Jamila H Siamwala, Ph D is an Assistant Professor of Molecular Pharmacology, Physiology and Biotechnology at Brown University and an affliate at Providence VA Medical Center. She is a graduate of Anna University, Chennai.
Dr. Siamwala's research focus is on cytokine mediated cardiac fibroblasts differentiation, metabolome, immune interactions and immune based therapies for cardiovascular diseases. She led the group investigating the mitochondrial functions of space and ground astronauts plasma components on skeletal muscle cells in the historic NASA twins study published in Science journal.
Dr. Siamwala is currently investigating the role of pro-inflammatory cytokines in right ventricular fibrosis and pulmonary hypertension. Her work is supported by grants from NIGMS CardioPulmonary Vascular Biology Center for Biomedical Research Excellence (COBRE CPVB), Rhode Island Foundation and National Institute of Aging. She is also a receipient of two summer 2019 team UTRA awards.
Dr. Siamwala serves on NASA grant review panel and is a reviewer of Scientific reports, British Journal of Pharmacology and American Journal of Physiology-Regulative, Integrative and Comparative Physiology.
Dr. Siamwala received the Young Scientist Award, Annual meeting of Society for Free Radical Research (SFRR) in 2011 and EEP National Space Biomedical Research Institute’s Gravitational Physiology Beginning Investigator Award from the American Physiology Society in 2015.
|Siamwala JH, Zhao A, Barthel H, Pagano FS, Gilbert RJ, Rounds S. "Adaptive and innate immune mechanisms in cardiac fibrosis complicating pulmonary arterial hypertension." Physiological reports, vol. 8, no. 15, 2020.|
|Weber NC, Schilling JM, Warmbrunn MV, Dhanani M, Kerindongo R, Siamwala J, Song Y, Zemljic-Harpf AE, Fannon MJ, Hollmann MW, Preckel B, Roth DM, Patel HH. "Helium-Induced Changes in Circulating Caveolin in Mice Suggest a Novel Mechanism of Cardiac Protection." International journal of molecular sciences, vol. 20, no. 11, 2019.|
|Siamwala JH, Kumar P, Veeriah V, Muley A, Rajendran S, Konikkat S, Majumder S, Mani KP, Chatterjee S. "Nitric Oxide Reverses the Position of the Heart during Embryonic Development." International journal of molecular sciences, vol. 20, no. 5, 2019.|
|Garrett-Bakelman FE, Darshi M, Green SJ, Gur RC, Lin L, Macias BR, McKenna MJ, Meydan C, Mishra T, Nasrini J, Piening BD, Rizzardi LF, Sharma K, Siamwala JH, Taylor L, Vitaterna MH, Afkarian M, Afshinnekoo E, Ahadi S, Ambati A, Arya M, Bezdan D, Callahan CM, Chen S, Choi AMK, Chlipala GE, Contrepois K, Covington M, Crucian BE, De Vivo I, Dinges DF, Ebert DJ, Feinberg JI, Gandara JA, George KA, Goutsias J, Grills GS, Hargens AR, Heer M, Hillary RP, Hoofnagle AN, Hook VYH, Jenkinson G, Jiang P, Keshavarzian A, Laurie SS, Lee-McMullen B, Lumpkins SB, MacKay M, Maienschein-Cline MG, Melnick AM, Moore TM, Nakahira K, Patel HH, Pietrzyk R, Rao V, Saito R, Salins DN, Schilling JM, Sears DD, Sheridan CK, Stenger MB, Tryggvadottir R, Urban AE, Vaisar T, Van Espen B, Zhang J, Ziegler MG, Zwart SR, Charles JB, Kundrot CE, Scott GBI, Bailey SM, Basner M, Feinberg AP, Lee SMC, Mason CE, Mignot E, Rana BK, Smith SM, Snyder MP, Turek FW. "The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight." Science, vol. 364, no. 6436, 2019.|
|Siamwala JH, Moossazadeh DG, Macaulay TR, Becker RL, Hargens RH, Hargens AR. "Aging Decreases Hand Volume Expansion with Water Immersion." Frontiers in Physiology, vol. 9, 2018, pp. 72.|
|Becker RL, Siamwala JH, Macias BR, Hargens AR. "Tibia Bone Microvascular Flow Dynamics as Compared to Anterior Tibial Artery Flow During Body Tilt." Aerospace medicine and human performance, vol. 89, no. 4, 2018, pp. 357-364.|
|Howden M, Siamwala JH, Hargens AR. "Bone microvascular flow differs from skin microvascular flow in response to head-down tilt." Journal of Applied Physiology, vol. 123, no. 4, 2017, pp. 860-866.|
|Siamwala JH, Macias BR, Lee PC, Hargens AR. "Gender differences in tibial microvascular flow responses to head down tilt and lower body negative pressure." Physiological reports, vol. 5, no. 4, 2017.|
|Macaulay TR, Siamwala JH, Hargens AR, Macias BR. "Thirty days of spaceflight does not alter murine calvariae structure despite increased <i>Sost</i> expression." Bone reports, vol. 7, 2017, pp. 57-62.|
|Mariappan I, Maddileti S, Joseph P, Siamwala JH, Vauhini V. "Enriched Cultures of Retinal Cells From BJNhem20 Human Embryonic Stem Cell Line of Indian Origin." Investigative Ophthalmology & Visual Science, vol. 56, no. 11, 2015, pp. 6714-23.|
|Siamwala JH, Lee PC, Macias BR, Hargens AR. "Lower-body negative pressure restores leg bone microvascular flow to supine levels during head-down tilt." Journal of Applied Physiology, vol. 119, no. 2, 2015, pp. 101-9.|
|Siamwala JH, Rajendran S, Chatterjee S. "Strategies of Manipulating BMP Signaling in Microgravity to Prevent Bone Loss." Vitamins and hormones, vol. 99, 2015, pp. 249-72.|
|Majumder S, Sinha S, Siamwala JH, Muley A, Reddy Seerapu H, Kolluru GK, Veeriah V, Nagarajan S, Sridhara SR, Priya MK, Kuppusamy M, Srinivasan S, Konikkat S, Soundararajan G, Venkataraman S, Saran U, Chatterjee S. "A comparative study of NONOate based NO donors: spermine NONOate is the best suited NO donor for angiogenesis." Nitric oxide : biology and chemistry, vol. 36, 2014, pp. 76-86.|
|Mariappan I, Kacham S, Purushotham J, Maddileti S, Siamwala J, Sangwan VS. "Spatial distribution of niche and stem cells in ex vivo human limbal cultures." STEM CELLS Translational Medicine, vol. 3, no. 11, 2014, pp. 1331-41.|
|Siamwala JH, Dias PM, Majumder S, Joshi MK, Sinkar VP, Banerjee G, Chatterjee S. "L-theanine promotes nitric oxide production in endothelial cells through eNOS phosphorylation." The Journal of nutritional biochemistry, vol. 24, no. 3, 2013, pp. 595-605.|
|Nagarajan S, Rajendran S, Saran U, Priya MK, Swaminathan A, Siamwala JH, Sinha S, Veeriah V, Sonar P, Jadhav V, Jaffar Ali BM, Chatterjee S. "Nitric oxide protects endothelium from cadmium mediated leakiness." Cell Biology International, vol. 37, no. 5, 2013, pp. 495-506.|
|Siamwala JH, Veeriah V, Priya MK, Rajendran S, Saran U, Sinha S, Nagarajan S, Pradeep T, Chatterjee S. "Nitric oxide rescues thalidomide mediated teratogenicity." Scientific reports, vol. 2, 2012, pp. 679.|
|Swaminathan A, Sridhara SR, Sinha S, Nagarajan S, Balaguru UM, Siamwala JH, Rajendran S, Saran U, Chatterjee S. "Nitrites derived from Foneiculum vulgare (fennel) seeds promotes vascular functions." Journal of food science, vol. 77, no. 12, 2012, pp. H273-9.|
|Majumder S, Siamwala JH, Srinivasan S, Sinha S, Sridhara SR, Soundararajan G, Seerapu HR, Chatterjee S. "Simulated microgravity promoted differentiation of bipotential murine oval liver stem cells by modulating BMP4/Notch1 signaling." Journal of cellular biochemistry, vol. 112, no. 7, 2011, pp. 1898-908.|
|Majumder S, Ilayaraja M, Seerapu HR, Sinha S, Siamwala JH, Chatterjee S. "Chick embryo partial ischemia model: a new approach to study ischemia ex vivo." PLoS ONE, vol. 5, no. 5, 2010, pp. e10524.|
|Kolluru GK, Siamwala JH, Chatterjee S. "eNOS phosphorylation in health and disease." Biochimie, vol. 92, no. 9, 2010, pp. 1186-98.|
|Seerapu Hb, Subramaniam GP, Majumder S, Sinha S, Bisana S, Mahajan S, Kolluru GK, Muley A, Siamwala JH, Illavazagan G, Chatterjee S. "Inhibition of dynamin-2 confers endothelial barrier dysfunctions by attenuating nitric oxide production." Cell Biology International, vol. 34, no. 7, 2010, pp. 755-61.|
|Kolluru GK, Sinha S, Majumder S, Muley A, Siamwala JH, Gupta R, Chatterjee S. "Shear stress promotes nitric oxide production in endothelial cells by sub-cellular delocalization of eNOS: A basis for shear stress mediated angiogenesis." Nitric oxide : biology and chemistry, vol. 22, no. 4, 2010, pp. 304-15.|
|Siamwala JH, Reddy SH, Majumder S, Kolluru GK, Muley A, Sinha S, Chatterjee S. "Simulated microgravity perturbs actin polymerization to promote nitric oxide-associated migration in human immortalized Eahy926 cells." Protoplasma, vol. 242, no. 1-4, 2010, pp. 3-12.|
|Siamwala JH, Majumder S, Tamilarasan KP, Muley A, Reddy SH, Kolluru GK, Sinha S, Chatterjee S. "Simulated microgravity promotes nitric oxide-supported angiogenesis via the iNOS-cGMP-PKG pathway in macrovascular endothelial cells." FEBS Letters, vol. 584, no. 15, 2010, pp. 3415-23.|
|Majumder S, Rajaram M, Muley A, Reddy HS, Tamilarasan KP, Kolluru GK, Sinha S, Siamwala JH, Gupta R, Ilavarasan R, Venkataraman S, Sivakumar KC, Anishetty S, Kumar PG, Chatterjee S. "Thalidomide attenuates nitric oxide-driven angiogenesis by interacting with soluble guanylyl cyclase." British Journal of Pharmacology, vol. 158, no. 7, 2009, pp. 1720-34.|
NIH NIGMS P20GM103652-01 (Rounds/ Harrington) Siamwala, JH (PI) 11/01/2018-11/30/2020
Endothelial Injury and Repair: CPVB COBRE PILOT Right Ventricular Fibrosis from Pulmonary Arterial Hypertension is Dependant on Macrophage IL-1b signaling.
The goal of this work is to generate preliminary data on the macrophage mediated inflammatory mechanisms in right ventricular fibrosis and right ventricular dysfunction, an unexplored avenue for the development of immunobased therapies for cardiovascular conditions.
RHODE ISLAND FOUNDATION 2809_20190594 Siamwala, JH (PI) 3/1/2019- 2/1/2020
Macrophages Under Pressure in Right Ventricular Dysfunction Associated with Pulmonary Arterial Hypertension
The goal of this work is to characterize the macrophage phenotypes and their role in impaired angiogenesis associated with right ventricular dysfunction and pulmonary hypertension
NIH NIGMS P20GM103652-01 (Rounds/ Harrington) Siamwala, JH (PI) 06/01/2019-05/31/2020
Endothelial Injury and Repair: CPVB COBRE administrative supplement. Neurovascular aging phenotypes of Alzheimer’s disease and Progeria: Focus on inflammation and blood brain barrier.
The goal of this work is to determine the inflammatory mechanisms of Alzheimer’s neuronal risk and Progeria neuronal resilience for the development of therapeutics for Alzheimer’s.
SUMMER TEAM UTRA AWARD (Alexander Zhao/Haley Barthel) Siamwala, JH (PI) 07/01/2019- 08/30/2019
|Post Doctoral Fellow||University of California San Diego, Anesthesiology||2015-2017||San Diego, CA, United States|
|Postdoctoral fellow||University of California, San Diego, Orthopedic Surgery||2014-2015||San Diego, California, United States|
|Postdoctoral trainee||LV Prasad Eye Institute, Stem cells||2012-2013||Hyderabad, Andhra Pradesh, India|
2004 National Languages Prize for Academic Proficiency
2004 Academic proficiency award, Women’s Christian College, Chennai
2005 Indian Academy of Science (IAS) award, summer research fellowship, Bangalore
2005 Arignar Anna Memorial Merit Scholarship, Vice-Chancellor, University of Madras, Chennai
2010 Department of Science and Technology (DST) travel award, India
2010 NO2010 Secretariat Award, Japan
2010 EMBO Global Exchange Lecture Course
2011 Young Scientist Award, Annual meeting of Society for Free Radical Research (SFRR)
2011 Journal of Cell Science Award (JCS) for research in Milan, Italy
2011 Boehringer Ingelheim Fonds (BIF) Award for research in Milan, Italy
2013 Wood Whelan Research Fellowship, International Union of Biochemistry and Molecular Biology (IUBMB)
2015 EEP National Space Biomedical Research Institute’s Gravitational Physiology Beginning Investigator Award from the American Physiology Society
2017 Dependent travel award from the post-doctoral association of University of California, San Diego
|Brayboy, Lynae||Assistant Professor of Obstetrics and Gynecology (Research), Assistant Professor of Molecular Biology, Cell Biology and Biochemistry (Research)|
|Clements, Richard||Assistant Professor of Surgery (Research)|
|Harrington, Elizabeth||Associate Dean for Graduate and Postdoctoral Studies in the Division of Biology and Medicine, Professor of Medicine|
|Morrison, Alan||Assistant Professor of Medicine|
|Rounds, Sharon||Associate Dean for Clinical Affairs, Professor of Medicine, Professor of Pathology and Laboratory Medicine|
|Spade, Daniel||Assistant Professor of Pathology and Laboratory Medicine|
Mentor to Alex Zhao, Haley Barthel, Rachell Diaz and Stephanie Carrero
Instructor of the BIOL1960 Independant Study Program