The first hurdle a virus encounters prior to virus infection is engagement at the cell surface. In turn, viruses utilize various strategies to overcome this barrier. Virus entry to a host cell is required for a productive viral infection. Interactions between viruses and their cognate receptors on the cell surface determine the route of virus entry. Understanding the interactions between viruses and their host cell receptors is required for a full understanding of the virus invasion process. My research focuses on understanding the mechanism by which JCPyV, a human polyoma virus, engages its target cell(s) in the host, identifying determinants of the tissue tropism of viruses, and pursuing possibilities for specific interference of infection.
| O'Hara BA, Garabian K, Yuan W, Atwood WJ, Haley SA. "Neurovascular pericytes are susceptible to infection by JC polyomavirus." Journal of Virology, vol. 99, no. 9, 2025, pp. e0061625. |
| Lukacher AS, O'Hara BA, Yuan W, Garabian K, Kaiserman J, MacLure E, Haley SA, Atwood WJ. "The microvascular endothelium of the blood-brain barrier is highly restrictive to JC Polyomavirus neuroinvasion." Microbiology spectrum, vol. 13, no. 5, 2025, pp. e0028225. |
| MacLure E, Garabian K, O'Hara BA, Yuan W, Kaiserman J, Lukacher AS, Haley SA, Atwood WJ. "Therapeutic potential of flavonols in the treatment of JCPyV." Microbiology spectrum, vol. 13, no. 10, 2025, pp. e0152725. |
| O'Hara BA, Lukacher AS, Garabian K, Kaiserman J, MacLure E, Ishikawa H, Schroten H, Haley SA, Atwood WJ. "Highly restrictive and directional penetration of the blood cerebral spinal fluid barrier by JCPyV." PLoS pathogens, vol. 20, no. 7, 2024, pp. e1012335. |
| Haley SA, O'Hara BA, Schorl C, Atwood WJ. "JCPyV infection of primary choroid plexus epithelial cells reduces expression of critical junctional proteins and increases expression of barrier disrupting inflammatory cytokines." Microbiology spectrum, vol. 12, no. 8, 2024, pp. e0062824. |
| Kaiserman J, O'Hara BA, Haley SA, Atwood WJ. "An Elusive Target: Inhibitors of JC Polyomavirus Infection and Their Development as Therapeutics for the Treatment of Progressive Multifocal Leukoencephalopathy." International Journal of Molecular Sciences, vol. 24, no. 10, 2023. |
| Kaiserman J, O'Hara BA, Garabian K, Lukacher A, Haley SA, Atwood WJ. "The Oxindole GW-5074 Inhibits JC Polyomavirus Infection and Spread by Antagonizing the MAPK-ERK Signaling Pathway." mBio, vol. 14, no. 2, 2023, pp. e0358322. |
| Morris-Love J, O'Hara BA, Gee GV, Dugan AS, O'Rourke RS, Armstead BE, Assetta B, Haley SA, Atwood WJ. "Biogenesis of JC polyomavirus associated extracellular vesicles." Journal of extracellular biology, vol. 1, no. 5, 2022. |
| O'Hara BA, Gee GV, Haley SA, Morris-Love J, Nyblade C, Nieves C, Hanson BA, Dang X, Turner TJ, Chavin JM, Lublin A, Koralnik IJ, Atwood WJ. "Teriflunomide Inhibits JCPyV Infection and Spread in Glial Cells and Choroid Plexus Epithelial Cells." International Journal of Molecular Sciences, vol. 22, no. 18, 2021. |
| Haley SA, O'Hara BA, Atwood WJ. "Adipocyte Plasma Membrane Protein (APMAP) promotes JC Virus (JCPyV) infection in human glial cells." Virology, vol. 548, 2020, pp. 17-24. |
| O'Hara BA, Morris-Love J, Gee GV, Haley SA, Atwood WJ. "JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor." PLoS pathogens, vol. 16, no. 3, 2020, pp. e1008371. |
| Assetta B, Morris-Love J, Gee GV, Atkinson AL, O'Hara BA, Maginnis MS, Haley SA, Atwood WJ. "Genetic and Functional Dissection of the Role of Individual 5-HT<sub>2</sub> Receptors as Entry Receptors for JC Polyomavirus." Cell Reports, vol. 27, no. 7, 2019, pp. 1960-1966.e6. |
| Morris-Love J, Gee GV, O'Hara BA, Assetta B, Atkinson AL, Dugan AS, Haley SA, Atwood WJ. "JC Polyomavirus Uses Extracellular Vesicles To Infect Target Cells." mBio, vol. 10, no. 2, 2019. |
| O'Hara, Bethany A., Gee, Gretchen V., Atwood, Walter J., Haley, Sheila A. "Susceptibility of Primary Human Choroid Plexus Epithelial Cells and Meningeal Cells to Infection by JC Virus." Journal of Virology, vol. 92, no. 8, 2018, pp. e00105-18. |
| Haley SA, Atwood WJ. "Progressive Multifocal Leukoencephalopathy: Endemic Viruses and Lethal Brain Disease." Annual review of virology, vol. 4, no. 1, 2017, pp. 349-367. |
| Haley, Sheila A., O'Hara, Bethany A., Nelson, Christian D.S., Brittingham, Frances L.P., Henriksen, Kammi J., Stopa, Edward G., Atwood, Walter J. "Human Polyomavirus Receptor Distribution in Brain Parenchyma Contrasts with Receptor Distribution in Kidney and Choroid Plexus." The American Journal of Pathology, vol. 185, no. 8, 2015, pp. 2246-2258. |
| Haley, Sheila A., Atwood, Walter J. "An animal model for progressive multifocal leukoencephalopathy." Journal of Clinical Investigation, vol. 124, no. 12, 2014, pp. 5103-5106. |
| Assetta B, Maginnis MS, Gracia Ahufinger I, Haley SA, Gee GV, Nelson CD, O'Hara BA, Allen Ramdial SA, Atwood WJ. "5-HT2 receptors facilitate JC polyomavirus entry." Journal of Virology, vol. 87, no. 24, 2013, pp. 13490-8. |
| de Paepe ME, Haley SA, Lacourse Z, Mao Q. "Effects of Fas-ligand overexpression on alveolar type II cell growth kinetics in perinatal murine lungs." Pediatric Research, vol. 68, no. 1, 2010, pp. 57-62. |
| Maginnis MS, Haley SA, Gee GV, Atwood WJ. "Role of N-linked glycosylation of the 5-HT2A receptor in JC virus infection." Journal of Virology, vol. 84, no. 19, 2010, pp. 9677-84. |
| Haley SA, O'Hara BA, Banerjee R, Atwood WJ. "Unique susceptibility of a human lung carcinoid tumor cell line to infection with BK virus." Virus research, vol. 149, no. 1, 2010, pp. 128-32. |
| De Paepe ME, Gundavarapu S, Tantravahi U, Pepperell JR, Haley SA, Luks FI, Mao Q. "Fas-ligand-induced apoptosis of respiratory epithelial cells causes disruption of postcanalicular alveolar development." The American Journal of Pathology, vol. 173, no. 1, 2008, pp. 42-56. |
| Haley SA, Zhao T, Zou L, Klysik JE, Padbury JF, Kochilas LK. "Forced expression of the cell cycle inhibitor p57Kip2 in cardiomyocytes attenuates ischemia-reperfusion injury in the mouse heart." BMC physiology, vol. 8, 2008, pp. 4. |
| Haley SA, Wessel GM. "Proteolytic cleavage of the cell surface protein p160 is required for detachment of the fertilization envelope in the sea urchin." Developmental Biology, vol. 272, no. 1, 2004, pp. 191-202. |
| Haley SA, Wessel GM. "Regulated proteolysis by cortical granule serine protease 1 at fertilization." Molecular biology of the cell, vol. 15, no. 5, 2004, pp. 2084-92. |
| Wessel GM, Brooks JM, Green E, Haley S, Voronina E, Wong J, Zaydfudim V, Conner S. "The biology of cortical granules." International review of cytology, vol. 209, 2001, pp. 117-206. |
| Haley SA, Wessel GM. "The cortical granule serine protease CGSP1 of the sea urchin, Strongylocentrotus purpuratus, is autocatalytic and contains a low-density lipoprotein receptor-like domain." Developmental Biology, vol. 211, no. 1, 1999, pp. 1-10. |
Haley, S.A., O’Hara, B.A., Nelson, C.D.S., Brittingham, F.L.P., Henriksen, K.J., Stopa, E.G., and Atwood, W.J. Human Polyomavirus JCPyV Receptor Distribution in Brain Parenchyma Contrasts with Receptor Distribution in Kidney and Choroid Plexus. (American Journal of Pathology, in press).
Haley S.A., Atwood W.J., 2014. An animal model for progressive multifocal leukoencephalopathy. J. Clinical Investigation, Nov 17: 1-4. PMID: 25401466
Assetta B., Maginnis M.S., Gracia Ahufinger I., Haley S.A., Gee G.V., Nelson C.D., O'Hara B.A., Allen Ramdial S.A., Atwood W.J., 2013. 5-HT2 receptors facilitate JC polyomavirus entry. Journal of Virology, 87(24):13490-8. PMID: 24089568
Haley, S.A., O’Hara, B.A., Banerjee, R., Atwood, W.J., 2010. Unique Susceptibility of a Human Lung Carcinoid Tumor Cell Line to Infection with BK Virus. Virus Research 149 (1): 128-132. PMID: 20122973
Maginnnis, M.S., Haley, S.A., Gee, G.V., and Atwood, W.J., 2010. Role of N-linked Glycosylation of the 5-HT2A Receptor in JC Virus Infection. Journal of Virology, 84 (19): 9677 – 9684. PMID: 20660194
De Paepe, M.E., Haley, S.A., Lacourse, Z., and Mao, Q., 2010. The Effects of Fas-Ligand Overexpression on Alveolar Type II Cell Growth Kinetics in Perinatal Murine Lungs. Pediatric Research, 68 (1): 57-62. PMID: 20375852
DePaepe, M.E., Gundavarapu, S., Tantravahi, U., Pepperell, J.R., Haley, S.A., Luks, F.I., Mao, Q., 2008. Fas-Ligand-Induced Apoptosis of Respiratory Epithelial Cells Causes Disruption of Postcanalicular Alveolar Development. Am. J. Pathology, 173(1):42-56. PMID: 18535181| Year | Degree | Institution |
|---|---|---|
| 2001 | PhD | Brown University |
| 1990 | BS | University of Massachusetts |
