Dr. Ming Li earned his PhD from Binghamton University (SUNY) and received postdoctoral training at Alpert Medical School of Brown University. After a two-year NIH-funded fellowship, he was promoted to Assistant Professor (Research) of Medicine. Combining large-scale proteomic screens and systemic molecular dissections, his research revealed new aspects of regulatory effects of extracellular vesicles in various settings and identified SLBP as a novel HIV-1 restriction factor.
Cheruiyot, C., Myall, J., Pataki, Z., Ramratnam, B. and Li, M.* Proteomic Characterization of Exosomes from HIV-1 Infected Cells. In press at Journal of Visualized Experiments
Cheruiyot, C., Pataki, Z., Ramratnam, B. and Li, M.* Proteomic analysis of exosomal proteins in HIV-infected cells. In revision at Proteomics Clin Appl.
Li, M.,* Liu, T., Monnig, M., Isabella, N., Hogan, G., Tucker, L., Park, S., Cheruiyot. C., Friedman, J., Mayer, K., Monti, P., Kahler, C. and Ramratnam, B. Alcohol and its impact on HIV-1 dependency factors. In revision
Li, M.,* Cheruiyot, C., Tucker, L., Lally, M., and Ramratnam, B. Stem-loop binding protein (SLBP) regulates the expression of APOBEC3G. Manuscript in preparation
Dr. Li’s primary research interests cover Proteomics, Extracellular Vesicles, HIV-1 and Lactobacillus. A) Extracellular Vesicles. By devising a stable isotope labelling methods, he found that certain intracellular transferred proteins pose unique regulatory effects on recipient cells. He further developed a systemic method to study exosomal proteins/proteome from HIV-1 infected cells. B) Host factors in HIV-1 control and pathogenesis. He identified SLBP as a novel HIV-1 host factor through proteomic screens and functional dissections. He also revealed that MED6 is an alcohol-responsive HIV-1 dependency factor. C) Lactobacillus. He engineered probiotic Lactobacilli as a novel/natural way to deliver biofunctional molecules against bacterial and viral infections.
Currently, Dr. Li focuses on: 1) finding ways of overcoming HIV-1 latency through regulating host factors and extracellular vesicle pathways. 2) studying immunomodulatory effects of Lactobacillus extracellular vesicles and genetically engineer them as biotherapeutic systems against infections.
Dr. Li’s research has been supported by Lifespan Corporation, RI Foundation, Univeristy Medicine Foundation, and NIH/COBRE.
PI, NIH R21 “Exosomes and their impact on inflammation-associated HIV acquisition” Under review
PI, NIH COBRE (Centers of Biomedical Research Excellence) Center for Antimicrobial Resistance and Therapeutic Discovery Project 3 “Lactobacillus-derived extracellular vesicles: Immunomodulation and Biotherapeutics” Pending
PI, University Medicine Foundation Research Fund (#:713-9051) “Lactobacillus extracellular vesicles modulate host functions” Oct. 2015 - Jan. 2016
PI, NIH/COBRE at University of RI/Lifespan Pilot Research Grant (#5P20GM104317) “Overcoming HIV-1 latency by regulating stem-loop binding protein (SLBP)” June 2014 - May 2015
PI, RI Foundation Medical Research Grant (#20133969) “Overcoming HIV-1 Vif led degradation of APOBEC3G by regulating stem-loop binding protein” Mar. 2014 – Aug. 2015
PI, Lifespan Pilot Research Fund (#701-5857) “Stem-loop binding protein (SLBP) regulates the expression of APOBEC3G” Oct. 2013 - Nov. 2014
Excellent Student Award, Henan Normal University, 1994-1997
Excellent Trainee Teacher, Henan Normal University, 1997
Guanghua Scholarship, Sun Yat-sen University, 1998-1999
Graduate Student Exemplary Progress Award, Binghamton University, 2003
Professional Development Award, Binghamton University, 2003
Szymanski and Graduate School Travel Award, Binghamton University, 2004
NIH National Research Service Award, Alpert Medical School of Brown University, 2009-2011
Young Investigator Awards, 19th Conference on Retroviruses and Opportunistic Infections, 2012
Human Proteome Organization (HUPO)
International Society for Computational Biology (ISCB)
American Association for the Advancement of Science (AAAS)
International Society for Extracellular Vesicles (ISEV)
Teaching Assistant at Binghamton University: Introductory Biology Laboratory; Principles of Cell Biology; Introduction to Organismal and Population Biology; Biochemistry; Molecular Genetics; Biochemistry Laboratory; Proteomics Laboratory.
Guest Lecturer at Brown University: The Biology of AIDS, 2012
Research Advisor at Brown University: Yang Long, 2008; Geoffrey Hogan, 2011, 2012; Isabella Newman, 2012-2013; Collins Cheruiyot, 2014-2016; James Myall, 2016; Vy Dang, 2016; Robert Williams Jr. 2016-; Gloria Mensah, 2016-