Dr. Ming Li earned his PhD from Binghamton University (SUNY) and received postdoctoral training at Alpert Medical School of Brown University. After a two-year NIH funded fellowship, he was promoted to Assistant Professor (research) of Medicine. Combining large-scale proteomic screens and systemic molecular dissections, his research revealed new aspects of regulatory effects of extracellular vesicles in various settings and identified SLBP as a novel HIV-1 restriction factor.
Li, M.* and Ramratnam, B. Proteomic characterization of exosomes from HIV-1 infected
cells. HIV Protocols (Methods in Molecular Biology) 3rd Ed
Li, M.,* Tucker, L., Asara, J.M., Cheruiyot, C., Lu, H., Park S., Wu, Z., Newstein M., Dooner, M., Friedman, J., Lally, M. and Ramratnam, B. Identification of stem-loop binding protein as a multifaceted HIV-1 restriction factor. In revision at Journal of Clinical Investigation
Cheruiyot, C., Ramratnam B. and Li, M. Proteomic analysis of exosomal proteins in HIV and retrovirus infected cells. In revision at Proteomics Clin Appl.
Li, M.,* Liu, T., Monnig, M., Isabella, N., Hogan, G., Tucker, L., Park, S., Cheruiyot. C., Friedman, J., Mayer, K., Monti, P., Kahler, C. and Ramratnam, B. Alcohol and its impact on HIV-1 dependency factors. In revision
Li, M.,* Cheruiyot, C., Tucker, L., Lally, M., and Ramratnam, B. Stem-loop binding protein (SLBP) regulates the expression of APOBEC3G. Manuscript in preparation
Dr. Li’s primary research interests cover proteomics, extracellular vesicles, HIV-1 and Lactobacillus. A) Extracellular vesicles. By devising mass spectrometry based methods, he found unique regulatory effects of intercellular transferred proteins as well as exosomal proteins from HIV-1 infected cells. B) Host factors in HIV-1 control and pathogenesis. He identified SLBP as a HIV-1 restriction factor through proteomic screens on nonprogressors and MED6 as an alcohol responsive HIV-1 dependency factor. C) Lactobacillus. He engineered probiotic Lactobacilli as novel/natural ways to deliver biofunctional molecules.
Currently, Dr. Li focuses on: 1) finding ways of overcoming HIV-1 latency through regulating host dependency factors and extracellular vesicle pathways. 2) studying immunomodulatory effects of Lactobacillus extracellular vesicles and genetically engineer them as biotherapeutic systems against infections.
Dr. Li’s research has been supported by Lifespan Corporation, RI foundation and NIH/COBRE.
Lifespan Corporation Pilot Grant, PI, Oct. 2013 - Nov. 2014
RI Foundation Medical Research Grant, PI, March, 2014 - August 2015
NIH COBRE URI/RIH Pilot Research Grant, PI, June 2014 - May 2015
Excellent Student Award, Henan Normal University, 1994-1997
Excellent Trainee Teacher, Henan Normal University, 1997
Guanghua Scholarship, Sun Yat-sen University, 1998-1999
Graduate Student Exemplary Progress Award, Binghamton University, 2003
Professional Development Award, Binghamton University, 2003
Szymanski and Graduate School Travel Award, Binghamton University, 2004
NIH National Research Service Award, Alpert Medical School of Brown University, 2009-2011
Young Investigator Awards, 19th Conference on Retroviruses and Opportunistic Infections, 2012
Human Proteome Organization (HUPO)
International Society for Computational Biology (ISCB)
American Association for the Advancement of Science (AAAS)
International Society for Extracellular Vesicles (ISEV)
Teaching Assistant at Binghamton University: Introductory Biology Laboratory; Introduction to Organismal and Population Biology; Principles of Cell Biology; Molecular Genetics; Biochemistry; Biochemistry Laboratory; Proteomics Laboratory.
Undergraduate Honors Thesis Advisor at Brown University: Yang Long, 2008
Undergraduate Summer Intern Advisor at Brown University: Geoffrey Hogan, 2011, 2012
Guest Lecturer for the class of “The Biology of AIDS” at Brown University, 2012
Undergraduate Research Advisor at Brown University: Isabella Newman, 2012-2013
Undergraduate Research and Honors Thesis Advisor at Brown University: Collins Cheruiyot, 2014-