Dr. Ming Li earned his Ph.D. from Binghamton University (SUNY) and received postdoctoral training at Alpert Medical School of Brown University. After a two-year NIH-funded fellowship, he was promoted to Assistant Professor of Medicine (Research). Combining large-scale proteomic screens and systematic molecular dissections, his research revealed new regulatory effects of extracellular vesicles in various settings and identified SLBP as a novel viral host factor.
Cheruiyot, C., Pataki, Z., Williams, R., Ramratnam, B. and Li, M.* Proteomic Characterization of Exosomes from HIV-1 Infected Cells. In press at Journal of Visualized Experiments
Cheruiyot, K.C., Pataki, Z., and Li, M.* Proteomic analysis of exosomes and its application in viral infections. In revision at Proteomics-Clinical Applications.
Li M.*, Lee, K., Hsu, M., Nau, G.J. Mylonakis, M. and Ramratnam, B. Lactobacillus-derived extracellular vehicles enhance host immune responses against vancomycin-resistant enterococci. Submitted to BMC Microbiology
Li M.*, Liu, T., Monnig, M., Isabella, N., Hogan, G., Williams, R., Park, S., Mayer, P., Monti, P., Kahler, C. and Ramratnam, B. Mediator of RNA polymerase II transcription subunit 6 is an alcohol-associated HIV-1 host factor. Submitted to Retrovirology.
(* Corresponding or Co-corresponding Author)
Dr. Li’s primary research interests cover Proteomics, Extracellular Vesicles, HIV-1, and Lactobacillus. A) Extracellular Vesicles. By devising a stable isotope labelling method, he found that a set of intracellular-transferred proteins have unique regulatory effects on the recipient cells. He further developed a systematic approach to studying the exosomal proteome. B) Host factors. He identified SLBP as a novel HIV-1 host factor through proteomic screens and functional dissections. He also revealed that MED6 is an alcohol-associated HIV-1 host factor. C) Lactobacillus. He engineered probiotic lactobacilli to secret biofunctional molecules in order to treat bacterial or viral infections.
Currently, Dr. Li focuses on: 1) The immunomodulatory and biotherapeutic potential of Lactobacillus-derived extracellular vesicles; 2) Extracellular vesicles and their impact in inflammation-associated HIV-1 acquisition; 3) Overcoming HIV-1 latency by regulating host factors and extracellular vesicle pathways.
Dr. Li’s research has been supported by Lifespan Corporation, RI Foundation, Univeristy Medicine Foundation, and NIH/COBRE.
PI, NIH R21 “Exosomes and their impact on inflammation-associated HIV acquisition” Preparing for resubmission.
PI, NIH COBRE (Centers of Biomedical Research Excellence) Center for Antimicrobial Resistance and Therapeutic Discovery Project 3 “Lactobacillus-derived extracellular vesicles: Immunomodulation and Biotherapeutics” Pending
PI, University Medicine Foundation Research Fund (#:713-9051) “Lactobacillus extracellular vesicles modulate host functions” Oct. 2015 - Jan. 2016
PI, NIH/COBRE at University of RI/Lifespan Pilot Research Grant (#5P20GM104317) “Overcoming HIV-1 latency by regulating stem-loop binding protein (SLBP)” June 2014 - May 2015
PI, RI Foundation Medical Research Grant (#20133969) “Overcoming HIV-1 Vif led degradation of APOBEC3G by regulating stem-loop binding protein” Mar. 2014 – Aug. 2015
PI, Lifespan Pilot Research Fund (#701-5857) “Stem-loop binding protein (SLBP) regulates the expression of APOBEC3G” Oct. 2013 - Nov. 2014
Young Investigator Awards, 19th Conference on Retroviruses and Opportunistic Infections, 2012
NIH National Research Service Award, Alpert Medical School of Brown University, 2009-2011
Szymanski and Graduate School Travel Award, Binghamton University, 2004
Professional Development Award, Binghamton University, 2003
Graduate Student Exemplary Progress Award, Binghamton University, 2003
Guanghua Scholarship, Sun Yat-sen University, 1998-1999
Excellent Trainee Teacher, Henan Normal University, 1997
Excellent Student Award, Henan Normal University, 1994-1997
International Society for Extracellular Vesicles (ISEV)
Human Proteome Organization (HUPO)
International Society for Computational Biology (ISCB)
American Association for the Advancement of Science (AAAS)
Teaching Assistant at Binghamton University: Introductory Biology Laboratory; Principles of Cell Biology; Introduction to Organismal and Population Biology; Biochemistry; Molecular Genetics; Biochemistry Laboratory; Proteomics Laboratory.
Guest Lecturer at Brown University: The Biology of AIDS, 2012
Research Advisor at Brown University: Yang Long, 2008; Geoffrey Hogan, 2011, 2012; Isabella Newman, 2012-2013; Collins Cheruiyot, 2014-2016; James Myall, 2016; Vy Dang, 2016; Robert Williams Jr. 2016-; Gloria Mensah, 2016-