Dr. Anne Hart obtained her Ph.D. in Neuroscience at UCLA with Dr. S.L. Zipursky working on cell fate specification in the Drosophila eye. She undertook her post-doctoral training in C. elegans genetics with Dr. Josh Kaplan in the Department of Molecular Biology at Massachusetts General Hospital. Dr. Hart joined the Center for Cancer Research at the Massachusetts General Hospital and the Harvard Medical School Department of Pathology as an assistant professor and taught numerous classes in genetics and neuroscience. She moved to the Department of Neuroscience at Brown University in the fall of 2009. She has served as faculty in neuroscience courses at the Marine Biological Laboratories and the Okinawa Institute of Science and Technology. Currently, she is the Speaker for the MBL Society. Her research focuses on the molecular and cellular mechanisms underlying neurological disease, sensory signaling, sleep, and fatigue.
| Baskoylu, Saba N., Chapkis, Natalie, Unsal, Burak, Lins, Jeremy, Schuch, Kelsey, Simon, Jonah, Hart, Anne C. "Disrupted autophagy and neuronal dysfunction in C. elegans knockin models of FUS amyotrophic lateral sclerosis." Cell Reports, vol. 38, no. 4, 2022, pp. 110195. |
| Hart AC, Bennett HL. "Starting a C. elegans Research Laboratory: Practical Advice." Methods in Molecular Biology, vol. 2468, 2022, pp. 1-24. |
| Lins J, Hopkins CE, Brock T, Hart AC. "The use of CRISPR to generate a whole-gene humanized MAPT and the examination of P301L and G272V clinical variants, along with the creation of deletion null alleles of ptl-1, pgrn-1 and alfa-1 loci." microPublication biology, vol. 2022, 2022. |
| Osborne JF, Yanagi KS, Hart AC. "Genetic interactions in a C. elegans sod-1 ALS model: glutamatergic neuron degeneration." microPublication biology, vol. 2021, 2021. |
| Ryan VH, Hart AC. "sym-2 loss-of-function causes glutamatergic neurodegeneration after oxidative stress." microPublication biology, vol. 2021, 2021. |
| Ryan, Veronica H, Perdikari, Theodora M, Naik, Mandar T, Saueressig, Camillo F, Lins, Jeremy, Dignon, Gregory L, Mittal, Jeetain, Hart, Anne C, Fawzi, Nicolas L. "Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration." The EMBO Journal, vol. 40, no. 3, 2021, pp. e105001. |
| Schuch KN, Govindarajan LN, Guo Y, Baskoylu SN, Kim S, Kimia B, Serre T, Hart AC. "Discriminating between sleep and exercise-induced fatigue using computer vision and behavioral genetics." Journal of Neurogenetics, 2020, pp. 1-13. |
| Walsh MB, Janzen E, Wingrove E, Hosseinibarkooie S, Muela NR, Davidow L, Dimitriadi M, Norabuena EM, Rubin LL, Wirth B, Hart AC. "Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy." BMC biology, vol. 18, no. 1, 2020, pp. 127. |
| Holdorf AD, Higgins DP, Hart AC, Boag PR, Pazour GJ, Walhout AJM, Walker AK. "WormCat: An Online Tool for Annotation and Visualization of Caenorhabditis elegans Genome-Scale Data." Genetics, vol. 214, no. 2, 2020, pp. 279-294. |
| Carskadon, Mary A., Chappell, Kenneth R., Barker, David H., Hart, Anne C., Dwyer, Kayla, Gredvig-Ardito, Caroline, Starr, Caitlyn, McGeary, John E. "A pilot prospective study of sleep patterns and DNA methylation-characterized epigenetic aging in young adults." BMC Research Notes, vol. 12, no. 1, 2019, pp. 583. |
| Nam YW, Baskoylu SN, Gazgalis D, Orfali R, Cui M, Hart AC, Zhang M. "A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model." Scientific reports, vol. 8, no. 1, 2018, pp. 10749. |
| Huang H, Hayden DJ, Zhu CT, Bennett HL, Venkatachalam V, Skuja LL, Hart AC. "Gap Junctions and NCA Cation Channels Are Critical for Developmentally-Timed Sleep and Arousal in <i>Caenorhabditis elegans</i>." Genetics, 2018. |
| Sorkaç A, DiIorio MA, O'Hern PJ, Baskoylu SN, Graham HK, Hart AC. "LIN-12/Notch Regulates GABA Signaling at the <i>Caenorhabditis elegans</i> Neuromuscular Junction." G3 (Bethesda, Md.), vol. 8, no. 8, 2018, pp. 2825-2832. |
| Bennett HL, Khoruzhik Y, Hayden D, Huang H, Sanders J, Walsh MB, Biron D, Hart AC. "Normal sleep bouts are not essential for C. elegans survival and FoxO is important for compensatory changes in sleep." BMC Neuroscience, vol. 19, no. 1, 2018, pp. 10. |
| Baskoylu SN, Yersak J, O'Hern P, Grosser S, Simon J, Kim S, Schuch K, Dimitriadi M, Yanagi KS, Lins J, Hart AC. "Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration." PLOS Genetics, vol. 14, no. 10, 2018, pp. e1007682. |
| Huang H, Zhu Y, Eliot MN, Knopik VS, McGeary JE, Carskadon MA, Hart AC. "Combining Human Epigenetics and Sleep Studies in Caenorhabditis elegans: A Cross-Species Approach for Finding Conserved Genes Regulating Sleep." Sleep, vol. 40, no. 6, 2017. |
| O'Hern, Patrick J, do Carmo G. Gonçalves, Inês, Brecht, Johanna, López Soto, Eduardo Javier, Simon, Jonah, Chapkis, Natalie, Lipscombe, Diane, Kye, Min Jeong, Hart, Anne C. "Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models." eLife, vol. 6, 2017. |
| Huang H, Zhu CT, Skuja LL, Hayden DJ, Hart AC. "Genome-Wide Screen for Genes Involved in Caenorhabditis elegans Developmentally Timed Sleep." G3: Genes|Genomes|Genetics, vol. 7, no. 9, 2017, pp. 2907-2917. |
| Huang H, Singh K, Hart AC. "Measuring <i>Caenorhabditis elegans</i> Sleep During the Transition to Adulthood Using a Microfluidics-based System." BIO-PROTOCOL, vol. 7, no. 6, 2017. |
| Riessland M, Kaczmarek A, Schneider S, Swoboda KJ, Löhr H, Bradler C, Grysko V, Dimitriadi M, Hosseinibarkooie S, Torres-Benito L, Peters M, Upadhyay A, Biglari N, Kröber S, Hölker I, Garbes L, Gilissen C, Hoischen A, Nürnberg G, Nürnberg P, Walter M, Rigo F, Bennett CF, Kye MJ, Hart AC, Hammerschmidt M, Kloppenburg P, Wirth B. "Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis." The American Journal of Human Genetics, vol. 100, no. 2, 2017, pp. 297-315. |
| Fry AL, Laboy JT, Huang H, Hart AC, Norman KR. "A Conserved GEF for Rho-Family GTPases Acts in an EGF Signaling Pathway to Promote Sleep-like Quiescence in Caenorhabditis elegans." Genetics, vol. 202, no. 3, 2016, pp. 1153-66. |
| Anderson EN, Corkins ME, Li JC, Singh K, Parsons S, Tucey TM, Sorkaç A, Huang H, Dimitriadi M, Sinclair DA, Hart AC. "C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins." Mechanisms of Ageing and Development, vol. 154, 2016, pp. 30-42. |
| Dimitriadi M, Derdowski A, Kalloo G, Maginnis MS, O'Hern P, Bliska B, Sorkaç A, Nguyen KC, Cook SJ, Poulogiannis G, Atwood WJ, Hall DH, Hart AC. "Decreased function of survival motor neuron protein impairs endocytic pathways." Proceedings of the National Academy of Sciences, vol. 113, no. 30, 2016, pp. E4377-86. |
| Sorkaç A, Alcantara IC, Hart AC. "In Vivo Modelling of ATP1A3 G316S-Induced Ataxia in C. elegans Using CRISPR/Cas9-Mediated Homologous Recombination Reveals Dominant Loss of Function Defects." PLoS ONE, vol. 11, no. 12, 2016, pp. e0167963. |
| Chalfie M, Hart AC, Rankin CH, Goodman MB. "Assaying mechanosensation." WormBook : the online review of C. elegans biology, 2014. |
| Singh, Komudi, Ju, Jennifer Y., Walsh, Melissa B., DiIorio, Michael A., Hart, Anne C. "Deep Conservation of Genes Required for Both Drosophila melanogaster and Caenorhabditis elegans Sleep Includes a Role for Dopaminergic Signaling." Sleep, 2014. |
| Moroz, Natalie, Carmona, Juan J., Anderson, Edward, Hart, Anne C., Sinclair, David A., Blackwell, T. Keith. "Dietary restriction involves NAD + -dependent mechanisms and a shift toward oxidative metabolism." Aging Cell, vol. 13, no. 6, 2014, pp. 1075-1085. |
| Moroz N, Carmona JJ, Anderson E, Hart AC, Sinclair DA, Blackwell TK. "Dietary restriction involves NAD(+)-dependent mechanisms and a shift toward oxidative metabolism." Aging Cell, vol. 13, no. 6, 2014, pp. 1075-85. |
| Singh K, Huang H, Hart AC. "Do C. elegans sleep? A closer look." Sleep, vol. 36, no. 3, 2013, pp. 307-8. |
| Sen A, Dimlich DN, Guruharsha KG, Kankel MW, Hori K, Yokokura T, Brachat S, Richardson D, Loureiro J, Sivasankaran R, Curtis D, Davidow LS, Rubin LL, Hart AC, Van Vactor D, Artavanis-Tsakonas S. "Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy." Proceedings of the National Academy of Sciences, vol. 110, no. 26, 2013, pp. E2371-80. |
| Kwon DY, Dimitriadi M, Terzic B, Cable C, Hart AC, Chitnis A, Fischbeck KH, Burnett BG. "The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein." Molecular biology of the cell, vol. 24, no. 12, 2013, pp. 1863-71. |
| Dimitriadi M, Kye MJ, Kalloo G, Yersak JM, Sahin M, Hart AC. "The neuroprotective drug riluzole acts via small conductance Ca2+-activated K+ channels to ameliorate defects in spinal muscular atrophy models." Journal of Neuroscience, vol. 33, no. 15, 2013, pp. 6557-62. |
| Walker AK, Jacobs RL, Watts JL, Rottiers V, Jiang K, Finnegan DM, Shioda T, Hansen M, Yang F, Niebergall LJ, Vance DE, Tzoneva M, Hart AC, Näär AM. "A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans." Cell, vol. 147, no. 4, 2011, pp. 840-52. |
| Singh K, Chao MY, Somers GA, Komatsu H, Corkins ME, Larkins-Ford J, Tucey T, Dionne HM, Walsh MB, Beaumont EK, Hart DP, Lockery SR, Hart AC. "C. elegans Notch signaling regulates adult chemosensory response and larval molting quiescence." Current Biology, vol. 21, no. 10, 2011, pp. 825-34. |
| Liu-Yesucevitz L, Bassell GJ, Gitler AD, Hart AC, Klann E, Richter JD, Warren ST, Wolozin B. "Local RNA translation at the synapse and in disease." Journal of Neuroscience, vol. 31, no. 45, 2011, pp. 16086-93. |
| Hyde, R., Corkins, M. E., Somers, G. A., Hart, A. C. "PKC-1 acts with the ERK MAPK signaling pathway to regulate Caenorhabditis elegans mechanosensory response." Genes, Brain and Behavior, vol. 10, no. 3, 2011, pp. 286-298. |
| Dimitriadi M, Sleigh JN, Walker A, Chang HC, Sen A, Kalloo G, Harris J, Barsby T, Walsh MB, Satterlee JS, Li C, Van Vactor D, Artavanis-Tsakonas S, Hart AC. "Conserved genes act as modifiers of invertebrate SMN loss of function defects." PLOS Genetics, vol. 6, no. 10, 2010, pp. e1001172. |
| Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM. "Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP." Genes & Development, vol. 24, no. 13, 2010, pp. 1403-17. |
| Haspel G, O'Donovan MJ, Hart AC. "Motoneurons dedicated to either forward or backward locomotion in the nematode Caenorhabditis elegans." Journal of Neuroscience, vol. 30, no. 33, 2010, pp. 11151-6. |
| Dimitriadi M, Hart AC. "Neurodegenerative disorders: insights from the nematode Caenorhabditis elegans." Neurobiology of disease, vol. 40, no. 1, 2010, pp. 4-11. |
| Jeong H, Then F, Melia TJ Jr, Mazzulli JR, Cui L, Savas JN, Voisine C, Paganetti P, Tanese N, Hart AC, Yamamoto A, Krainc D. "Acetylation targets mutant huntingtin to autophagosomes for degradation." Cell, vol. 137, no. 1, 2009, pp. 60-72. |
| Guo ZV, Hart AC, Ramanathan S. "Optical interrogation of neural circuits in Caenorhabditis elegans." Nature methods, vol. 6, no. 12, 2009, pp. 891-6. |
| Chang HC, Dimlich DN, Yokokura T, Mukherjee A, Kankel MW, Sen A, Sridhar V, Fulga TA, Hart AC, Van Vactor D, Artavanis-Tsakonas S. "Modeling spinal muscular atrophy in Drosophila." PLoS ONE, vol. 3, no. 9, 2008, pp. e3209. |
| Komatsu H, Chao MY, Larkins-Ford J, Corkins ME, Somers GA, Tucey T, Dionne HM, White JQ, Wani K, Boxem M, Hart AC. "OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development." PLoS biology, vol. 6, no. 8, 2008, pp. e196. |
| Jia, Kailiang, Hart, Anne C., Levine, Beth. "Autophagy Genes Protect Against Disease Caused by Polyglutamine Expansion Proteins in Caenorhabditis elegans." Autophagy, vol. 3, no. 1, 2007, pp. 21-25. |
| Jia K, Hart AC, Levine B. "Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans." Autophagy, vol. 3, no. 1, 2007, pp. 21-5. |
| Ferkey DM, Hyde R, Haspel G, Dionne HM, Hess HA, Suzuki H, Schafer WR, Koelle MR, Hart AC. "C. elegans G protein regulator RGS-3 controls sensitivity to sensory stimuli." Neuron, vol. 53, no. 1, 2007, pp. 39-52. |
| Voisine C, Varma H, Walker N, Bates EA, Stockwell BR, Hart AC. "Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans." PLoS ONE, vol. 2, no. 6, 2007, pp. e504. |
| Varma H, Cheng R, Voisine C, Hart AC, Stockwell BR. "Inhibitors of metabolism rescue cell death in Huntington's disease models." Proceedings of the National Academy of Sciences, vol. 104, no. 36, 2007, pp. 14525-30. |
| Varma H, Voisine C, DeMarco CT, Cattaneo E, Lo DC, Hart AC, Stockwell BR. "Selective inhibitors of death in mutant huntingtin cells." Nature Chemical Biology, vol. 3, no. 2, 2007, pp. 99-100. |
| Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun ZY, Watts JL, DeBeaumont R, Saito RM, Hyberts SG, Yang S, Macol C, Iyer L, Tjian R, van den Heuvel S, Hart AC, Wagner G, Näär AM. "An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis." J. Geophys. Res., vol. 442, no. 7103, 2006, pp. 700-4. |
| Hart, Anne. "Behavior." WormBook, 2006. |
| Bates EA, Victor M, Jones AK, Shi Y, Hart AC. "Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity." Journal of Neuroscience, vol. 26, no. 10, 2006, pp. 2830-8. |
| Chao MY, Larkins-Ford J, Tucey TM, Hart AC. "lin-12 Notch functions in the adult nervous system of C. elegans." BMC neuroscience, vol. 6, 2005, pp. 45. |
| Voisine C, Hart AC. "Caenorhabditis elegans as a model system for triplet repeat diseases." Methods in Molecular Biology, vol. 277, 2004, pp. 141-60. |
| Chao MY, Komatsu H, Fukuto HS, Dionne HM, Hart AC. "Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit." Proceedings of the National Academy of Sciences, vol. 101, no. 43, 2004, pp. 15512-7. |
| Fukuto HS, Ferkey DM, Apicella AJ, Lans H, Sharmeen T, Chen W, Lefkowitz RJ, Jansen G, Schafer WR, Hart AC. "G protein-coupled receptor kinase function is essential for chemosensation in C. elegans." Neuron, vol. 42, no. 4, 2004, pp. 581-93. |
| Chao MY, Hart AC. "Sensory biology: how the nose knows." Current Biology, vol. 13, no. 6, 2003, pp. R226-8. |
| Faber PW, Voisine C, King DC, Bates EA, Hart AC. "Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity." Proceedings of the National Academy of Sciences, vol. 99, no. 26, 2002, pp. 17131-6. |
| Nathoo AN, Moeller RA, Westlund BA, Hart AC. "Identification of neuropeptide-like protein gene families in Caenorhabditiselegans and other species." Proceedings of the National Academy of Sciences, vol. 98, no. 24, 2001, pp. 14000-5. |
Anne Hart is a neurobiologist who uses genetic and molecular approaches in the small nematode C. elegans to understand the conserved mechanisms underlying neurodegenerative disease and nervous system function. She focuses on delineating cellular and molecular pathways pertinent to Huntington's disease, Spinal Muscular Atrophy, Amyotrophic Lateral Sclerosis, Frontal Temporal Dementia and other neurodegenerative diseases. Dr. Hart also studies the genetic and molecular mechanisms regulating sleep and fatigue.
Dr. Hart's research has focused primarily on neurodegenerative disease and neuronal signaling using the C. elegans nervous system. Currently, she and her lab members are working on 1) neurodegnerative diseases and on 2) sleep and fatigue.
Dr. Hart uses forward and reverse genetic techniques to identify pathways critical for neurodegenerative disease and has established the utility of C. elegans for modeling these human disorders by establishing the first explicit models of human neurodegenerative disease in C. elegans. In the last few years, her laboratory has primarily focused on delineating the cellular and molecular pathways that play critical roles in Spinal Muscular Atrophy (SMA), Amyotrophic Lateral sclerosis (ALS), and Frontal Temporal Dementia (FTD).
Dr. Hart and her laboratory also undertake behavioral, molecular, and genetic studies to understand the conserved mechanisms underlying behavior. Past work focused on how animals respond to changes in the environment. This resulted in the identification of a new family of conserved Notch co-ligands in C. elegans that play diverse roles regulating stress response. Current research examines the targets of Notch signaling in sleep and examines pathways underlying fatigue
Our work has been funded by the ALS Association, Hereditary Disease Foundation, The Whitehall Foundation, The March of Dimes, The SMA Foundation, The Muscular Dystrophy Association, the Judith & Jean Pape Adams Charitable Foundation, the National Institute of General Medical Science, and National Institute of Neurological Disorders and Stroke.
Lins J, Hopkins CE, Brock T, Hart AC. “The use of CRISPR to generate a whole-gene humanized MAPT and the examination of P301L and G272V clinical variants, along with the creation of deletion null alleles of ptl-1, pgrn-1 and alfa-1 loci.” MicroPublication Biology, 2022.
Baskoylu SN, Chapkis N, Unsal B, Lins J, Schuch K, Simon J, Hart AC. “Disrupted autophagy and neuronal dysfunction in C. elegans knockin models of FUS amyotrophic lateral sclerosis.” Cell Reports, 2022.
Hart AC, Bennett HL. “Starting a C. elegans Research Laboratory: Practical Advice.” Methods in Molecular Biology, 2022.
Ryan VH, Hart AC. “sym-2 loss-of-function causes glutamatergic neurodegeneration after oxidative stress.” MicroPublication Biology, 2021.
Ryan VH, Perdikari TM, Naik MT, Saueressig, Camillo F, Lins J, Dignon GL, Mittal J, Hart AC, Fawzi NL. “Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration.” The EMBO journal, 2021.
Osborne JF, Yanagi KS, Hart AC. “Genetic interactions in a C. elegans sod-1 ALS model: glutamatergic neuron degeneration.” MicroPublication Biology, 2021.
Walsh MB, Janzen E, Wingrove E, Hosseinibarkooie S, Muela NR, Davidow L, Dimitriadi M, Norabuena EM, Rubin LL, Wirth B, Hart AC. "Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy." BMC biology, vol. 18, no. 1, 2020, pp. 127
Ryan, Veronica H, Perdikari, Theodora M, Naik, Mandar T, Saueressig, Camillo F, Lins, Jeremy, Dignon, Gregory L, Mittal, Jeetain, Hart, Anne C, Fawzi, Nicolas L. "Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration." The EMBO Journal, vol. 40, no. 3, 2020, pp. e105001.
Holdorf AD, Higgins DP, Hart AC, Boag PR, Pazour GJ, Walhout AJM, Walker AK. 2019 WormCat: An Online Tool for Annotation and Visualization of Caenorhabditis elegans Genome-Scale Data. Genetics. Dec 6. pii: genetics.302919.2019
Yanagi KS, Wu Z, Amaya J, Chapkis N, Duffy AM, Hajdarovic KH, Held A, Mathur AD, Russo K, Ryan VH, Steinert BL, Whitt JP, Fallon JR, Fawzi NL, Lipscombe D, Reenan RA, Wharton KA, Hart AC. 2019 Meta-analysis of Genetic Modifiers Reveals Candidate Dysregulated Pathways in Amyotrophic Lateral Sclerosis. Neuroscience. 2019 Jan 1;396:A3-A20.
Carskadon MA, Chappell KR, Barker DH, Hart, AC, Dwyer K, Gredvig-Ardito C, Starr C, McGeary JE 2019 A pilot prospective study of sleep patterns and DNA methylation-characterized epigenetic aging in young adults BMC Res Notes 12: 583.
Sorkaç A, DiIorio MA, O'Hern PJ, Baskoylu SN, Graham HK, Hart AC. 2018 LIN-12/Notch Regulates GABA Signaling at the Caenorhabditis elegans Neuromuscular Junction
Huang H, Hayden DJ, Zhu CT, Bennett HL, Venkatachalam V, Skuja LL, Hart AC 2018 2018 Gap Junctions and NCA Cation Channels Are Critical for Developmentally Timed Sleep and Arousal in Caenorhabditis elegans. Genetics 210(4):1369-1381.
Baskoylu SN, Yersak J, O'Hern P, Grosser S, Simon J, Kim S, Schuch K, Dimitriadi M, Yanagi KS, Lins J, Hart AC. 2018 Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration. PLoS Genetics 14(10):e1007682
Bennett HL, Khoruzhik Y, Hayden D, Huang H, Sanders J, Walsh MB, Biron D, Hart AC. 2018 Normal sleep bouts are not essential for C. elegans survival and FoxO is important for compensatory changes in sleep BMC Neuroscience 19(1):10.
Nam YW, Baskoylu SN, Gazgalis D, Orfali R, Cui M, Hart AC, Zhang M. 2018 A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model. Sci Rep. 8(1):10749.
Huang H, Zhu CT, Skuja LL, Hayden DJ, Hart AC. 2017 Genome-Wide Screen for Genes Involved in Caenorhabditis elegans Developmentally Timed Sleep. G3 (Bethesda). 7(9):2907-2917
O'Hern P, Carmo I, Gonçalves G, Brecht J, Soto EL, Simon J, Chapkis N, Lipscombe D, Kye MJ, Hart AC 2017 Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models eLife 6:e20752.
Fry AL, Laboy JT, Huang H, Hart AC, Norman KR 2016 A Conserved GEF for Rho-Family GTPases Acts in an EGF Signaling Pathway to Promote Sleep-like Quiescence in Caenorhabditis elegans. Genetics 2016; 202(3):1153-66. PMCID:PMC4788115
Dimitriadi M, Derdowski A, Kalloo G, Maginnis MS, O'Hern P, Bliska B, Sorkaç A, Nguyen KC, Cook SJ, Poulogiannis G, Atwood WJ, Hall DH, Hart AC. 2016 Decreased function of survival motor neuron protein impairs endocytic pathways. PNAS 113(30):E4377-86. PMCID:PMC4968725
Anderson EN, Corkins ME, Li JC, Singh K, Parsons S, Tucey TM, Sorkaç A, Huang H, Dimitriadi M, Sinclair DA, Hart AC 2016 C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins. Mechanisms of Ageing and Development 154:30-42. PMCID:PMC4789167
Sorkaç A, Alcantara IC, Hart AC 2016 In Vivo Modelling of ATP1A3 G316S-Induced Ataxia in C. elegans Using CRISPR/Cas9-Mediated Homologous Recombination Reveals Dominant Loss of Function Defects. PLOS One 11(12):e0167963. PMCID: PMC5148073
Moroz N, Carmona JJ, Anderson E, Hart AC, Sinclair DA, Blackwell TK 2014 Dietary restriction involves NAD(+)-dependent mechanisms and a shift toward oxidative metabolism Aging Cell 13(6):1075-85 PMCID: PMC4244309
Singh K, Ju JY, Walsh MB, DiIorio MA, Hart AC 2014 Deep conservation of genes required for both D. melanogaster and C. elegans sleep includes a role for dopaminergic signaling Sleep 37(9):1439-51 PMC4153065
Kwon DY, Dimitriadi M, Terzic B, Cable C, Hart AC, Chitnis A, Fischbeck KH, Burnett BG. 2013 The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein. Molecular Biology of the Cell 24(12):1863-71 PMCID: PMC3681692
Dimitriadi M, Kye MJ, Kalloo G, Yersak J, Sahin M, Hart AC 2013 The neuroprotective drug riluzole acts via small conductance Ca2+-activated K+ channels to ameliorate defects in Spinal Muscular Atrophy models. Journal of Neuroscience 33(15)6557-62 PMID: 23575853
Sen A, Dimlich DN, Guruharsha KG, Kankel MW, Hori K, Yokokura T, Brachat S, Richardson D, Loureiro J, Sivasankaran R, Curtis D, Davidow LS, Rubin LL, Hart AC, Van Vactor D, Artavanis-Tsakonas S. 2013 Genetic circuitry of Survival motor neuron, the protein underlying spinal muscular atrophy PNAS 110(26):E2371-80 PMID: 23757500
Chao MC, Singh K, Somers GA, Komatsu H, Corkins ME, Larkins-Ford J, Tucey T, Dionne HM, Walsh MB, Beaumont EK, Hart DP, Lockery S, Hart AC 2011 C. elegans Notch signaling regulates adult chemosensory response and larval molting quiescence. Current Biology 21(10):825-34 PMID: 21549604
Hyde R, Corkins ME, Somers GA, Hart AC 2011 Genes, Brain and Behavior PKC-1 acts with the ERK MAPK signaling pathway to regulate Caenorhabditis elegans mechanosensory response. Genes, Brain and Behavior 10: 286–298 PMID: 21143768
Walker AK, PhD, Jacobs RL, Watts JL, Rottiers V, Jiang K, Finnegan DM, Shioda T, Hansen, M, Yang F, Niebergall L, Vance D, Tzoneva M, Hart AC, Näär, AM 2011 A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell 147(4):840-52. PMID: 22035958
Dimitriadi M, Sleigh JN, Walker AK, Chang HC-H, Sen A, Kalloo G, Harris J, Barsby T, Walsh MB, Satterlee JS, Li C, Van Vactor D, Artavanis-Tsakonas S, Hart AC 2010 Conserved genes act as modifiers of invertebrate SMN loss of function defects. PLoS Genetics 6(10): e1001172 PMID: 21124729
Haspel G, O’Donovan, Hart AC 2010 Motorneurons dedicated to either forward or backward locomotion in the nematode C. elegans. Journal of Neuroscience 30(33):11151 PMID: 20720122
Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM 2010 Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes and Development 24(13):1403-17. PMID: 20595232
Guo ZV, Hart AC, Ramanathan S Optical interrogation of neural circuits in Caenorhabditis elegans Nature Methods 2009 6: 891-96. PMID: 19898486
Jeong H, Then F, Savas J, Tanese N., Hart AC, Krainc D Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation in Huntington’s Disease. Cell 2009 137(1):60-72. PMID: 19345187
Chang HC-H, Dimlich DN, Yokokura T, Mukherjee A, Kankel MW, Sen A, Sridhar V, Fulga TA, Hart, AC, Van Vactor D, Artavanis-Tsakonas S Modeling Spinal Muscular Atrophy in Drosophila 2008 PLoS ONE 3(9):e3209 PMID: 18791638
Komatsu H, Chao MC, Larkins-Ford J, Corkins ME, Somers GA, Tucey T, Dionne HM, White JQ, Wani K, Boxem M, Hart AC OSM-11 facilitates LIN-12 Notch signaling during C. elegans vulval development 2008 PLoS Biology 6(8):e196. PMID: 18700817
Ferkey D, Hyde R, Haspel G, Dionne HM, Hess HA, Suzuki H, Schafer WR, Koelle MR, Hart AC C. elegans G Protein Regulator RGS-3 Controls Sensitivity to Sensory Stimuli 2007 Neuron 53(1):39-5. PMID: 17196529
Voisine C, Varma H, Walker N, Bates EA, Stockwell BR and Hart AC 2007 Identification of Potential Therapeutic Drugs for Huntington's Disease using Caenorhabditis elegans PLoS ONE 6:e504 (ACS Chemical Biology Spotlight paper). PMID: 17551584
Varma H, Cheng R, Voisine C, Hart AC, Stockwell BR 2007 Inhibitors of metabolism rescue cell death in Huntington’s disease models PNAS 104(36):14525-30
Varma H, Voisine C, De Marco CT, Cattaneo E, Lo DC, Hart AC, Stockwell BR 2006 Selective inhibitors of death in mutant huntingtin cells Nature Chemical Biology 3(2):99-100.
E.A. Bates, M. Victor, M.J. Alkema, A.K. Jones, Y. Shi, H.R. Horvitz, and A.C. Hart. 2006. Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity. Journal of Neuroscience 26: 2830-2838. PMID: 16525063
M.Y. Chao, J. Larkins-Ford, T.M. Tucey, and A.C. Hart. 2005. lin-12 Notch functions in the adult nervous system. BMC Neuroscience 6:45. PMID: 16011804
M.Y. Chao, H. Komatsu, and A.C. Hart. 2004. Feeding status and serotonin rapidly and reversibly modulate a C. elegans chemosensory circuit. PNAS 101:15512-17 (PNAS Track II) PMID: 15492222
H.S. Fukuto, D.M. Ferkey, A.J. Apicella, H. Lans, T. Sharmeen, W. Chen, R.J. Lefkowitz, G. Jansen, W.R. Schafer, and A.C. Hart. 2004. G Protein-Coupled Receptor Kinase Function Is Essential for Chemosensation in C. elegans. Neuron 42: 581-593. PMID: 15157420
Invited peer-reviewed publications (last 10 years):
Singh K, Huang H, Hart AC. 2013 Do C. elegans sleep? A closer look. Sleep 36(3):307-8 PMID: 23450901
Liu-Yesucevitz L, Bassell G, Gitler A, Hart AC, Klann E, Richter J, Warren S and Wolozin B 2011 Local RNA Translation at the Synapses and in Disease. Journal of Neuroscience 9:31(45):16086-93. PMID:22072660
Hart AC and Chao MY 2010 “from Odors to Behaviors in Caenorhabditis elegans” In: Menini A, editor Neurobiology of Olfaction Boca Raton, FL CRC Press; PMID: 21882435
Dimitriadi M and Hart AC 2010 Neurodegenerative disorders: Insights from the nematode Caenorhabditis elegans Neurobiology of Disease 40:4-11.
Hart AC. 2006. Editor “Behavior” in WormBook, ed. The C. elegans Research Community, WormBook
Voisine C, Hart AC 2004 C. elegans as a model system for Triplet Repeat Diseases. In: Kohwi Y, editor. Methods in Molecular Biology, Trinucleotide Repeat Protocols. Totowa, NJ: Humana Press; 277:141-60.
| Year | Degree | Institution |
|---|---|---|
| 1992 | PhD | University of California, Los Angeles |
| 1985 | BS | Michigan State University |
1985-1989 ARCS Scholar and Ursula Mandel Scholar, UCLA
1988-1991 NRSA Traineeship, Genetics Training Grant, UCLA
1993-1995 Muscular Dystrophy Assoc. Postdoctoral Fellowship
1995-1996 Medical Foundation Postdoctoral Fellowship
1998-2000 Basil O'Connor Award, March of Dimes Foundation
1998-2001 Searle Scholar Program Award
2016 Dean's Award for Excellence in Graduate and/or Postdoctoral Teaching and Mentoring
1996-date Society for Neuroscience
2005-date Genetics Society of America
2007-2019 PLoS One Editorial Board
2008-date Neuroscience Editorial Board
2009-date Member of Marine Biological Laboratories Corporation
2009-2016 Member of MBL Science Advisory Council
2016-date Adjunct Ryan Research Professor of Neuroscience, University of Rhode Island
2018-date PLoS Genetics Academic Editor
| NEUR 2030 - Advanced Molecular and Cellular Neurobiology I |
