Michael G. Ehrlich Vincent Zecchino, MD Professor of Orthopaedic Surgery, Professor of Orthopaedics

Dr. Ehrlich is a graduate of Dartmouth College, Summa Cum Laude and Phi Beta Kappa, and Columbia University College of Physicians and Surgeons, AOA. His orthopaedic residency was followed by a pediatric orthopaedic/research fellowship at the Hospital for Joint Diseases. Dr. Ehrlich was the Chief of Pediatric Orthopaedics at Massachusetts General Hospital and Harvard Medical School before coming to Brown University in 1990. He served six years as the Chairman of the Research Committee for both the Academic Orthopaedic Society and the American Academy of Orthopaedic Surgeons, and has twice been a permanent member of the Study Section on Orthopaedics and Musculoskeltal Disease for the National Institutes of Health. He was also Chairman of the Committee on Research of the Pediatric Orthopaedic Society. He received the M.A. ad eundem award at Brown, the Excellence in Research Award from the American Orthopaedic Society for Sports Medicine, and the Kappa Delta Award from the AAOS for the best orthopaedic research in the United States. Dr. Ehrlich became President of the Academic Orthopaedic Society in 1999. He was previously President of the Orthopaedic Research Society. In 1998 he received the Arthur H. Huene Memorial Award, Lifetime Contribution to Pediatric Orthopaedics from the Pediatric Orthopaedics Society of North America. In 1998 he received an Endowed Chair, the Vincent Zecchino, M.D. Professorship of Orthopaedic Surgery, and was honored with the creation of the Michael G. Ehrlich M.D. Professorship of Orthopaedic Research. Dr. Ehrlich became Chair of the Orthopaedic Department at Brown University and Orthopedic Surgeon-in-Chief at Rhode Island Hospital from 1990 to 2016. He also was Chief of Orthopaedics at the Miriam Hospital after they joined Rhode Island Hospital as part of the Lifespan Corporation in 1994. He was on the Board of Directors at the Lifespan Corporation from 1994 through 2015. After he stepped down as Chair in 2016, he became Director of Orthopedic Research for the Lifespan Health System, a position he still holds. He has authored more than 200 journal articles, book chapters and abstracts. Some of Dr. Ehrlich's research interests include limb-lengthening physiology, neuromuscular disorders in children, biologic epiphyseodesis and degradative enzyme systems in cartilage. Dr. Ehrlich was awarded the Milton W. Hamolsky Outstanding Physician of the Year Award in 2005. 

Brown Affiliations

scholarly work

Tuttle JR, Feltman PR, Ritterman SA, Ehrlich MG. Effects of Tranexamic Acid Cytotoxicity on In Vitro Chondrocytes. AM J Orthop 2015 Dec;44(12):E497-502.

Zhou Y, Mohan A, Moore DC, Lin L, Zhou FL, Cao J, Wu Q, Qin YX, Reginato AM, Ehrlich MG, Yang W.  SHP2 Regulates Osteoclastogenesis by Promoting Preosteoclast Fusion. FASEB J. Jan. 2015.

Wang S, Wei , Xhou J, Zhang J, Li K, Chen Q, Terek R, Fleming BC, Goldring MB, Ehrlich, MG, Zhang G, Wei L. Identification of Alpha 2 Macroglobulin (A2M) as Master Inhibitor of Cartilage Degrading Factors that Attenuates Post-Traumatic Osteoarthritis Progression. Arthritis Rheumatol, Feb. 27, 2014.

Wang S, Wei X, Xhou J, Ahang J, Li K, Chen Q, Terek R, Feming BC, Goldring MB, Ehrlich MG, Zhang G, Wei L. Identification of a2-macroglobulin as a Mastr Inhibitor of Cartilage-Degrading Factors  that Attenuates the Progression of Posttraumatic Osteoarthrits.  Arthritis Rheumatol. Jul;66(7):1843-53, July, 2014.

Yang W, Wang J, Moore DC, Liang H, Dooner M, Wu Q, Terek R, Chen Q, Ehrlich MG.  Ptpn 11  Deletion in a Novel Progenitor Causes Metachondromatosis by Inducing Hedgehog Signalling. Nature.  2013 July25;499(7459):491-5. EPub 2013 Jul 17.

 Daniels, AH, McDonnell M, Born CT, Hayda RA, Ehrlich MG, Trafton PG, Fischer SA, DiGiovanni  CW. Critical Analysis of a Trauma Fellowship-Modeled, Six-Year Orthopaedic Surgery Training   Program. JBJS.7:95(15);e108,dol:10.2106/JBJS, Aug 2013.

Brunner AM, Henn CM, Lesieur-Brooks A, Drewniak EL, Machan J, Crisco JJ, Ehrlich MG. High  Dietary Fat and the Development of Osteoarthritis in a Rabbit Model. Osteoarthritis and Cartilage. Feb. 2012.

 Deren ME, Machan JT, DiGiovanni CW, Ehrlich, MG, Gillerman RG.  Prewarming Operating Rooms for Prevention of Intraoperative Hypothermia During Total Knee and Hip Arthroplasties.  J Athroplasty.   Feb. 2011

Thakur N, Plante M, Kayiaros S, Reinert S, Ehrlich MG: Inappropriate Transfer of Patients with Orthopaedic Injuries to a Level I Trauma Center: A Prospective Study. J Orthopaedics Trauma, June;2(6):336-9, 2010.

Moore DC, Ehrlich MG, McAllister SC, Machan JT, Hart CE, Voigt C, Lesieur-Brooks AM, Weber EW.  Recombinant human platelet-derived growth factor-BB augmentation of new bone formation in a rat model of distraction ostogenesis. Journal of Bone and Joint Surgery AM. Aug. 91:1973-1984, 2009.

Appleyard DV, Schiller JR, Eberson CP, Ehrlich MG.  Idiopathic Chondrolysis Treated with Etanercept.  Orthopedics. Mar;32(3):214, 2009.

Phornphutkul C, Lee M, Voight C, Wu K, Ehrlich, MG, Gruppuso P, Chen Q.  The Effect of Rapamycinon Bone Growth in Rabbits. J Orthop Res. Sept;27(9):1157-61, 2009.

Henn F, Crawford D, Eberson C, Ehrlich MG: Subtalar Release in Clubfeet: A Retrospective Study of 10 Year Outcomes, Foot and Ankle International, Apr,29(4):390-5, 2008.

Schiller JR, Moore DC, Ehrlich MG: Increased Lengthening Rate Decreases Expression of Fibroblast Growth Factor 2, Platelet-Derived Growth Factor, Vascular Endothelial Growth Factor, and CD31 in a Rat Model of Distraction Osteogenesis, Journal Pediatric Orthopaedics, 27(8):961-8, Dec. 2007.

Alford JW, Bradley MP, Fadale PD, Crisco JJ, Moore DC, Ehrlich MG: Resorbable Fillers Reduce Stress Risers from Empty Screw Holes, J Trauma, Sept;63(3):647-54, 2007.

Valdes M, Moore DC, Palumbo M, Lucas PR, Robertson A, Appel J, Ehrlich MG, Keeping H: rhBMP-6 Stimulated Osteoprogenitor Cells Enhance Posterolateral Spinal Fusion in the New Zealand White Rabbit. Spine Journal, May-June 7(3):318-25, 2007.

Lee MC, Bier AD, Nickisch F, Eberson CP, Ehrlich MG, Chen Q: Epiphysiodesis with Infusion of Stromal Cell-Derived Factor-1 in Rabbit Growth Plates, J Bone Joint Surg Am, 89(1);102-13, Jan 2007.

Aaron R, Herr H, Ciombor D, Hochberg L, Donoghue J, Briant C, Morgan J, Ehrlich MG. Horizons in Prosthetic Development for the Restoration of Limb Function. Journal of the American Academy of Orthopaedic Surgeons, Volume 14 (Supplement) 2006

Moore DC, Pedrozzo HA, Crisco JJ, Ehrlich MG: Preformed Grafts of Porcine Small Intestine Submucosa (SIS) for Bridging Segmental Bone Defects. J. Biomed Mater Res. May 1;69A(2):259-66, 2004.

Jofe, MH, Lehman, WB, Ehrlich MG: Chondrolysis Following Slipped Capital Femoral Epiphysis, Journal of Pediatric Orthopaedics. Jan;13(1):29-31, 2004.

Landam PR, Alford JW, Ehrlich, MG. The Risks of Overly Effective Postoperative Epidural Analgesia, Am J Orthop. Jul;32(7):353-5, 2003.

Eberson CP, Hogan KA, Moore DC, Ehrlich MG. Effect of Low-Intensity Ultrasound Stimulation on Consolidation of the Regenerate Zone in a Rat Model of Distraction Osteogenesis. J Pediatric Orthop. Jan-Feb;23(1):46-51,2003.

Moore DC, LeBlanc CW, Müller R, Crisco JJ 3rd, Ehrlich MG. Physiologic Weight-Bearing Increases New Vessel Formation During Distraction Osteogenesis: A micro-Tomographic Imaging Study. J Orthop. Res. May;21(3):489-496, 2003.

Valdes M, Palumbo M, Appel J, McAllister S, Ehrlich MG. Posterolateral Intertransverse Lumbar Arthrodesis in the New Zealand White Rabbit Model: II. Operative Technique. The Spine Journal Aug:pp.293-299, 2003.

Armstrong, AL, Barrach HJ, Ehrlich, MG. Identification of the Metalloproteinase Stromelysin in the Physis. Journal of Orthop. Res. Mar;20(2):289-94, 2002.

Pacicca DM, Moore DC, Ehrlich MG. Physiologic Weight-Bearing and Consolidation of New Bone in a Rat Model of Distraction Osteogenesis. J Pediatric Orthop. Sept-Oct.;22(5):652-659, 2002.

Radomisli TE, Moore DC, Barrach HJ, Keeping HS, Ehrlich MG. Weight-Bearing Alters the Expression of Collagen Types I and II, BMP, 2/4 and Osteocalcin in the Early Stages of Distraction Osteogenesis. J Orthop. Res. Nov;19(6):1049-56, 2001.

Babat LB, Ehrlich MG: A Paradigm for the Age-Related Treatment of Knee Dislocations in Larson's Syndrome. J Pediatric Orthop. May-Jun;20(3):396-401, 2000.

Eberson CP, Pacicca DM, Ehrlich MG. The Role of Ketorolac in Decreasing Length of Stay and Narcotic Complications in the Postoperative Pediatric Orthopaedic Patient. J Pediatric Orthop.Sept.-Oct;19(5):688-692, 1999.

Lockhart GR, Longobard, YL, Ehrlich, MG: Transient Synovitis: Lack of Serolgic Evidence for Acute Parvovirus B-19 or Human Herpesvirus-6 Infection. Journal of Pediatric Orthop., Mar-Apr;19(2):185-187, 1999.

Ferris DM, Moodie GD, Dimond PM, Gioranni CW, Ehrlich MG. Valentini RF: RGD-Coated Titanium Implants Stimulate Increased Bone Formation in Vivo, Biomaterials. Dec;20(23-24):2323-31, 1999.

Belanger MJ, Moore DC, Fadale PD, Hulstyn MJ, Crisco JJ, Ehrlich MG: Knee Laxity Does Not Vary With the Menstrual Cycle, Before or After Exercise. American Journal of Sports Medicine, Jul.Aug:32,(5):1150-1157. 2004. Winner of the 1999 Aircast Award.

DiGiovanni CW, Ehrlich MG. Treatment of Congenital Pseudarthrosis of the Fibula with Interposition Allograft. Orthopedics. Nov;21(11):1225-1228, 1998.

DaSilva MF, Williams JS, Fadale PD, Hulstyn MJ, Ehrlich MG. Pediatric Throwing Injuries About the Elbow. American J Orthop. Feb;27(2):90-96,1998.

Barnum, MJ, Ehrlich MG, Zaleske DJ. Long-Term Patient-Oriented Outcome Study of a Modified Evans Procedure. J Pediatric Orthop. Nov.-Dec.;18(6):783-788, 1998.

Cole PA, Ehrlich MG. Management of the Completely Stiff Pediatric Knee. J Pediatric Orthop. Jan-Feb;17(1):67-73 1997.

Ehrlich MG, Armstrong AL. Aggregate Degradation by Growth Plate Proteases. Clinical Orthop. Jan; (334):298-304, 1997.

Walsh WR, Sherman P, Howlett CR, Sonnabend DH, Ehrlich MG. Fracture Healing in a Rat Osteopenia Model. Clinical Orthop. Sept;(342):218-227, 1997.

Wiggins ME, Fadale PD, Ehrlich MG, Walsh WR. Effects of Local Injection of Corticosteroids of the Healing of Ligaments. A Follow-up Report. JBJS. Nov;77 (11):1682-1691, 1995.

Walsh WR, Wiggins ME, Fadale PD, Ehrlich MG. The Effects of a Delayed Steroid Injection on Ligament Healing Using a Rabbit Medial Collateral Ligament Model. Biomaterials. Aug; 16(12):905-910, 1995.

Lefkoe TP, Walsh WR, Anastasatos J, Ehrlich MG, Barrach HJ. Remodeling of Articular Step-Offs: Is Osteoarthrosis Dependent on Defect Size? Clinical Orthop. May; (314):253-265, 1995.

Nord KD, Dore DD, Deeney VF, Armstrong AL, Cundy PJ, Ehrlich MG. Evaluation of Treatment Modalities for Septic Arthritis with Histologic Grading and Analysis of Levels of Uronic Acid, Neutral Protease and Interleukin-1. JBJS, Feb;77 (2):258-265, 1995.

Hamdy RC, Walsh W, Olmedo M, Wallach M, Ehrlich MG: Correlation Between Ultrasound Imaging and Mechanical and Physical Properties of Lengthened Bone: An Experimental Study in a Canine Model. J Pediatric Orthop. Mar-Apr;15(2)206-211, 1995.

Siu-Caldera ML, Zou L, Ehrlich MG, Schwartz, ER, Ishizuka S, Reddy GS. Human Osteoblasts in Culture Metabolize Both 1 Alpha, 25-Dihydroxyvitamin D3 and its Precursor 25-Hydroxyvitamin D3 Into Respective Lactones. Endrinology, Oct.;136 (10):4195-4203, 1995.

Williams JS Jr, Hulstyn MJ, Fadale PD, Lindy PB, Ehrlich MG, Cronan J, Dorfman G. Incidence of Deep Vein Thrombosis after Arthroscopic Knee Surgery: A Prospective Study. Arthroscopy. Dec;11(6):701-705. 1995.

Sachar K, Akelman E, Ehrlich MG. Radioulnar Synostosis. Hand Clin. Aug;10(3)399-404, 1994.

Wiggins ME, Fadale PD, Barrach H, Ehrlich MG, Walsh WR. Healing Characteristics of a Type I Collagenous Structure Treated with Corticosteroids. Am J Sports Med, Mar-Apr;22(2):279-288, 1994.

Hamdy RC, Ehrlich MG. Subtrochanteric Derotation Osteotomy of the Femur Using Three or Four Wires. A Technical Note. Clinical Orthop. May; 302:111-114, 1994.

Walsh WR, Hamdy RC, Ehrlich MG. Biomechanical and Physical Properties of Lengthened Bone in a Canine Model. Clinical Orthop. Sept; (306) 230-238, 1994.

Lefkoe TP, Trafton PG, Ehrlich MG, Walsh WR, Dennehy DT, Barrach HJ, Akelman E. An Experimental Model of Femoral Condylar Defect Leading to Osteoarthrosis. J. Orthop. Trauma 7(5):458-467, 1993.

Experimental Model of Femoral Condylar Defect Leading to Osteoarthrosis. J. Orthop. Trauma 7(5):458-467, 1993.

Ehrlich MG, Hulstyn M, d'Amato C. Sports Injuries in Children and the Clumsy Child. Pediatric. Clin. North Am. Jun; 39(3)433-449, 1992.

Elmer EB, Ehrlich MG, Zaleske DJ, Polsky C, Mankin HJ. Chondrodiastasis in Rabbits: A Study of the Effect of Transphyseal Bone Lengthening on Cell Division, Synthetic Function, and Microcirculation in the Growth Plate. J. Pedi. Orthop. Mar-Apr;12(2):181-190, 1992.

Boskey AL, Maresca M, Armstrong AL, Ehrlich MG. Treatment of Proteoglycan Aggregates with Physeal Enzymes Reduces Their Ability to Inhibit Hydroxyapatite Proliferation in a Gelatin Gel. J. Orthop. Res. May;10(3):313-319, 1992.

Sternlicht AL, Ehrlich MG, Armstrong AL, Zaleske DJ. Role of Pin Protrusion in the Etiology of Chrondrolysis: A Surgical Model with Radiographic, Histologic, and Biochemical Analysis. J Pedatric Orthop. Jul-Aug;12(4)428-433. 1992.

Cundy PJ, Jofe M, Zaleske DJ, Ehrlich MG, Mankin HJ. Physeal Reconstruction Using Tissue Donated from Early Postnatal Limbs in a Murine Model. J. Orthop. Res. May;9(3):360-366, 1991.

Leibovic SJ, Ehrlich MG, Zaleske DJ: Sprengel Deformity. JBJS. Feb;72(2):192-197, 1990.

Ehrlich MG, Stefanich R, Ishizue KK, Armstrong AL, Mankin HJ. In Vitro and In Vivo Effects of Metal Chelators on Cartilage Metabolism. J. Orthop. Res. Jan;8(1):72-77, 1990.

Lalanadnham T, Ehrlich MG, Zaleske DJ, Deeney VF, Mankin HJ: Viability and Metabolism of Cartilage Transplanted to Physeal Regions. J Pediatric Orthop. Jul-Aug:10(4): 450-458. 1990.

Diao E, Zaleske DJ, Avella D, Trahan C, Armstrong AL, Ehrlich MG, Mankin HJ: Kinetic and Biochemical Heterogeneity in Vertebrate Chondroepiphyseal Regions During Development. J. Orthop. Res. 7:(4):502-510, 1989.

Ishizue KK, Ehrlich MG, Mankin HJ. Drug Induced Inhibition of Proteoglycanase Activity in the Hulth-Telhag Model. J. Orthop. Res. 7(6):806-811, 1989.

Bell DF, Ehrlich MG, Zaleske DJ. Brace Treatment for Symptomatic Spondylisthesis. Clinical Orthop. Nov;(236):192-198, 1988.

Zaleske DJ, Floyd WE 3rd, Hallett J, Kushner, D, Jupiter J, Trahan C, Ehrlich MG, Mankin HJ. Epiphyseal Replacement Using Developing Tissue Donors in a Murine Model: A Combined Histologic and Radiologic Study. J Orthop. Res. 6(2);155-165, 1988.

Kawabe N, Ehrlich MG, Mankin HJ: Growth Plate Reconstruction Using Chondrocyte Allograft Transplants. J Pediatric Orthop. Jul-Aug;7(4):381-388, 1987.

Buckwalter JA, Ehrlich MG, Armstrong AL, Mankin HJ. Electron Microscopic Analysis of Articular Cartilage Proteoglycan Degradation by Growth Plate Enzymes. J. Orthop. Res. 5(1):128-132, 1987.

Mercier P, Ehrlich MG, Armstrong AL, Mankin HJ. Elaboration of Neutral Proteoglycanase by Growth-Plate Tissue Cultures. JBJS. Jan;69(1):76-82, 1987.

Ehrlich MG, Armstrong AL, Treadwell BV, Mankin HJ. The Role of Proteases in the Pathogenesis Osteoarthritis. J. Rheumatol. May;14Spec No;30-32, 1987.

Lhowe D, Ehrlich MG, Chapman PH, Zaleske DJ. Congenital Intraspinal Lipomas: Clinical Presentation and Response to Treatment. J Pediatric Orthop. Sep-Oct;7(5):531-537.1987.

Kawabe N, Ehrlich MG, Mankin JH: In Vivo Degradation Systems of the Epiphyseal Cartilage. Clin. Orthop. Oct;(211):244-251, 1986.

Kushner DC, Cleveland RH, Herman TE, Zaleske DJ, Ehrlich MG, Correira JA: Radiation Dose Reduction in the Evaluation of Scoliosis: An Application of Digital Radiography. Radiology. Oct;161(1):175-181, 1986.

Ehrlich MG and Zaleske DJ: Pediatric Orthopedic Pain of Unknown Origin. J. Pediatric. Orthop. Jul-Aug;6(4):460-468, 1986.

Ehrlich MG, Armstrong AL, Treadwell BV, Mankin HJ: Degradative Enzyme Systems in Cartilage. Clin. Orthop. Dec;(213): 62-68, 1986.

Kushner DC, Cleveland RH, Ehrlich MG, Zaleske DJ, DeLuca SA, Herman TE, Webster EW. Evaluation of Anteversion of the Femur During Childhood. Invest Radiol. Dec;20(9):978-982, 1985.

Ehrlich MG: Degradative Enzyme Systems in Osteoarthritic Cartilage. J Orthop. Res. 3(2):170-184, 1985.

Ehrlich MG, Tebor GB, Armstrong AL, Mankin HJ: Comparative Study of Neutral Proteoglycanase Activity by Growth Plate Zone. J. Orthop. Res. 3-3:269-276, 1985.

Creasman C, Zaleske DJ, Ehrlich MG: Analyzing Forearm Fractures in Children. The More Subtle Signs of Impending Problems. Clinical Orthop. Sept;(188):40-53, 1984.

Leeds HC, Ehrlich MG: Instability of the Distal Tibiofibular Syndesmosis after Bimalleolar and Trimalleolar Ankle Fracture. JBJS. Apr;66(4):490-503, 1984.

Ehrlich MG, Armstrong AL, Mankin HJ: Partial Purification and Characterization of a Proteoglycan-Degrading Neutral Protease from Bovine Epiphyseal Cartilage. J. Orthop. Res. 2(2):126-133, 1984.

Hahn PF, Rosenthal DI, Ehrlich MG: Case Report 286: Gas Within a Solitary Bone Cyst of the Proximal End of the Left Humerus. Skeletal Radiol. 12:(3)214-217, 1984.

Zaleske DJ, Ehrlich MG, Kushner D, Cleveland R, and McCarten K: Transaxial Tomography: An Alternative to Computerized Tomography in Pediatric Orthopaedic Problems. J. Pediatric Orthop. Nov; 3(5)616-619, 1983.

1. Clark SA, Ehrlich MG, Mankin HJ, Ryan HJ, Doppelt SH: Hematoma-Induced Febrile Response in the Pediatric Patient. J. Pediatric Orthop. Jul;3(3):333-340, 1983.

1. Tebor GB, Ehrlich MG, Herrin J. Slippage of the Distal Tibial Epiphysis. J. Pediatric Orthop. May;3(2):211-215, 1983.

Amadio PC, Ehrlich MG, Mankin HJ: Matrix Synthesis in High Density Cultures of Bovine Epiphyseal Plate Chondrocytes. Connect Tissue Res. 11(1):11-19, 1983.

Herring JA, Ehrlich MG: Valgus Knee Deformity-Etiology and Treatment. J Pediatric Orthop. Sep;3(4):527-530, 1983.

Jupiter JB, Ehrlich MG, Novelline RA, Leeds HC, Keim D: The Association of Septic Thrombophlebitis with Subperiosteal Abscesses in Children. J Pediatric Nov;101(5):690-695, 1982.

Ray RL, Ehrlich MG, Mankin HJ: Isolation of Proliferating Chondrocytes from Bovine Growth Plate Cartilage by Rate-Zonal Centrifugation in a Ficoll Density Gradient. JBJS. Oct;64(8):1221-1224, 1982.

Scheinberg RD, Ehrlich MG, Lippiello L, Mankin HJ: Degradative Enzyme Activity in Isolated Chondrocyte Populations. Clinical Orthop. Apr;(164):279-285, 1982.

Zaleske DJ. Ehrlich MG, Piliero C, May JW Jr, Mankin HJ: Growth Plate Behavior in Whole Joint Replantation in the Rabbit. JBJS. Feb; 64(2):249-258, 1982.

Ehrlich MG, Armstrong AL, Neuman RG, Davis MW, Mankin HJ: Patterns of Proteglycan Degradation by a Neutral Protease from Human Growth Plate Epiphyseal Cartilage. JBJS. Dec;64(9):1350-1354, 1982.

Trippel SB, Ehrlich MG, Lippiello L, Mankin HJ: Characterization of Chondrocytes from Bovine Articular Cartilage: I. Metabolic and Morphological Experimental Studies. J Bone Joint Surg Am, Jul;62(5):816-820,1980.

Zaleske DJ, Ehrlich MG, Hall JE: Association of Glycosaminoglycan Depletion and Degradative Enzyme Activity in Scoliosis. Clin. Orthop. May(148): 177-181, 1980.

Norris S, Ehrlich MG, McKusick K: Early Diagnosis of Disk Space Infection with 67Ga in an Experimental Model. Clin. Orthop. Oct.(144): 293-298, 1979.

Ehrlich MG, Strain RE Jr. Epiphyseal Injuries About the Knee. Orthop. Clinical North Am. Jan;10(1):91-103, 1979.

Ray RL, Ehrlich MG: Lateral Hamstring Transfer and Gait Improvement in the Cerebral Palsy Patient. JBJS. Jul;61(5): 719-723, 1979.

Ehrlich MG, Houle PA, Vigliani G, Mankin HJ: Correlation Between Articular Cartilage Collagenase Activity and Osteoarthritis. Arthritis Rheum. Sep-Oct;21(7):761-766, 1078.

Ehrlich MG, Broudy AG: Compression Plate Fixation of Subtrochanteric Osteotomies in Children. Bull. Hosp. Joint Dis. Apr.39(1): 83-85, 1978.

Norris S, Ehrlich MG, Keim D, Guiterman H, McKusick KA: Early Diagnosis of Disc Space Infection Using Gallium 67. J. Nucl. Med. Apr;19(4): 384-386, 1978.

Radin EL, Ehrlich MG, Chernack R, Abernethy P, Paul IL, Rose RM: Effect of Repetitive Impulsive Loading on the Knee Joints of Rabbits. Clin Orthop. Mar-Apr(131):288-293, 1978.

Ehrlich MG, Mankin HJ, Jones H, Wright R, Crispen C, Vigliani G: Collagenase and Collagenase Inhibitors in Osteoarthritic and Normal Human Cartilage. J Clin. Invest. Feb;59(2): 226-233, 1977.

Zaleske DJ, Ehrlich MG, Huddleston JI Jr: Combined Biochemical and Clinical Investigation of Chemonucleolysis Failures. Clin. Orthop. Jul-Aug;(126): 121-126,1977.

Southmayd W, Ehrlich, MG: Idiopathic Subluxation of the Radial Head. Clin. Orthop. Nov-Dec;(121):271-274, 1976.

Ehrlich MG, Mankin HJ, Jones H, and Grossman A, Crispen C, Ancona D: Biochemical Confirmation of an Experimental Osteoarthritis Model. JBJS Apr;57(3): 392-396, 1975.

Ehrlich MG, Chaglassian JH: Unicameral Bone Cyst in the Scapula. Clin Orthop. (103):80-81, 1975.

Mitchell C, Ehrlich MG, Siffert RS: Comparative Bacteriology of Late and Early Orthopaedic Infection. Clin. Orthop. Oct;96: 277-287, 1973.

Ehrlich MG, Mankin HJ, Treadwell BV: Acid Hydrolases Activity in Osteoarthritic and Normal Human Cartilage. JBJS. Jul;55(5): 1068-1076, 1973.

Ehrlich MG, Weiss C, Mankin HJ, Treadwell BV, Sanzone C. Histochemical, Metabolic and Ultrastructural Studies of the Maturation Zone of the Rachitic Rat Epiphyseal Plate. JBJS. Jun;55(4):785—794, 1973.

Siffert RS, Ehrlich MG, Katz RF. Management of Congenital Dislocation of the Hip. Clinical Orthop. Jul-Aug;86:28-33,1972.

Ehrlich MG, Mankin HJ, Treadwell BV. Biochemical and Physiological Events During Closure of the Stapled Distal Femoral Epiphyseal Plate in Rats. JBJS, Mar;54(2):309-322, 1972.

Ehrlich MG, Goldstein M, Heinemann HO. Hypocalcemia, Hypoparathyroidism and Osteoblastic Metastases. Met. 12:515, 1963

Posterolateral Spine Fusion with rhBMP-6 Exposed Osteoprogenitor Cells, ORS, Submitted

research overview

Dr. Ehrlich's research interests include physiology of distraction osteogenesis, neuromuscular disorders in children, biologic epiphyseodesis and degradative enzyme systems in cartilage.

research statement

Current projects include the use of cytokines, such as PDGF, to enhance consolidation in distraction osteogenesis. Work over the last two decades has addressed the physiology of lengthening. Another project addresses the use of SDF-1, somatic-derived-factor, which acts like Interleukin-1 to stimulate degradative enzymes. This material is delivered via a continuous infusion by catheter into the physis, leading to growth plate closure (biologic epiphyseodesis). We are attempting to determine at what level of stress, in a model of bowing, degradative enzymes will be expressed.

funded research

Extramural Funding:

  • DePuy SIS in Segmental Bone Defects - $34,641.95
  • PI: Moore DC.  Co-Invest: JJ Crisco, MG Ehrlich.  DePuy Orthopaedics, Warsaw, IN (12/1/99-3/1/01)
  • Intraarticular Injection of Capsaicin for Long-Term Pain Relief - $173,318.02
  • PIs: Moore DC, Ehrlich MG.  AlgoRx, Inc.  (9/1/02-12/31/03)
  • rhPDGF in Distraction Osteogensis  $150,000
  • PI: Ehrlich MG, Moore DC    Biomimetics (6/07-6/08)


1973-1975                                            Orthopaedic Research and Education Foundation

                                                            Collagenase in articular cartilage ($12,000)

1975-1988                                            Co-Investigator in NIADDKD #16262

                                                            Co-Investigator in NIAMS

                                                -           #AM11382, #AM16265, #AM21896

                                                -           Cartilage metabolism (over $2,000,000)

1995-1997                                            Orthopaedic Research and Education Foundation-Co-investigator

Bone response to implants covalently grafted with integrin-specific attachment peptides  ($100,000)

  • 2004-2009 VA Grant—A3772C, Rebuilding, Regenerating & Restoring Function after Limb Loss $7,500,000
  • 2004-2009 Distraction Osteogenesis Project: $300,000
  • 2005-2007 Biomimetics Corporation, PDGF Stimulation of Healing, $83,359