Mahasin Osman received her Ph.D. from Cornell University in Biochemistry Cell and Molecular Biology. Her postdoctoral work also at Cornell focused on cell polarity and cytokinesis and was the first to define IQGAP1 as the now widely used secretion marker in cytokinesis. Funded by the National Cancer Institute her laboratory identified a unique signaling pathway that couples cell growth and division and regulates the mTORC1/S6K-Akt axis, and links cancer and metabolic disease
Research in the Osman lab is both basic mechanistic and translational, focused on the mechanisms that govern cell homeostasis and their dysfunction in human disease. These mechanisms are produced by evolutionarily conserved multi-protein complexes involved in decoding, transmitting and executing intrinsic and extrinsic signals, such as nutrients and growth factors, to regulate cell function. Using well-established and new technology the Osman lab investigates signaling networks that underlie the link between cancer and diabetes, and aims at identifying biomarkers and drug targets for personalized medicine.
In addition, Dr. Osman serves as a scientific reviewer for many journals as well as national and international grants agencies, including the DoD, VA and AHA. Working through the American Society for Cell Biology (ASCB) International Affairs Committee and the UNDP she is actively involved in training junior faculty and graduate students internationally, developing pertinent courses in cell and cancer cell biology in developing African countries like Ghana, Tanzania, and Sudan, and in Turkey. She has organized several international conferences and workshops focusing on technology transfer and frontiers in biomedical sciences. Beside book chapters, she has published numerous frequently cited articles in high-impact peer reviewed journals, listing many of her undergraduate students as co-authors.
|Tanos, B. E., Perez Bay, A. E., Salvarezza, S., Vivanco, I., Mellinghoff, I., Osman, M., Sacks, D. B., Rodriguez-Boulan, E. IQGAP1 controls tight junction formation through differential regulation of claudin recruitment. Journal of cell science. 2015; 128 (5) : 853-862.|
|Mahasin A. Osman Regulation of Cytoskeleton Dynamics in Health and Disease: role of molecular switches and rheostats. 2015; : 11-62.|
|Slavica Tudzarova and Mahasin A. Osman The double trouble of metabolic diseases: the diabetes–cancer link. Molecular biology of the cell. 2015; 26 (18) : 3129-3139.|
|Osman MA Role of Signal Dynamics in the Link Between Type 2 Diabetes and Cancer. . Journal of the Pancreas. 2014; 15 (5) : 530.|
|Osman MA, Sarkar FH, Rodriguez-Boulan E A molecular rheostat at the interface of cancer and diabetes.. Biochimica et biophysica acta. 2013; 1836 (1) : 166-76.|
|Osman MA, Bloom GS, Tagoe EA Helicobacter pylori-induced alteration of epithelial cell signaling and polarity: a possible mechanism of gastric carcinoma etiology and disparity.. Cytoskeleton (Hoboken, N.J.). 2013; 70 (7) : 349-59.|
|Osman M An emerging role for IQGAP1 in regulating protein traffic.. TheScientificWorldJournal. 2010; 10 : 944-53.|
Research in the Osman lab is both basic mechanistic and translational, focused on the mechanisms governing cell homeostasis and their dysfunction in human disease. Using well-established and new technology the Osman lab investigates signaling networks that underlie complex diseases, and aims at identifying biomarkers and drug targets.
Three main projects are being pursued to define how a newly identified pathway regulates modulates cell proliferation and apoptosis; links cancer and diabetes and how it mediates infection-generated cancers
Project 1: Pharmaco-genetic analyses of Endocrine-resistant Cancers: Triple negative Breast cancer is a group of heterogeneous mammary gland cancers defined by lack of overexpression of female hormone receptors and Her2. As such TNBC lacks diagnostic biomarkers and therapeutic targets and remains lethal, particularly for women from minority or economically disadvantaged populations. Our research has identified 2 distinct pathways with promise of providing selective markers and drug targets. Because, the same pathways appear to affect prostate cancer; comparative studies are underway to determine efficacy/pathway of identified small molecule regulators on both diseases
Project 2: IQGAP1 Control of cell Proliferation: IQGAP1 is a signaling scaffold protein that acts as a rheostat to modulate apoptosis and cell proliferation and is associated with several human cancers. Our research revealed that different mutants of IQGAP1 promote cell proliferation or apoptosis via different pathways. We are using molecular, cellular and pharmacological assays to elucidate these pathways.
Project 3: The link between cancer and diabetes: It has recently been recognized that Type 2 diabetes predisposes to several types of cancers, including breast cancers. Our lab has identified a possible mechanism that links these two metabolic diseases. This is a collaborative project with colleagues at Augusta Medical College
Project 4: Gastric cancer: We are using a combination of molecular, cellular analyses and patient-derived tissues to define how H.Pylor infection leads to the inception of gastric cancer. This is a collaborative project with the University of Ghana at Legon Department of Biochemistry Cell and Molecular Biology (Emmanuel Tagoe’s Ph.D. thesis in my lab) funded by a grant from the World Bank
2017- The World Bank, Wellcome Trust, African Centres of Excellence (ACE) in Higher Education Project to WACCBIP –PhD thesis research in my lab (Emmanuel Tagoe)
2004- no-cost extension until 2009 CA104285-03: NIH, NCI, (PI) Roles for IQGAP1 in Polarity and Cytokinesis. (~$500,000)
2003-2004 American Cancer Society (PI): Roles for IQGAP1 in cytokinesis and trafficking ($20,000 direct)
2007-2009 American Society for Cell Biology Visiting Professors Awards (PI) Roles for IQGAP1 in ER-Golgi trafficking in epithelial cells ($40,000 direct)
2003-2008 Hunter R. Rawlings III Presidential Research Scholar, Cornell University, (Mentor) awarded for outstanding undergraduate student proposals conducting research in my laboratory ($20,000 direct).
2003-2008 Cornell Tradition Scholarships Program, (Mentor) awarded for outstanding proposals by undergraduate student conducting research in my laboratory.
Scholarly Publications in National Journals (edited non-peer reviewed):
Osman MA and Aktas RG (2014). Diabetes, Cancer, and Their Connection. IAC’s Second Turkey Meeting Addresses Regional Health Concerns. American Society for Cell Biology Newsletter, 37: 18-20.
Osman, M. A. (2012). ASCB Launches Its Turkey Initiative with a Microscopy Course in Istanbul American society for Cell Biology Newsletter 35 (no 10): 24-26.
Osman, M. A. (1996). Basic Science and the Future of Scientific Development in Africa. Cornell University Africa Notes
Osman, M. A. (1999). Biotechnology and Scientific Research in Africa. Cornell University Africa Notes
2014 Frontiers in Medical Sciences: Cancer, Diabetes and their Connection, an ASCB-IAC and Maltepe University conference, Istanbul, Turkey June 6-8, 2014. Designed the conference, recruited the faculty and biotech companies http://fims.maltepe.edu.tr/
2014 Modern Cell Biology in Research and Disease: A training course at the Faculty of Science-Medical School, University of Khartoum (UofK), Sudan (February 2014), organized and taught the course, funded by the United Nation Development Program (UNDP) and the UofK
2012 Fundamentals and Applications of Fluorescence Microscopy (FAFM) in Modern Cell Biology at Koc University, Istanbul, Turkey (http://fafm.ku.edu.tr; August 11-17, 2012). Designed the course material, recruited faculty and biotech companies, selected students, taught and evaluated the course for improvement of this annually ongoing course
2012 Modern Cell Biology in Research and Disease: A training course at the Faculty of Science-Medical School, University of Khartoum (UofK), Sudan (January 16-February 1 2012), organized and taught the course, funded by the United Nation Development Program (UNDP) and the UofK.
2011 Learning and Teaching Modern Cell Biology: a route to successful biomedical research. July 4-15, 2011, College of Health Sciences, Kwame Nkrumah. University of Science and Technology (KNUST), Kumasi, Ghana. Designed and taught three modules composed of lectures, lab-practical, and journal clubs in 1- Membrane Traffic. 2-Regulation of Eukaryotic Gene Expression and 3- Oncogenesis and Tumor Suppressors, Cell Biology and Disease. Funded by Carnegie Foundation under the auspices of the American Society for Cell Biology (ASCB)
2009 International Teaching Faculty in Cell Biology, The Cell Biology of Protozoan Pathogens. First West African Regional Workshop, JULY 13-24, 2009, University of Ghana, Legon, Accra. Funded by Carnegie Foundation and Olympus under the auspices of the ASCB
2008 International Teaching and Organizing Faculty, East African Regional Training workshop. July 2008. Sokoine University of Agriculture, Morogoro, Tanzania. Funded by Carnegie Foundation under the auspices of the ASCB
National and International Service:
University, State, and Other Service:
|Senior Research associate||Cornell University, molecular medicine||2002-2004||Ithaca, NY, USA|
2017 Top Fundraiser, Team Osman Lab, Certificate of Fundraising Excellence, Susan G. Komen, Savannah Race for the Cure, Savannah, GA, April 22nd 2017
2016 Most Inspiring Professor, STEM 360 Award, nominated by undergraduate students, Savannah State University, December 2016,
2016 Travel Award, NIH-NIDDK, Symposium on Ancillary Studies in the CKiD and CRIC (kidney Disease). Arlington, VA, November 3-4
2016 First Place Poster Prize Winner, Savannah State University 6th Annual Research Conference Award Winners for undergraduate research (trainee Cristel Kpegba), April 5th 2016
2015 Travel Award, NIDDK NMRI South Regional Workshop, Tulane University School of Public Health, New Orleans, LA, November 15-17
2014 Certificate of Service Appretiation, Maltepe University School of Medicine, Turkey, Istanbul and The American Society for Cell Biology, for Designing and Organizing the FIMS [Frontiers in Medical Sciences: Diabetes, Cancer and their connections] Conference
2012 Certificate, Koc University School of Medicine, Istanbul, Turkey and The American Society for Cell Biology, for Designing and Organizing the FAFM workshop (http://fafm.ku.edu.tr).
2012 Certificate and Award, United Nation Development Program (UNDP), for designing and teaching "Modern Cell Biology in research and disease" workshop at the University of Khartoum, Sudan
2011 AACR Award, Minority Scholars in Cancer Research. The AACR 102nd Annual Meeting, 2011, Orlando, FL.
2009 First Place Poster Prize winner, Translational Cancer Research, 22nd Annual International Symposium of the Hunter College Center for Study of Gene Structure and Function, Sloan Kettering and Weill Cornell Medical College.
2007 ASCB, Visiting Professors award, Weill Cornell Medical College, NY, was funding research project to study protein trafficking by live imaging.
2007 First Place Prize winner for the best solution of the spectral problem competition in the Analytical and Quantitative Light Microscopy (AQLM) Course, MBL Woods Hole, MA
2004-2009 Grant (CA104285) from the NIH-National Cancer Institute (NCI).
2003-2004 American Cancer Society grant ($20K)
1997-2001 NIH fellowship in Molecular and Cell Biology of Cancer from the National Cancer Institute (NCI)
|Dworkin, Lance||Professor of Medicine|
|Yakirevich, Evgeny||Associate Professor of Pathology and Laboratory Medicine|
Cell Biology lecture and lab
Human Biology lecture and lab
2003- 2009. BIOG 2990 - Introduction to Research Methods in Biology (3-5 credits course).
2006- 2008. BIOG 4990 - Independent Undergraduate Research in Biology (3-9 credits course)
The Cell Biology of Protozoan Pathogens. First West African Regional Workshop, JULY 13-24, 2009, University of Ghana, Accra, Ghana (The American Society for Cell Biology)
East African Regional Training workshop. Cell Biology of Infectious Disease JULY 2008, Sokoine University of Agriculture, Morogoro, Tanzania (The American Society for Cell Biology)
633, 638 Molecular biology course at Cornell university (teaching assistant).
Taught genetics, physiology, anatomy and Biochemistry undergrad courses.