C, Nikolich J, O'Connor C, Ono A, Orenstein W, Ornelles D, Ou JH, Parker J, Parrish C, Pekosz A, Pellett P, Pfeiffer J, Plemper R, Polyak S, Purdy J, Pyeon D, Quinones-Mateu M, Renne R, Rice C, Schoggins J, Roller R, Russell C, Sandri-Goldin R, Sapp M, Schang L, Schmid S, Schultz-Cherry S, Semler B, Shenk T, Silvestri G, Simon V, Smith G, Smith J, Spindler K, Stanifer M, Subbarao K, Sundquist W, Suthar M, Sutton T, Tai A, Tarakanova V, tenOever B, Tibbetts S, Tompkins S, Toth Z, van Doorslaer K, Vignuzzi M, Wallace N, Walsh D, Weekes M, Weinberg J, Weitzman M, Weller S, Whelan S, White E, Williams B, Wobus C, Wong S, Yurochko A. "Virology under the Microscope-a Call for Rational Discourse." mSphere, vol. 8, no. 2, 2023, pp. e0003423. |
| Morris-Love J, O'Hara BA, Gee GV, Dugan AS, O'Rourke RS, Armstead BE, Assetta B, Haley SA, Atwood WJ. "Biogenesis of JC polyomavirus associated extracellular vesicles." Journal of extracellular biology, vol. 1, no. 5, 2022. |
| Morris-Love, Jenna, Atwood, Walter J. "Complexities of JC Polyomavirus Receptor-Dependent and -Independent Mechanisms of Infection." Viruses, vol. 14, no. 6, 2022, pp. 1130. |
| O'Hara BA, Gee GV, Haley SA, Morris-Love J, Nyblade C, Nieves C, Hanson BA, Dang X, Turner TJ, Chavin JM, Lublin A, Koralnik IJ, Atwood WJ. "Teriflunomide Inhibits JCPyV Infection and Spread in Glial Cells and Choroid Plexus Epithelial Cells." International Journal of Molecular Sciences, vol. 22, no. 18, 2021. |
| Haley, Sheila A., O'Hara, Bethany A., Atwood, Walter J. "Adipocyte Plasma Membrane Protein (APMAP) promotes JC Virus (JCPyV) infection in human glial cells." Virology, vol. 548, 2020, pp. 17-24. |
| Zou W, Vue GS, Assetta B, Manza H, Atwood WJ, Imperiale MJ. "Control of archetype BK polyomavirus miRNA expression." Journal of Virology, 2020. |
| Atkinson AL, Atwood WJ. "Fifty Years of JC Polyomavirus: A Brief Overview and Remaining Questions." Viruses, vol. 12, no. 9, 2020. |
| O'Hara BA, Morris-Love J, Gee GV, Haley SA, Atwood WJ. "JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor." PLoS pathogens, vol. 16, no. 3, 2020, pp. e1008371. |
| Clark P, Gee GV, Albright BS, Assetta B, Han Y, Atwood WJ, DiMaio D. "Phosphoinositide 3'-Kinase γ Facilitates Polyomavirus Infection." Viruses, vol. 12, no. 10, 2020. |
| Assetta B, De Cecco M, O'Hara B, Atwood WJ. "Correction for Assetta et al., "JC Polyomavirus Infection of Primary Human Renal Epithelial Cells Is Controlled by a Type I IFN-Induced Response"." mBio, vol. 10, no. 5, 2019. |
| Assetta, Benedetta, De Cecco, Marco, O’Hara, Bethany, Atwood, Walter J. "Correction for Assetta et al., “JC Polyomavirus Infection of Primary Human Renal Epithelial Cells Is Controlled by a Type I IFN-Induced Response”." mBio, vol. 10, no. 5, 2019. |
| Assetta B, Morris-Love J, Gee GV, Atkinson AL, O'Hara BA, Maginnis MS, Haley SA, Atwood WJ. "Genetic and Functional Dissection of the Role of Individual 5-HT<sub>2</sub> Receptors as Entry Receptors for JC Polyomavirus." Cell Reports, vol. 27, no. 7, 2019, pp. 1960-1966.e6. |
| Morris-Love J, Gee GV, O'Hara BA, Assetta B, Atkinson AL, Dugan AS, Haley SA, Atwood WJ. "JC Polyomavirus Uses Extracellular Vesicles To Infect Target Cells." mBio, vol. 10, no. 2, 2019. |
| O'Hara, Bethany A., Gee, Gretchen V., Atwood, Walter J., Haley, Sheila A. "Susceptibility of Primary Human Choroid Plexus Epithelial Cells and Meningeal Cells to Infection by JC Virus." Journal of Virology, vol. 92, no. 8, 2018, pp. e00105-18. |
| Haley SA, Atwood WJ. "Progressive Multifocal Leukoencephalopathy: Endemic Viruses and Lethal Brain Disease." Annual review of virology, 2017. |
| Assetta, Benedetta, Atwood, Walter J. "The biology of JC polyomavirus." Biological Chemistry, vol. 398, no. 8, 2017, pp. 839-855. |
| Dimitriadi M, Derdowski A, Kalloo G, Maginnis MS, O'Hern P, Bliska B, Sorkaç A, Nguyen KC, Cook SJ, Poulogiannis G, Atwood WJ, Hall DH, Hart AC. "Decreased function of survival motor neuron protein impairs endocytic pathways." Proceedings of the National Academy of Sciences, vol. 113, no. 30, 2016, pp. E4377-86. |
| Luo Y, Motamedi N, Magaldi TG, Gee GV, Atwood WJ, DiMaio D. "Interaction between Simian Virus 40 Major Capsid Protein VP1 and Cell Surface Ganglioside GM1 Triggers Vacuole Formation." mBio, vol. 7, no. 2, 2016, pp. e00297. |
| Assetta B, De Cecco M, O'Hara B, Atwood WJ. "JC Polyomavirus Infection of Primary Human Renal Epithelial Cells Is Controlled by a Type I IFN-Induced Response." mBio, vol. 7, no. 4, 2016, pp. e00903-16. |
| Haley, Sheila A., O'Hara, Bethany A., Nelson, Christian D.S., Brittingham, Frances L.P., Henriksen, Kammi J., Stopa, Edward G., Atwood, Walter J. "Human Polyomavirus Receptor Distribution in Brain Parenchyma Contrasts with Receptor Distribution in Kidney and Choroid Plexus." The American Journal of Pathology, vol. 185, no. 8, 2015, pp. 2246-2258. |
| Maginnis MS, Nelson CD, Atwood WJ. "JC polyomavirus attachment, entry, and trafficking: unlocking the keys to a fatal infection." Journal of NeuroVirology, vol. 21, no. 6, 2015, pp. 601-13. |
| Nelson, Christian D. S., Ströh, Luisa J., Gee, Gretchen V., O'Hara, Bethany A., Stehle, Thilo, Atwood, Walter J. "Modulation of a pore in the capsid of JC polyomavirus reduces infectivity and prevents exposure of the minor capsid proteins." Journal of Virology, vol. 89, no. 7, 2015, pp. 3910-3921. |
| Yatawara A, Gaidos G, Rupasinghe CN, O'Hara BA, Pellegrini M, Atwood WJ, Mierke DF. "Small-molecule inhibitors of JC polyomavirus infection." Journal of peptide science : an official publication of the European Peptide Society, vol. 21, no. 3, 2015, pp. 236-42. |
| Ströh LJ, Maginnis MS, Blaum BS, Nelson CD, Neu U, Gee GV, O'Hara BA, Motamedi N, DiMaio D, Atwood WJ, Stehle T. "The Greater Affinity of JC Polyomavirus Capsid for α2,6-Linked Lactoseries Tetrasaccharide c than for Other Sialylated Glycans Is a Major Determinant of Infectivity." Journal of Virology, vol. 89, no. 12, 2015, pp. 6364-75. |
| Ströh LJ, Gee GV, Blaum BS, Dugan AS, Feltkamp MC, Atwood WJ, Stehle T. "Trichodysplasia spinulosa-Associated Polyomavirus Uses a Displaced Binding Site on VP1 to Engage Sialylated Glycolipids." PLoS pathogens, vol. 11, no. 8, 2015, pp. e1005112. |
| Haley, Sheila A., Atwood, Walter J. "An animal model for progressive multifocal leukoencephalopathy." Journal of Clinical Investigation, vol. 124, no. 12, 2014, pp. 5103-5106. |
| O'Hara BA, Rupasinghe C, Yatawara A, Gaidos G, Mierke DF, Atwood WJ. "Gallic acid-based small-molecule inhibitors of JC and BK polyomaviral infection." Virus research, vol. 189, 2014, pp. 280-5. |
| Bouley SJ, Maginnis MS, Derdowski A, Gee GV, O'Hara BA, Nelson CD, Bara AM, Atwood WJ, Dugan AS. "Host cell autophagy promotes BK virus infection." Virology, vol. 456-457, 2014, pp. 87-95. |
| Carney, Daniel W., Nelson, Christian D.S., Ferris, Bennett D., Stevens, Julia P., Lipovsky, Alex, Kazakov, Teymur, DiMaio, Daniel, Atwood, Walter J., Sello, Jason K. "Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses." Bioorganic & Medicinal Chemistry, vol. 22, no. 17, 2014, pp. 4836-4847. |
| Zins SR, Nelson CD, Maginnis MS, Banerjee R, O'Hara BA, Atwood WJ. "The human alpha defensin HD5 neutralizes JC polyomavirus infection by reducing endoplasmic reticulum traffic and stabilizing the viral capsid." Journal of Virology, vol. 88, no. 2, 2014, pp. 948-60. |
| Assetta B, Maginnis MS, Gracia Ahufinger I, Haley SA, Gee GV, Nelson CD, O'Hara BA, Allen Ramdial SA, Atwood WJ. "5-HT2 receptors facilitate JC polyomavirus entry." Journal of Virology, vol. 87, no. 24, 2013, pp. 13490-8. |
| Nelson CD, Carney DW, Derdowski A, Lipovsky A, Gee GV, O'Hara B, Williard P, DiMaio D, Sello JK, Atwood WJ. "A retrograde trafficking inhibitor of ricin and Shiga-like toxins inhibits infection of cells by human and monkey polyomaviruses." mBio, vol. 4, no. 6, 2013, pp. e00729-13. |
| Neu U, Allen SA, Blaum BS, Liu Y, Frank M, Palma AS, Ströh LJ, Feizi T, Peters T, Atwood WJ, Stehle T. "A structure-guided mutation in the major capsid protein retargets BK polyomavirus." PLoS pathogens, vol. 9, no. 10, 2013, pp. e1003688. |
| Lipovsky A, Popa A, Pimienta G, Wyler M, Bhan A, Kuruvilla L, Guie MA, Poffenberger AC, Nelson CD, Atwood WJ, DiMaio D. "Genome-wide siRNA screen identifies the retromer as a cellular entry factor for human papillomavirus." Proceedings of the National Academy of Sciences, vol. 110, no. 18, 2013, pp. 7452-7. |
| Maginnis MS, Ströh LJ, Gee GV, O'Hara BA, Derdowski A, Stehle T, Atwood WJ. "Progressive multifocal leukoencephalopathy-associated mutations in the JC polyomavirus capsid disrupt lactoseries tetrasaccharide c binding." mBio, vol. 4, no. 3, 2013, pp. e00247-13. |
| Gee GV, O'Hara BA, Derdowski A, Atwood WJ. "Pseudovirus mimics cell entry and trafficking of the human polyomavirus JCPyV." Virus research, vol. 178, no. 2, 2013, pp. 281-6. |
| Ferenczy MW, Marshall LJ, Nelson CD, Atwood WJ, Nath A, Khalili K, Major EO. "Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain." Clinical microbiology reviews, vol. 25, no. 3, 2012, pp. 471-506. |
| Audu CO, O'Hara B, Pellegrini M, Wang L, Atwood WJ, Mierke DF. "Reining in polyoma virus associated nephropathy: design and characterization of a template mimicking BK viral coat protein cellular binding." Biochemistry, vol. 51, no. 41, 2012, pp. 8092-9. |
| Nelson CD, Derdowski A, Maginnis MS, O'Hara BA, Atwood WJ. "The VP1 subunit of JC polyomavirus recapitulates early events in viral trafficking and is a novel tool to study polyomavirus entry." Virology, vol. 428, no. 1, 2012, pp. 30-40. |
| Goodwin EC, Lipovsky A, Inoue T, Magaldi TG, Edwards AP, Van Goor KE, Paton AW, Paton JC, Atwood WJ, Tsai B, DiMaio D. "BiP and multiple DNAJ molecular chaperones in the endoplasmic reticulum are required for efficient simian virus 40 infection." mBio, vol. 2, no. 3, 2011, pp. e00101-11. |
| Johne R, Buck CB, Allander T, Atwood WJ, Garcea RL, Imperiale MJ, Major EO, Ramqvist T, Norkin LC. "Taxonomical developments in the family Polyomaviridae." Archives of virology, vol. 156, no. 9, 2011, pp. 1627-34. |
| Shen PS, Enderlein D, Nelson CD, Carter WS, Kawano M, Xing L, Swenson RD, Olson NH, Baker TS, Cheng RH, Atwood WJ, Johne R, Belnap DM. "The structure of avian polyomavirus reveals variably sized capsids, non-conserved inter-capsomere interactions, and a possible location of the minor capsid protein VP4." Virology, vol. 411, no. 1, 2011, pp. 142-52. |
| Maginnis MS, Haley SA, Gee GV, Atwood WJ. "Role of N-linked glycosylation of the 5-HT2A receptor in JC virus infection." Journal of Virology, vol. 84, no. 19, 2010, pp. 9677-84. |
| Neu U, Maginnis MS, Palma AS, Ströh LJ, Nelson CD, Feizi T, Atwood WJ, Stehle T. "Structure-function analysis of the human JC polyomavirus establishes the LSTc pentasaccharide as a functional receptor motif." Cell Host & Microbe, vol. 8, no. 4, 2010, pp. 309-19. |
| Gee GV, Stanifer ML, Christensen BC, Atwood WJ, Ugolini D, Bonassi S, Resnick MB, Nelson HH, Marsit CJ, Kelsey KT. "SV40 associated miRNAs are not detectable in mesotheliomas." Br J Cancer, vol. 103, no. 6, 2010, pp. 885-8. |
| Jordan JA, Manley K, Dugan AS, O'Hara BA, Atwood WJ. "Transcriptional regulation of BK virus by nuclear factor of activated T cells." Journal of Virology, vol. 84, no. 4, 2010, pp. 1722-30. |
| Haley SA, O'Hara BA, Banerjee R, Atwood WJ. "Unique susceptibility of a human lung carcinoid tumor cell line to infection with BK virus." Virus research, vol. 149, no. 1, 2010, pp. 128-32. |
| Goodwin EC, Atwood WJ, DiMaio D. "High-throughput cell-based screen for chemicals that inhibit infection by simian virus 40 and human polyomaviruses." Journal of Virology, vol. 83, no. 11, 2009, pp. 5630-9. |
| Maginnis MS, Atwood WJ. "JC virus: an oncogenic virus in animals and humans?." Seminars in Cancer Biology, vol. 19, no. 4, 2009, pp. 261-9. |
| Gasparovic ML, Maginnis MS, O'Hara BA, Dugan AS, Atwood WJ. "Modulation of PML protein expression regulates JCV infection." Virology, vol. 390, no. 2, 2009, pp. 279-88. |
| Neu U, Stehle T, Atwood WJ. "The Polyomaviridae: Contributions of virus structure to our understanding of virus receptors and infectious entry." Virology, vol. 384, no. 2, 2009, pp. 389-99. |
| Dugan AS, Gasparovic ML, Atwood WJ. "Direct correlation between sialic acid binding and infection of cells by two human polyomaviruses (JC virus and BK virus)." Journal of Virology, vol. 82, no. 5, 2008, pp. 2560-4. |
| Seo GJ, Fink LH, O'Hara B, Atwood WJ, Sullivan CS. "Evolutionarily conserved function of a viral microRNA." Journal of Virology, vol. 82, no. 20, 2008, pp. 9823-8. |
| Dugan AS, Maginnis MS, Jordan JA, Gasparovic ML, Manley K, Page R, Williams G, Porter E, O'Hara BA, Atwood WJ. "Human alpha-defensins inhibit BK virus infection by aggregating virions and blocking binding to host cells." Journal of Biological Chemistry, vol. 283, no. 45, 2008, pp. 31125-32. |
| Schaumburg C, O'Hara BA, Lane TE, Atwood WJ. "Human embryonic stem cell-derived oligodendrocyte progenitor cells express the serotonin receptor and are susceptible to JC virus infection." Journal of Virology, vol. 82, no. 17, 2008, pp. 8896-9. |
| O'Hara BA, Atwood WJ. "Interferon beta1-a and selective anti-5HT(2a) receptor antagonists inhibit infection of human glial cells by JC virus." Virus research, vol. 132, no. 1-2, 2008, pp. 97-103. |
| Manley K, O'Hara BA, Atwood WJ. "Nuclear factor of activated T-cells (NFAT) plays a role in SV40 infection." Virology, vol. 372, no. 1, 2008, pp. 48-55. |
| Dugan AS, Gasparovic ML, Tsomaia N, Mierke DF, O'Hara BA, Manley K, Atwood WJ. "Identification of amino acid residues in BK virus VP1 that are critical for viability and growth." Journal of Virology, vol. 81, no. 21, 2007, pp. 11798-808. |
| Manley K, Gee GV, Simkevich CP, Sedivy JM, Atwood WJ. "Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression." Virology, vol. 366, no. 2, 2007, pp. 394-404. |
| Querbes W, O'Hara BA, Williams G, Atwood WJ. "Invasion of host cells by JC virus identifies a novel role for caveolae in endosomal sorting of noncaveolar ligands." Journal of Virology, vol. 80, no. 19, 2006, pp. 9402-13. |
| Gasparovic ML, Gee GV, Atwood WJ. "JC virus minor capsid proteins Vp2 and Vp3 are essential for virus propagation." Journal of Virology, vol. 80, no. 21, 2006, pp. 10858-61. |
| Manley K, O'hara BA, Gee GV, Simkevich CP, Sedivy JM, Atwood WJ. "NFAT4 is required for JC virus infection of glial cells." Journal of Virology, vol. 80, no. 24, 2006, pp. 12079-85. |
| Eash S, Manley K, Gasparovic M, Querbes W, Atwood WJ. "The human polyomaviruses." Cellular and molecular life sciences : CMLS, vol. 63, no. 7-8, 2006, pp. 865-76. |
| Gee GV, Dugan AS, Tsomaia N, Mierke DF, Atwood WJ. "The role of sialic acid in human polyomavirus infections." Glycoconj J, vol. 23, no. 1-2, 2006, pp. 19-26. |
| Josephson MA, Gillen D, Javaid B, Kadambi P, Meehan S, Foster P, Harland R, Thistlethwaite RJ, Garfinkel M, Atwood W, Jordan J, Sadhu M, Millis MJ, Williams J. "Treatment of renal allograft polyoma BK virus infection with leflunomide." Transplantation, vol. 81, no. 5, 2006, pp. 704-10. |
| Dugan AS, Eash S, Atwood WJ. "Update on BK virus entry and intracellular trafficking." Transplant Infectious Disease, vol. 8, no. 2, 2006, pp. 62-7. |
| Ashok A, Atwood WJ. "Virus receptors and tropism." Systems Biology of RNA Binding Proteins, vol. 577, 2006, pp. 60-72. |
| Elphick, Gwendolyn F., Atwood, Walter J. "#35 Distribution of JC virus receptors in human tissue: Implications for infection." Psychoneuroendocrinology, vol. 19, no. 4, 2005, pp. e18. |
| Dugan AS, Eash S, Atwood WJ. "An N-linked glycoprotein with alpha(2,3)-linked sialic acid is a receptor for BK virus." Journal of Virology, vol. 79, no. 22, 2005, pp. 14442-5. |
| Eash S, Atwood WJ. "Involvement of cytoskeletal components in BK virus infectious entry." Journal of Virology, vol. 79, no. 18, 2005, pp. 11734-41. |
| Williams JW, Javaid B, Kadambi PV, Gillen D, Harland R, Thistlewaite JR, Garfinkel M, Foster P, Atwood W, Millis JM, Meehan SM, Josephson MA. "Leflunomide for polyomavirus type BK nephropathy." New England Journal of Medicine, vol. 352, no. 11, 2005, pp. 1157-8. |
| Querbes W, Benmerah A, Tosoni D, Di Fiore PP, Atwood WJ. "A JC virus-induced signal is required for infection of glial cells by a clathrin- and eps15-dependent pathway." Journal of Virology, vol. 78, no. 1, 2004, pp. 250-6. |
| Trofe J, Gordon J, Roy-Chaudhury P, Koralnik I, Atwood W, Eash S, Alloway RR, Khalili K, Alexander JW, Woodle ES. "Basic and clinical research in polyomavirus nephropathy." Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, vol. 2, no. 1, 2004, pp. 162-73. |
| Eash S, Tavares R, Stopa EG, Robbins SH, Brossay L, Atwood WJ. "Differential distribution of the JC virus receptor-type sialic acid in normal human tissues." The American Journal of Pathology, vol. 164, no. 2, 2004, pp. 419-28. |
| Eash S, Querbes W, Atwood WJ. "Infection of vero cells by BK virus is dependent on caveolae." Journal of Virology, vol. 78, no. 21, 2004, pp. 11583-90. |
| Gee GV, Tsomaia N, Mierke DF, Atwood WJ. "Modeling a sialic acid binding pocket in the external loops of JC virus VP1." Journal of Biological Chemistry, vol. 279, no. 47, 2004, pp. 49172-6. |
| Qu Q, Sawa H, Suzuki T, Semba S, Henmi C, Okada Y, Tsuda M, Tanaka S, Atwood WJ, Nagashima K. "Nuclear entry mechanism of the human polyomavirus JC virus-like particle: role of importins and the nuclear pore complex." Journal of Biological Chemistry, vol. 279, no. 26, 2004, pp. 27735-42. |
| Trofe, Jennifer, Gordon, Jennifer, Roy-Chaudhury, Prabir, Koralnik, Igor, Atwood, Walter, Alloway, Rita, Khalili, Kamel, Woodle, E. "Polyomavirus nephropathy in kidney transplantation." Progress in Transplantation, vol. 14, no. 2, 2004, pp. 130-142. |
| Trofe J, Gordon J, Roy-Chaudhury P, Koralnik IJ, Atwood WJ, Alloway RR, Khalili K, Woodle ES. "Polyomavirus nephropathy in kidney transplantation." Progress in Transplantation, vol. 14, no. 2, 2004, pp. 130-40; quiz 141-2. |
| Elphick GF, Querbes W, Jordan JA, Gee GV, Eash S, Manley K, Dugan A, Stanifer M, Bhatnagar A, Kroeze WK, Roth BL, Atwood WJ. "The human polyomavirus, JCV, uses serotonin receptors to infect cells." Science, vol. 306, no. 5700, 2004, pp. 1380-3. |
| Ashok A, Atwood WJ. "Contrasting roles of endosomal pH and the cytoskeleton in infection of human glial cells by JC virus and simian virus 40." Journal of Virology, vol. 77, no. 2, 2003, pp. 1347-56. |
| Gee GV, Manley K, Atwood WJ. "Derivation of a JC virus-resistant human glial cell line: implications for the identification of host cell factors that determine viral tropism." Virology, vol. 314, no. 1, 2003, pp. 101-9. |
| Baum S, Ashok A, Gee G, Dimitrova S, Querbes W, Jordan J, Atwood WJ. "Early events in the life cycle of JC virus as potential therapeutic targets for the treatment of progressive multifocal leukoencephalopathy." Journal of NeuroVirology, vol. 9 Suppl 1, 2003, pp. 32-7. |
| Atwood WJ. "Genotypes, archetypes, and tandem repeats in the molecular epidemiology and pathogenesis of JC virus induced disease." Journal of NeuroVirology, vol. 9, no. 5, 2003, pp. 519-21. |
| Chen BJ, Atwood WJ. "Construction of a novel JCV/SV40 hybrid virus (JCSV) reveals a role for the JCV capsid in viral tropism." Virology, vol. 300, no. 2, 2002, pp. 282-90. |
| Komagome R, Sawa H, Suzuki T, Suzuki Y, Tanaka S, Atwood WJ, Nagashima K. "Oligosaccharides as receptors for JC virus." Journal of Virology, vol. 76, no. 24, 2002, pp. 12992-3000. |
| Atwood WJ. "A combination of low-dose chlorpromazine and neutralizing antibodies inhibits the spread of JC virus (JCV) in a tissue culture model: implications for prophylactic and therapeutic treatment of progressive multifocal leukencephalopathy." Journal of NeuroVirology, vol. 7, no. 4, 2001, pp. 307-10. |
| Schweighardt B, Shieh JT, Atwood WJ. "CD4/CXCR4-independent infection of human astrocytes by a T-tropic strain of HIV-1." Journal of NeuroVirology, vol. 7, no. 2, 2001, pp. 155-62. |
| Schweighardt B, Atwood WJ. "Glial cells as targets of viral infection in the human central nervous system." Progress in brain research, vol. 132, 2001, pp. 721-35. |
| Schweighardt B, Atwood WJ. "HIV type 1 infection of human astrocytes is restricted by inefficient viral entry." AIDS Research and Human Retroviruses, vol. 17, no. 12, 2001, pp. 1133-42. |
| Liu CK, Atwood WJ. "Propagation and assay of the JC virus." Methods in Molecular Biology, vol. 165, 2001, pp. 9-17. |
| Schweighardt B, Atwood WJ. "Virus receptors in the human central nervous system." Journal of NeuroVirology, vol. 7, no. 3, 2001, pp. 187-95. |
| Wei G, Liu CK, Atwood WJ. "JC virus binds to primary human glial cells, tonsillar stromal cells, and B-lymphocytes, but not to T lymphocytes." Journal of NeuroVirology, vol. 6, no. 2, 2000, pp. 127-36. |
| Pho MT, Ashok A, Atwood WJ. "JC virus enters human glial cells by clathrin-dependent receptor-mediated endocytosis." Journal of Virology, vol. 74, no. 5, 2000, pp. 2288-92. |
| Liu CK, Wei G, Atwood WJ. "Infection of glial cells by the human polyomavirus JC is mediated by an N-linked glycoprotein containing terminal alpha(2-6)-linked sialic acids." Journal of Virology, vol. 72, no. 6, 1998, pp. 4643-9. |
| Liu CK, Hope AP, Atwood WJ. "The human polyomavirus, JCV, does not share receptor specificity with SV40 on human glial cells." Journal of NeuroVirology, vol. 4, no. 1, 1998, pp. 49-58. |
| Tornatore C, Baker-Cairns B, Yadid G, Hamilton R, Meyers K, Atwood W, Cummins A, Tanner V, Major E. "Expression of tyrosine hydroxylase in an immortalized human fetal astrocyte cell line; in vitro characterization and engraftment into the rodent striatum." Cell transplantation, vol. 5, no. 2, 1996, pp. 145-63. |
| Monaco MC, Atwood WJ, Gravell M, Tornatore CS, Major EO. "JC virus infection of hematopoietic progenitor cells, primary B lymphocytes, and tonsillar stromal cells: implications for viral latency." Journal of Virology, vol. 70, no. 10, 1996, pp. 7004-12. |
| Atwood WJ, Wang L, Durham LC, Amemiya K, Traub RG, Major EO. "Evaluation of the role of cytokine activation in the multiplication of JC virus (JCV) in human fetal glial cells." Journal of NeuroVirology, vol. 1, no. 1, 1995, pp. 40-9. |
| Conant K, Atwood WJ, Traub R, Tornatore C, Major EO. "An increase in p50/p65 NF-kB binding to the HIV-1 LTR is not sufficient to increase viral expression in the primary human astrocyte." Virology, vol. 205, no. 2, 1994, pp. 586-90. |
| Conant K, Tornatore C, Atwood W, Meyers K, Traub R, Major EO. "In vivo and in vitro infection of the astrocyte by HIV-1." Advances in neuroimmunology, vol. 4, no. 3, 1994, pp. 287-9. |
| Atwood WJ, Tornatore CS, Traub R, Conant K, Drew PD, Major EO. "Stimulation of HIV type 1 gene expression and induction of NF-kappa B (p50/p65)-binding activity in tumor necrosis factor alpha-treated human fetal glial cells." AIDS Research and Human Retroviruses, vol. 10, no. 10, 1994, pp. 1207-11. |
| Tornatore C, Meyers K, Atwood W, Conant K, Major E. "Temporal patterns of human immunodeficiency virus type 1 transcripts in human fetal astrocytes." Journal of Virology, vol. 68, no. 1, 1994, pp. 93-102. |
| Atwood WJ, Tornatore CS, Meyers K, Major EO. "HIV-1 mRNA transcripts from persistently infected human fetal astrocytes." Annals of the New York Academy of Sciences, vol. 693, 1993, pp. 324-5. |
| Atwood WJ, Berger JR, Kaderman R, Tornatore CS, Major EO. "Human immunodeficiency virus type 1 infection of the brain." Clinical microbiology reviews, vol. 6, no. 4, 1993, pp. 339-66. |
| Breau WC, Atwood WJ, Norkin LC. "Class I major histocompatibility proteins are an essential component of the simian virus 40 receptor." Journal of Virology, vol. 66, no. 4, 1992, pp. 2037-45. |
| Atwood WJ, Amemiya K, Traub R, Harms J, Major EO. "Interaction of the human polyomavirus, JCV, with human B-lymphocytes." Virology, vol. 190, no. 2, 1992, pp. 716-23. |
| Atwood WJ, Norkin LC. "Class I major histocompatibility proteins as cell surface receptors for simian virus 40." Journal of Virology, vol. 63, no. 10, 1989, pp. 4474-7. |
Research in our laboratory focuses on studying the human polyomaviruses, JCPyV and BKPyV. JCPyV and BKPyV both infect greater than 60% of the human population worldwide. The viruses establish life-long persistent infection in the kidney and are excreted in the urine. In immunosuppressed patients or in patients being treated with immunomodulatory drugs JCPyV spreads to the central nervous system (CNS) where it infects oligodendrocytes causing a fatal demyelinating disease known as progressive multifocal leukoencephalopathy (PML). Reactivation of BKPyV in kidney and bone marrow transplant recipients gives rise to polyomavirus nephropathy and hemorrhagic cystitis and has emerged as a major contributor to transplant failure. Our major goals are to understand mechanisms of persistence, reactivation, and virus tropism that leads to the development of polyomavirus induced disease. Our efforts are largely but not exclusively focused on identifying receptor dependent and receptor independent mechanisms of infection, identifying early biomarkers of disease, and developing strategies to prevent or treat PML.
The Laboratory of Molecular Virology at Brown University (Atwood Lab)
Our laboratory is focused on studying the pathogenesis of the human polyomaviruses, JC Virus (JCPyV) and BK Virus (BKPyV). Reactivation of JCPyV under conditions of immunosuppression leads to the fatal demyelinating disease in humans known as Progressive Multifocal Leukoencephalopathy (PML). Approximately 5% of patients with AIDS will develop PML and the majority succumb within two years of diagnosis. Reactivation of BKPyV in kidney transplant recipients has emerged as a major problem in the last decade and contributes to kidney transplant failure. The major focus of the lab is studying early events that mediate infection of cells by these viruses. These early events include but are not limited to studies of virus-host cell receptor interactions, endocytic trafficking of virus from the plasma membrane to the nucleus, and virus induced membrane signaling. We have a general interest in studying events that contribute to viral tropism and regulate the balance between infection and resistance. We also focus our efforts at screening lead compounds that block any of these key steps in the viral life cycle as potential therapies to treat or prevent disease caused by JCPyV and BKPyV. We approach these problems using state of the art techniques in cell and molecular biology and genetics. Examples of projects of interest are listed below.
-Receptor dependent and independent mechanisms of infection. JCPyV and BKPyV can infect cells either directly or indirectly by being cloaked within extracellular vesicles. We are interested in defining how these viruses come to exist within the vesicles and how these vesicles interact with diverse cells and tissues.
-Neurotropism. The mechanism by which JCPyV invades the brain to cause disease is not known. We are interested in exploring the interactions between free virus and vesicle-associated virus with cell types that form barriers between the blood and the brain.
-Persistent infection. JCPyV and BKPyV establish persistent infection in kidney cells. We are interested in identifying viral and cellular components that contribute to the establishment and maintenance of persistence in different cell and tissue types.
A retrograde trafficking inhibitor of ricin and Shiga-like toxins inhibits infection of cells by human and monkey polyomaviruses. Nelson CD, Carney DW, Derdowski A, Lipovsky A, Gee GV, O'Hara B, Williard P, DiMaio D, Sello JK, Atwood WJ. MBio. 2013 Nov 12;4(6):e00729-13.
The human alpha defensin HD5 neutralizes JC polyomavirus infection by reducing endoplasmic reticulum traffic and stabilizing the viral capsid. Zins SR, Nelson CD, Maginnis MS, Banerjee R, O'Hara BA, Atwood WJ. J Virol. 2014 Jan;88(2):948-60.
A structure-guided mutation in the major capsid protein retargets BK polyomavirus. Neu U, Allen SA, Blaum BS, Liu Y, Frank M, Palma AS, Ströh LJ, Feizi T, Peters T, Atwood WJ, Stehle T. PLoS Pathog. 2013;9(10):e1003688.
Pseudovirus mimics cell entry and trafficking of the human polyomavirus JCPyV. Gee GV, O'Hara BA, Derdowski A, Atwood WJ. Virus Res. 2013 Dec 26;178(2):281-6.
5-HT2 receptors facilitate JC polyomavirus entry. Assetta B, Maginnis MS, Gracia Ahufinger I, Haley SA, Gee GV, Nelson CD, O'Hara BA, Allen Ramdial SA, Atwood WJ. J Virol. 2013 Dec;87(24):13490-8.
Progressive multifocal leukoencephalopathy-associated mutations in the JC polyomavirus capsid disrupt lactoseries tetrasaccharide c binding. Maginnis MS, Ströh LJ, Gee GV, O'Hara BA, Derdowski A, Stehle T, Atwood WJ. MBio. 2013 Jun 11;4(3):e00247-13.
Genome-wide siRNA screen identifies the retromer as a cellular entry factor for human papillomavirus. Lipovsky A, Popa A, Pimienta G, Wyler M, Bhan A, Kuruvilla L, Guie MA, Poffenberger AC, Nelson CD, Atwood WJ, DiMaio D.Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7452-7.
Reining in polyoma virus associated nephropathy: design and characterization of a template mimicking BK viral coat protein cellular binding. Audu CO, O'Hara B, Pellegrini M, Wang L, Atwood WJ, Mierke DF. Biochemistry. 2012 Oct 16;51(41):8092-9.
Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain. Ferenczy MW, Marshall LJ, Nelson CD, Atwood WJ, Nath A, Khalili K, Major EO. Clin Microbiol Rev. 2012 Jul;25(3):471-506.
The VP1 subunit of JC polyomavirus recapitulates early events in viral trafficking and is a novel tool to study polyomavirus entry. Nelson CD, Derdowski A, Maginnis MS, O'Hara BA, Atwood WJ. Virology. 2012 Jun 20;428(1):30-40.
BiP and multiple DNAJ molecular chaperones in the endoplasmic reticulum are required for efficient simian virus 40 infection.Goodwin EC, Lipovsky A, Inoue T, Magaldi TG, Edwards AP, Van Goor KE, Paton AW, Paton JC, Atwood WJ, Tsai B, DiMaio D. MBio. 2011 Jun 14;2(3):e00101-11.
Taxonomical developments in the family Polyomaviridae. Johne R, Buck CB, Allander T, Atwood WJ, Garcea RL, Imperiale MJ, Major EO, Ramqvist T, Norkin LC. Arch Virol. 2011 Sep;156(9):1627-34.
The structure of avian polyomavirus reveals variably sized capsids, non-conserved inter-capsomere interactions, and a possible location of the minor capsid protein VP4. Shen PS, Enderlein D, Nelson CD, Carter WS, Kawano M, Xing L, Swenson RD, Olson NH, Baker TS, Cheng RH, Atwood WJ, Johne R, Belnap DM. Virology. 2011 Mar 1;411(1):142-52.
Structure-function analysis of the human JC polyomavirus establishes the LSTc pentasaccharide as a functional receptor motif. Neu U,Maginnis MS, Palma AS, Ströh LJ, Nelson CD, Feizi T, Atwood WJ, Stehle T. Cell Host Microbe. 2010 Oct 21;8(4):309-19.
SV40 associated miRNAs are not detectable in mesotheliomas. Gee GV, Stanifer ML, Christensen BC, Atwood WJ, Ugolini D, Bonassi S, Resnick MB, Nelson HH, Marsit CJ, Kelsey KT. Br J Cancer. 2010 Sep 7;103(6):885-8.
Role of N-linked glycosylation of the 5-HT2A receptor in JC virus infection. Maginnis MS, Haley SA, Gee GV, Atwood WJ. J Virol. 2010 Oct;84(19):9677-84.
Unique susceptibility of a human lung carcinoid tumor cell line to infection with BK virus. Haley SA, O'Hara BA, Banerjee R, Atwood WJ. Virus Res. 2010 Apr;149(1):128-32.
Transcriptional regulation of BK virus by nuclear factor of activated T cells. Jordan JA, Manley K, Dugan AS, O'Hara BA, Atwood WJ. J Virol. 2010 Feb;84(4):1722-30.
Modulation of PML protein expression regulates JCV infection. Gasparovic ML, Maginnis MS, O'Hara BA, Dugan AS, Atwood WJ. Virology. 2009 Aug 1;390(2):279-88.
JC virus: an oncogenic virus in animals and humans? Maginnis MS, Atwood WJ. Semin Cancer Biol. 2009 Aug;19(4):261-9.
High-throughput cell-based screen for chemicals that inhibit infection by simian virus 40 and human polyomaviruses. Goodwin EC, Atwood WJ, DiMaio D. J Virol. 2009 Jun;83(11):5630-9.
The Polyomaviridae: Contributions of virus structure to our understanding of virus receptors and infectious entry. Neu U, Stehle T, Atwood WJ. Virology. 2009 Feb 20;384(2):389-99.
Human alpha-defensins inhibit BK virus infection by aggregating virions and blocking binding to host cells. Dugan AS, Maginnis MS, Jordan JA, Gasparovic ML, Manley K, Page R, Williams G, Porter E, O'Hara BA, Atwood WJ. J Biol Chem. 2008 Nov 7;283(45):31125-32.
Evolutionarily conserved function of a viral microRNA. Seo GJ, Fink LH, O'Hara B, Atwood WJ, Sullivan CS. J Virol. 2008 Oct;82(20):9823-8.
Human embryonic stem cell-derived oligodendrocyte progenitor cells express the serotonin receptor and are susceptible to JC virus infection. Schaumburg C, O'Hara BA, Lane TE, Atwood WJ. J Virol. 2008 Sep;82(17):8896-9.
Direct correlation between sialic acid binding and infection of cells by two human polyomaviruses (JC virus and BK virus). Dugan AS, Gasparovic ML, Atwood WJ. J Virol. 2008 Mar;82(5):2560-4.
Interferon beta1-a and selective anti-5HT(2a) receptor antagonists inhibit infection of human glial cells by JC virus. O'Hara BA, Atwood WJ. Virus Res. 2008 Mar;132(1-2):97-103.
Nuclear factor of activated T-cells (NFAT) plays a role in SV40 infection. Manley K, O'Hara BA, Atwood WJ. Virology. 2008 Mar 1;372(1):48-55.
Identification of amino acid residues in BK virus VP1 that are critical for viability and growth.vDugan AS, Gasparovic ML, Tsomaia N, Mierke DF, O'Hara BA, Manley K, Atwood WJ. J Virol. 2007 Nov;81(21):11798-808.
Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression. Manley K, Gee GV, Simkevich CP, Sedivy JM, Atwood WJ. Virology. 2007 Sep 30;366(2):394-404.
JC virus minor capsid proteins Vp2 and Vp3 are essential for virus propagation. Gasparovic ML, Gee GV, Atwood WJ. J Virol. 2006 Nov;80(21):10858-61.
NFAT4 is required for JC virus infection of glial cells. Manley K, O'hara BA, Gee GV, Simkevich CP, Sedivy JM, Atwood WJ. J Virol. 2006 Dec;80(24):12079-85.
Invasion of host cells by JC virus identifies a novel role for caveolae in endosomal sorting of noncaveolar ligands. Querbes W, O'Hara BA, Williams G, Atwood WJ. J Virol. 2006 Oct;80(19):9402-13.
Update on BK virus entry and intracellular trafficking. Dugan AS, Eash S, Atwood WJ. Transpl Infect Dis. 2006 Jun;8(2):62-7.
Virus receptors and tropism. Ashok A, Atwood WJ. Adv Exp Med Biol. 2006;577:60-72.
The role of sialic acid in human polyomavirus infections. Gee GV, Dugan AS, Tsomaia N, Mierke DF, Atwood WJ. Glycoconj J. 2006 Feb;23(1-2):19-26.
The human polyomaviruses. Eash S, Manley K, Gasparovic M, Querbes W, Atwood WJ. Cell Mol Life Sci. 2006 Apr;63(7-8):865-76.
An N-linked glycoprotein with alpha(2,3)-linked sialic acid is a receptor for BK virus. Dugan AS, Eash S, Atwood WJ. J Virol. 2005 Nov; 79(22):14442-5.
Involvement of cytoskeletal components in BK virus infectious entry. Eash S, Atwood WJ. J Virol. 2005 Sep;79(18):11734-41.
The human polyomavirus, JCV, uses serotonin receptors to infect cells. Elphick GF, Querbes W, Jordan JA, Gee GV, Eash S, Manley K, Dugan A, Stanifer M, Bhatnagar A, Kroeze WK, Roth BL, Atwood WJ. Science. 2004 Nov 19;306(5700):1380-3.
Infection of vero cells by BK virus is dependent on caveolae. Eash S, Querbes W, Atwood WJ. J Virol. 2004 Nov;78(21):11583-90.
Modeling a sialic acid binding pocket in the external loops of JC virus VP1. Gee GV, Tsomaia N, Mierke DF, Atwood WJ. J Biol Chem. 2004 Nov 19;279(47):49172-6.
Polyomavirus nephropathy in kidney transplantation. Trofe J, Gordon J, Roy-Chaudhury P, Koralnik IJ, Atwood WJ, Alloway RR, Khalili K, Woodle ES. Prog Transplant. 2004 Jun;14(2):130-40
Nuclear entry mechanism of the human polyomavirus JC virus-like particle: role of importins and the nuclear pore complex. Qu Q, Sawa H, Suzuki T, Semba S, Henmi C, Okada Y, Tsuda M, Tanaka S, Atwood WJ, Nagashima K. J Biol Chem. 2004 Jun 25;279(26):27735-42.
Differential distribution of the JC virus receptor-type sialic acid in normal human tissues. Eash S, Tavares R, Stopa EG, Robbins SH, Brossay L, Atwood WJ. Am J Pathol. 2004 Feb;164(2):419-28.
A JC virus-induced signal is required for infection of glial cells by a clathrin- and eps15-dependent pathway. Querbes W, Benmerah A, Tosoni D, Di Fiore PP, Atwood WJ. J Virol. 2004 Jan;78(1):250-6.
Derivation of a JC virus-resistant human glial cell line: implications for the identification of host cell factors that determine viral tropism. Gee GV, Manley K, Atwood WJ. Virology. 2003 Sep 15;314(1):101-9.
Genotypes, archetypes, and tandem repeats in the molecular epidemiology and pathogenesis of JC virus induced disease. Atwood WJ. J Neurovirol. 2003 Oct;9(5):519-21.
Early events in the life cycle of JC virus as potential therapeutic targets for the treatment of progressive multifocal leukoencephalopathy. Baum S, Ashok A, Gee G, Dimitrova S, Querbes W, Jordan J, Atwood WJ. J Neurovirol. 2003;9 Suppl 1:32-7.
Contrasting roles of endosomal pH and the cytoskeleton in infection of human glial cells by JC virus and simian virus 40. Ashok A, Atwood WJ. J Virol. 2003 Jan;77(2):1347-56.
Oligosaccharides as receptors for JC virus. Komagome R, Sawa H, Suzuki T, Suzuki Y, Tanaka S, Atwood WJ, Nagashima K. J Virol. 2002 Dec;76(24):12992-3000.
Construction of a novel JCV/SV40 hybrid virus (JCSV) reveals a role for the JCV capsid in viral tropism. Chen BJ, Atwood WJ. Virology. 2002 Sep 1;300(2):282-90.
Glial cells as targets of viral infection in the human central nervous system. Schweighardt B, Atwood WJ. Prog Brain Res. 2001;132:721-35.
HIV type 1 infection of human astrocytes is restricted by inefficient viral entry. Schweighardt B, Atwood WJ. AIDS Res Hum Retroviruses. 2001 Aug 10;17(12):1133-42.
A combination of low-dose chlorpromazine and neutralizing antibodies inhibits the spread of JC virus (JCV) in a tissue culture model: implications for prophylactic and therapeutic treatment of progressive multifocal leukencephalopathy. Atwood WJ. J Neurovirol. 2001 Aug;7(4):307-10.
Virus receptors in the human central nervous system. Schweighardt B, Atwood WJ. J Neurovirol. 2001 Jun;7(3):187-95. CD4/CXCR4-independent infection of human astrocytes by a T-tropic strain of HIV-1. Schweighardt B, Shieh JT, Atwood WJ. J Neurovirol. 2001 Apr;7(2):155-62.
Propagation and assay of the JC virus. Liu CK, Atwood WJ. Methods Mol Biol. 2001;165:9-17.
JC virus binds to primary human glial cells, tonsillar stromal cells, and B-lymphocytes, but not to T lymphocytes. Wei G, Liu CK, Atwood WJ. J Neurovirol. 2000 Apr;6(2):127-36
JC virus enters human glial cells by clathrin-dependent receptor-mediated endocytosis. Pho MT, Ashok A, Atwood WJ. J Virol. 2000 Mar;74(5):2288-92.
Infection of glial cells by the human polyomavirus JC is mediated by an N-linked glycoprotein containing terminal alpha(2-6)-linked sialic acids. Liu CK, Wei G, Atwood WJ. J Virol. 1998 Jun;72(6):4643-9.
The human polyomavirus, JCV, does not share receptor specificity with SV40 on human glial cells. Liu CK, Hope AP, Atwood WJ. J Neurovirol. 1998 Feb;4(1):49-58.
JC virus infection of hematopoietic progenitor cells, primary B lymphocytes, and tonsillar stromal cells: implications for viral latency. Monaco MC, Atwood WJ, Gravell M, Tornatore CS, Major EO. J Virol. 1996 Oct;70(10):7004-12.
Evaluation of the role of cytokine activation in the multiplication of JC virus (JCV) in human fetal glial cells. Atwood WJ, Wang L, Durham LC, Amemiya K, Traub RG, Major EO. J Neurovirol. 1995 Mar;1(1):40-9.
An increase in p50/p65 NF-kB binding to the HIV-1 LTR is not sufficient to increase viral expression in the primary human astrocyte. Conant K, Atwood WJ, Traub R, Tornatore C, Major EO. Virology. 1994 Dec;205(2):586-90.
Stimulation of HIV type 1 gene expression and induction of NF-kappa B (p50/p65)-binding activity in tumor necrosis factor alpha-treated human fetal glial cells. Atwood WJ, Tornatore CS, Traub R, Conant K, Drew PD, Major EO. AIDS Res Hum Retroviruses. 1994 Oct;10(10):1207-11. HIV-1 mRNA transcripts from persistently infected human fetal astrocytes. Atwood WJ, Tornatore CS, Meyers K, Major EO. Ann N Y Acad Sci. 1993 Oct 29;693:324-5.
Human immunodeficiency virus type 1 infection of the brain. Atwood WJ, Berger JR, Kaderman R, Tornatore CS, Major EO. Clin Microbiol Rev. 1993 Oct;6(4):339-66.
Interaction of the human polyomavirus, JCV, with human B-lymphocytes. Atwood WJ, Amemiya K, Traub R, Harms J, Major EO. Virology. 1992 Oct;190(2):716-23.
Class I major histocompatibility proteins are an essential component of the simian virus 40 receptor. Breau WC, Atwood WJ, Norkin LC. J Virol. 1992 Apr;66(4):2037-45.
Class I major histocompatibility proteins as cell surface receptors for simian virus 40. Atwood WJ, Norkin LC. J Virol. 1989 Oct;63(10):4474-7.
| Year | Degree | Institution |
|---|---|---|
| 1991 | PhD | University of Massachusetts, Amherst |
| 1986 | BS | University of Massachusetts, Amherst |
Fellow, American Academy of Microbiology
Editorial Board Member, Journal of Virology
Editorial Board Member, Virology
Editorial Board Member, Virus Research
National Institutes of Health Virology Study Section Member
Master of Arts Ad Eundem, Brown University
Dean's Teaching Excellence Award, Brown Medical School
Patent US0096951556B2BU2165, Compounds for the Treatment and Prevention of Infections, Issued July 4, 2017
| BIOL 0940A - Viral Epidemics |
