Dr. Michelow's experience and interests span clinical, laboratory-based and translational research topics. He has conducted studies in clinical epidemiology and biomarkers of pneumonia and viral infections in hospitalized neonates and children, innovative diagnostic assays for infants with congenital syphilis, and PK/PD parameters of novel antimicrobials in pre-clinical meningitis models. His research is at the interface between infectious diseases and immunology. He recently developed novel innate immune molecules (recombinant chimeric lectins) for use as immunotherapeutic agents against emerging infectious diseases such as Ebola virus, and described new insights into lectin-dependent enhancement of glycosylated virus infections which may explain the evolutionary selection of mutations in certain innate immune molecules.
Dr. Michelow currently collaborates with Drs. Jonathan Kurtis and Jennifer Friedman in the Center for International Health Research at Rhode Island Hospital and Brown University. His research focuses on early-stage development of falciparum malaria vaccines for pregnant women and their offspring.
Dr. Michelow is supported by the Rhode Island Foundation, Women & Infants Hospital, Lifespan Inc., the Department of Pediatrics at Hasbro Children's Hospital, NIH/NIAID K08 and NIH/NIGMS COBRE grants.
| Sánchez PJ, Moallem M, Cantey JB, Milton A, Michelow IC. Empiric Therapy with Vancomycin in the Neonatal Intensive Care Unit: Let’s “Get Smart” Globally. . J Pediatr. 2016; 92 (5) |
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Theresa M. Fiorito, Kimberle Chapin, Jaclyn Skidmore, Ian C. Michelow.
Cluster of Vaccine-related Invasive Pneumococcal Disease in Previously Vaccinated Healthy Children in Rhode Island. .
RI medical journal. 2015; 98 (5) : 12-13.
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| Fiorito TM, Chapin K, Skidmore J, Michelow IC Cluster of Vaccine-related Invasive Pneumococcal Disease in Previously Vaccinated Healthy Children in Rhode Island.. Rhode Island medical journal (2013). 2015; 98 (5) : 13-4. |
| Michelow IC, Mandell JG. Sequential Intravenous Oral Antibiotic Therapy for Osteomyelitis: How Short Is Long Enough? . JAMA Pediatrics. 2015; 169 (7) : 698-9. |
| Raj DK, Nixon CP, Nixon CE, Dvorin JD, DiPetrillo CG, Pond-Tor S, Wu HW, Jolly G, Pischel L, Lu A, Michelow IC, Cheng L, Conteh S, McDonald EA, Absalon S, Holte SE, Friedman JF, Fried M, Duffy PE, Kurtis JD Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection.. Science. 2014; 344 (6186) : 871-7. |
| Ronchi A, Michelow IC, Chapin KC, Bliss JM, Pugni L, Mosca F, Sánchez PJ Viral respiratory tract infections in the neonatal intensive care unit: the VIRIoN-I study.. The Journal of Pediatrics. 2014; 165 (4) : 690-6. |
| Brudner M, Karpel M, Lear C, Chen L, Yantosca LM, Scully C, Sarraju A, Sokolovska A, Zariffard MR, Eisen DP, Mungall BA, Kotton DN, Omari A, Huang IC, Farzan M, Takahashi K, Stuart L, Stahl GL, Ezekowitz AB, Spear GT, Olinger GG, Schmidt EV, Michelow IC Lectin-dependent enhancement of Ebola virus infection via soluble and transmembrane C-type lectin receptors.. PLoS ONE. 2013; 8 (4) : e60838. |
| Hyle EP, Shu B, Lindstrom S, Klimov A, Hancock K, Ferraro MJ, Traum AZ, Michelow IC A severely immunocompromised child with uncomplicated oseltamivir-resistant 2009 H1N1 pandemic influenza infection.. Pediatric transplantation. 2012; 16 (5) : E158-61. |
| Chiu CH, Michelow IC, Cronin J, Ringer SA, Ferris TG, Puopolo KM Effectiveness of a guideline to reduce vancomycin use in the neonatal intensive care unit.. The Pediatric Infectious Disease Journal. 2011; 30 (4) : 273-8. |
| Michelow IC, Lear C, Scully C, Prugar LI, Longley CB, Yantosca LM, Ji X, Karpel M, Brudner M, Takahashi K, Spear GT, Ezekowitz RA, Schmidt EV, Olinger GG High-dose mannose-binding lectin therapy for Ebola virus infection.. Journal of Infectious Diseases. 2011; 203 (2) : 175-9. |
| Chang WC, Hartshorn KL, White MR, Moyo P, Michelow IC, Koziel H, Kinane BT, Schmidt EV, Fujita T, Takahashi K Recombinant chimeric lectins consisting of mannose-binding lectin and L-ficolin are potent inhibitors of influenza A virus compared with mannose-binding lectin.. Biochemical pharmacology. 2011; 81 (3) : 388-95. |
| Michelow IC, Dong M, Mungall BA, Yantosca LM, Lear C, Ji X, Karpel M, Rootes CL, Brudner M, Houen G, Eisen DP, Kinane TB, Takahashi K, Stahl GL, Olinger GG, Spear GT, Ezekowitz RA, Schmidt EV A novel L-ficolin/mannose-binding lectin chimeric molecule with enhanced activity against Ebola virus.. Journal of Biological Chemistry. 2010; 285 (32) : 24729-39. |
| Russell G, Kaplan J, Ferraro M, Michelow IC Fecal bacteriotherapy for relapsing Clostridium difficile infection in a child: a proposed treatment protocol.. PEDIATRICS. 2010; 126 (1) : e239-42. |
| Michelow IC, Yantosca LM, Karpel M, Schmidt EV Complex role of mannose-binding lectin in infectious diseases.. The Journal of Pediatrics. 2009; 155 (2) : 301. |
| Michelow IC, Fracchia MS, Kinane TB Asthma and neonatal airway colonization.. New England Journal of Medicine. 2008; 358 (4) : 423; author reply 424-5. |
| Harris JB, Michelow IC, Westra SJ, Kradin RL Case records of the Massachusetts General Hospital. Case 21-2008. An 11-month-old boy with fever and pulmonary infiltrates.. New England Journal of Medicine. 2008; 359 (2) : 178-87. |
| Tucker JD, Montecino R, Winograd JM, Ferraro M, Michelow IC Pyogenic flexor tenosynovitis associated with Cellulosimicrobium cellulans.. Journal of clinical microbiology. 2008; 46 (12) : 4106-8. |
| Michelow IC, Katz K, McCracken GH, Hardy RD Systemic cytokine profile in children with community-acquired pneumonia.. Pediatric pulmonology. 2007; 42 (7) : 640-5. |
| Takahashi K, Ip WE, Michelow IC, Ezekowitz RA The mannose-binding lectin: a prototypic pattern recognition molecule.. Current Opinion in Immunology. 2006; 18 (1) : 16-23. |
| Michelow IC, Olsen K, Lozano J, Duffy LB, McCracken GH, Hardy RD Diagnostic utility and clinical significance of naso- and oropharyngeal samples used in a PCR assay to diagnose Mycoplasma pneumoniae infection in children with community-acquired pneumonia.. Journal of clinical microbiology. 2004; 42 (7) : 3339-41. |
| Michelow IC, Olsen K, Lozano J, Rollins NK, Duffy LB, Ziegler T, Kauppila J, Leinonen M, McCracken GH Jr Epidemiology and clinical characteristics of community-acquired pneumonia in hospitalized children.. PEDIATRICS. 2004; 113 (4) : 701-7. |
| Rodriguez-Cerrato V, McCoig CC, Saavedra J, Barton T, Michelow IC, Hardy RD, Bowlware K, Iglehart J, Katz K, McCracken GH Jr Garenoxacin (BMS-284756) and moxifloxacin in experimental meningitis caused by vancomycin-tolerant pneumococci.. Antimicrobial Agents and Chemotherapy. 2003; 47 (1) : 211-5. |
| Engle WD, Jackson GL, Sendelbach DM, Stehel EK, Ford DM, McHugh KM, Norris MR, Vedro DA, Velaphi S, Michelow IC, Olsen KD Pneumonia in term neonates: laboratory studies and duration of antibiotic therapy.. Journal of perinatology : official journal of the California Perinatal Association. 2003; 23 (5) : 372-7. |
| Michelow IC, Wendel GD Jr, Norgard MV, Zeray F, Leos NK, Alsaadi R, Sánchez PJ Central nervous system infection in congenital syphilis.. New England Journal of Medicine. 2002; 346 (23) : 1792-8. |
| Michelow IC, Lozano J, Olsen K, Goto C, Rollins NK, Ghaffar F, Rodriguez-Cerrato V, Leinonen M, McCracken GH Jr Diagnosis of Streptococcus pneumoniae lower respiratory infection in hospitalized children by culture, polymerase chain reaction, serological testing, and urinary antigen detection.. Clinical Infectious Diseases. 2002; 34 (1) : E1-11. |
| Rodriguez-Cerrato V, Ghaffar F, Saavedra J, Michelow IC, Hardy RD, Iglehart J, Olsen K, McCracken GH Jr BMS-284756 in experimental cephalosporin-resistant pneumococcal meningitis.. Antimicrobial Agents and Chemotherapy. 2001; 45 (11) : 3098-103. |
| Rodriguez-Cerrato V, McCoig CC, Michelow IC, Ghaffar F, Jafri HS, Hardy RD, Patel C, Olsen K, McCracken GH Jr Pharmacodynamics and bactericidal activity of moxifloxacin in experimental Escherichia coli meningitis.. Antimicrobial Agents and Chemotherapy. 2001; 45 (11) : 3092-7. |
| Michelow IC, McCracken GH Jr, Luckett PM, Krisher K Abiotrophia spp. brain abscess in a child with Down's syndrome.. The Pediatric Infectious Disease Journal. 2000; 19 (8) : 760-3. |
| Michelow IC, Nicol M, Tiemessen C, Chezzi C, Pettifor JM Value of cerebrospinal fluid leukocyte aggregation in distinguishing the causes of meningitis in children.. The Pediatric Infectious Disease Journal. 2000; 19 (1) : 66-72. |
Sánchez PJ, Moallem M, Cantey JB, Milton A, Michelow IC. Empiric Therapy with Vancomycin in the Neonatal Intensive Care Unit: Let’s “Get Smart” Globally. J Pediatr (Rio J) 2016;92(5)
Sequential Intravenous Oral Antibiotic Therapy for Osteomyelitis: How Short Is Long Enough? Michelow IC, Mandell JG. JAMA Pediatr. 2015;169(7):698-699
Theresa M. Fiorito, Kimberle Chapin, Jaclyn Skidmore, Ian C. Michelow. Cluster of Vaccine-related Invasive Pneumococcal Disease in Previously Vaccinated Healthy Children in Rhode Island. RI Med J 2015;98(5):12-3
Michelow IC. American Academy of Pediatrics. Hemorrhagic fevers and related syndromes caused by viruses of the family Bunyaviridae. In: Kimberlin DW, ed. Red Book: 2015 Report of the Committee on Infectious Diseases. 30th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2015
Michelow IC. American Academy of Pediatrics. Hemorrhagic fevers caused by arenaviruses. In: Kimberlin DW, ed. Red Book: 2015 Report of the Committee on Infectious Diseases. 30th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2015
Dennehy PD, Michelow IC, Alexander N, Koster M. Active immunizing agents. In: Feigin, Cherry, Demmler-Harrison, and Kaplan: Textbook of Pediatric Infectious Diseases, 7th ed. Philadelphia, Saunders; 2015
Dipak K. Raj,Christian P. Nixon, Christina E. Nixon, Jeffrey D. Dvorin, Christen G. DiPetrillo, Sunthorn Pond-Tor, Hai-Wei Wu, Grant Jolly, Lauren Pischel, Ailin Lu, Ian C. Michelow, Ling Cheng, Solomon Conteh, Emily A. McDonald, Sabrina Absalon, Sarah E. Holte, Jennifer F. Friedman, Michal Fried, Patrick E. Duffy, Jonathan D. Kurtis. Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection. Science 2014;344:871-7
Ronchi A, Michelow IC, Chapin KC, Bliss JM, Pugni L, Mosca F, Sánchez PJ. Viral respiratory tract infections in the neonatal intensive care unit: the VIRIoN-I Study. J Pediatr 2014;165:690-6
Matthew Brudner, Marshall Karpel, Calli Lear, Li Chen, L. Michael Yantosca, Corinne Scully, Ashish Sarraju, Anna Sokolovska, M. Reza Zariffard, Damon P. Eisen, Bruce A. Mungall, Darrell N. Kotton, Amel Omari, I-Chueh Huang, Michael Farzan, Kazue Takahashi, Lynda Stuart, Gregory L. Stahl, Alan B. Ezekowitz, Gregory T. Spear, Gene G. Olinger, Emmett V. Schmidt, Ian C. Michelow. Lectin-dependent enhancement of Ebola virus infection via soluble and transmembrane C-type lectin receptors. PLoS ONE 2013; 8(4): e60838. doi:10.1371/journal.pone. 0060838
Chia-Hua Chiu*, Ian C. Michelow*, Valerie Buckley, Jonathan Cronin, Timothy G. Ferris, Steven A. Ringer, Karen M. Puopolo. Effectiveness of a Guideline to Reduce Vancomycin Administration in the Neonatal Intensive Care Unit. Pediatr Infect Dis J 2011;30:273-8 (* these authors contributed equally)
Ian C. Michelow, Callie Lear, Xin Ji, Mathew Brudner, Marshall Karpel, Kazue Takahashi, Gregory T. Spear, Alan B. Ezekowitz, Emmett V. Schmidt, Gene G. Olinger. High-Dose Mannose-binding lectin therapy for Ebola virus infection.J Infect Dis 2011;203:175-9
George Russell, Jess Kaplan, Maryjane Ferraro, Ian C. Michelow. Fecal bacteriotherapy for relapsing Clostridium difficile infection in a child: a proposed treatment protocol. Pediatrics 2010;126(1):e239-42
Ian C. Michelow, Mingdong Dong, Bruce A. Mungall, L. Michael Yantosca, Callie Lear, Xin Ji, Marshall Karpel, Christina L. Rootes, Gunnar Houen, Damon P. Eisen, T. Bernard Kinane, Kazue Takahashi, Gregory L. Stahl, Gene G. Olinger, Gregory T. Spear, Alan B. Ezekowitz, Emmett V. Schmidt. A Novel L-Ficolin/Mannose Binding Lectin Chimeric Molecule with Enhanced Anti-viral Activity against Ebola Virus.J Biol Chem 2010;285:24729-39
Michelow IC and McCracken GH, Jr. Antibacterial therapeutic agents. In : Feigin, Cherry, Demmler-Harrison, and Kaplan: Textbook of Pediatric Infectious Diseases, 6th ed. Philadelphia, Saunders. 2009: 3178-227
Takahashi K, Ip EWK, Michelow IC, Ezekowitz, RAB. The mannose-binding lectin: a prototypic pattern recognition molecule. Curr Opin Immunol 2006;18:16-23
Ian C. Michelow, Kurt Olsen, Juanita Lozano, Lynn B. Duffy, George H. McCracken, and R. Doug Hardy. Diagnostic Utility and Clinical Significance of Naso- and Oropharyngeal Samples Used in a PCR Assay to Diagnose Mycoplasma pneumoniae Infection in Children with Community-Acquired Pneumonia. J Clin Microbiol 2004;42:3339-41
Ian C. Michelow, Kurt Olsen, Juanita Lozano, Nancy K. Rollins, Lynn B. Duffy, Thedi Ziegler, Jaana Kauppila, Maija Leinonen, George H. McCracken, Jr. Epidemiology and outcome of community-acquired pneumonia in hospitalized children. Pediatrics 2004;113:701-7
Michelow IC, Wendel GD, Norgard M, Zeray F, Leos NK, Alsaadi R, and Sánchez PJ. Central nervous system invasion by Treponema pallidum in congenital syphilis. N Engl J Med 2002; 346:1792-8
Michelow IC, Lozano J, Olsen K, Goto C, Rollins NK, Ghaffar F, Rodriguez-Cerrato V, Leinonen M, and McCracken GH Jr. Diagnosis of Streptococcus pneumoniae lower respiratory infection in hospitalized children by culture, polymerase chain reaction, serological testing, and urinary antigen detection. Clin Infect Dis 2002; 34: e1-11
| Year | Degree | Institution |
|---|---|---|
| 1997 | M-Med | University of the Witwatersrand |
| 1990 | MD | University of the Witwatersrand |
| Research Fellow | Harvard Medical School, Boston Children's Hospital, molecular medicine | 2003-2004 | Boston, MA |
| Chief Resident | Massachusetts General Hospital, Pediatrics | 2002-2003 | Boston, MA |
| Resident | Massachusetts General Hospital, Pediatrics | 2001-2002 | Boston, MA |
| Clinical Fellow | Guy's Hospital, pediatric intensive care | 1998-1998 | London, UK |
| Clinical Fellow; Research Fellow | University of Texas Southwestern Medical Center, pediatric infectious diseases | 1998-2001 | Dallas, TX |
| Resident | Johannesburg Academic Complex, Pediatrics | 1994-1997 | Johannesburg, South Africa |
| Senior House Officer | Johannesburg Academic Complex, Johannesburg Hospital, Pediatrics | 1993-1993 | Johannesburg, South Africa |
| Senior House Officer | Johannesburg Academic Complex, Baragwanath Hospital, Pediatrics | 1992-1992 | Johannesburg, South Africa |
| Intern | Hillbrow Hospital, internal medicine; surgery; orthopedic surgery; and gynecology | 1991-1991 | Johannesburg, South Africa |
Duncan Prize
London School of Hygiene and Tropical Medicine, United Kingdom, 1998
Dean's Excellence in Teaching Award
Alpert Medical School of Brown University, Providence, RI, 2012
Exemplary Teaching Award
Alpert Medical School of Brown University, Providence, RI, 2013
Dean's Excellence in Teaching Award
Alpert Medical School of Brown University, Providence, RI, 2014
Exemplary Teaching Award
Alpert Medical School of Brown University, Providence, RI, 2015
Dean's Excellence in Teaching Award
Alpert Medical School of Brown University, Providence, RI, 2016
| Name | Title |
|---|---|
| Dennehy, Penelope | Professor of Pediatrics, Vice Chair of Pediatrics |
| Friedman, Jennifer | Professor of Epidemiology, Professor of Pediatrics |
| Kurtis, Jonathan | Stanley M. Aronson Professor of Pathology and Laboratory Medicine, Professor of Pathology and Laboratory Medicine, Chair of Pathology and Laboratory Medicine |
| Certification | American Academy of Pediatrics, neonatal resuscitation | 2012- | |
| Certification | American Heart Association, pediatric advanced life support | 2012- | |
| Medical License | Rhode Island | 2010- | |
| Certification | American Board of Pediatrics, pediatric infectious diseases | 2005- | |
| Certification | American Board of Pediatrics, general pediatrics | 2003- | |
| Medical License | Massachusetts | 2002- | |
| Certification | College of Pediatricians, South Africa, Pediatrics | 1997- | |
| Certification | Educational Commission for Foreign Medical Graduates | 1997- | |
| Medical License | United Kingdom | 1992- | |
| Medical License | South Africa | 1991- |
Pediatric Infectious Diseases
Parasitology
Clinical Immunology
Primary Immunodeficiencies
