Nagib Ahsan, PhD is an Assistant Professor (Research) of Biology and Medicine at the Alpert Medical School of Brown University. Dr. Ahsan also working as a Co-Director of the COBRE, Center for Cancer Research Development (CCRD), Proteomics Core Facility at Rhode Island Hospital. Before joining the Brown faculty in 2015, Dr. Ahsan was a research staff in the Biochemistry Department at University of Missouri. He also closely worked with many international pharmaceutical and agro-based food companies where he was a Study Director in multiple food allergen projects.
Dr. Ahsan obtained his PhD from Kyungpook National University, South Korea in 2007. He subsequently completed a postdoctoral fellowship in National Agriculture and Food Research Organization, Japan.
Dr. Ahsan has extensive experience in the field of discovery proteomics, quantitative proteomics, post-translational modifications of proteins and targeted proteomics using AQUA-MRM technology. His particular interest in all aspects of the application of mass spectrometry based characterization of proteins and peptides from any biological samples. He has authored over 35 peer-reviewed publications on the topic and is on the editorial board of two international journals.
| Ahsan N, Wilson RS, Rao RSP, Salvato F, Sabila M, Ullah H, Miernyk JA. "Mass Spectrometry-Based Identification of Phospho-Tyr in Plant Proteomics." Journal of Proteome Research, 2020. |
| Scrimgeour, Laura A., Potz, Brittany A., Aboul Gheit, Ahmad, Shi, Guangbin, Stanley, Melissa, Zhang, Zhiqi, Sodha, Neel R., Ahsan, Nagib, Abid, M. Ruhul, Sellke, Frank W. "Extracellular Vesicles Promote Arteriogenesis in Chronically Ischemic Myocardium in the Setting of Metabolic Syndrome." Journal of the American Heart Association, vol. 8, no. 15, 2019, pp. e012617. |
| Curtis, Marion, Kenny, Hilary A., Ashcroft, Bradley, Mukherjee, Abir, Johnson, Alyssa, Zhang, Yilin, Helou, Ynes, Batlle, Raquel, Liu, Xiaojing, Gutierrez, Nuria, Gao, Xia, Yamada, S. Diane, Lastra, Ricardo, Montag, Anthony, Ahsan, Nagib, Locasale, Jason W., Salomon, Arthur R., Nebreda, Angel R., Lengyel, Ernst. "Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis." Cell Metabolism, 2019. |
| Lu H, Tang X, Sibley M, Coburn J, Rao RSP, Ahsan N, Ramratnam B. "Impact of exosomal HIV-1 Tat expression on the human cellular proteome." Oncotarget, vol. 10, no. 54, 2019, pp. 5632-5644. |
| Shaheen N, Halima O, Akhter KT, Nuzhat N, Rao RSP, Wilson RS, Ahsan N. "Proteomic characterization of low molecular weight allergens and putative allergen proteins in lentil (Lens culinaris) cultivars of Bangladesh." Food chemistry, vol. 297, 2019, pp. 124936. |
| Al-Mohanna T, Ahsan N, Bokros NT, Dimlioglu G, Reddy KR, Shankle M, Popescu GV, Popescu SC. "Proteomics and Proteogenomics Analysis of Sweetpotato ( Ipomoea batatas) Leaf and Root." Journal of Proteome Research, 2019. |
| James NE, Cantillo E, Yano N, Chichester CO, DiSilvestro PA, Hovanesian V, Rao RSP, Kim KK, Moore RG, Ahsan N, Ribeiro JR. "Septin-2 is overexpressed in epithelial ovarian cancer and mediates proliferation via regulation of cellular metabolic proteins." Oncotarget, vol. 10, no. 31, 2019, pp. 2959-2972. |
| Ahsan N, Wilson RS, Thelen JJ. "Absolute Quantitation of Plant Proteins." Current Protocols in Plant Biology, vol. 3, no. 1, 2018, pp. 1-13. |
| Chorzalska A, Morgan J, Ahsan N, Treaba DO, Olszewski AJ, Petersen M, Kingston N, Cheng Y, Lombardo K, Schorl C, Yu X, Zini R, Pacilli A, Tepper A, Coburn J, Hryniewicz-Jankowska A, Zhao TC, Oancea E, Reagan JL, Liang O, Kotula L, Quesenberry PJ, Gruppuso PA, Manfredini R, Vannucchi AM, Dubielecka PM. "Bone marrow-specific loss of <i>ABI1</i> induces myeloproliferative neoplasm with features resembling human myelofibrosis." Blood, vol. 132, no. 19, 2018, pp. 2053-2066. |
| Lo, Wan-Lin, Shah, Neel H., Ahsan, Nagib, Horkova, Veronika, Stepanek, Ondrej, Salomon, Arthur R., Kuriyan, John, Weiss, Arthur. "Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT." Nature Immunology, 2018. |
| Chorzalska A, Ahsan N, Rao RSP, Roder K, Yu X, Morgan J, Tepper A, Hines S, Zhang P, Treaba DO, Zhao TC, Olszewski AJ, Reagan JL, Liang O, Gruppuso PA, Dubielecka PM. "Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK-ERK and NF-κB pathways in a model of chronic myeloid leukemia." Molecular oncology, vol. 12, no. 5, 2018, pp. 630-647. |
| Oehlenschlæger CB, Gersby LBA, Ahsan N, Pedersen JT, Kristensen A, Solakova TV, Thelen JJ, Fuglsang AT. "Activation of the LRR Receptor-Like Kinase PSY1R Requires Transphosphorylation of Residues in the Activation Loop." Frontiers in Plant Science, vol. 8, 2017, pp. 2005. |
| Ahsan N, Chen M, Salvato F, Wilson RS, Shyama Prasad Rao R, Thelen JJ. "Comparative proteomic analysis provides insight into the biological role of protein phosphatase inhibitor-2 from Arabidopsis." Journal of Proteomics, 2017. |
| Dongqin Chen, Yangrong Cao, Hong Li, Daewon Kim, Nagib Ahsan, Jay Thelen, Gary Stacey. "Extracellular ATP elicits DORN1-mediated RBOHD phosphorylation to regulate stomatal aperture." Nature Communications, 2017. |
| Chen D, Cao Y, Li H, Kim D, Ahsan N, Thelen J, Stacey G. "Extracellular ATP elicits DORN1-mediated RBOHD phosphorylation to regulate stomatal aperture." Nature Communications, vol. 8, no. 1, 2017, pp. 2265. |
| Ahsan N, Belmont J, Chen Z, Clifton JG, Salomon AR. "Highly reproducible improved label-free quantitative analysis of cellular phosphoproteome by optimization of LC-MS/MS gradient and analytical column construction." Journal of Proteomics, vol. 165, 2017, pp. 69-74. |
| Chorzalska A, Kim JF, Roder K, Tepper A, Ahsan N, Rao RSP, Olszewski AJ, Yu X, Terentyev D, Morgan J, Treaba DO, Zhao TC, Liang O, Gruppuso PA, Dubielecka PM. "Long-term exposure to imatinib mesylate downregulates Hippo pathway and activates YAP in a model of chronic myelogenous leukemia." Stem Cells and Development, vol. 26, no. 9, 2017, pp. 656-677. |
| Adeola O. Adebayo Michael, Nagib Ahsan, Valerie Zabala, Heather Francois-Vaughan, Stephanie Post, Kate E. Brilliant, Arthur R. Salomon, Jennifer A. Sanders, Philip A. Gruppuso. "Proteomic analysis of laser capture microdissected focal lesions in a rat model of progenitor marker-positive hepatocellular carcinoma." Oncotarget, vol. 8, no. 16, 2017, pp. 26041-26056. |
| Nagib Ahsan and Arthur R. Salomon. "Quantitative Phosphoproteomic Analysis of T-Cell Receptor Signaling." The Immune Synapse: Methods and Protocols, Methods in Molecular Biology, edited by Cosima T. Baldari and Michael L. Dustin, Springer Science+Business Media LLC 2017, 2017, pp. 369-382. |
| Zhiyong Li, Yao Wang, Jian Huang, Nagib Ahsan, Gabriel Biener, Joel Paprocki, Jay J. Thelen, Valerica Raicu, and Dazhong Zhao. "Two SERK receptor-like kinases interact with the receptor-like kinase EMS1 in Anther Cell Fate Determination." PLANT PHYSIOLOGY, vol. 173, no. 1, 2017, pp. 326-337. |
| Ahsan, Nagib, Rao, R. Shyama Prasad, Gruppuso, Philip A., Ramratnam, Bharat, Salomon, Arthur R. "Targeted proteomics: Current status and future perspectives for quantification of food allergens." Journal of Proteomics, vol. 143, 2016, pp. 15-23. |
| Brauer, Elizabeth Kalinda, Ahsan, Nagib, Dale, Renee, Kato, Naohiro, Coluccio, Alison E, Piñeros, Miguel A, Kochian, Leon Vincent, Thelen, Jay J., Popescu, Sorina C. "The Raf-like kinase ILK1 and the high affinity K+ transporter HAK5 are required for Innate Immunity and Abiotic Stress Response." PLANT PHYSIOLOGY, vol. 171, no. 2, 2016, pp. pp.00035.2016. |
| Swatek, Kirby N., Wilson, Rashaun S., Ahsan, Nagib, Tritz, Rebecca L., Thelen, Jay J. "Multisite phosphorylation of 14-3-3 proteins by calcium-dependent protein kinases." Biochem. J., vol. 459, no. 1, 2014, pp. 15-25. |
| Ahsan N, Stevenson SE. "Proteomic mapping for legume nodule organogenesis." PROTEOMICS, vol. 14, no. 2-3, 2014, pp. 153-154. |
| Ahsan, Nagib, Huang, Yadong, Tovar-Mendez, Alejandro, Swatek, Kirby N., Zhang, Jingfen, Miernyk, Ján A., Xu, Dong, Thelen, Jay J. "A Versatile Mass Spectrometry-Based Method to Both Identify Kinase Client-Relationships and Characterize Signaling Network Topology." Journal of Proteome Research, vol. 12, no. 2, 2013, pp. 937-948. |
| Ahsan N, Swatek KN, Zhang J, Miernyk JA, Xu D, Thelen JJ. "Scanning mutagenesis" of the amino acid sequences flanking phosphorylation site 1 of the mitochondrial pyruvate dehydrogenase complex." Frontiers in Plant Science, vol. 3, 2012. |
| Ahsan, Nagib, Lee, Dong-Gi, Kim, Kyung-Hee, Alam, Iftekhar, Lee, Sang-Hoon, Lee, Ki-Won, Lee, Hyoshin, Lee, Byung-Hyun. "Analysis of arsenic stress-induced differentially expressed proteins in rice leaves by two-dimensional gel electrophoresis coupled with mass spectrometry." Chemosphere, vol. 78, no. 3, 2010, pp. 224-231. |
| Ahsan, Nagib, Nakamura, Takuji, Komatsu, Setsuko. "Differential responses of microsomal proteins and metabolites in two contrasting cadmium (Cd)-accumulating soybean cultivars under Cd stress." Amino Acids, vol. 42, no. 1, 2010, pp. 317-327. |
| Ahsan, Nagib, Nanjo, Yohei, Sawada, Hiroko, Kohno, Yoshihisa, Komatsu, Setsuko. "Ozone stress-induced proteomic changes in leaf total soluble and chloroplast proteins of soybean reveal that carbon allocation is involved in adaptation in the early developmental stage." PROTEOMICS, vol. 10, no. 14, 2010, pp. 2605-2619. |
| Hashiguchi, Akiko, Ahsan, Nagib, Komatsu, Setsuko. "Proteomics application of crops in the context of climatic changes." Food Research International, vol. 43, no. 7, 2010, pp. 1803-1813. |
| Ahsan, Nagib, Donnart, Tifenn, Nouri, Mohammad-Zaman, Komatsu, Setsuko. "Tissue-Specific Defense and Thermo-Adaptive Mechanisms of Soybean Seedlings under Heat Stress Revealed by Proteomic Approach." Journal of Proteome Research, vol. 9, no. 8, 2010, pp. 4189-4204. |
| Lee, Dong-Gi, Ahsan, Nagib, Lee, Sang-Hoon, Lee, Jeung Joo, Bahk, Jeong Dong, Kang, Kyu Young, Lee, Byung-Hyun. "Chilling stress-induced proteomic changes in rice roots." Journal of Plant Physiology, vol. 166, no. 1, 2009, pp. 1-11. |
| Ahsan, Nagib, Komatsu, Setsuko. "Comparative analyses of the proteomes of leaves and flowers at various stages of development reveal organ-specific functional differentiation of proteins in soybean." PROTEOMICS, vol. 9, no. 21, 2009, pp. 4889-4907. |
| Afroz, Amber, Khan, Muhammad Rashid, Ahsan, Nagib, Komatsu, Setsuko. "Comparative proteomic analysis of bacterial wilt susceptible and resistant tomato cultivars." Peptides, vol. 30, no. 9, 2009, pp. 1600-1607. |
| Razavizadeh, Roya, Ehsanpour, Ali Akbar, Ahsan, Nagib, Komatsu, Setsuko. "Proteome analysis of tobacco leaves under salt stress." Peptides, vol. 30, no. 9, 2009, pp. 1651-1659. |
| Ahsan, Nagib, Renaut, Jenny, Komatsu, Setsuko. "Recent developments in the application of proteomics to the analysis of plant responses to heavy metals." PROTEOMICS, vol. 9, no. 10, 2009, pp. 2602-2621. |
| Komatsu, Setsuko, Ahsan, Nagib. "Soybean proteomics and its application to functional analysis." Journal of Proteomics, vol. 72, no. 3, 2009, pp. 325-336. |
| Renaut, Jenny, Bohler, Sacha, Hausman, Jean-François, Hoffmann, Lucien, Sergeant, Kjell, Ahsan, Nagib, Jolivet, Yves, Dizengremel, Pierre. "The impact of atmospheric composition on plants: A case study of ozone and poplar." Mass Spectrom. Rev., vol. 28, no. 3, 2009, pp. 495-516. |
| Ahsan, Nagib, Lee, Dong-Gi, Alam, Iftekhar, Kim, Pil Joo, Lee, Jeung Joo, Ahn, Young-Ock, Kwak, Sang-Soo, Lee, In-Jung, Bahk, Jeong Dong, Kang, Kyu Young, Renaut, Jenny, Komatsu, Setsuko, Lee, Byung-Hyun. "Comparative proteomic study of arsenic-induced differentially expressed proteins in rice roots reveals glutathione plays a central role during As stress." PROTEOMICS, vol. 8, no. 17, 2008, pp. 3561-3576. |
| Ahsan, Nagib, Lee, Dong-Gi, Lee, Ki-Won, Alam, Iftekhar, Lee, Sang-Hoon, Bahk, Jeong Dong, Lee, Byung-Hyun. "Glyphosate-induced oxidative stress in rice leaves revealed by proteomic approach." Plant Physiology and Biochemistry, vol. 46, no. 12, 2008, pp. 1062-1070. |
| Ahsan N, Lee DG, Lee SH, Kang KY, Bahk JD, Choi MS, Lee IJ, Renaut J, Lee BH. "A comparative proteomic analysis of tomato leaves in response to waterlogging stress." Physiologia plantarum, vol. 131, no. 4, 2007, pp. 555-70. |
| Lee DG, Ahsan N, Lee SH, Kang KY, Bahk JD, Lee IJ, Lee BH. "A proteomic approach in analyzing heat-responsive proteins in rice leaves." PROTEOMICS, vol. 7, no. 18, 2007, pp. 3369-83. |
| Lee DG, Ahsan N, Lee SH, Kang KY, Lee JJ, Lee BH. "An approach to identify cold-induced low-abundant proteins in rice leaf." Comptes Rendus Biologies, vol. 330, no. 3, 2007, pp. 215-25. |
| Ahsan N, Lee DG, Lee SH, Kang KY, Lee JJ, Kim PJ, Yoon HS, Kim JS, Lee BH. "Excess copper induced physiological and proteomic changes in germinating rice seeds." Chemosphere, vol. 67, no. 6, 2007, pp. 1182-93. |
| Ahsan N, Lee SH, Lee DG, Lee H, Lee SW, Bahk JD, Lee BH. "Physiological and protein profiles alternation of germinating rice seedlings exposed to acute cadmium toxicity." Comptes Rendus Biologies, vol. 330, no. 10, 2007, pp. 735-46. |
| Lee SH, Ahsan N, Lee KW, Kim DH, Lee DG, Kwak SS, Kwon SY, Kim TH, Lee BH. "Simultaneous overexpression of both CuZn superoxide dismutase and ascorbate peroxidase in transgenic tall fescue plants confers increased tolerance to a wide range of abiotic stresses." Journal of Plant Physiology, vol. 164, no. 12, 2007, pp. 1626-38. |
| Alam MF, Khan MR, Nuruzzaman M, Parvez S, Swaraz AM, Alam I, Ahsan N. "Genetic basis of heterosis and inbreeding depression in rice (Oryza sativa L.)." Journal of Zhejiang University. Science, vol. 5, no. 4, 2004, pp. 406-11. |
| Year | Degree | Institution |
|---|---|---|
| 2007 | PhD | Kyungpook National University |
| 2001 | BSc | Rajshahi University |
1. Achieved Brain Korea Project 21 (BK21) Post Doctoral Fellowship, by Gyeongsang National University, Jinju, South Korea, 2007
2. Achieved Japan Society for the Promotion Science (JSPS) Post Doctoral Fellowship, by Japan Society for the Promotion Science, 2008
3. Awarded by American Chemical Society publication as potential Contributor, 2010
4. Awarded by American Chemical Society publication as potential Contributor, 2013
| Name | Title |
|---|---|
| Abid, Ruhul | Associate Professor of Surgery (Research) |
| Dubielecka-Szczerba, Patrycja | Associate Professor of Medicine |
| El-Deiry, Wafik | Mencoff Family University Professor of Medical Science, Professor of Pathology and Laboratory Medicine |
| Gruppuso, Philip | Professor of Pediatrics, Professor of Medical Science, Professor of Molecular Biology, Cell Biology and Biochemistry (Research) |
| Jayasuriya, Chathuraka | Assistant Professor of Orthopaedics |
| Ramratnam, Bharat | Associate Professor of Medicine |
| Salomon, Arthur | Professor of Molecular Biology, Cell Biology, and Biochemistry, Professor of Chemistry |
| Yajima, Mamiko | Assistant Professor of Molecular Biology, Cell Biology and Biochemistry (Research) |
| Yang, Wentian | Associate Professor of Orthopaedics, Associate Professor of Medicine |
