Martinez-Moreno M, O'Shea TM, Zepecki JP, Olaru A, Ness JK, Langer R, Tapinos NRegulation of Peripheral Myelination through Transcriptional Buffering of Egr2 by an Antisense Long Non-coding RNA..
Cell Reports. 2017; 20 (8) : 1950-1963.
Pujato M, Kieken F, Skiles AA, Tapinos N, Fiser APrediction of DNA binding motifs from 3D models of transcription factors; identifying TLX3 regulated genes..
Nucleic acids research. 2014; 42 (22) : 13500-12.
Tapinos N, Rambukkana AInsights into regulation of human Schwann cell proliferation by Erk1/2 via a MEK-independent and p56Lck-dependent pathway from leprosy bacilli..
Proceedings of the National Academy of Sciences. 2005; 102 (26) : 9188-93.
Rambukkana A, Zanazzi G, Tapinos N, Salzer JLContact-dependent demyelination by Mycobacterium leprae in the absence of immune cells..
Science. 2002; 296 (5569) : 927-31.
In the Molecular Neuroscience & Neurooncology Lab we employ multidisciplinary approaches and outside-the-box thinking to discover mechanisms that regulate myelination, plasticity, cellular motility and oncogenic transformation of glial cells.
Our work in Molecular Neuro-oncology is focused on the following:
Modeling of human glioma stem cell migration – role of glioma cell pseudopodia
Novel glioma therapies: Methods to attract and trap migrating glioma cells
Development of 3D human brain macrotissues harboring patient derived glioblastomas
RNA epigenetics of human Glioma Stem Cells:
Role of m6A RNA methylation in the regulation of the functional glioma stem cell proteome.
Role of antisense RNA in the oncogenic transformation of neural stem cells – origin of cancer in the brain.
Richard and Edna Salomon Distinguished Professor of Molecular Biology, Cell Biology, and Biochemistry, Assistant Professor of Molecular Biology, Cell Biology and Biochemistry, Assistant Professor of Neurology
