Expertise/Certifications: Breast Pathology, Surgical Pathology, Anatomic Pathology, Clinical Pathology
Office number: 444-5152
(Lab Customer Service: 401-793-4242)
Dr. Wang is on the faculty of Pathology and Laboratory Medicine at the Warren Alpert School of Medicine at Brown University, and the director of breast pathology for Lifespan Laboratories. She obtained her MD from Shandong Medical University, and her PhD from Ohio University. She completed her pathology residency and breast fellowship training at Harvard Medical School (HMS) /Beth Israel Deaconess Medical Center (BIDMC) in Boston.
| Nam, Gahie, Donegan, Linda, Gorbounov, Mikhail, Hacking, Sean, Wiggins, Doreen, Ward, Robert, Yakirevich, Evgeny, Wang, Yihong. "Growing fibroadenoma": Are there clinical and pathological features predicting a phyllodes tumor on surgical excision?." Annals of Diagnostic Pathology, vol. 62, 2023, pp. 152069. |
| Ostertag-Hill CA, Wang Y, Nickolich S, Wiggins DL. "Bloody nipple discharge due to intraductal papilloma in an adolescent girl." BMJ Case Reports, vol. 16, no. 3, 2023, pp. e254177. |
| Hacking SM, Pavlick D, Wang Y, Carneiro BA, Mullally M, Lu S, Canepa M, Bratslavsky G, Jacob J, Necchi A, Spiess PE, Wang L, Yakirevich E, Ross J. "Comprehensive Genomic Profiling of NF2-Mutated Kidney Tumors Reveals Potential Targets for Therapy." The oncologist, 2023. |
| Hacking, Sean M, Yakirevich, Evgeny, Wang, Yihong. "Defining triple‐negative breast cancer with neuroendocrine differentiation." The Journal of Pathology: Clinical Research, 2023. |
| Yilmaz, Fazilet, Hacking, Sean M, Donegan, Linda, Wang, Lijuan, Yakirevich, Evgeny, Wang, Yihong. "In Search of Calcifications : Histologic Analysis and Diagnostic Yield of Stereotactic Core Needle Breast Biopsies." American Journal of Clinical Pathology, 2023. |
| Hacking, Sean, Chou, Charissa, Baykara, Yigit, Wang, Yihong, Uzun, Alper, Gamsiz Uzun, Ece D. "MMR Deficiency Defines Distinct Molecular Subtype of Breast Cancer with Histone Proteomic Networks." International Journal of Molecular Sciences, vol. 24, no. 6, 2023, pp. 5327. |
| Saetern, Lonnie C., Wang, Yihong, Ribizzi-Akhtar, Iole. "Molecular profiling of a high-grade squamous cell carcinoma arising from sinonasal inverted papilloma." Otolaryngology Case Reports, vol. 27, 2023, pp. 100523. |
| Hacking, Sean M., Wang, Yihong. "Stromal grading predicts pathologic complete response and prognosis in triple-negative breast cancer." Virchows Archiv, 2023. |
| Hacking, Sean M., Karam, Julie, Singh, Kamaljeet, Gamsiz Uzun, Ece D., Brickman, Arlen, Yakirevich, Evgeny, Taliano, Ross, Wang, Yihong. "Whole slide image features predict pathologic complete response and poor clinical outcomes in triple-negative breast cancer." Pathology - Research and Practice, vol. 246, 2023, pp. 154476. |
| Pigg, Nicholas, Gordillo, Claudia, Wang, Yihong, Ward, Robert C. "Breast cancer cryoablation with radiologic–pathologic correlation." The British Journal of Radiology, vol. 95, no. 1140, 2022, pp. 20220480. |
| Hacking SM, Yakirevich E, Wang Y. "From Immunohistochemistry to New Digital Ecosystems: A State-of-the-Art Biomarker Review for Precision Breast Cancer Medicine." Cancers, vol. 14, no. 14, 2022, pp. 3469. |
| Ben Khadra, Shaza, Hacking, Sean M., Carpentier, Bianca, Singh, Kamaljeet, Wang, Lijuan, Yakirevich, Evgeny, Wang, Yihong. "Mass-forming ductal carcinoma in situ: An ultrasonographic and histopathologic correlation study." Pathology - Research and Practice, vol. 237, 2022, pp. 154035. |
| Hacking, Sean M., Leonard, Kara-Lynne, Wu, Dongling, Banks, Mara, Graves, Theresa, Wang, Lijuan, Yakirevich, Evgeny, Wang, Yihong. "Microinvasive breast cancer and the role of sentinel lymph node biopsy." Scientific Reports, vol. 12, no. 1, 2022. |
| Hacking, Sean M., Wang, Yihong. "Practical Issues of Ki-67 Evaluation in Breast Cancer Clinical Practice." Journal of Clinical and Translational Pathology, vol. 000, no. 000, 2022, pp. 000-000. |
| Hacking SM, Khadra SB, Singh K, Brickman A, Taliano R, Yakirevich E, Wang Y. "Stromal computational signatures predict upgrade to invasive carcinoma in mass-forming DCIS: A brief report of 44 cases." Pathology - Research and Practice, vol. 231, 2022, pp. 153771. |
| Mingrino J, Wang Y. "Apocrine ductal carcinoma in situ associated with testosterone therapy in a transgender individual." The Breast Journal, vol. 27, no. 5, 2021, pp. 475-477. |
| Nam G, Singh K, Lopresti ML, Ouseph MM, Wang LJ, Wang Y. "How Does Invasive Breast Cancer Oncotype Dx Recurrence Score on Core Needle Biopsies Influence Neoadjuvant Treatment Decision? A Descriptive Study." Technology in Cancer Research and Treatment, vol. 20, 2021, pp. 15330338211035037. |
| Wang Y, Singh K, Dizon D, Graves T, Amin A, Yakirevich E. "Immunohistochemical HER2 score correlates with response to neoadjuvant chemotherapy in HER2-positive primary breast cancer." Breast cancer research and treatment, vol. 186, no. 3, 2021, pp. 667-676. |
| Rohan TE, Arthur R, Wang Y, Weinmann S, Ginsberg M, Loi S, Salgado R. "Infiltrating immune cells in benign breast disease and risk of subsequent invasive breast cancer." Breast Cancer Research, vol. 23, no. 1, 2021, pp. 15. |
| Rohan TE, Ginsberg M, Wang Y, Couch FJ, Feigelson HS, Greenlee RT, Honda S, Stark A, Chitale D, Wang T, Xue X, Oktay MH, Sparano JA, Loudig O. "Molecular markers of risk of subsequent invasive breast cancer in women with ductal carcinoma in situ: protocol for a population-based cohort study." BMJ Open, vol. 11, no. 10, 2021, pp. e053397. |
| Wang, Yihong, Song, Elizabeth C. "Papillary neoplasm of the breast – A review and update." Human Pathology Reports, vol. 26, 2021, pp. 300581. |
| Figueroa JD, Gierach GL, Duggan MA, Fan S, Pfeiffer RM, Wang Y, Falk RT, Loudig O, Abubakar M, Ginsberg M, Kimes TM, Richert-Boe K, Glass AG, Rohan TE. "Risk factors for breast cancer development by tumor characteristics among women with benign breast disease." Breast cancer research : BCR, vol. 23, no. 1, 2021, pp. 34. |
| Lu S, Yakirevich E, Yang D, Xiao Y, Wang LJ, Wang Y. "Wnt Family Member 9b (Wnt9b) Is a New Sensitive and Specific Marker for Breast Cancer." The American Journal of Surgical Pathology, vol. 45, no. 12, 2021, pp. 1633-1640. |
| Canepa, Mariana, Wiggins, Doreen, Ram, Shruthi, Wang, Yihong. "Young woman with multicentric bilateral fibroadenomas and enchondroma, a possible association with Maffucci syndrome." Human Pathology Reports, vol. 26, 2021, pp. 300575. |
| Haghayeghi K, Najibi M, Wang H, Donegan L, Wang Y. "Clinicopathologic update of calcium oxalate in breast: A 15‐year retrospective review." The Breast Journal, vol. 26, no. 9, 2020, pp. 1736-1741. |
| Wang Y, Lu S, Amin A, Wang L. "Coexpress of GATA-3 and ER in Anorectal and Head and Neck Squamous Cell Carcinoma Mimicking Metastatic Breast Cancer." Applied Immunohistochemistry & Molecular Morphology, vol. 29, no. 6, 2020, pp. 409-413. |
| He, Li-Xia, Abdolmaleky, Hamid M., Yin, Sheng, Wang, Yihong, Zhou, Jin-Rong. "Dietary Fermented Soy Extract and Oligo-Lactic Acid Alleviate Chronic Kidney Disease in Mice via Inhibition of Inflammation and Modulation of Gut Microbiota." Nutrients, vol. 12, no. 8, 2020, pp. 2376. |
| Wang Y, Song EC, Resnick MB. "Elastin in the Tumor Microenvironment." Systems Biology of RNA Binding Proteins, vol. 1272, 2020, pp. 1-16. |
| Nam, Gahie, Strenger, Rochelle, Cutitar, Marlene, Wang, Yihong. "Low-grade adenosquamous carcinoma of the breast: A case with pathogenic germline mutation in the BRIP1 gene." Human Pathology: Case Reports, vol. 22, 2020, pp. 200444. |
| Lu S, Yakirevich E, Hart J, Wang L, Wang Y. "PAX8 Expression in Breast Cancer." Applied Immunohistochemistry & Molecular Morphology, vol. Publish Ahead of Print, no. 4, 2020, pp. 293-298. |
| Rohan, Thomas E., Wang, Tao, Weinmann, Sheila, Wang, Yihong, Lin, Juan, Ginsberg, Mindy, Loudig, Olivier. "A miRNA Expression Signature in Breast Tumor Tissue Is Associated with Risk of Distant Metastasis." Cancer Research, vol. 79, no. 7, 2019, pp. 1705-1713. |
| Nam G, Singer TM, Lourenco AP, Wang Y. "Cholesteroloma of the breast: A 10 year retrospective review of 79 cases with radiology correlation." The Breast Journal, vol. 25, no. 6, 2019, pp. 1177-1181. |
| Ma Y, Xu T, Huang X, Wang X, Li C, Jerwick J, Ning Y, Zeng X, Wang B, Wang Y, Zhang Z, Zhang X, Zhou C. "Computer-Aided Diagnosis of Label-Free 3-D Optical Coherence Microscopy Images of Human Cervical Tissue." IEEE Transactions on Biomedical Engineering, vol. 66, no. 9, 2019, pp. 2447-2456. |
| Lu S, Yakirevich E, Wang LJ, Resnick MB, Wang Y. "Cytokeratin 7-negative and GATA binding protein 3-negative breast cancers: Clinicopathological features and prognostic significance." BMC Cancer, vol. 19, no. 1, 2019, pp. 1085. |
| Paccez, Juliano D., Duncan, Kristal, Sekar, Durairaj, Correa, Ricardo G., Wang, Yihong, Gu, Xuesong, Bashin, Manoj, Chibale, Kelly, Libermann, Towia A., Zerbini, Luiz F. "Dihydroartemisinin inhibits prostate cancer via JARID2/miR-7/miR-34a-dependent downregulation of Axl." Oncogenesis, vol. 8, no. 3, 2019, pp. 14. |
| Wang Y, Hui Y, Resnick MB. "In reply to Lambein et al.: 'HER2 protein overexpression in non-amplified ductal carcinoma in situ: quality issue or transcription mechanisms gone awry?'." Histopathology, vol. 74, no. 4, 2019, pp. 666. |
| Ward RC, Donegan L, Khalil H, Wang Y. "Pilomatricoma of the male breast." The Breast Journal, vol. 25, no. 5, 2019, pp. 1012-1013. |
| Zhao, Chaohui Lisa, Singh, Kamaljeet, Brodsky, Alexander S., Lu, Shaolei, Graves, Theresa A., Fenton, Mary Anne, Yang, Dongfang, Sturtevant, Ashlee, Resnick, Murray B., Wang, Yihong. "Stromal ColXα1 expression correlates with tumor-infiltrating lymphocytes and predicts adjuvant therapy outcome in ER-positive/HER2-positive breast cancer." BMC Cancer, vol. 19, no. 1, 2019, pp. 1036. |
| Ward RC, Wang Y, Lourenco AP, Mainiero MB. "Symptomatic Fibroadenoma Resolves Status Post Cryoablation." Rhode Island medical journal (2013), vol. 102, no. 8, 2019, pp. 49-52. |
| He, Xin, Wang, Yihong, Nam, Gahie, Lourenco, Ana P, Pisharodi, Latha. "A 10 year retrospective review of fine needle aspiration cytology of cystic lesions of the breast with emphasis on papillary cystic lesions." Diagnostic Cytopathology, vol. 47, no. 5, 2018, pp. 400-403. |
| Suyama K, Yao J, Liang H, Benard O, Loudig OD, Amgalan D, McKimpson WM, Phillips GR, Segall J, Wang Y, Fineberg S, Norton L, Kitsis RN, Hazan RB. "An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis." Cancer Research, vol. 78, no. 1, 2018, pp. 103-114. |
| Zavitsanos, Peter J., Wazer, David E., Hepel, Jaroslaw T., Wang, Yihong, Singh, Kamaljeet, Leonard, Kara L. "BRCA1 Mutations Associated With Increased Risk of Brain Metastases in Breast Cancer." American Journal of Clinical Oncology, vol. 41, no. 12, 2018, pp. 1252-1256. |
| Wang Y, Lu S, Xiong J, Singh K, Hui Y, Zhao C, Brodsky AS, Yang D, Jolly G, Ouseph M, Schorl C, DeLellis RA, Resnick MB. "ColXα1 is a stromal component that colocalizes with elastin in the breast tumor extracellular matrix." The journal of pathology. Clinical research, vol. 5, no. 1, 2018, pp. 40-52. |
| Wang, Yihong, LeGolvan, Mark, Chapin, Kimberle, Mainiero, Martha. "Cystic neutrophilic granulomatous mastitis with corynebacterium and staphylococcus mimicking breast carcinoma." Clinical Case Reports, vol. 6, no. 11, 2018, pp. 2208-2210. |
| Hui, Yiang, Wang, Yihong, Nam, Gahie, Fanion, Jacqueline, Sturtevant, Ashlee, Lombardo, Kara A., Resnick, Murray B. "Differentiating breast carcinoma with signet ring features from gastrointestinal signet ring carcinoma: assessment of immunohistochemical markers." Human Pathology, vol. 77, 2018, pp. 11-19. |
| Hui, Yiang, Elco, Christopher P., Heinl, Nicole F., Lourenco, Ana P., Wiggins, Doreen L., Wang, Yihong. "Diffuse dermal angiomatosis mimicking inflammatory breast carcinoma." The Breast Journal, vol. 24, no. 2, 2018, pp. 196-198. |
| Hui Y, Lu S, Wang H, Resnick MB, Wang Y. "Discordant HER2 immunohistochemical expression and gene amplification in ductal carcinoma in situ - evaluating HER2 in synchronous in-situ and invasive carcinoma." Histopathology, vol. 74, no. 2, 2018, pp. 358-362. |
| Jackson CL, Hang S, Hansen K, He M, Sung CJ, Quddus MR, Xiong M, Wang Y, Patel NR, Lawrence WD, Xiong J. "Endometrial Adenocarcinomas With Significant Mucinous Differentiation: A Characterization of Intratumoral Heterogeneity of KRAS Mutations in Mucinous and Endometrioid Histologic Components." International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, vol. 28, no. 2, 2018, pp. 241-247. |
| Singh K, Paquette C, Kalife ET, Wang Y, Mangray S, Quddus MR, Steinhoff MM. "Evaluating agreement, histological features, and relevance of separating pleomorphic and florid lobular carcinoma in situ subtypes." Human Pathology, vol. 78, 2018, pp. 163-170. |
| Singh K, DiazGomez B, Wang Y, Ou J, Hansen K. "Invasive Lobular Carcinoma With Extracellular Mucin: Not All Mucinous Mammary Carcinomas Are Ductal!." International Journal of Surgical Pathology, vol. 27, no. 1, 2018, pp. 55-58. |
| Rohan, Thomas, Ye, Kenny, Wang, Yihong, Glass, Andrew G., Ginsberg, Mindy, Loudig, Olivier. "MicroRNA expression in benign breast tissue and risk of subsequent invasive breast cancer." PLOS ONE, vol. 13, no. 2, 2018, pp. e0191814. |
| Guo, Tianhua, Wang, Yihong, Shapiro, Nella, Fineberg, Susan. "Pleomorphic Lobular Carcinoma in Situ Diagnosed by Breast Core Biopsy: Clinicopathologic Features and Correlation With Subsequent Excision." Clinical Breast Cancer, vol. 18, no. 4, 2018, pp. e449-e454. |
| Singh, Kamaljeet, He, Xin, Kalife, Elizabeth T., Ehdaivand, Shahrzad, Wang, Yihong, Sung, C. James. "Relationship of histologic grade and histologic subtype with oncotype Dx recurrence score; retrospective review of 863 breast cancer oncotype Dx results." Breast Cancer Research and Treatment, vol. 168, no. 1, 2018, pp. 29-34. |
| Rohan, Thomas E., Miller, Christopher A., Li, Tiandao, Wang, Yihong, Loudig, Olivier, Ginsberg, Mindy, Glass, Andrew, Mardis, Elaine. "Somatic mutations in benign breast disease tissue and risk of subsequent invasive breast cancer." British Journal of Cancer, vol. 118, no. 12, 2018, pp. 1662-1664. |
| Wang Y, Brodsky AS, Xiong J, Lopresti ML, Yang D, Resnick MB. "Stromal Clusterin Expression Predicts Therapeutic Response to Neoadjuvant Chemotherapy in Triple Negative Breast Cancer." Clinical Breast Cancer, vol. 18, no. 3, 2018, pp. e373-e379. |
| Zeng X, Zhang X, Li C, Wang X, Jerwick J, Xu T, Ning Y, Wang Y, Zhang L, Zhang Z, Ma Y, Zhou C. "Ultrahigh-resolution optical coherence microscopy accurately classifies precancerous and cancerous human cervix free of labeling." Theranostics, vol. 8, no. 11, 2018, pp. 3099-3110. |
| Hendry S, Salgado R, Gevaert T, Russell PA, John T, Thapa B, Christie M, van de Vijver K, Estrada MV, Gonzalez-Ericsson PI, Sanders M, Solomon B, Solinas C, Van den Eynden GGGM, Allory Y, Preusser M, Hainfellner J, Pruneri G, Vingiani A, Demaria S, Symmans F, Nuciforo P, Comerma L, Thompson EA, Lakhani S, Kim SR, Schnitt S, Colpaert C, Sotiriou C, Scherer SJ, Ignatiadis M, Badve S, Pierce RH, Viale G, Sirtaine N, Penault-Llorca F, Sugie T, Fineberg S, Paik S, Srinivasan A, Richardson A, Wang Y, Chmielik E, Brock J, Johnson DB, Balko J, Wienert S, Bossuyt V, Michiels S, Ternes N, Burchardi N, Luen SJ, Savas P, Klauschen F, Watson PH, Nelson BH, Criscitiello C, O'Toole S, Larsimont D, de Wind R, Curigliano G, André F, Lacroix-Triki M, van de Vijver M, Rojo F, Floris G, Bedri S, Sparano J, Rimm D, Nielsen T, Kos Z, Hewitt S, Singh B, Farshid G, Loibl S, Allison KH, Tung N, Adams S, Willard-Gallo K, Horlings HM, Gandhi L, Moreira A, Hirsch F, Dieci MV, Urbanowicz M, Brcic I, Korski K, Gaire F, Koeppen H, Lo A, Giltnane J, Rebelatto MC, Steele KE, Zha J, Emancipator K, Juco JW, Denkert C, Reis-Filho J, Loi S, Fox SB. "Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research." Advances in anatomic pathology, vol. 24, no. 5, 2017, pp. 235-251. |
| Arthur R, Wang Y, Ye K, Glass AG, Ginsberg M, Loudig O, Rohan T. "Association between lifestyle, menstrual/reproductive history, and histological factors and risk of breast cancer in women biopsied for benign breast disease." Breast Cancer Research and Treatment, vol. 165, no. 3, 2017, pp. 623-631. |
| Wang Y, Lu S, Graves T, Ouseph MM, Resnick MB, Yakirevich E. "Can Sentinel Lymph Node Biopsy Be Spared in Papillary Carcinoma of the Breast?." Clinical Breast Cancer, vol. 17, no. 2, 2017, pp. 127-133. |
| Singh K, Wang Y, Marketkar S, Kalife ET, Steinhoff MM. "Comparison of estrogen receptor, progesterone receptor and HER2 results in concurrent ipsilateral samples with invasive breast carcinoma: a retrospective study of 246 biopsies from 119 patients." Human Pathology, vol. 65, 2017, pp. 123-132. |
| Loudig O, Wang T, Ye K, Lin J, Wang Y, Ramnauth A, Liu C, Stark A, Chitale D, Greenlee R, Multerer D, Honda S, Daida Y, Spencer Feigelson H, Glass A, Couch FJ, Rohan T, Ben-Dov IZ. "Evaluation and Adaptation of a Laboratory-Based cDNA Library Preparation Protocol for Retrospective Sequencing of Archived MicroRNAs from up to 35-Year-Old Clinical FFPE Specimens." International Journal of Molecular Sciences, vol. 18, no. 3, 2017. |
| Ward, Robert C., Donegan, Linda, Wang, Yihong, Chadashvili, Tamuna, Lourenco, Ana P. "Glomangioma of the male breast." The Breast Journal, vol. 24, no. 1, 2017, pp. 87-89. |
| Kalife ET, Lourenco AP, Baird GL, Wang Y. "Clinical and Radiologic Follow-up Study for Biopsy Diagnosis of Radial Scar/Radial Sclerosing Lesion without Other Atypia." The Breast Journal, vol. 22, no. 6, 2016, pp. 637-644. |
| Wang Y, Resnick MB, Lu S, Hui Y, Brodsky AS, Yang D, Yakirevich E, Wang L. "Collagen type III α1 as a useful diagnostic immunohistochemical marker for fibroepithelial lesions of the breast." Human Pathology, vol. 57, 2016, pp. 176-181. |
| Brodsky, Alexander S., Xiong, Jinjun, Yang, Dongfang, Schorl, Christoph, Fenton, Mary Anne, Graves, Theresa A., Sikov, William M., Resnick, Murray B., Wang, Yihong. "Identification of stromal ColXα1 and tumor-infiltrating lymphocytes as putative predictive markers of neoadjuvant therapy in estrogen receptor-positive/HER2-positive breast cancer." BMC Cancer, vol. 16, no. 1, 2016, pp. 274. |
| Yeo EJ, Cassetta L, Qian BZ, Lewkowich I, Li JF, Stefater JA 3rd, Smith AN, Wiechmann LS, Wang Y, Pollard JW, Lang RA. "Myeloid WNT7b mediates the angiogenic switch and metastasis in breast cancer." Cancer Research, vol. 74, no. 11, 2014, pp. 2962-73. |
| Year | Degree | Institution |
|---|---|---|
| 2000 | PhD | Ohio State University |
| 1994 | MD | Shandong University |
Assistant Professor, Lifespan Medical Center/Alpert Medical School of Brown University
Lecturer: BIOL 3643 IMS I: Histology – endocrine lecture 2016 -
Small group instructor: BIOL 3643 IMS I: Histology – Laboratory session
Small group instructor: BIO-Med 184 General Pathology – Laboratory session
Hands-on teaching interactive microscopy of histopathology of 3rd or 4th year brown medical student during pathology rotation
