Dr. Chen is a medical professional and researcher with a diverse academic background. He earned his M.D. degree from Shanghai Medical College of Fudan University in China and went on to obtain a Master's degree in Neurobiology and a Ph.D. in Human Biology from the Philipp University of Marburg in Germany. Dr. Chen joined Women & Infants' Hospital in 2010 as a postdoctoral researcher in the Department of Pediatrics, where he worked under Dr. Barbara Stonestreet. Currently, he holds the position of assistant professor and is highly specialized in the field of perinatal brain injury.
Dr. Chen's research is focused on perinatal brain injury, which he investigates using unique fetal ovine and neonatal rat in vivo models, primary cerebral and cerebellar neuronal cultures, and stem cell-derived in vitro blood-brain barrier models. He has over twelve years of experience in biomedical research, with expertise in drug discovery, pharmacology, cell signaling, molecular and cell biology, and neurobiology. His primary specialization is in perinatal brain injury, including the underlying mechanisms such as neuroinflammation, blood-brain barrier breakdown, and cell death, and the development of neuroprotective strategies, such as neuroimmunological treatment.
| Chen XF, Wu Y, Kim B, Nguyen KV, Chen A, Qiu J, Santoso AR, Disdier C, Lim YP, Stonestreet BS. "Neuroprotective efficacy of hypothermia and Inter-alpha Inhibitor Proteins after hypoxic ischemic brain injury in neonatal rats." Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2024, pp. e00341. |
| Girolamo F, Lim YP, Virgintino D, Stonestreet BS, Chen XF. "Inter-Alpha Inhibitor Proteins Modify the Microvasculature after Exposure to Hypoxia-Ischemia and Hypoxia in Neonatal Rats." International Journal of Molecular Sciences, vol. 24, no. 7, 2023. |
| Chen X, Malaeb SN, Pan J, Wang L, Scafidi J. "Editorial: Perinatal hypoxic-ischemic brain injury: Mechanisms, pathogenesis, and potential therapeutic strategies." Frontiers in Cellular Neuroscience, vol. 16, 2022, pp. 1086692. |
| Koehn LM, Nguyen K, Chen X, Santoso A, Tucker R, Lim YP, Stonestreet BS. "Effects of Three Different Doses of Inter-Alpha Inhibitor Proteins on Severe Hypoxia-Ischemia-Related Brain Injury in Neonatal Rats." International Journal of Molecular Sciences, vol. 23, no. 21, 2022. |
| Chen X, Zhang J, Wu Y, Tucker R, Baird GL, Domonoske R, Barrios-Anderson A, Lim YP, Bath K, Walsh EG, Stonestreet BS. "Inter-alpha Inhibitor Proteins Ameliorate Brain Injury and Improve Behavioral Outcomes in a Sex-Dependent Manner After Exposure to Neonatal Hypoxia Ischemia in Newborn and Young Adult Rats." Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, vol. 19, no. 2, 2022, pp. 528-549. |
| Abou Mehrem A, Al Awad E, Anninck K, Au-Young S, Aydinol N, Bartmann P, Benders M, Benlamri A, Bolderheij L, Celik Y, Chan N, Chau C, Chau V, Chen X, Chetcuti Ganado C, Coetser A, Cools F, Da Rocha G, Deigner HP, Dereymaeker A, Deshmukh L, Domonoske R, Dossani S, Dsouza JM, El Gamal M, Eshemokhai P, Esser M, Fiedrich E, Franz A, Ghosh A, Groenendaal F, Grunau RE, Venkata SKRG, Hamitoglu S, Hellström-Westas L, Irvine L, Jansen K, Javadyan A, Jenkin G, Kamanga N, Kaur N, Keles E, Keller M, Kelly E, Kesting SJ, Kgwadi D, Kim B, Kohl M, Kowal D, Kricitober JD, Leijser L, LePine M, Lim YP, Lodha A, Londhe A, Ly L, Maes E, Malhotra A, Marlow N, Mathew JL, McDonald C, McLean M, Metcalfe C, Meyer R, Miller SP, Miller S, Mogajane T, Mohammad K, Momin S, Montpetit J, Mukiza N, Murthy P, Scott JN, Nakibuuka V, Nakwa F, Naulaers G, Noort J, Ntuli N, Ondongo-Ezhet C, Paul R, Pepper M, Plum A, Rombough B, Saugstad O, Scotland J, Scott J, Seake K, Sebunya R, Selvanathan T, Sepeng L, Simsek H, Steins-Rang C, Stonestreet B, Tang S, Taskin E, Thewissen L, Thomas S, Thomas R, van Kwawegen A, van Rensburg J, Velaphi S, Wu Y, Yaman A, Yapicioglu-Yildizdas H, Yawno T, Zaki P, Zein H, Zhou L. "Proceedings of the 13th International Newborn Brain Conference: Neuroprotection strategies in the neonate." Journal of neonatal-perinatal medicine, vol. 15, no. 2, 2022, pp. 427-439. |
| Hatayama K, Riddick S, Awa F, Chen X, Virgintino D, Stonestreet BS. "Time Course of Changes in the Neurovascular Unit after Hypoxic-Ischemic Injury in Neonatal Rats." International Journal of Molecular Sciences, vol. 23, no. 8, 2022. |
| Kazuki Hatayama,Boram Kim,Xiaodi Chen,Yow-Pin Lim, Joanne O. Davidson, Laura Bennet, Alistair J. Gunn, and Barbara S. Stonestreet. "Changes in Cellular Localization of Inter-Alpha Inhibitor Proteins after Cerebral Ischemia in the Near-Term Ovine Fetus." IJMS, vol. 22, no. 19, 2021. |
| Hatayama K, Kim B, Chen X, Lim YP, Davidson JO, Bennet L, Gunn AJ, Stonestreet BS. "Changes in Cellular Localization of Inter-Alpha Inhibitor Proteins after Cerebral Ischemia in the Near-Term Ovine Fetus." International Journal of Molecular Sciences, vol. 22, no. 19, 2021. |
| Kazuki Hatayama, Ray H Chen, Jordan Hanson, Kiyoshi Teshigawara, Joseph Qiu, Andre Santoso, Clémence Disdier, Sakura Nakada, Xiaodi Chen, Masahiro Nishibori, Yow-Pin Lim,* and Barbara S. Stonestreet*. "High Mobility Group Box-1 and Inter-alpha Inhibitor Proteins: In vitro binding and co-localization in cerebral cortex after hypoxic-ischemic injury." The FASEB Journal, 2021. |
| de la Monte SM, Gallucci GM, Lin A, Tong M, Chen X, Stonestreet BS. "Critical Shifts in Cerebral White Matter Lipid Profiles After Ischemic–Reperfusion Brain Injury in Fetal Sheep as Demonstrated by the Positive Ion Mode MALDI-Mass Spectrometry." Cell Medicine, vol. 12, 2020, pp. 215517901989700. |
| Schuffels S, Nakada S, Wu Y, Lim YP, Chen X*, Stonestreet BS* (shared senior authorship). "Effects of inter-alpha inhibitor proteins on brain injury after exposure of neonatal rats to severe hypoxia-ischemia." Experimental Neurology, vol. 334, 2020, pp. 113442. |
| Logsdon AF, Erickson MA, Chen X, Qiu J, Lim YP, Stonestreet BS, Banks WA. "Inter-alpha inhibitor proteins attenuate lipopolysaccharide-induced blood-brain barrier disruption and downregulate circulating interleukin 6 in mice." Journal of Cerebral Blood Flow & Metabolism, vol. 40, no. 5, 2020, pp. 1090-1102. |
| Disdier C, Awa F, Chen X, Dhillon SK, Galinsky R, Davidson JO, Lear CA, Bennet L, Gunn AJ, Stonestreet BS. "Lipopolysaccharide-induced changes in the neurovascular unit in the preterm fetal sheep brain." Journal of neuroinflammation, vol. 17, no. 1, 2020, pp. 167. |
| Koehn, Liam M., Chen, Xiaodi, Logsdon, Aric F., Lim, Yow-Pin, Stonestreet, Barbara S. "Novel Neuroprotective Agents to Treat Neonatal Hypoxic-Ischemic Encephalopathy: Inter-Alpha Inhibitor Proteins." International Journal of Molecular Sciences, vol. 21, no. 23, 2020, pp. 9193. |
| Kim B, De La Monte S, Hovanesian V, Patra A, Chen X, Chen RH, Miller MC, Pinar MH, Lim YP, Stopa EG, Stonestreet BS. "Ontogeny of inter-alpha inhibitor protein (IAIP) expression in human brain." Journal of neuroscience research, vol. 98, no. 5, 2020, pp. 869-887. |
| Chen X, Song D, Nakada S, Qiu J, Iwamoto K, Chen RH, Lim YP, Jusko WJ, Stonestreet BS. "Pharmacokinetics of Inter-Alpha Inhibitor Proteins and Effects on Hemostasis After Hypoxic-Ischemic Brain Injury in Neonatal Rats." Current pharmaceutical design, vol. 26, no. 32, 2020, pp. 3997-4006. |
| Chen X. "Potential neuroinvasive and neurotrophic properties of SARS-CoV-2 in pediatric patients: comparison of SARS-CoV-2 with non-segmented RNA viruses." Journal of NeuroVirology, 2020. |
| Chen X, Zhang J, Kim B, Jaitpal S, Meng SS, Adjepong K, Imamura S, Wake H, Nishibori M, Stopa EG, Stonestreet BS. "High-mobility group box-1 translocation and release after hypoxic ischemic brain injury in neonatal rats." Experimental Neurology, vol. 311, 2019, pp. 1-14. |
| Barrios-Anderson A, Chen X, Nakada S, Chen R, Lim YP, Stonestreet BS. "Inter-alpha Inhibitor Proteins Modulate Neuroinflammatory Biomarkers After Hypoxia-Ischemia in Neonatal Rats." Journal of Neuropathology and Experimental Neurology, 2019. |
| Chen X, Nakada S, Donahue JE, Chen RH, Tucker R, Qiu J, Lim YP, Stopa EG, Stonestreet BS. "Neuroprotective effects of inter-alpha inhibitor proteins after hypoxic-ischemic brain injury in neonatal rats." Experimental Neurology, vol. 317, 2019, pp. 244-259. |
| Gallucci GM, Tong M, Chen X, Stonestreet BS, Lin A, de la Monte SM. "Rapid Alterations in Cerebral White Matter Lipid Profiles After Ischemic-Reperfusion Brain Injury in Fetal Sheep as Demonstrated by MALDI-Mass Spectrometry." Pediatric and Developmental Pathology, vol. 22, no. 4, 2019, pp. 344-355. |
| Disdier C, Chen X, Kim JE, Threlkeld SW, Stonestreet BS. "Anti-Cytokine Therapy to Attenuate Ischemic-Reperfusion Associated Brain Injury in the Perinatal Period." Brain sciences, vol. 8, no. 6, 2018. |
| Chen X, Patra A, Sadowska GB, Stonestreet BS. "Ischemic-Reperfusion Injury Increases Matrix Metalloproteinases and Tissue Metalloproteinase Inhibitors in Fetal Sheep Brain." Developmental Neuroscience, vol. 40, no. 3, 2018, pp. 234-245. |
| Chen X, Hovanesian V, Naqvi S, Lim YP, Tucker R, Donahue JE, Stopa EG, Stonestreet BS. "Systemic infusions of anti-interleukin-1β neutralizing antibodies reduce short-term brain injury after cerebral ischemia in the ovine fetus." Brain, Behavior, and Immunity, vol. 67, 2018, pp. 24-35. |
| Spasova, Mariya S., Chen, Xiaodi, Sadowska, Grazyna B., Horton, Edward R., Lim, Yow-Pin, Stonestreet, Barbara S. "Ischemia reduces inter-alpha inhibitor proteins in the brain of the ovine fetus." Developmental Neurobiology, vol. 77, no. 6, 2017, pp. 726-737. |
| Patra A, Chen X, Sadowska GB, Zhang J, Lim YP, Padbury JF, Banks WA, Stonestreet BS. "Neutralizing anti-interleukin-1β antibodies reduce ischemia-related interleukin-1β transport across the blood-brain barrier in fetal sheep." Neuroscience, vol. 346, 2017, pp. 113-125. |
| Chen, X., Rivard, L., Naqvi, S., Nakada, S., Padbury, J.F., Sanchez-Esteban, J., Stopa, E.G., Lim, Y.-P., Stonestreet, B.S. "Expression and localization of Inter-alpha Inhibitors in rodent brain." Neuroscience, vol. 324, 2016, pp. 69-81. |
| Chen X, Jiang Y, Huang Z, Li D, Chen X, Cao M, Meng Q, Pang H, Sun L, Zhao Y, Cai L. "miRNA-378 reverses chemoresistance to cisplatin in lung adenocarcinoma cells by targeting secreted clusterin." Scientific reports, vol. 6, 2016, pp. 19455. |
| Zhang J, Sadowska GB, Chen X, Park SY, Kim JE, Bodge CA, Cummings E, Lim YP, Makeyev O, Besio WG, Gaitanis J, Banks WA, Stonestreet BS. "Anti-IL-6 neutralizing antibody modulates blood-brain barrier function in the ovine fetus." The FASEB Journal, vol. 29, no. 5, 2015, pp. 1739-53. |
| Sadowska GB, Chen X, Zhang J, Lim YP, Cummings EE, Makeyev O, Besio WG, Gaitanis J, Padbury JF, Banks WA, Stonestreet BS. "Interleukin-1β transfer across the blood-brain barrier in the ovine fetus." Journal of Cerebral Blood Flow & Metabolism, vol. 35, no. 9, 2015, pp. 1388-95. |
| Chen X, Sadowska GB, Zhang J, Kim JE, Cummings EE, Bodge CA, Lim YP, Makeyev O, Besio WG, Gaitanis J, Threlkeld SW, Banks WA, Stonestreet BS. "Neutralizing anti-interleukin-1β antibodies modulate fetal blood-brain barrier function after ischemia." Neurobiology of disease, vol. 73, 2015, pp. 118-29. |
| Sadowska GB, Ahmedli N, Chen X, Stonestreet BS. "Ontogeny of tight junction protein expression in the ovine cerebral cortex during development." Neuroscience, vol. 310, 2015, pp. 422-9. |
| Cohen SS, Min M, Cummings EE, Chen X, Sadowska GB, Sharma S, Stonestreet BS. "Effects of interleukin-6 on the expression of tight junction proteins in isolated cerebral microvessels from yearling and adult sheep." Neuroimmunomodulation, vol. 20, no. 5, 2013, pp. 264-73. |
| Chen X, Threlkeld SW, Cummings EE, Sadowska GB, Lim YP, Padbury JF, Sharma S, Stonestreet BS. "In-vitro validation of cytokine neutralizing antibodies by testing with ovine mononuclear splenocytes." Journal of comparative pathology, vol. 148, no. 2-3, 2013, pp. 252-8. |
| Chen X, Threlkeld SW, Cummings EE, Juan I, Makeyev O, Besio WG, Gaitanis J, Banks WA, Sadowska GB, Stonestreet BS. "Ischemia-reperfusion impairs blood-brain barrier function and alters tight junction protein expression in the ovine fetus." Neuroscience, vol. 226, 2012, pp. 89-100. |
| Vriens J, Owsianik G, Hofmann T, Philipp SE, Stab J, Chen X, Benoit M, Xue F, Janssens A, Kerselaers S, Oberwinkler J, Vennekens R, Gudermann T, Nilius B, Voets T. "TRPM3 is a nociceptor channel involved in the detection of noxious heat." Neuron, vol. 70, no. 3, 2011, pp. 482-94. |
| Hofmann T, Chubanov V, Chen X, Dietz AS, Gudermann T, Montell C. "Drosophila TRPM channel is essential for the control of extracellular magnesium levels." PLoS ONE, vol. 5, no. 5, 2010, pp. e10519. |
R21NS133544
Role: Multiple Principal Investigator
PIs: Dr. John Marshall (contact) and Dr. Xiaodi Chen
Funding Agency: NINDS/NIMH
Total Award Amount (including Indirect Costs): $482,753
Duration of Award: 04/01/2024-03/31/2026
Role: Principal Investigator
Funding Agency: NIH
Duration of Award: April 2021- March 2026
Total Funds/Indirect Funds: $2,489,955
Role: Subcontract Principal Investigator
PI: Dr. Yow-Pin Lin
Funding Agency: NIH
Duration of Award: Sep 2023- Aug 2026
Total Funds/Indirect Funds: $2,776,920
Role: Senior Researcher
Funding Agency: NIH
Duration of Award: August 2017- July 2022
Total Funds/Indirect Funds: $1,431,875/849,245
Role: Co-Investigator/Research Consultant
Funding Agency: NIH
Duration of Award: June 2017- October 2021
Total Funds/Indirect Funds: $ 1,824,564
Role: Senior Researcher
Funding Agency: NIH/NINDS
Duration of Award: 08/2017 – 07/2020
Role: Principal Investigator
Funding Agency: Women & Infants' Hospital of RI, Alpert Medical School of Brown University
Duration of Award: June 2019 - May 2020
Amount per Year: $20,000
Role: Principal Investigator
Funding Agency: Women & Infants' Hospital of RI, Alpert Medical School of Brown University
Duration of Award: June 2018 - May 2019
Amount per Year: $20,000
Role: Senior Researcher
Funding Agency: NIH
Duration of Award: August 2016- July 2018
Amount per Year: $ 275,000/165,550
Role: Principal Investigator
Funding Agency: Women & Infants' Hospital of RI, Alpert Medical School of Brown University
Duration of Award: May 2015 - April 2016 (Extended to April 2017)
Amount per Year: $20,000
| Year | Degree | Institution |
|---|---|---|
| 2009 | PhD | Philipps University, Marburg |
| 2009 | PhD | Philipps Universitaet Marburg |
| 2006 | MSc | Philipps Universitaet Marburg |
| 2006 | MMSc | Philipps University, Marburg |
| 1996 | MD | Shanghai Medical University |
| 1996 | MD | Shanghai Medical School of Fudan University (Former: Shanghai Medical University) |
| Postdoc Research Associate | Women & Infants' Hospital of RI, Women & Infants' Hospital of RI, Pediatrics | 2010-2015 | Providence , RI, USA |
| Name | Title |
|---|---|
| Bath, Kevin | Associate Professor of Cognitive, Linguistic and Psychological Sciences |
| De La Monte, Suzanne | Professor of Pathology and Laboratory Medicine, Professor of Neurosurgery |
| Fallon, Justin | Professor of Medical Science, Professor of Psychiatry and Human Behavior |
| Lim, Yow-Pin | Adjunct Professor of Pathology and Laboratory Medicine |
| Marshall, John | Professor of Medical Science |
| Padbury, James | William and Mary Oh - William and Elsa Zopfi Professor of Pediatrics for Perinatal Research |
| Stopa, Edward | Professor of Pathology and Laboratory Medicine, Professor of Neurosurgery |
| Walsh, Edward | Associate Professor of Brain Science (Research) |
| Associate Professor. Alpert Medical School, Brown University, 2023- |
| Senior Researcher. Women & Infants' Hospital of RI, 2016- |
| Assistant Professor. Alpert Medical School of Brown University, 2016- |
