Lori Daiello PharmD, ScM is a cognitive aging researcher. A long-standing interest in the impact of prescription medications on late-life cognitive and functional outcomes informs her work with collaborators at the School of Public Health; however, her primary research focuses on topics related to novel biomarkers of neurodegeneration, preclinical Alzheimer's Disease, delirium, and postoperative cognitive dysfunction.
She is the principal investigator of an NIH-funded study of postoperative delirium and persistent cognitive impairment among older adults undergoing major surgeries. The CREATES study utilizes brain MRI and other measures to investigate blood-brain barrier dysfunction and neuroinflammation as mediators of perioperative cognitive disorders and the risk of late-onset Alzheimer's Disease.
Brown University Department of Neurology
Carney Institute for Brain Science
| Margolis SA, Kelly DA, Daiello LA, Davis J, Tremont G, Pillemer S, Denby C, Ott BR. "Anticholinergic/Sedative Drug Burden and Subjective Cognitive Decline in Older Adults at Risk of Alzheimer's Disease." The Journals of Gerontology: Series A, vol. 76, no. 6, 2021, pp. 1037-1043. |
| Reznik ME, Kalagara R, Moody S, Drake J, Margolis SA, Cizginer S, Mahta A, Rao SS, Stretz C, Wendell LC, Thompson BB, Asaad WF, Furie KL, Jones RN, Daiello LA. "Common biomarkers of physiologic stress and associations with delirium in patients with intracerebral hemorrhage." Journal of Critical Care, vol. 64, 2021, pp. 62-67. |
| Zullo AR, Lee Y, Lary C, Daiello LA, Kiel DP, Berry SD. "Comparative effectiveness of denosumab, teriparatide, and zoledronic acid among frail older adults: a retrospective cohort study." Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 32, no. 3, 2021, pp. 565-573. |
| Cheng, Shibin, Banerjee, Sayani, Daiello, Lori A., Nakashima, Akitoshi, Jash, Sukanta, Huang, Zheping, Drake, Jonathan D., Ernerudh, Jan, Berg, Goran, Padbury, James, Saito, Shigeru, Ott, Brian R., Sharma, Surendra. "Novel blood test for early biomarkers of preeclampsia and Alzheimer’s disease." Scientific Reports, vol. 11, no. 1, 2021. |
| Drake, Jonathan D., Chambers, Alison B., Ott, Brian R., Daiello, Lori A., None, None. "Peripheral Markers of Vascular Endothelial Dysfunction Show Independent but Additive Relationships with Brain-Based Biomarkers in Association with Functional Impairment in Alzheimer’s Disease." Journal of Alzheimer's Disease, vol. 80, no. 4, 2021, pp. 1553-1565. |
| Korthauer, Laura E., Denby, Charles, Molina, David, Wanjiku, Janet, Daiello, Lori A., Drake, Jonathan D., Grill, Josh D., Ott, Brian R. "Pilot study of an Alzheimer's disease risk assessment program in a primary care setting." Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, vol. 13, no. 1, 2021, pp. e12157. |
| Gerlach LB, Fashaw S, Strominger J, Ogarek J, Zullo AR, Daiello LA, Teno J, Shireman TI, Bynum JPW. "Trends in antipsychotic prescribing among long-term care residents receiving hospice care." Journal of the American Geriatrics Society, vol. 69, no. 8, 2021, pp. 2152-2162. |
| Reznik ME, Drake J, Margolis SA, Moody S, Murray K, Costa S, Mahta A, Wendell LC, Thompson BB, Rao SS, Barrett AM, Boukrina O, Daiello LA, Asaad WF, Furie KL, Jones RN. "Deconstructing Poststroke Delirium in a Prospective Cohort of Patients With Intracerebral Hemorrhage." Critical care medicine, vol. 48, no. 1, 2020, pp. 111-118. |
| Reznik ME, Daiello LA, Thompson BB, Wendell LC, Mahta A, Potter NS, Yaghi S, Levy MM, Fehnel CR, Furie KL, Jones RN. "Fluctuations of consciousness after stroke: Associations with the confusion assessment method for the intensive care unit (CAM-ICU) and potential undetected delirium." Journal of Critical Care, vol. 56, 2020, pp. 58-62. |
| Reznik ME, Moody S, Murray K, Costa S, Grory BM, Madsen TE, Mahta A, Wendell LC, Thompson BB, Rao SS, Stretz C, Sheth KN, Hwang DY, Zahuranec DB, Schrag M, Daiello LA, Asaad WF, Jones RN, Furie KL. "The impact of delirium on withdrawal of life-sustaining treatment after intracerebral hemorrhage." Neurology, vol. 95, no. 20, 2020, pp. e2727-e2735. |
| Margolis SA, Zughaft Sears M, Daiello LA, Solon C, Nakhutina L, Hoogendoorn CJ, Gonzalez JS. "Anticholinergic/sedative drug burden predicts worse memory acquisition in older racially/ethnically diverse patients with type 2 diabetes mellitus." International Journal of Geriatric Psychiatry, vol. 34, no. 10, 2019, pp. 1545-1554. |
| Jones RN, Cizginer S, Pavlech L, Albuquerque A, Daiello LA, Dharmarajan K, Gleason LJ, Helfand B, Massimo L, Oh E, Okereke OI, Tabloski P, Rabin LA, Yue J, Marcantonio ER, Fong TG, Hshieh TT, Metzger ED, Erickson K, Schmitt EM, Inouye SK, Better Assessment of Illness (BASIL) Study Group. "Assessment of Instruments for Measurement of Delirium Severity: A Systematic Review." JAMA Internal Medicine, vol. 179, no. 2, 2019, pp. 231-239. |
| Miller SC, Cai S, Daiello LA, Shireman TI, Wilson IB. "Nursing Home Residents by Human Immunodeficiency Virus Status: Characteristics, Dementia Diagnoses, and Antipsychotic Use." Journal of the American Geriatrics Society, vol. 67, no. 7, 2019, pp. 1353-1360. |
| Daiello LA, Racine AM, Yun Gou R, Marcantonio ER, Xie Z, Kunze LJ, Vlassakov KV, Inouye SK, Jones RN, Alsop D, Travison T, Arnold S, Cooper Z, Dickerson B, Fong T, Metzger E, Pascual-Leone A, Schmitt EM, Shafi M, Cavallari M, Dai W, Dillon ST, McElhaney J, Guttmann C, Hshieh T, Kuchel G, Libermann T, Ngo L, Press D, Saczynski J, Vasunilashorn S, O'Connor M, Kimchi E, Strauss J, Wong B, Belkin M, Ayres D, Callery M, Pomposelli F, Wright J, Schermerhorn M, Abrantes T, Albuquerque A, Bertrand S, Brown A, Callahan A, D'Aquila M, Dowal S, Fox M, Gallagher J, Anna Gersten R, Hodara A, Helfand B, Inloes J, Kettell J, Kuczmarska A, Nee J, Nemeth E, Ochsner L, Palihnich K, Parisi K, Puelle M, Rastegar S, Vella M, Xu G, Bryan M, Guess J, Enghorn D, Gross A, Gou Y, Habtemariam D, Isaza I, Kosar C, Rockett C, Tommet D, Gruen T, Ross M, Tasker K, Gee J, Kolanowski A, Pisani M, de Rooij S, Rogers S, Studenski S, Stern Y, Whittemore A, Gottlieb G, Orav J, Sperling R, SAGES Study Group*. "Postoperative Delirium and Postoperative Cognitive Dysfunction: Overlap and Divergence." Anesthesiology, vol. 131, no. 3, 2019, pp. 477-491. |
| Ott BR, Jones RN, Daiello LA, de la Monte SM, Stopa EG, Johanson CE, Denby C, Grammas P. "Blood-Cerebrospinal Fluid Barrier Gradients in Mild Cognitive Impairment and Alzheimer's Disease: Relationship to Inflammatory Cytokines and Chemokines." Frontiers in Aging Neuroscience, vol. 10, 2018, pp. 245. |
| Zullo AR, Zhang T, Lee Y, McConeghy KW, Daiello LA, Kiel DP, Mor V, Berry SD. "Effect of Bisphosphonates on Fracture Outcomes Among Frail Older Adults." Journal of the American Geriatrics Society, vol. 67, no. 4, 2018, pp. 768-776. |
| Zhang T, Zullo AR, Shireman TI, Lee Y, Mor V, Liu Q, McConeghy KW, Daiello L, Kiel DP, Berry SD. "Epidemiology of hip fracture in nursing home residents with multiple sclerosis." Disability and Health Journal, vol. 11, no. 4, 2018, pp. 591-597. |
| Zullo, Andrew R., Zhang, Tingting, Banerjee, Geetanjoli, Lee, Yoojin, McConeghy, Kevin W., Kiel, Douglas P., Daiello, Lori A., Mor, Vincent, Berry, Sarah D. "Facility and State Variation in Hip Fracture in U.S. Nursing Home Residents." Journal of the American Geriatrics Society, vol. 66, no. 3, 2018, pp. 539-545. |
| Reznik ME, Yaghi S, Jayaraman MV, McTaggart RA, Hemendinger M, Mac Grory BC, Burton TM, Cutting SM, Thompson BB, Wendell LC, Mahta A, Potter NS, Daiello LA, Kosar CM, Jones RN, Furie KL. "Level of consciousness at discharge and associations with outcome after ischemic stroke." Journal of the Neurological Sciences, vol. 390, 2018, pp. 102-107. |
| Zullo, Andrew R., Hersey, Michelle, Lee, Yoojin, Sharmin, Sadia, Bosco, Elliott, Daiello, Lori A., Shah, Nishant R., Mor, Vincent, Boscardin, W. John, Berard-Collins, Christine M., Dore, David D., Steinman, Michael A. "Outcomes of “Diabetes-Friendly” versus “Diabetes-Unfriendly” Beta-blockers in Older Nursing Home Residents with Diabetes after Acute Myocardial Infarction." Diabetes, Obesity and Metabolism, vol. 20, no. 12, 2018, pp. 2724-2732. |
| Zullo AR, Zhang T, Beaudoin FL, Lee Y, McConeghy KW, Kiel DP, Daiello LA, Mor V, Berry SD. "Pain Treatments After Hip Fracture Among Older Nursing Home Residents." Journal of the American Medical Directors Association, vol. 19, no. 2, 2018, pp. 174-176. |
| Daiello LA, Tannenbaum C. "Patient-Oriented Policies To Reduce The Harmful Effects Of Medication On Seniors' Brain Function." Public Policy & Aging Report, vol. 28, no. 4, 2018, pp. 124-128. |
| Berry SD, Zullo AR, McConeghy K, Lee Y, Daiello L, Kiel DP. "Defining hip fracture with claims data: outpatient and provider claims matter." Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 28, no. 7, 2017, pp. 2233-2237. |
| McConeghy KW, Lee Y, Zullo AR, Banerjee G, Daiello L, Dosa D, Kiel DP, Mor V, Berry SD. "Influenza Illness and Hip Fracture Hospitalizations in Nursing Home Residents: Are They Related?." The Journals of Gerontology: Series A, vol. 73, no. 12, 2017, pp. 1638-1642. |
| Zullo AR, Sharmin S, Lee Y, Daiello LA, Shah NR, John Boscardin W, Dore DD, Lee SJ, Steinman MA. "Secondary Prevention Medication Use After Myocardial Infarction in U.S. Nursing Home Residents." Journal of the American Geriatrics Society, vol. 65, no. 11, 2017, pp. 2397-2404. |
| Steinman MA, Zullo AR, Lee Y, Daiello LA, Boscardin WJ, Dore DD, Gan S, Fung K, Lee SJ, Komaiko KD, Mor V. "Association of β-Blockers With Functional Outcomes, Death, and Rehospitalization in Older Nursing Home Residents After Acute Myocardial Infarction." JAMA Internal Medicine, vol. 177, no. 2, 2016, pp. 254-262. |
| Zullo, Andrew R., Lee, Yoojin, Daiello, Lori A., Mor, Vincent, John Boscardin, W., Dore, David D., Miao, Yinghui, Fung, Kathy Z., Komaiko, Kiya D. R., Steinman, Michael A. "Beta-Blocker Use in U.S. Nursing Home Residents After Myocardial Infarction: A National Study." Journal of the American Geriatrics Society, vol. 65, no. 4, 2016, pp. 754-762. |
| Zullo, Andrew R., Dore, David D., Daiello, Lori, Baier, Rosa R., Gutman, Roee, Gifford, David R., Smith, Robert J. "National Trends in Treatment Initiation for Nursing Home Residents With Diabetes Mellitus, 2008 to 2010." Journal of the American Medical Directors Association, vol. 17, no. 7, 2016, pp. 602-608. |
| Daiello LA, Gongvatana A, Dunsiger S, Cohen RA, Ott BR, Alzheimer's Disease Neuroimaging Initiative. "Association of fish oil supplement use with preservation of brain volume and cognitive function." Alzheimer's & Dementia, vol. 11, no. 2, 2015, pp. 226-235. |
| Dahabreh IJ, Adam GP, Halladay CW, Steele DW, Daiello LA, Wieland LS, Zgodic A, Smith BT, Herliczek TW, Shah N, Trikalinos TA. "Diagnosis of Right Lower Quadrant Pain and Suspected Acute Appendicitis." 2015. |
| Ott, Brian R., Daiello, Lori A., Dahabreh, Issa J., Springate, Beth A., Bixby, Kimberly, Murali, Manjari, Trikalinos, Thomas A. "Do statins impair cognition? A systematic review and meta-analysis of randomized controlled trials." J GEN INTERN MED, vol. 30, no. 3, 2015, pp. 348-58. |
| Daiello LA, Gardner R, Epstein-Lubow G, Butterfield K, Gravenstein S. "Association of dementia with early rehospitalization among Medicare beneficiaries." Archives of gerontology and geriatrics, vol. 59, no. 1, 2014, pp. 162-8. |
| Snyder PJ, Lim YY, Schindler R, Ott BR, Salloway S, Daiello L, Getter C, Gordon CM, Maruff P. "Microdosing of scopolamine as a "cognitive stress test": rationale and test of a very low dose in an at-risk cohort of older adults." Alzheimer's & Dementia, vol. 10, no. 2, 2014, pp. 262-7. |
| Daniels AH, Daiello LA, Lareau CR, Robidoux KA, Luo W, Ott B, Hayda RA, Born CT. "Preoperative cognitive impairment and psychological distress in hospitalized elderly hip fracture patients." American journal of orthopedics (Belle Mead, N.J.), vol. 43, no. 7, 2014, pp. E146-52. |
| Jalbert JJ, Daiello LA, Eaton CB, Miller SC, Lapane KL. "Antipsychotic use and the risk of diabetes in nursing home residents with dementia." The American journal of geriatric pharmacotherapy, vol. 9, no. 3, 2011, pp. 153-63. |
| Lapane KL, Hughes CM, Daiello LA, Cameron KA, Feinberg J. "Effect of a pharmacist-led multicomponent intervention focusing on the medication monitoring phase to prevent potential adverse drug events in nursing homes." Journal of the American Geriatrics Society, vol. 59, no. 7, 2011, pp. 1238-45. |
| Lapane KL, Hughes CM, Christian JB, Daiello LA, Cameron KA, Feinberg J. "Evaluation of the fleetwood model of long-term care pharmacy." Journal of the American Medical Directors Association, vol. 12, no. 5, 2011, pp. 355-63. |
| Parsons C, Alldred D, Daiello L, Hughes C. "Prescribing for older people in nursing homes: strategies to improve prescribing and medicines use in nursing homes." International Journal of Older People Nursing, vol. 6, no. 1, 2011, pp. 55-62. |
| Daiello LA, Ott BR, Festa EK, Friedman M, Miller LA, Heindel WC. "Effects of cholinesterase inhibitors on visual attention in drivers with Alzheimer disease." Journal of Clinical Psychopharmacology, vol. 30, no. 3, 2010, pp. 245-251. |
| Ott BR, Daiello LA. "How does dementia affect driving in older patients?." Aging Health, vol. 6, no. 1, 2010, pp. 77-85. |
| Daiello LA, Ott BR, Lapane KL, Reinert SE, Machan JT, Dore DD. "Effect of discontinuing cholinesterase inhibitor therapy on behavioral and mood symptoms in nursing home patients with dementia." The American journal of geriatric pharmacotherapy, vol. 7, no. 2, 2009, pp. 74-83. |
| Ott, B. R., Heindel, W. C., Papandonatos, G. D., Festa, E. K., Davis, J. D., Daiello, L. A., Morris, J. C. "A longitudinal study of drivers with Alzheimer disease." Neurology, vol. 70, no. 14, 2008, pp. 1171-1178. |
| Jalbert JJ, Daiello LA, Lapane KL. "Dementia of the Alzheimer type." Epidemiologic reviews, vol. 30, 2008, pp. 15-34. |
| Daiello LA. "Atypical antipsychotics for the treatment of dementia-related behaviors: an update." Medicine and health, Rhode Island, vol. 90, no. 6, 2007, pp. 191-4. |
| Daiello LA. "Current issues in dementia pharmacotherapy." The American Journal of Managed Care, vol. 13 Suppl 8, 2007, pp. S198-202. |
| Daiello LA, Beier MT, Hoffmann VP, Kennedy JS. "Pharmacotherapy of behavioral and psychological symptoms of dementia: a review of atypical antipsychotics." The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, vol. 18, no. 2, 2003, pp. 138-52, 155-7. |
| Golden AG, Daiello LA, Silverman MA, Llorente M, Preston RA. "University of Miami Division of Clinical Pharmacology Therapeutic Rounds: medications used to treat anorexia in the frail elderly." American journal of therapeutics, vol. 10, no. 4, 2003, pp. 292-8. |
| Nelson JC, Tune LE, Daiello LA, Porsteinsson A. "Interactive grand rounds: mood stabilizers in dementia." Geriatrics, vol. 57, no. 9, 2002, pp. suppl 2-5. |
| Ryan JM, Kidder SW, Daiello LA, Tariot PN. "Psychopharmacologic interventions in nursing homes: what do we know and where should we go?." PS, vol. 53, no. 11, 2002, pp. 1407-13. |
Title: Blood-Brain Barrier Disruption as a Biomarker for Perioperative Neurocognitive Disorders: Cognitive Recovery After Elective Surgery (CREATES) Study
Role in Project: Principal Investigator
Type of Grant: R01
Funding Source: NIA
Years Funded: 2019 – 2024
Direct Costs: $3,864,309
Title: Inside the Black Box: Culture Change and Behavioral Outcomes in Dementia
Role in Project: Principal Investigator
Type of Grant: R03
Funding Source: NIA
Years Funded: 2015-2018
Direct Costs: $178,852
Title: Neglected by the evidence: the intersection between medical complexity and dementia
Role in Project: Principal Investigator
Type of Grant: K08
Funding Source: NIH/AHRQ
Years Funded: 2009-2014
Direct Costs: $706,018
Title: Tailored DVD to improve medication management for low literate elderly patients
Role in Project: Sub-Investigator
Type of Grant: R18
Funding Source: NIH/AHRQ
Years Funded: 2007-2010
Direct Costs: $1,199,549
Title: Naturalistic assessment of driving in cognitively impaired elders.
Role in Project: Sub-Investigator
Type of Grant: R01
Funding Source: NIH/NIA
Years Funded: 2007-2011
Direct Costs: $1,783,538
Title: A longitudinal study of drivers with dementia.
Role in Project: Sub-Investigator
Type of Grant: R01
Funding Source: NIH/NIA
Years Funded: 2001-2007
Direct Costs: $1,439,916
Title: Impact of psychopharmacology consultation to high risk community elderly
Role in Project: Principal Investigator
Funding Source: Administration on Aging
Years Funded: 2001-2002
Direct Costs: $20,000
| Year | Degree | Institution |
|---|---|---|
| 2012 | MS | Brown University |
| 1993 | PharmD | Ohio State University |
| 1986 | BS | Ohio State University |
| Name | Title |
|---|---|
| Boxerman, Jerrold | Professor of Diagnostic Imaging |
| Cioffi, William | J. Murray Beardsley Professor of Surgery, Chair of Surgery |
| Cizginer, Sevdenur | Associate Professor of Health Services, Policy and Practice, Clinician Educator |
| Drake, Jonathan | Assistant Professor of Neurology |
| Jones, Rich | Professor of Psychiatry and Human Behavior, Professor of Neurology |
| Kendall, Mark | Associate Professor of Anesthesiology |
| Machan, Jason | Associate Professor of Surgery (Research), Associate Professor of Orthopaedics (Research) |
| Ott, Brian | Professor Emeritus of Neurology |
| Reznik, Michael | Assistant Professor of Neurosurgery, Assistant Professor of Neurology |
| Sharma, Surendra | Professor of Pathology and Laboratory Medicine (Research), Professor of Pediatrics (Research) |
| Shireman, Theresa | Director of the Center for Gerontology and Health Care Research, Professor of Health Services, Policy and Practice, Professor of Epidemiology |
| Tremont, Geoffrey | Associate Professor of Psychiatry and Human Behavior |
| Zhang, Tingting | Assistant Professor of Health Services, Policy and Practice |
| Zullo, Andrew | Associate Professor of Epidemiology, Associate Professor of Health Services, Policy and Practice |
Neurology
Health Services, Policy & Practice
| Associate Professor of Neurology. Alpert Medical School of Brown University, - |
| Senior Research Scientist. Rhode Island Hospital, - |
