| Zhao, Xiaoai, Petrashen, Anna P., Sanders, Jennifer A., Peterson, Abigail L., Sedivy, John M. "SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long‐lived Myc hypomorphic mice." Aging Cell, vol. 18, no. 3, 2019, pp. e12947. |
| Zabala V, Boylan JM, Thevenot P, Frank A, Senthoor D, Iyengar V, Kim H, Cohen A, Gruppuso PA, Sanders JA. "Transcriptional changes during hepatic ischemia-reperfusion in the rat." PLoS ONE, vol. 14, no. 12, 2019, pp. e0227038. |
| Hurley E, Zabala V, Boylan JM, Gruppuso PA, Sanders JA. "Hepatic Gene Expression During the Perinatal Transition in the Rat." Gene expression, vol. 19, no. 1, 2018, pp. 1-13. |
| Gruppuso PA, Boylan JM, Zabala V, Neretti N, Abshiru NA, Sikora JW, Doud EH, Camarillo JM, Thomas PM, Kelleher NL, Sanders JA. "Stability of histone post-translational modifications in samples derived from liver tissue and primary hepatic cells." PLoS ONE, vol. 13, no. 9, 2018, pp. e0203351. |
| Boylan JM, Francois-Vaughan H, Gruppuso PA, Sanders JA. "Engraftment and Repopulation Potential of Late Gestation Fetal Rat Hepatocytes." Transplantation, vol. 101, no. 10, 2017, pp. 2349-2359. |
| Sanders JA. "Late Gestation Fetal Hepatocytes for Liver Repopulation in the Rat." Methods in Molecular Biology, vol. 1506, 2017, pp. 45-60. |
| Adebayo Michael AO, Ahsan N, Zabala V, Francois-Vaughan H, Post S, Brilliant KE, Salomon AR, Sanders JA, Gruppuso PA. "Proteomic analysis of laser capture microdissected focal lesions in a rat model of progenitor marker-positive hepatocellular carcinoma." Oncotarget, vol. 8, no. 16, 2017, pp. 26041-26056. |
| Francois-Vaughan, Heather, Adebayo, Adeola O., Brilliant, Kate E., Parry, Nicola M.A., Gruppuso, Philip A., Sanders, Jennifer A. "Persistent effect of mTOR inhibition on preneoplastic foci progression and gene expression in a rat model of hepatocellular carcinoma." Carcinogenesis, vol. 37, no. 4, 2016, pp. 408-419. |
| Boylan JM, Sanders JA, Gruppuso PA. "Regulation of fetal liver growth in a model of diet restriction in the pregnant rat." American journal of physiology. Regulatory, integrative and comparative physiology, vol. 311, no. 3, 2016, pp. R478-88. |
| Gruppuso, Philip A, Sanders, Jennifer A. "Regulation of liver development: implications for liver biology across the lifespan." J Mol Endocrinol, vol. 56, no. 3, 2016, pp. R115-25. |
| Huse SM, Gruppuso PA, Boekelheide K, Sanders JA. "Patterns of gene expression and DNA methylation in human fetal and adult liver." BMC genomics, vol. 16, no. 1, 2015, pp. 981. |
| Boylan JM, Sanders JA, Neretti N, Gruppuso PA. "Profiling of the fetal and adult rat liver transcriptome and translatome reveals discordant regulation by the mechanistic target of rapamycin (mTOR)." American journal of physiology. Regulatory, integrative and comparative physiology, vol. 309, no. 1, 2015, pp. ajpregu.00114.2015. |
| Spade, Daniel J., McDonnell, Elizabeth V., Heger, Nicholas E., Sanders, Jennifer A., Saffarini, Camelia M., Gruppuso, Philip A., De Paepe, Monique E., Boekelheide, Kim. "Xenotransplantation Models to Study the Effects of Toxicants on Human Fetal Tissues." Birth Defects Res B, vol. 101, no. 6, 2014, pp. 410-422. |
| Garcia B, Francois-Vaughan H, Onikoyi O, Kostadinov S, De Paepe ME, Gruppuso PA, Sanders JA. "Xenotransplantation of human fetal adipose tissue: a model of in vivo adipose tissue expansion and adipogenesis." Journal of lipid research, vol. 55, no. 12, 2014, pp. 2685-91. |
| Sanders JA, Schorl C, Patel A, Sedivy JM, Gruppuso PA. "Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion." BMC physiology, vol. 12, 2012, pp. 1. |
| Sanders JA, Brilliant KE, Clift D, Patel A, Cerretti B, Claro P, Mills DR, Hixson DC, Gruppuso PA. "The inhibitory effect of rapamycin on the oval cell response and development of preneoplastic foci in the rat." Experimental and molecular pathology, vol. 93, no. 1, 2012, pp. 40-9. |
| Gruppuso PA, Boylan JM, Sanders JA. "The physiology and pathophysiology of rapamycin resistance: implications for cancer." Cell Cycle, vol. 10, no. 7, 2011, pp. 1050-8. |
| Jimenez RH, Lee JS, Francesconi M, Castellani G, Neretti N, Sanders JA, Sedivy J, Gruppuso PA. "Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR)." PLoS ONE, vol. 5, no. 2, 2010, pp. e9084. |
| Jimenez RH, Boylan JM, Lee JS, Francesconi M, Castellani G, Sanders JA, Gruppuso PA. "Rapamycin response in tumorigenic and non-tumorigenic hepatic cell lines." PLoS ONE, vol. 4, no. 10, 2009, pp. e7373. |
| Gruppuso PA, Tsai SW, Boylan JM, Sanders JA. "Hepatic translation control in the late-gestation fetal rat." American journal of physiology. Regulatory, integrative and comparative physiology, vol. 295, no. 2, 2008, pp. R558-67. |
| Yoo SJ, Jimenez RH, Sanders JA, Boylan JM, Brautigan DL, Gruppuso PA. "The alpha4-containing form of protein phosphatase 2A in liver and hepatic cells." Journal of cellular biochemistry, vol. 105, no. 1, 2008, pp. 290-300. |
| Sanders JA, Lakhani A, Phornphutkul C, Wu KY, Gruppuso PA. "The effect of rapamycin on DNA synthesis in multiple tissues from late gestation fetal and postnatal rats." AJP: Cell Physiology, vol. 295, no. 2, 2008, pp. C406-13. |
| Sanders JA, Gruppuso PA. "Coordinated regulation of c-Myc and Max in rat liver development." American journal of physiology. Gastrointestinal and liver physiology, vol. 290, no. 1, 2006, pp. G145-55. |
| Sanders JA, Gruppuso PA. "Nucleolar localization of hepatic c-Myc: a potential mechanism for c-Myc regulation." Biochimica et biophysica acta, vol. 1743, no. 1-2, 2005, pp. 141-50. |
| Awad MM, Sanders JA, Gruppuso PA. "A potential role for p15(Ink4b) and p57(Kip2) in liver development." FEBS Letters, vol. 483, no. 2-3, 2000, pp. 160-4. |
R01DK100301-01 Sanders/Gruppuso (PI) 05/01/2014 to 02/28/2018
NIH (NICHD)
The Fetal Hepatocyte Phenotype and Cell Based Therapy for Liver Disease
Role: co-PI
R01 HD 24455 Gruppuso (PI) 04/01/1989 to 03/31/2017
NIH (NICHD)
Novel Approaches to Understanding the Nutrient Regulation of Fetal Somatic Growth
Role: Co-Investigator
| Year | Degree | Institution |
|---|---|---|
| 2005 | PhD | Brown University |
| 1999 | BS | Dickinson College |
| Postdoctoral Fellow | Brown University, Rhode Island Hospital, gastroenterology | 2005-2007 | Providence, RI |
Honorable Mention, National Science Foundation Graduate Research Fellowship, 2001
NIH Graduate Training Fellowship
NIH Postdoctoral Training Fellowship, 2005
Elected Member, Society for Pediatric Research, 2014
| Name | Title |
|---|---|
| Gruppuso, Philip | Professor of Pediatrics, Professor of Medical Science, Professor of Molecular Biology, Cell Biology and Biochemistry (Research) |
| Neretti, Nicola | Associate Professor of Molecular Biology, Cell Biolgy, and Biochemistry |
| Sedivy, John | Hermon C. Bumpus Professor of Biology, Associate Dean and Director, Center for the Biology of Aging |
Member, American Association for Cancer Research, 2003-Present
Member, American Society for Biochemistry and Molecular Biology, 2005-Present
Member, American Society for Investigate Pathology, 2010-Present
| Research Associate. Rhode Island Hospital, 2007-Present |
