J Donald Easton Professor Emeritus of Neurology

Dr. Easton was born in Saskatoon, Saskatchewan, Canada. He graduated from the University of Washington School of Medicine. He was elected to membership in Phi Beta Kappa and Alpha Omega Alpha.

He was a Medicine Intern and Neurology Resident at the New York Hospital-Cornell Medical Center and assumed his first academic appointment at the University of California at San Diego. He assumed his present position, in 1986, of Professor & Chairman, Department of Clinical Neuroscience, Brown Medical School, and Neurologist-in-Chief at the Rhode Island Hospital.
He has been a Director of the American Board of Psychiatry & Neurology, a Councilor of the American Neurological Association, Officer of the Association of University Professors of Neurology, Chairman of the Residency Review Committee for Neurology, Chairman of the American Heart Association Stroke Council, Chairman of the Neurological Disorders Program, Project Review Committee-A at the NIH, and is presently on the NIH Advisory Council for the Neurological Institute.

Dr. Easton has served on numerous Steering, Advisory, Organizing and Monitoring Committees for many clinical trials and congresses. He also has served on the editorial boards of many journals. He has published more than 270 journal articles, books, chapters & miscellaneous publications.

Dr. Easton is an honorary member of the Stroke Society of Australasia, the Austrian Society for Stroke Research, the Belgian Stroke Society and the Mexican Association of Cerebral Vascular Disease.

Brown Affiliations

Research Areas

scholarly work

Alberts MJ, Easton JD. Stroke Best Practices: a team approach to evidence-based care. J Natl Med Assoc. 2004 Apr;96(4 Suppl):5S-20S. Review.

Easton JD, Albers GW, Caplan LR, Saver JL, Sherman DG; TIA Working Group. Discussion: Reconsideration of TIA terminology and definitions. Neurology. 2004 Apr 27;62(8 Suppl 6):S29-34.

Creager MA, Jones DW, Easton JD, Halperin JL, Hirsch AT, Matsumoto AH, O'Gara PT, Safian RD, Schwartz GL, Spittell JA; American Heart Association. Atherosclerotic vascular disease conference: Writing Group V: medical decision making and therapy. Circulation. 2004 Jun 1;109(21):2634-42. No abstract available.

Albers GW, Amarenco P, Easton JD, Sacco RL, Teal P. Antithrombotic and thrombolytic therapy for ischemic stroke: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004 Sep;126(3 Suppl):483S-512S.

Easton JD. Evidence with antiplatelet therapy and ADP-receptor antagonists. Cerebrovasc Dis. 2003;16 Suppl 1:20-6. Review.

Belch JJ, Topol EJ, Agnelli G, Bertrand M, Califf RM, Clement DL, Creager MA, Easton JD, Gavin JR 3rd, Greenland P, Hankey G, Hanrath P, Hirsch AT, Meyer J, Smith SC, Sullivan F, Weber MA; Prevention of Atherothrombotic Disease Network. Critical issues in peripheral arterial disease detection and management: a call to action. Arch Intern Med. 2003 Apr 28;163(8):884-92.

Johnston SC, Easton JD. Are patients with acutely recovered cerebral ischemia more unstable? Stroke. 2003 Oct;34(10):2446-50. Epub 2003 Sep 04.

Hart RG, Easton JD. Do we really need a better way to give heparin in acute cerebral ischemia? Stroke. 2002 Mar;33(3):659-60.

Wilterdink JL, Easton JD. Related Articles, Links Cerebral ischemia in pregnancy. Adv Neurol. 2002;90:51-62. Review.

Alberts MJ, Easton JD. Clopidogrel plus aspirin for stroke prevention. Stroke. 2002 Nov;33(11):2546-7; author reply 2546-7.

Albers GW, Caplan LR, Easton JD, Fayad PB, Mohr JP, Saver JL, Sherman DG; TIA Working Group. Transient ischemic attack--proposal for a new definition. N Engl J Med. 2002 Nov 21;347(21):1713-6.

Albers GW, Amarenco P, Easton JD, Sacco RL, Teal P. Antithrombotic and thrombolytic therapy for ischemic stroke. Chest. 2001 Jan;119(1 Suppl):300S-320S.

Easton JD. Future perspectives for optimizing oral antiplatelet therapy. Cerebrovasc Dis. 2001;11 Suppl 2:23-8.

Topol EJ, Easton JD, Amarenco P, Califf R, Harrington R, Graffagnino C, Davis S, Diener HC, Ferguson J, Fitzgerald D, Shuaib A, Koudstaal PJ, Theroux P, Van de Werf F, Willerson JT, Chan R, Samuels R, Ilson B, Granett J. Design of the blockade of the glycoprotein IIb/IIIa receptor to avoid vascular occlusion (BRAVO) trial. Am Heart J. 2000 Jun;139(6):927-33.

Easton JD, Wilterdink JL. Dipyridamole Plus Aspirin in Cerebrovascular Disease. Arch Neurol. 2000 Jul;57(7):1086-1087.

research overview

J. Donald Easton has research interests in antiplatelet agents in prevention of stroke and other vascular diseases, carotid artery surgery in stroke prevention, patent foramen ovale and stroke, and rimonabant in vascular diseases.

research statement

Dr. Easton is a Co-Primary Investigator (PI) or Executive Committee member on three international, multicenter clinical trials for prevention of atherothrombosis. He is one of the designers of the scope and methodology of these trials. These trials include:

CASTIA—Clopidogrel in Acute Stroke and TIA (CASTIA) Trial, Co-Principal Investigator, Trial Coordinating Center—UC San Francisco (Sponsor: Sanofi Aventis), 2005- ;

CRESCENDO—Comprehensive Rimonabant Evaluation Study of Cardiovascular Endpoints and Outcomes (CRESCENDO) Study, Trial Coordinating Center—Cleveland Clinic Foundation (Sponsor: Sanofi Aventis), 2005- ;

ARISTOTLE—Apixaban in Afib trial.

funded research

Co-Principal Investigator Submission date-10/01/07 % Effort 10
NINDS $14,000,000

Clopidogrel in Acute Stroke and TIA (CASTIA) Trial, Principal Investigator: Claiborne S. Johnston, Trial Coordinating Center- UC San Francisco

The major goal of this multicenter, randomized clinical trial is to determine the efficacy and safety of clopidogrel plus aspirin versus aspirin alone in reducing the 90-day risk of stroke, myocardial infarction, and vascular death after TIA or minor stroke.