Haiyan Xu, MD,PhD, joined the faculty as assistant professor of medicine in the division of endocrinology in 2005. Her education includes a MD degree from Beijing Medical University, a MS from the same school and a PhD from Harvard University.She was a researcher in the department of metabolic disease biology at Millennium Pharmaceuticals, Inc. from 2000 to 2003 and moved to the metabolic disease research division at Abbott Laboratories in 2004. Her honors include the Edgar Haber Award in Biological Sciences and the Medical Sigma Xi Harvard-Radcliffe Chapter Scientific Recognition Award from Harvard University as well as Bruce M. Selya research excellence award from Rhode Island Hospital.
|Feng B, He Q, Xu H. "FOXO1-dependent up-regulation of MAP kinase phosphatase 3 (MKP-3) mediates glucocorticoid-induced hepatic lipid accumulation in mice." Molecular and cellular endocrinology, vol. 393, no. 1-2, 2014, pp. 46-55.|
|Feng, B., Jiao, P., Helou, Y., Li, Y., He, Q., Walters, M. S., Salomon, A., Xu, H. "Mitogen-Activated Protein Kinase Phosphatase 3 (MKP-3)-Deficient Mice Are Resistant to Diet-Induced Obesity." Diabetes, vol. 63, no. 9, 2014, pp. 2924-34.|
|Jiao P, Feng B, Li Y, He Q, Xu H. "Hepatic ERK activity plays a role in energy metabolism." Molecular and cellular endocrinology, vol. 375, no. 1-2, 2013, pp. 157-66.|
|Feng B, Zhang T, Xu H. "Human adipose dynamics and metabolic health." Annals of the New York Academy of Sciences, vol. 1281, 2013, pp. 160-77.|
|Li Y, Nie Y, Helou Y, Ding G, Feng B, Xu G, Salomon A, Xu H. "Identification of sucrose non-fermenting-related kinase (SNRK) as a suppressor of adipocyte inflammation." Diabetes, vol. 62, no. 7, 2013, pp. 2396-409.|
|Neacsu O, Cleveland K, Xu H, Tchkonia TT, Kirkland JL, Boney CM. "IGF-I attenuates FFA-induced activation of JNK1 phosphorylation and TNFα expression in human subcutaneous preadipocytes." Obesity, vol. 21, no. 9, 2013, pp. 1843-9.|
|Xu, Haiyan. "Obesity and metabolic inflammation." Drug Discovery Today: Disease Mechanisms, vol. 10, no. 1-2, 2013, pp. e21-e25.|
|Jiao, Ping, Feng, Bin, Ma, Jie, Nie, Yaohui, Paul, Erin, Li, Yujie, Xu, Haiyan. "Constitutive Activation of IKKβ in Adipose Tissue Prevents Diet-Induced Obesity in Mice." Endocrinology, vol. 153, no. 1, 2012, pp. 154-165.|
|Nie, Y., Ma, R. C., Chan, J. C. N., Xu, H., Xu, G. "Glucose-dependent insulinotropic peptide impairs insulin signaling via inducing adipocyte inflammation in glucose-dependent insulinotropic peptide receptor-overexpressing adipocytes." The FASEB Journal, vol. 26, no. 6, 2012, pp. 2383-2393.|
|Jiao P, Feng B, Xu H. "Mapping MKP-3/FOXO1 interaction and evaluating the effect on gluconeogenesis." PLoS ONE, vol. 7, no. 7, 2012, pp. e41168.|
|Feng B, Jiao P, Yang Z, Xu H. "MEK/ERK pathway mediates insulin-promoted degradation of MKP-3 protein in liver cells." Molecular and cellular endocrinology, vol. 361, no. 1-2, 2012, pp. 116-23.|
|Feng, Bin, Jiao, Ping, Nie, Yaohui, Kim, Thomas, Jun, Dale, van Rooijen, Nico, Yang, Zaiqing, Xu, Haiyan. "Clodronate Liposomes Improve Metabolic Profile and Reduce Visceral Adipose Macrophage Content in Diet-Induced Obese Mice." PLoS ONE, vol. 6, no. 9, 2011, pp. e24358.|
|Yang, S., Xu, H., Yu, S., Cao, H., Fan, J., Ge, C., Fransceschi, R. T., Dong, H. H., Xiao, G. "Foxo1 Mediates Insulin-like Growth Factor 1 (IGF1)/Insulin Regulation of Osteocalcin Expression by Antagonizing Runx2 in Osteoblasts." Journal of Biological Chemistry, vol. 286, no. 21, 2011, pp. 19149-19158.|
|Wu, Zhidan, Jiao, Ping, Huang, Xueming, Feng, Bin, Feng, Yajun, Yang, Shengyong, Hwang, Phillip, Du, Jing, Nie, Yaohui, Xiao, Guozhi, Xu, Haiyan. "MAPK phosphatase–3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice." Journal of Clinical Investigation, vol. 120, no. 11, 2010, pp. 3901-3911.|
|Lyn-Cook LE Jr, Lawton M, Tong M, Silbermann E, Longato L, Jiao P, Mark P, Wands JR, Xu H, de la Monte SM. "Hepatic ceramide may mediate brain insulin resistance and neurodegeneration in type 2 diabetes and non-alcoholic steatohepatitis." Journal of Alzheimer's disease : JAD, vol. 16, no. 4, 2009, pp. 715-29.|
|Moroz N, Tong M, Longato L, Xu H, de la Monte SM. "Limited Alzheimer-type neurodegeneration in experimental obesity and type 2 diabetes mellitus." Journal of Alzheimer's disease : JAD, vol. 15, no. 1, 2008, pp. 29-44.|
|Jiao, P., Chen, Q., Shah, S., Du, J., Tao, B., Tzameli, I., Yan, W., Xu, H. "Obesity-Related Upregulation of Monocyte Chemotactic Factors in Adipocytes: Involvement of Nuclear Factor- B and c-Jun NH2-Terminal Kinase Pathways." Diabetes, vol. 58, no. 1, 2008, pp. 104-115.|
|Du, Jing, Chen, Qiu, Takemori, Hiroshi, Xu, Haiyan. "SIK2 Can be Activated by Deprivation of Nutrition and It Inhibits Expression of Lipogenic Genes in Adipocytes." Obesity, vol. 16, no. 3, 2008, pp. 531-538.|
|Xu, Haiyan. "Hepatic knockdown of stearoyl-COA desaturase 1 via RNA interference in obese mice decreases lipid content and changes fatty acid composition." Frontiers in Bioscience, vol. 12, no. 8-12, 2007, pp. 3781.|
|Xu H, Wilcox D, Nguyen P, Voorbach M, Suhar T, Morgan SJ, An WF, Ge L, Green J, Wu Z, Gimeno RE, Reilly R, Jacobson PB, Collins CA, Landschulz K, Surowy T. "Hepatic knockdown of mitochondrial GPAT1 in ob/ob mice improves metabolic profile." Biochemical and Biophysical Research Communications, vol. 349, no. 1, 2006, pp. 439-48.|
|Hong, Suk-Bong, Lubben, Thomas H., Dolliver, Christine M., Petrolonis, Anthony J., Roy, Rebecca A., Li, Zhi, Parsons, Thomas F., Li, Ping, Xu, Haiyan, Reilly, Regina M., Trevillyan, James M., Nichols, Andrew J., Tummino, Peter J., Gant, Thomas G. "Expression, purification, and enzymatic characterization of the dual specificity mitogen-activated protein kinase phosphatase, MKP-4." Bioorganic Chemistry, vol. 33, no. 1, 2005, pp. 34-44.|
|Xu H, Hirosumi J, Uysal KT, Guler AD, Hotamisligil GS. "Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance." Endocrinology, vol. 143, no. 4, 2002, pp. 1502-11.|
|Chiellini C, Bertacca A, Novelli SE, Görgün CZ, Ciccarone A, Giordano A, Xu H, Soukas A, Costa M, Gandini D, Dimitri R, Bottone P, Cecchetti P, Pardini E, Perego L, Navalesi R, Folli F, Benzi L, Cinti S, Friedman JM, Hotamisligil GS, Maffei M. "Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha." Journal of cellular physiology, vol. 190, no. 2, 2002, pp. 251-8.|
|Xu H, Hotamisligil GS. "Signaling pathways utilized by tumor necrosis factor receptor 1 in adipocytes to suppress differentiation." FEBS Letters, vol. 506, no. 2, 2001, pp. 97-102.|
|Sethi JK, Xu H, Uysal KT, Wiesbrock SM, Scheja L, Hotamisligil GS. "Characterisation of receptor-specific TNFalpha functions in adipocyte cell lines lacking type 1 and 2 TNF receptors." FEBS Letters, vol. 469, no. 1, 2000, pp. 77-82.|
|Tong Q, Dalgin G, Xu H, Ting CN, Leiden JM, Hotamisligil GS. "Function of GATA transcription factors in preadipocyte-adipocyte transition." Science, vol. 290, no. 5489, 2000, pp. 134-8.|
1. Haiyan Xu, Qing Yang, Minhui Shen, Xueming Huang, Marlene Dembski, Ruth, Gimeno, Louis A. Tartaglia, Rosana Kapeller, and Zhidan Wu. Dual specificity MAPK phosphatase 3 activates PEPCK gene transcription and increases gluconeogenesis in rat hepatoma cells. J. Bio. Chem. 280: 36013-36018, 2005
3. Haiyan Xu, Marlene Dembski, Qing Yang, Daseng Yang, Ann Moriarty, Olga Tayber, Hong Chen, Rosana Kapeller and Louis A. Tartaglia. Dual specificity MAP kinase phosphatase 4 plays a potential role in insulin resistance. J Biol Chem 278: 30187-30192, 2003.
2. Haiyan Xu, Glenn T. Barnes, Qing Yang, Guo Tan, Daseng Yang, Chieh J. Chou, Jason Sole, Andrew Nichols, Jeffrey S. Ross, Louis A. Tartaglia and Hong Chen. Chronic inflammation in adipose tissue plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112: 1821-1830, 2003.
5. Haiyan Xu, K. Teoman Uysal, J. David Becherer, Peter Arner and Gökhan S. Hotamisligil. Altered TNF-alpha processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity. Diabetes 51 (6), 1876-1883, 2002.
4. Haiyan Xu, Jiro Hirosumi, K. Teoman Uysal, A. Deniz Guler and Gökhan S. Hotamisligil. Exclusive action of transmembrane TNF-alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance Endocrinology 143 (4): 1502-11, 2002.
6. Qiang Tong, Gökhan Dalgin, Haiyan Xu, Chao-Nan Ting, Jeffrey M. Leiden, Gökhan S. Hotamisligil. Function of GATA transcription factors in preadipocyte-adipocyte transition. Science 290: 134-38, 2000.
7. Haiyan Xu, Jaswinder Sethi, Gökhan S. Hotamisligil. The transmembrane form of tumor necrosis factor alpha inhibits adipocyte differentiation by selectively activating tumor necrosis factor receptor I. J Biol Chem 274: 26287-26295, 1999.
|Postdoctoral Fellow||Millennium Pharmaceuticals Inc., metabolic disease biology||2000-2001||Cambridge, MA|