Dr. Michelow's experience and interests span clinical, laboratory-based and translational research topics with a focus on immune-mediated interventions in pediatric infectious diseases. His activities include the study of malaria pathogenesis and vaccine discovery, Ebola virus disease, clinical epidemiology and biomarkers of pneumonia and viral infections in hospitalized children, and pediatric osteoarticular infections. His research is at the interface between infectious diseases and immunology.
Dr. Michelow collaborates with colleagues in the Center for International Health Research at Rhode Island Hospital and Brown University, adn other investigators who study malaria and the Ebola virus.
Dr. Michelow is supported by the Rhode Island Foundation, Women & Infants Hospital, Lifespan Inc., the Department of Pediatrics at Hasbro Children's Hospital, NIH/NIAID K08, NIH/NIGMS COBRE, NIH/NIAID R25 grants.
| Choe YJ, Blatt DB, Yalcindag A, Geffert SF, Bobenchik AM, Michelow IC. "Cryptococcus albidus Fungemia in an Immunosuppressed Child: Case Report and Systematic Literature Review." Journal of the Pediatric Infectious Diseases Society, vol. 9, no. 1, 2020, pp. 100-105. |
| Alhinai Z, Elahi M, Park S, Foo B, Lee B, Chapin K, Koster M, Sánchez PJ, Michelow IC. "Prediction of Adverse Outcomes in Pediatric Acute Hematogenous Osteomyelitis." Clinical Infectious Diseases, 2020. |
| Karanovic D, Michelow IC, Hayward AR, DeRavin SS, Delmonte OM, Grigg ME, Dobbs AK, Niemela JE, Stoddard J, Alhinai Z, Rybak N, Hernandez N, Pittaluga S, Rosenzweig SD, Uzel G, Notarangelo LD. "Disseminated and Congenital Toxoplasmosis in a Mother and Child With Activated PI3-Kinase δ Syndrome Type 2 (APDS2): Case Report and a Literature Review of Toxoplasma Infections in Primary Immunodeficiencies." Frontiers in immunology, vol. 10, 2019, pp. 77. |
| Nixon CP, Nixon CE, Michelow IC, Silva-Viera RA, Colantuono B, Obeidallah AS, Jha A, Dockery D, Raj D, Park S, Duffy PE, Kurtis JD. "Antibodies to PfsEGXP, an Early Gametocyte-Enriched Phosphoprotein, Predict Decreased Plasmodium falciparum Gametocyte Density in Humans." Journal of Infectious Diseases, vol. 218, no. 11, 2018, pp. 1792-1801. |
| Michelow IC, Sánchez PJ. "Azithromycin and Childhood Mortality in Africa." New England Journal of Medicine, vol. 379, no. 14, 2018, pp. 1382. |
| Kurtis JD, Raj DK, Michelow IC, Park S, Nixon CE, McDonald EA, Nixon CP, Pond-Tor S, Jha A, Taliano RJ, Kabyemela ER, Friedman JF, Duffy PE, Fried M. "Maternally-derived Antibodies to Schizont Egress Antigen-1 and Protection of Infants From Severe Malaria." Clinical Infectious Diseases, vol. 68, no. 10, 2018, pp. 1718-1724. |
| Smit MA, Michelow IC, Glavis-Bloom J, Wolfman V, Levine AC. "Characteristics and Outcomes of Pediatric Patients With Ebola Virus Disease Admitted to Treatment Units in Liberia and Sierra Leone: A Retrospective Cohort Study." Clinical Infectious Diseases, vol. 64, no. 3, 2017, pp. 243-249. |
| Michelow IC, Alhinai Z, Dennehy PH. "Hydrocortisone, Vitamin C and Thiamine for Sepsis: Whither the Ethics in Research?." Chest, vol. 152, no. 3, 2017, pp. 689-690. |
| Sánchez PJ, Moallem M, Cantey JB, Milton A, Michelow IC. "Empiric therapy with vancomycin in the neonatal intensive care unit: let's "get smart" globally!." Jornal de pediatria, vol. 92, no. 5, 2016, pp. 432-5. |
| Sánchez PJ, Moallem M, Cantey JB, Milton A, Michelow IC. "Empiric Therapy with Vancomycin in the Neonatal Intensive Care Unit: Let’s “Get Smart” Globally." J Pediatr, vol. 92, no. 5, 2016. |
| Cooper JM, Michelow IC, Wozniak PS, Sánchez PJ. "In time: the persistence of congenital syphilis in Brazil - More progress needed!." Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo, vol. 34, no. 3, 2016, pp. 251-3. |
| Holland SB, Michelow IC. "Tularemia Masquerading as Ecthyma." The Journal of Pediatrics, vol. 178, 2016, pp. 299. |
| Theresa M. Fiorito, Kimberle Chapin, Jaclyn Skidmore, Ian C. Michelow. "Cluster of Vaccine-related Invasive Pneumococcal Disease in Previously Vaccinated Healthy Children in Rhode Island." RI medical journal, vol. 98, no. 5, 2015, pp. 12-13. |
| Michelow IC, Mandell JG. "Sequential Intravenous Oral Antibiotic Therapy for Osteomyelitis: How Short Is Long Enough?." JAMA Pediatrics, vol. 169, no. 7, 2015, pp. 698-9. |
| Raj DK, Nixon CP, Nixon CE, Dvorin JD, DiPetrillo CG, Pond-Tor S, Wu HW, Jolly G, Pischel L, Lu A, Michelow IC, Cheng L, Conteh S, McDonald EA, Absalon S, Holte SE, Friedman JF, Fried M, Duffy PE, Kurtis JD. "Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection." Science, vol. 344, no. 6186, 2014, pp. 871-7. |
| Ronchi A, Michelow IC, Chapin KC, Bliss JM, Pugni L, Mosca F, Sánchez PJ. "Viral respiratory tract infections in the neonatal intensive care unit: the VIRIoN-I study." The Journal of Pediatrics, vol. 165, no. 4, 2014, pp. 690-6. |
| Brudner M, Karpel M, Lear C, Chen L, Yantosca LM, Scully C, Sarraju A, Sokolovska A, Zariffard MR, Eisen DP, Mungall BA, Kotton DN, Omari A, Huang IC, Farzan M, Takahashi K, Stuart L, Stahl GL, Ezekowitz AB, Spear GT, Olinger GG, Schmidt EV, Michelow IC. "Lectin-dependent enhancement of Ebola virus infection via soluble and transmembrane C-type lectin receptors." PLoS ONE, vol. 8, no. 4, 2013, pp. e60838. |
| Hyle EP, Shu B, Lindstrom S, Klimov A, Hancock K, Ferraro MJ, Traum AZ, Michelow IC. "A severely immunocompromised child with uncomplicated oseltamivir-resistant 2009 H1N1 pandemic influenza infection." Pediatric transplantation, vol. 16, no. 5, 2012, pp. E158-61. |
| Chiu CH, Michelow IC, Cronin J, Ringer SA, Ferris TG, Puopolo KM. "Effectiveness of a guideline to reduce vancomycin use in the neonatal intensive care unit." The Pediatric Infectious Disease Journal, vol. 30, no. 4, 2011, pp. 273-8. |
| Michelow IC, Lear C, Scully C, Prugar LI, Longley CB, Yantosca LM, Ji X, Karpel M, Brudner M, Takahashi K, Spear GT, Ezekowitz RA, Schmidt EV, Olinger GG. "High-dose mannose-binding lectin therapy for Ebola virus infection." Journal of Infectious Diseases, vol. 203, no. 2, 2011, pp. 175-9. |
| Chang, Wei-Chuan, Hartshorn, Kevan L., White, Mitchell R., Moyo, Patience, Michelow, Ian C., Koziel, Henry, Kinane, Bernard T., Schmidt, Emmett V., Fujita, Teizo, Takahashi, Kazue. "Recombinant chimeric lectins consisting of mannose-binding lectin and L-ficolin are potent inhibitors of influenza A virus compared with mannose-binding lectin." Biochemical Pharmacology, vol. 81, no. 3, 2011, pp. 388-395. |
| Michelow IC, Dong M, Mungall BA, Yantosca LM, Lear C, Ji X, Karpel M, Rootes CL, Brudner M, Houen G, Eisen DP, Kinane TB, Takahashi K, Stahl GL, Olinger GG, Spear GT, Ezekowitz RA, Schmidt EV. "A novel L-ficolin/mannose-binding lectin chimeric molecule with enhanced activity against Ebola virus." Journal of Biological Chemistry, vol. 285, no. 32, 2010, pp. 24729-39. |
| Russell G, Kaplan J, Ferraro M, Michelow IC. "Fecal bacteriotherapy for relapsing Clostridium difficile infection in a child: a proposed treatment protocol." PEDIATRICS, vol. 126, no. 1, 2010, pp. e239-42. |
| Michelow IC, Yantosca LM, Karpel M, Schmidt EV. "Complex role of mannose-binding lectin in infectious diseases." The Journal of Pediatrics, vol. 155, no. 2, 2009, pp. 301. |
| Michelow IC, Fracchia MS, Kinane TB. "Asthma and neonatal airway colonization." New England Journal of Medicine, vol. 358, no. 4, 2008, pp. 423; author reply 424-5. |
| Harris JB, Michelow IC, Westra SJ, Kradin RL. "Case records of the Massachusetts General Hospital. Case 21-2008. An 11-month-old boy with fever and pulmonary infiltrates." New England Journal of Medicine, vol. 359, no. 2, 2008, pp. 178-87. |
| Tucker JD, Montecino R, Winograd JM, Ferraro M, Michelow IC. "Pyogenic flexor tenosynovitis associated with Cellulosimicrobium cellulans." Journal of clinical microbiology, vol. 46, no. 12, 2008, pp. 4106-8. |
| Michelow IC, Katz K, McCracken GH, Hardy RD. "Systemic cytokine profile in children with community-acquired pneumonia." Pediatric pulmonology, vol. 42, no. 7, 2007, pp. 640-5. |
| Takahashi K, Ip WE, Michelow IC, Ezekowitz RA. "The mannose-binding lectin: a prototypic pattern recognition molecule." Current Opinion in Immunology, vol. 18, no. 1, 2006, pp. 16-23. |
| Michelow IC, Olsen K, Lozano J, Duffy LB, McCracken GH, Hardy RD. "Diagnostic utility and clinical significance of naso- and oropharyngeal samples used in a PCR assay to diagnose Mycoplasma pneumoniae infection in children with community-acquired pneumonia." Journal of clinical microbiology, vol. 42, no. 7, 2004, pp. 3339-41. |
| Michelow IC, Olsen K, Lozano J, Rollins NK, Duffy LB, Ziegler T, Kauppila J, Leinonen M, McCracken GH Jr. "Epidemiology and clinical characteristics of community-acquired pneumonia in hospitalized children." PEDIATRICS, vol. 113, no. 4, 2004, pp. 701-7. |
| Rodriguez-Cerrato V, McCoig CC, Saavedra J, Barton T, Michelow IC, Hardy RD, Bowlware K, Iglehart J, Katz K, McCracken GH Jr. "Garenoxacin (BMS-284756) and moxifloxacin in experimental meningitis caused by vancomycin-tolerant pneumococci." Antimicrobial Agents and Chemotherapy, vol. 47, no. 1, 2003, pp. 211-5. |
| Engle WD, Jackson GL, Sendelbach DM, Stehel EK, Ford DM, McHugh KM, Norris MR, Vedro DA, Velaphi S, Michelow IC, Olsen KD. "Pneumonia in term neonates: laboratory studies and duration of antibiotic therapy." Journal of perinatology : official journal of the California Perinatal Association, vol. 23, no. 5, 2003, pp. 372-7. |
| Michelow IC, Wendel GD Jr, Norgard MV, Zeray F, Leos NK, Alsaadi R, Sánchez PJ. "Central nervous system infection in congenital syphilis." New England Journal of Medicine, vol. 346, no. 23, 2002, pp. 1792-8. |
| Michelow IC, Lozano J, Olsen K, Goto C, Rollins NK, Ghaffar F, Rodriguez-Cerrato V, Leinonen M, McCracken GH Jr. "Diagnosis of Streptococcus pneumoniae lower respiratory infection in hospitalized children by culture, polymerase chain reaction, serological testing, and urinary antigen detection." Clinical Infectious Diseases, vol. 34, no. 1, 2002, pp. E1-11. |
| Rodriguez-Cerrato V, Ghaffar F, Saavedra J, Michelow IC, Hardy RD, Iglehart J, Olsen K, McCracken GH Jr. "BMS-284756 in experimental cephalosporin-resistant pneumococcal meningitis." Antimicrobial Agents and Chemotherapy, vol. 45, no. 11, 2001, pp. 3098-103. |
| Rodriguez-Cerrato V, McCoig CC, Michelow IC, Ghaffar F, Jafri HS, Hardy RD, Patel C, Olsen K, McCracken GH Jr. "Pharmacodynamics and bactericidal activity of moxifloxacin in experimental Escherichia coli meningitis." Antimicrobial Agents and Chemotherapy, vol. 45, no. 11, 2001, pp. 3092-7. |
| Michelow IC, McCracken GH Jr, Luckett PM, Krisher K. "Abiotrophia spp. brain abscess in a child with Down's syndrome." The Pediatric Infectious Disease Journal, vol. 19, no. 8, 2000, pp. 760-3. |
| Michelow IC, Nicol M, Tiemessen C, Chezzi C, Pettifor JM. "Value of cerebrospinal fluid leukocyte aggregation in distinguishing the causes of meningitis in children." The Pediatric Infectious Disease Journal, vol. 19, no. 1, 2000, pp. 66-72. |
Dr. Michelow and his team use an innovative strategy to identify lead malaria vaccine candidates by screening virtually the entire falciparum malaria proteome. They use plasma from individuals with mild or severe malaria to interrogate malarial antigens expressed on bacteriophage display libraries. His goal is to rationally identify immunoprotective malaria antigens that can be used as vaccines for women and children. His team has identified a promising malaria vaccine candidate that targets a conserved protein expressed on both infected red blood cells and merozoites that he has designated as Plasmodium falciparum Erythrocyte Membrane and Merozoite Antigen (PfEMMA1). This protein represents a "first-in-class" vaccine candidate that is undergoing further trials. His team's research techniques include immunoepidemiologic modeling, differential affinity selection of peptides, protein expression and purification, antibody production, growth inhibition assays using live malaria parasites, high-resolution imaging and pre-clinical challenge models.
Dr. Michelow also conducts clinical research related to Ebola virus disease, osteoarticular infections in children, and interactions between viral and bacterial infections and host immunity. He supervises the research of Brown University undergraduate students, medical students and Fellows in Pediatric Infectious Diseases.
See Publication list
| Year | Degree | Institution |
|---|---|---|
| 1997 | M-Med | University of the Witwatersrand |
| 1990 | MD | University of the Witwatersrand |
| Summer Program in Clinical Effectiveness | Harvard School of Public Health Harvard School of Public Health Harvard School of Public Health, clinical epidemiology | 2014-2014 | |
| Research Fellow | Harvard Medical School, Boston Children's Hospital, molecular medicine | 2003-2004 | Boston, MA |
| Chief Resident | Massachusetts General Hospital, Pediatrics | 2002-2003 | Boston, MA |
| Resident | Massachusetts General Hospital, Pediatrics | 2001-2002 | Boston, MA |
| Clinical Fellow | Guy's Hospital, pediatric intensive care | 1998-1998 | London, UK |
| Clinical Fellow; Research Fellow | University of Texas Southwestern Medical Center, pediatric infectious diseases | 1998-2001 | Dallas, TX |
| Resident | Johannesburg Academic Complex, Pediatrics | 1994-1997 | Johannesburg, South Africa |
| Senior House Officer | Johannesburg Academic Complex, Johannesburg Hospital, Pediatrics | 1993-1993 | Johannesburg, South Africa |
| Senior House Officer | Johannesburg Academic Complex, Baragwanath Hospital, Pediatrics | 1992-1992 | Johannesburg, South Africa |
Duncan Prize
London School of Hygiene and Tropical Medicine, United Kingdom, 1998
Dean's Excellence in Teaching Award
Alpert Medical School of Brown University, Providence, RI, 2012
Exemplary Teaching Award
Alpert Medical School of Brown University, Providence, RI, 2013
Dean's Excellence in Teaching Award
Alpert Medical School of Brown University, Providence, RI, 2014
Exemplary Teaching Award
Alpert Medical School of Brown University, Providence, RI, 2015
Dean's Excellence in Teaching Award
Alpert Medical School of Brown University, Providence, RI, 2016
Exemplary Teaching Award
Alpert Medical School of Brown University, Providence, RI, 2017
Dean's Excellence in Teaching Award
Alpert Medical School of Brown University, Providence, RI, 2018
Exemplary Teaching Award
Alpert Medical School of Brown University, Providence, RI, 2019
| Name | Title |
|---|---|
| Bobenchik, April | Assistant Professor of Pathology and Laboratory Medicine |
| Chapin, Kimberle | Professor of Pathology and Laboratory Medicine, Professor of Medicine |
| Dumenco, Luba | Assistant Dean of Medical Education, Assistant Professor of Medical Science, Clinician Educator, Assistant Professor of Pathology and Laboratory Medicine, Clinician Educator |
| Flanigan, Timothy | Professor of Medicine, Professor of Health Services, Policy and Practice |
| Friedman, Jennifer | Professor of Epidemiology, Professor of Pediatrics |
| Koster, Michael | Associate Professor of Pediatrics, Clinician Educator |
| Kurtis, Jonathan | Stanley M. Aronson Professor of Pathology and Laboratory Medicine, Chair of Pathology and Laboratory Medicine |
| Mather, Thais | Associate Director, Preclinical Curriculum Year 1, Assistant Professor of Medical Science, Assistant Professor of Molecular Microbiology and Immunology |
| Monteiro, Kristina | Assistant Professor of Medical Science |
| Nixon, Christian | Assistant Professor of Pathology and Laboratory Medicine (Research) |
| Certification | American Academy of Pediatrics, Neonatal resuscitation | 2018- | |
| Certification | American Heart Association, Pediatric advanced life support | 2018- | |
| Medical License | Rhode Island | 2010- | |
| Certification | American Board of Pediatrics, Pediatric infectious diseases | 2005- | |
| Certification | American Board of Pediatrics, General pediatrics | 2003- | |
| Medical License | Massachusetts | 2002- | |
| Certification | College of Pediatricians, South Africa, Pediatrics | 1997- | |
| Certification | Educational Commission for Foreign Medical Graduates | 1997- | |
| Medical License | United Kingdom | 1992- | |
| Medical License | South Africa | 1991- |
| Attending Physician. Hasbro Children's Hospital & Rhode Island Hospital, 2011-Present |
| Consulting Physician. Women & Infants Hospital of Rhode Island, 2011-Present |
| Consulting Pediatrician. Shriners Burn Hospital, 2008-2010 |
| Assistant Pediatrician. Massachusetts General Hospital, 2007-Present |
| Consulting Pediatrician. Newton-Wellesley Hospital, 2005-2010 |
| Consulting Pediatrician. Spaulding Rehabilitation Hospital, 2005-2010 |
| Consulting Pediatrician. Emerson Hospital, 2003-Present |
| Assistant in Pediatrics. Massachusetts General Hospital, 2003-2007 |
| Consulting Pediatrician. Cambridge Health Alliance, 2003-Present |
Pediatric Infectious Diseases
Parasitology
Clinical Immunology
