Bong Sook Jhun, PhD is an Assistant Professor of Medicine at Brown University and Research Scientist at Rhode Island Hospital (RIH). Dr. Jhun received her PhD degree at Kyung Hee University School of Medicine in Seoul, Republic of Korea. She completed postdoctoral training at Harbor-UCLA Medical Center and University of Rochester, and worked as a Research Associate and Instructor at Thomas Jefferson University. Subsequently, she joined Cardiovascular Research Center (CVRC) at RIH and Brown University as an Instructor of Medicine in January 2016. Her recent research has focused on the molecular mechanisms and functional roles of mitochondrial fission and mitochondrial Ca2+ influx for regulating mitochondrial and cellular functions in physiological and pathophysiological conditions. In continuing this line of research, she is currently exploring the novel role of Protein Kinase D (PKD) in cardiac mitochondrial damage during heart failure. This research is specifically focused on the cellular signaling mechanisms underlying abnormal mitochondrial morphology and mitochondrial dysfunction that contribute to cardiomyocyte death and heart failure development. Elucidation of these regulatory mechanisms will facilitate the design of novel therapeutic targets for the pharmacological management of heart failure.
|O-Uchi, Jin, Jhun, Bong Sook, Mishra, Jyotsna, Sheu, Shey-Shing Organellar Ion Channels and Transporters. Cardiac Electrophysiology: From Cell to Bedside/Cardiac Electrophysiology: From Cell to Bedside. 2018; : 66-79.|
|Jhun BS, O-Uchi J, Adaniya SM, Mancini TJ, Cao JL, King ME, Landi AK, Ma H, Shin M, Yang D, Xu X, Yoon Y, Choudhary G, Clements RT, Mende U, Sheu SS Protein kinase D activation induces mitochondrial fragmentation and dysfunction in cardiomyocytes.. The Journal of Physiology. 2018;|
|Allawzi AM, Vang A, Clements RT, Jhun BS, Kue NR, Mancini TJ, Landi AK, Terentyev D, O-Uchi J, Comhair SA, Erzurum SC, Choudhary G Activation of Anoctamin-1 Limits Pulmonary Endothelial Cell Proliferation via p38-MAPK-dependent Apoptosis.. American Journal of Respiratory Cell and Molecular Biology. 2017;|
|Mishra J, Jhun BS, Hurst S, O-Uchi J, Csordás G, Sheu SS The Mitochondrial Ca<sup>2+</sup> Uniporter: Structure, Function, and Pharmacology.. Handbook of experimental pharmacology. 2017;|
|Jhun BS, Mishra J, Monaco S, Fu D, Jiang W, Sheu SS, O-Uchi J The mitochondrial Ca2+ uniporter: Regulation by auxiliary subunits and signal transduction pathways.. AJP: Cell Physiology. 2016; : ajpcell.00319.2015.|
|O-Uchi J, Sorenson J, Jhun BS, Mishra J, Hurst S, Williams K, Sheu SS, Lopes CM Isoform-specific dynamic translocation of PKC by α1-adrenoceptor stimulation in live cells.. Biochemical and Biophysical Research Communications. 2015; 465 (3) : 464-70.|
|O-Uchi J, Jhun BS, Xu S, Hurst S, Raffaello A, Liu X, Yi B, Zhang H, Gross P, Mishra J, Ainbinder A, Kettlewell S, Smith GL, Dirksen RT, Wang W, Rizzuto R, Sheu SS Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter.. Antioxidants & redox signaling. 2014; 21 (6) : 863-79.|
|O-Uchi J, Ryu SY, Jhun BS, Hurst S, Sheu SS Mitochondrial ion channels/transporters as sensors and regulators of cellular redox signaling.. Antioxidants & redox signaling. 2014; 21 (6) : 987-1006.|
|Jakob R, Beutner G, Sharma VK, Duan Y, Gross RA, Hurst S, Jhun BS, O-Uchi J, Sheu SS Molecular and functional identification of a mitochondrial ryanodine receptor in neurons.. Neuroscience Letters. 2014; 575 : 7-12.|
|O-Uchi, Jin, Jhun, Bong Sook, Sheu, Shey-Shing Structural and Molecular Bases of Mitochondrial Ion Channel Function. Cardiac Electrophysiology: From Cell to Bedside/Cardiac Electrophysiology: From Cell to Bedside. 2014; : 71-84.|
|O-Uchi J, Komukai K, Kusakari Y, Morimoto S, Kawai M, Jhun BS, Hurst S, Hongo K, Sheu SS, Kurihara S Alpha1-adrenenoceptor stimulation inhibits cardiac excitation-contraction coupling through tyrosine phosphorylation of beta1-adrenoceptor.. Biochemical and Biophysical Research Communications. 2013; 433 (2) : 188-93.|
|Jhun BS, Lee H, Jin ZG, Yoon Y Glucose stimulation induces dynamic change of mitochondrial morphology to promote insulin secretion in the insulinoma cell line INS-1E.. PLoS ONE. 2013; 8 (4) : e60810.|
|O-Uchi J, Jhun BS, Hurst S, Bisetto S, Gross P, Chen M, Kettlewell S, Park J, Oyamada H, Smith GL, Murayama T, Sheu SS Overexpression of ryanodine receptor type 1 enhances mitochondrial fragmentation and Ca2+-induced ATP production in cardiac H9c2 myoblasts.. American Journal of Physiology - Heart and Circulatory Physiology. 2013; 305 (12) : H1736-51.|
|Jhun BS, O-Uchi J, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CM, Jin ZG Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1.. Circulation research. 2012; 110 (1) : 59-70.|
|Galloway CA, Lee H, Nejjar S, Jhun BS, Yu T, Hsu W, Yoon Y Transgenic control of mitochondrial fission induces mitochondrial uncoupling and relieves diabetic oxidative stress.. Diabetes. 2012; 61 (8) : 2093-104.|
|Yu T, Jhun BS, Yoon Y High-glucose stimulation increases reactive oxygen species production through the calcium and mitogen-activated protein kinase-mediated activation of mitochondrial fission.. Antioxidants & redox signaling. 2011; 14 (3) : 425-37.|
|Yoon Y, Galloway CA, Jhun BS, Yu T Mitochondrial dynamics in diabetes.. Antioxidants & redox signaling. 2011; 14 (3) : 439-57.|
|Wang W, Ha CH, Jhun BS, Wong C, Jain MK, Jin ZG Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS.. Blood. 2010; 115 (14) : 2971-9.|
|Ha CH, Kim JY, Zhao J, Wang W, Jhun BS, Wong C, Jin ZG PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy.. Proceedings of the National Academy of Sciences. 2010; 107 (35) : 15467-72.|
|Ma Z, Jhun B, Jung SY, Oh CK Binding of upstream stimulatory factor 1 to the E-box regulates the 4G/5G polymorphism-dependent plasminogen activator inhibitor 1 expression in mast cells.. Journal of Allergy and Clinical Immunology. 2008; 121 (4) : 1006-1012.e2.|
|Xu X, Jhun BS, Ha CH, Jin ZG Molecular mechanisms of ghrelin-mediated endothelial nitric oxide synthase activation.. Endocrinology. 2008; 149 (8) : 4183-92.|
|Ha CH, Wang W, Jhun BS, Wong C, Hausser A, Pfizenmaier K, McKinsey TA, Olson EN, Jin ZG Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis.. Journal of Biological Chemistry. 2008; 283 (21) : 14590-9.|
|Ha CH, Jhun BS, Kao HY, Jin ZG VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis.. Arteriosclerosis, thrombosis, and vascular biology. 2008; 28 (10) : 1782-8.|
|Ma Z, Jhun B, Oh CK Upstream stimulating factor-1 mediates the E-box-dependent transcriptional repression of the plasminogen activator inhibitor-1 gene in human mast cells.. FEBS Letters. 2007; 581 (23) : 4485-90.|
|Lee JY, Jhun BS, Oh YT, Lee JH, Choe W, Baik HH, Ha J, Yoon KS, Kim SS, Kang I Activation of adenosine A3 receptor suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of PI 3-kinase/Akt and NF-kappaB activation in murine BV2 microglial cells.. Neuroscience Letters. 2006; 396 (1) : 1-6.|
|Jhun BS, Lee JY, Oh YT, Lee JH, Choe W, Baik HH, Kim SS, Yoon KS, Ha J, Kang I Inhibition of AMP-activated protein kinase suppresses IL-2 expression through down-regulation of NF-AT and AP-1 activation in Jurkat T cells.. Biochemical and Biophysical Research Communications. 2006; 351 (4) : 986-92.|
|Jhun BS, Oh YT, Lee JY, Kong Y, Yoon KS, Kim SS, Baik HH, Ha J, Kang I AICAR suppresses IL-2 expression through inhibition of GSK-3 phosphorylation and NF-AT activation in Jurkat T cells.. Biochemical and Biophysical Research Communications. 2005; 332 (2) : 339-46.|
|Jhun BS, Jin Q, Oh YT, Kim SS, Kong Y, Cho YH, Ha J, Baik HH, Kang I 5-Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages.. Biochemical and Biophysical Research Communications. 2004; 318 (2) : 372-80.|
|Jin Q, Jhun BS, Lee SH, Lee J, Pi Y, Cho YH, Baik HH, Kang I Differential regulation of phosphatidylinositol 3-kinase/Akt, mitogen-activated protein kinase, and AMP-activated protein kinase pathways during menadione-induced oxidative stress in the kidney of young and old rats.. Biochemical and Biophysical Research Communications. 2004; 315 (3) : 555-61.|
Lim JI, Bae BN, Jhun BS, Kang I. Kim SJ
A simple preparative polyacrylamide gel electrophoresis for the purification of chymotrypsin inhibitor isoforms from ganoderma lucidum.
Bull Korean Chem Soc. 2003; 24 (10) : 1531-1534.
|Hong F, Kwon SJ, Jhun BS, Kim SS, Ha J, Kim SJ, Sohn NW, Kang C, Kang I Insulin-like growth factor-1 protects H9c2 cardiac myoblasts from oxidative stress-induced apoptosis via phosphatidylinositol 3-kinase and extracellular signal-regulated kinase pathways.. Life sciences. 2001; 68 (10) : 1095-105.|
Kim SJ, Kim YJ, Seo MR, Jhun BS
Regulatory mechanism of L-alanine dehydrogenase from bacillus subtilis.
Bull Korean Chem Soc. 2000; 21 (12) : 1217-1221.
1. U54GM115677 (Padbury, PI) 07/20/2017-04/29/2018
NIH/NIGMS Total direct cost: $75,000
Advance-CTR, Pilot Project
Title: “A novel therapy to reduce cardiac injury and dysfunction after myocardial Infarction”
The goal of this project is to design a pilot study evaluating the activity levels of PKD-DLP1 signaling in atrial myocardium and white blood cells in patients with coronary artery disease, to seek the possibility for using this signaling as a biomarker to determine the severity of myocardial dysfunction.
Role: Pilot Project PI
2. P30GM1114750 (Shaw, PI) 05/01/2017-04/29/2018
NIH/NIGMS Total direct cost: $50,000
COBRE Center for Perinatal Biology, Pilot Project
Title: “Role of mitochondrial Ca2+ and ROS in the early postnatal cardiac development”
This project is to examine the molecular mechanisms underlying the proliferation of neonatal cardiac fibroblasts under angiotensin II stimulation, especially focusing on the role of mitochondrial Ca2+ uniporter (MCU) and mitochondrial ROS.
Role: Pilot Project Co-I
3. Medical Research Grant #20174335 (Jhun, PI) 04/01/2018-03/31/2019
Rhode Island Foundation Total direct cost: $25,000
Title: “Role of PKD in right ventricular dysfunction under pulmonary arterial hypertension”
The goal of this project is to determine the pathophysiological role of protein kinase D (PKD)-mediated mitochondrial injury in right ventricular dysfunction under pulmonary arterial hypertension in vivo.
* The grant was relinquished because of institutional transfer to the University of Minnesota on April 30, 2018.
|2006||PhD||Kyung Hee University|
|2001||MS||Kyung Hee University|
|1999||BS||Kyung Hee University|
|Research associate||Thomas Jefferson University, Department of Medicine||2012-2015||Philadelphia, PA|
|Postdoctoral Research Associate||University of Rochester School of Medicine and Dentistry, Department of Medicine||2007-2012||Rochester, NY|
|Postdoctoral Fellow||Harbor-UCLA Medical Center, Los Angeles Biomedical Research Institute , Department of Pediatrics||2006-2007||Torrance, CA|
Career Development Award, American Heart Association, 2018
New Investigator Award, American Physiological Society, Cell and Molecular Physiology Section, 2018
Medical Research Grant Award, Rhode Island Foundation, 2018
Advance-Clinical and Translational Research (Advance-CTR) Pilot Projects Program Award, NIH/NIGMS, 2017
2012 - Present Member, Biophysical Society (BPS)
2012 - Present Member, Cardiac Muscle Society
2012 - Present Member, American Heart Association (AHA)
2013 - Present Member, International Society for Heart Research (ISHR)
2015 - Present Member, American Physiological Society (APS)
|Assistant Professor (Research). , Department of Medicine 2017-2020|
|Research Scientist. Rhode Island Hospital, Division of Cardiology and Cardiovascular Research Center 2016-2018|