I started my career as a Med. Lab Tech and microbiologist. I accomplished my bachelor's and master’s graduation in Microbiology at the Department of Microbiology, Bharathidasan University, India. I pursued my Ph. D on the Inhibitory effects of piperine compound on Helicobacter pylori and its effects on gastric cancer. Then I moved to the Rhode Island Hospital, U.S.A for my Post-Doctoral studies with Prof. Eleftherios Mylanokis, where I am actively involved in research projects and engaged in teaching research to undergrad students.
My primary interests are Novel antibiotic molecules against ESKAPE pathogens and gastric cancer-inducing pathogen- H. pylori. I am involved in repurposing clinical and novel synthesized molecules to combat bacterial pathogens.
Currently working as a
1. Research Scientist in infectious disease
2. Instructor of Medicine in Research at Alpert Medical School of Brown University.
3. Associate Editor in a. Frontiers in Microbiology- Antimicrobials; b. Frontiers in Antibiotics- Antibiotic development section
Mayakrishnan, Vijayakumar, Kannappan, Priya, Tharmalingam, Nagendran, Bose, Rajendran J C, Madheswaran, Thiagarajan, Ramasamy, Mohankandhasamy. "Bacterial cancer therapy: A turning point for new paradigms." Drug Discovery Today, 2022. |
Possamai Rossatto, Fernanda Cristina, Tharmalingam, Nagendran, Escobar, Iliana E., d’Azevedo, Pedro Alves, Zimmer, Karine Rigon, Mylonakis, Eleftherios. "Antifungal Activity of the Phenolic Compounds Ellagic Acid (EA) and Caffeic Acid Phenethyl Ester (CAPE) against Drug-Resistant Candida auris." Journal of Fungi, vol. 7, no. 9, 2021, pp. 763. |
Karthikeyan, Chandrasekaran, Tharmalingam, Nagendran, Varaprasad, Kokkarachedu, Mylonakis, Eleftherios, Yallapu, Murali M. "Biocidal and biocompatible hybrid nanomaterials from biomolecule chitosan, alginate and ZnO." Carbohydrate Polymers, vol. 274, 2021, pp. 118646. |
Chandrasekaran, Ramya, Madheswaran, Thiagarajan, Tharmalingam, Nagendran, Bose, Rajendran JC, Park, Hansoo, Ha, Don-Hyung. "Labeling and tracking cells with gold nanoparticles." Drug Discovery Today, vol. 26, no. 1, 2021, pp. 94-105. |
Bose, Rajendran, Tharmalingam, Nagendran, Choi, Yonghyun, Madheswaran, Thiagarajan, Paulmurugan, Ramasamy, McCarthy, Jason, Lee, Soo-Hong, Park, Hansoo. "<p>Combating Intracellular Pathogens with Nanohybrid-Facilitated Antibiotic Delivery</p>." International Journal of Nanomedicine, vol. Volume 15, 2020, pp. 8437-8449. |
Khader, Rajamohammed, Tharmalingam, Nagendran, Mishra, Biswajit, Felix, LewisOscar, Ausubel, Frederick M., Kelso, Michael J., Mylonakis, Eleftherios. "Characterization of Five Novel Anti-MRSA Compounds Identified Using a Whole-Animal Caenorhabditis elegans/Galleria mellonella Sequential-Screening Approach." Antibiotics, vol. 9, no. 8, 2020, pp. 449. |
Khan, Amir Afzal, Ali, Asad, Tharmalingam, Nagendran, Mylonakis, Eleftherios, Zahra, Rabaab. "First report of mecC gene in clinical methicillin resistant S. aureus (MRSA) from tertiary care hospital Islamabad, Pakistan." Journal of Infection and Public Health, vol. 13, no. 10, 2020, pp. 1501-1507. |
Jing, Jane Lee Jia, Pei Yi, Thong, Bose, Rajendran J. C., McCarthy, Jason R., Tharmalingam, Nagendran, Madheswaran, Thiagarajan. "Hand Sanitizers: A Review on Formulation Aspects, Adverse Effects, and Regulations." International Journal of Environmental Research and Public Health, vol. 17, no. 9, 2020, pp. 3326. |
Bose, Rajendran J. C., Tharmalingam, Nagendran, Garcia Marques, Fernando J., Sukumar, Uday Kumar, Natarajan, Arutselvan, Zeng, Yitian, Robinson, Elise, Bermudez, Abel, Chang, Edwin, Habte, Frezghi, Pitteri, Sharon J., McCarthy, Jason R., Gambhir, Sanjiv S., Massoud, Tarik F., Mylonakis, Eleftherios, Paulmurugan, Ramasamy. "Reconstructed Apoptotic Bodies as Targeted “Nano Decoys” to Treat Intracellular Bacterial Infections within Macrophages and Cancer Cells." ACS Nano, vol. 14, no. 5, 2020, pp. 5818-5835. |
Kim, Sa-Hyun, Woo, Hyun Jun, Lee, Min Ho, Park, Min, Nagendran, Tharmalingam, Rhee, Ki-Jong, Lee, Dongsup, Jin, Yeung-Bae, Choi, Sik-Won, Seo, Woo Duck, Kim, Jong Bae. "Antimicrobial effects of black rice extract on Helicobacter pylori infection in Mongolian gerbil." Journal of Cereal Science, vol. 85, 2019, pp. 1-5. |
Tharmalingam N, Ribeiro NQ, da Silva DL, Naik MT, Cruz LI, Kim W, Shen S, Dos Santos JD, Ezikovich K, D'Agata EM, Mylonakis E, Fuchs BB. "Auranofin is an effective agent against clinical isolates of Staphylococcus aureus." Future Medicinal Chemistry, vol. 11, no. 12, 2019, pp. 1417-1425. |
Liu, Hanyang, Shukla, Shashank, Vera-González, Noel, Tharmalingam, Nagendran, Mylonakis, Eleftherios, Fuchs, Beth Burgwyn, Shukla, Anita. "Auranofin Releasing Antibacterial and Antibiofilm Polyurethane Intravascular Catheter Coatings." Frontiers in Cellular and Infection Microbiology, vol. 9, 2019, pp. 37. |
Rajasekar, Sakthidevi, Krishna, T. P. Adarsh, Tharmalingam, Nagendran, Andivelu, Ilangovan, Mylonakis, Eleftherios. "Metal-Free C-H Thiomethylation of Quinones Using Iodine and DMSO and Study of Antibacterial Activity." ChemistrySelect, vol. 4, no. 8, 2019, pp. 2281-2287. |
Tharmalingam, Nagendran, Khader, Rajamohammed, Fuchs, Beth Burgwyn, Mylonakis, Eleftherios. "The Anti-virulence Efficacy of 4-(1,3-Dimethyl-2,3-Dihydro-1H-Benzimidazol-2-yl)Phenol Against Methicillin-Resistant Staphylococcus aureus." Frontiers in Microbiology, vol. 10, 2019. |
Cruz, Lana, Lopes, Larissa, de Camargo Ribeiro, Felipe, de Sá, Nívea, Lino, Cleudiomar, Tharmalingam, Nagendran, de Oliveira, Renata, Rosa, Carlos, Mylonakis, Eleftherios, Fuchs, Beth, Johann, Susana. "Anti-Candida albicans Activity of Thiazolylhydrazone Derivatives in Invertebrate and Murine Models." Journal of Fungi, vol. 4, no. 4, 2018, pp. 134. |
Tharmalingam N, Rajmuthiah R, Kim W, Fuchs BB, Jeyamani E, Kelso MJ, Mylonakis E. "Antibacterial Properties of Four Novel Hit Compounds from a Methicillin-Resistant Staphylococcus aureus–Caenorhabditis elegans High-Throughput Screen." Microbial Drug Resistance, vol. 24, no. 5, 2018, pp. 666-674. |
Zheng Z, Liu Q, Kim W, Tharmalingam N, Fuchs BB, Mylonakis E. "Antimicrobial activity of 1,3,4-oxadiazole derivatives against planktonic cells and biofilm of Staphylococcus aureus." Future Medicinal Chemistry, vol. 10, no. 3, 2018, pp. 283-296. |
Tharmalingam, Nagendran. "Need To Act Hastily against the Gastric Cancer Pathogen Helicobacter Pylori." Journal of Ancient Diseases & Preventive Remedies, vol. 06, no. 01, 2018. |
Tharmalingam, Nagendran, Port, Jenna, Castillo, Dawilmer, Mylonakis, Eleftherios. "Repurposing the anthelmintic drug niclosamide to combat Helicobacter pylori." Scientific Reports, vol. 8, no. 1, 2018. |
Fuchs, Beth Burgwyn, Tharmalingam, Nagendran, Mylonakis, Eleftherios. "Vulnerability of long-term care facility residents to Clostridium difficile infection due to microbiome disruptions." Future Microbiology, vol. 13, no. 13, 2018, pp. 1537-1547. |
Tharmalingam N, Jayamani E, Rajamuthiah R, Castillo D, Fuchs BB, Kelso MJ, Mylonakis E. "Activity of a novel protonophore against methicillin-resistant Staphylococcus aureus." Future Medicinal Chemistry, vol. 9, no. 12, 2017, pp. 1401-1411. |
Jayamani, Elamparithi, Tharmalingam, Nagendran, Rajamuthiah, Rajmohan, Coleman, Jeffrey J., Kim, Wooseong, Okoli, Ikechukwu, Hernandez, Ana M., Lee, Kiho, Nau, Gerard J., Ausubel, Frederick M., Mylonakis, Eleftherios. "Characterization of a Francisella tularensis-Caenorhabditis elegans Pathosystem for the Evaluation of Therapeutic Compounds." Antimicrobial Agents and Chemotherapy, vol. 61, no. 9, 2017. |
Kim, Sa-Hyun, Lee, Min Ho, Park, Min, Woo, Hyun Jun, Kim, Yoon Suk, Tharmalingam, Nagendran, Seo, Woo-Duck, Kim, Jong-Bae. "Regulatory Effects of Black Rice Extract on Helicobacter pylori Infection-Induced Apoptosis." Molecular Nutrition & Food Research, vol. 62, no. 3, 2017, pp. 1700586. |
Gwisai, Tinotenda, Hollingsworth, Nisha Rosita, Cowles, Sarah, Tharmalingam, Nagendran, Mylonakis, Eleftherios, Fuchs, Beth Burgwyn, Shukla, Anita. "Repurposing niclosamide as a versatile antimicrobial surface coating against device-associated, hospital-acquired bacterial infections." Biomedical Materials, vol. 12, no. 4, 2017, pp. 045010. |
Zheng, Zhaojun, Tharmalingam, Nagendran, Liu, Qingzhong, Jayamani, Elamparithi, Kim, Wooseong, Fuchs, Beth Burgwyn, Zhang, Rijun, Vilcinskas, Andreas, Mylonakis, Eleftherios. "Synergistic Efficacy of Aedes aegypti Antimicrobial Peptide Cecropin A2 and Tetracycline against Pseudomonas aeruginosa." Antimicrobial Agents and Chemotherapy, vol. 61, no. 7, 2017. |
Lee MH, Cho Y, Kim DH, Woo HJ, Yang JY, Kwon HJ, Yeon MJ, Park M, Kim SH, Moon C, Tharmalingam N, Kim TU, Kim JB. "Menadione induces G2/M arrest in gastric cancer cells by down-regulation of CDC25C and proteasome mediated degradation of CDK1 and cyclin B1." American journal of translational research, vol. 8, no. 12, 2016, pp. 5246-5255. |
Tharmalingam N, Park M, Lee MH, Woo HJ, Kim HW, Yang JY, Rhee KJ, Kim JB. "Piperine treatment suppresses Helicobacter pylori toxin entry in to gastric epithelium and minimizes β-catenin mediated oncogenesis and IL-8 secretion in vitro." American journal of translational research, vol. 8, no. 2, 2016, pp. 885-98. |
Tharmalingam, Nagendran, Kim, Sa-Hyun, Park, Min, Woo, Hyun Jun, Kim, Hyun Woo, Yang, Ji Yeong, Rhee, Ki-Jong, Kim, Jong Bae. "Inhibitory effect of piperine on Helicobacter pylori growth and adhesion to gastric adenocarcinoma cells." Infectious Agents and Cancer, vol. 9, no. 1, 2014. |
Kim, Sa-Hyun, Park, Min, Woo, Hyunjun, Tharmalingam, Nagendran, Lee, Gyusang, Rhee, Ki-Jong, Eom, Yong Bin, Han, Sang Ik, Seo, Woo Duck, Kim, Jong Bae. "Inhibitory Effects of Anthocyanins on Secretion of Helicobacter pylori CagA and VacA Toxins." International Journal of Medical Sciences, vol. 9, no. 10, 2012, pp. 838-842. |
"Microbiologically influenced corrosion on rails." current science, 2010. |
Associate Editor. Serving as an associate editor in Frontiers in Microbiology (#1 most-cited journal in the world (field-microbiology); Impact Factor 5.6)- Antimicrobials section since 04/2022
Editorial Experience.
Guest-Editor in MDPI-Molecules (IF-4.1); Topic- “Potential Application of Small Molecules in Molecular Medicine”
Guest-editor in MDPI-Molecules (IF-4.1); Topic- "Bioactive Molecules for Biodegradation and Antimicrobials"
Guest Associate Editor in Frontiers in Microbiology (IF 5.6); Topic- "Therapeutics targeting intracellular bacteria."
Editorial Board member – Severing as an Editorial Board member of Recent Advances in Anti-Infective Drug Discovery, MDPI- Antibiotics and as an Editor of Journal of Infectious Diseases and Preventive Medicine, Journal of Antimicrobial agents.
Volunteering in research.
Peer-Reviewed 150 + manuscripts, notably in Frontiers of Microbiology (IF-5.6), Journal of Antimicrobial chemotherapy (IF-5.6), Journal of Medical Microbiology (IF-3.6), International Journal of Biological Macromolecules (IF-6.6), Journal of Applied Microbiology (IF-3.2), and other international journals.
Poster judge. I Served as one of the Judges in a poster session at the 25th Boston Bacterial Meeting held at Harvard University on June 6, 2019.
Research Associate | Rhode Island Hospital, infectious diseases | 2020-2022 | |
Post Doctoral Research Associate | Rhode Island Hospital, medicine | 2015-2020 | Rhode Island |
Research Scientist. 2022- |
Quality Control- Microbiologist. 2010-2011 |
Med. Lab Tech. 2003-2006 |