Mahasin Osman received her Ph.D. from Cornell University in Biochemistry Cell and Molecular Biology. Her postdoctoral work also at Cornell focused on cell polarity and cytokinesis and was the first to define IQGAP1 as the now widely used secretion marker in cytokinesis. Funded by the National Cancer Institute her laboratory identified a unique signaling pathway that couples cell growth and division and regulates the mTORC1/S6K-Akt axis, and links cancer and metabolic disease
Research in the Osman lab is both basic mechanistic and translational, focused on the mechanisms that govern cell homeostasis and their dysfunction in human disease. These mechanisms are produced by evolutionarily conserved multi-protein complexes involved in decoding, transmitting and executing intrinsic and extrinsic signals, such as nutrients and growth factors, to regulate cell function. Using well-established and new technology the Osman lab investigates signaling networks that underlie the link between cancer and diabetes, and aims at identifying biomarkers and drug targets for personalized medicine.
In addition, Dr. Osman serves as a scientific reviewer for many journals as well as national and international grants agencies, including the DoD, VA and AHA. Working through the American Society for Cell Biology (ASCB) International Affairs Committee and the UNDP she is actively involved in training junior faculty and graduate students internationally, developing pertinent courses in cell and cancer cell biology in developing African countries like Ghana, Tanzania, and Sudan, and in Turkey. She has organized several international conferences and workshops focusing on technology transfer and frontiers in biomedical sciences. Beside book chapters, she has published numerous frequently cited articles in high-impact peer reviewed journals, listing many of her undergraduate students as co-authors.