Peter Damian Richardson Professor Emeritus of Engineering and Physiology

Professor Richardson was elected a Fellow of the Royal Society in 1986, and was awarded the Jung Prize in Medicine in 1987. He was a recipient of the Alexander von Humboldt Senior Scientist Prize in 1976. He is a Founding Fellow of the American Institute for medical and Biological Engineering, A Fellow of the City & Guilds of London Institute, and of the American Society of Mechanical Engineers, Inaugural Fellow of the Biomedical Engineering Society, Honorary Fellow of the Royal College of Physicians (London),Member of the American Society for Artificial Internal Organs, American Society for Engineering Education, Honorary Member of the British Atherosclerosis Society, and other professional societies. He has authored a book (with M. Steiner) entitled, "Principles of Cell Adhesion" (CRC Press, 1995). An alumnus of the Imperial College of Science, Technology and Medicine of the University of London, he was appointed Professor of Engineering and Physiology in 1984.

Brown Affiliations

Research Areas

scholarly work

Liew S, Man A, Parente J, Samaroo H, Stoner I, Richardson PD. Adhesion and rouleau formation of red cells in a shear flow. Proc 33rd NorthEast Bioengineering Conf, IEEE, 179-180, 2007

Richardson PD. "Mechanical properties of atherosclerotic tissues", Proceedings of International Union of Theoretical and Applied Mechanics (IUTAM) Symposium, Graz: publ. in Mechanics of Biological Tissue, Holtzapfel GA, Ogden RW, eds. Springer, pp. 207-223, 2006

Guo D, Richardson P. "Detection of cardiac cycle from intercoronary ultrasound", Ultrasound in Medicine and Biology 32: 345-356, March 2006

Richardson PD, Pivkin IV, Karniadakis GE, Laidlaw DH. Blood flow at arterial branches: Complexities to resolve for the angioplasty suite. Alexandrov VN, van Albada GD, Sloot PMA, Dogarra J (eds.) Computational Science - ICCS 2006, Part III, Lecture Notes in Computer Science 3993, 538-545, Springer-Verlag Berlin Heidelberg 2006

Richardson PD, Tsuyuki GT. Approximate analysis for conjugate heat transfer in solids under steady convection. Proc. Internat. Heat Transfer Conf-13, Sydney Australia, Contrib Paper FCV-15, Aug 2006

Pivkin IV, Richardson PD, Karniadakis G. Blood flow velocity effects and role of activation delay time on growth and form of platelet thrombi. Proc. Natl. Acad. Sci. U.S. 103(46): 17164-17169, November 14, 2006

Richardson PD. "The artificial lung facility at Brown: More than a dozen years with Pierre Galletti." ASAIO J 51(2): 165-172, March/Apl 2005.

Pivkin IV, Richardson PD, Laidlaw DH, Karniadakis GE. "Combined effects of pulsatile flow and dynamic curvature on wall shear stress in a coronary artery bifurcation model." J Biomechanics 38: 1283-1290, June 2005

Forsberg A, Laidlaw D, Sobel JS, Zelenik R, Keefe D, Richardson PD,Karniadakis GE, Pivkin I. "Particle flurries: A case study of synoptic 3D pulsatile flow visualization." (Feature Article) IEEE Computer Graphics and Applications 24(2): 76-85, March-Apl 2004

Richardson PD. "Elliptic delamination as an early stage in atherosclerotic plaque evolution: Fluid mechanical aspects." Biorheology 40: 417-421, 2003.

Richardson PD, Participant in and Contributor to "The Recent History of Platelets in Thrombosis and Other Disorders" Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, 25 November 2003: edited by L.A. Reynolds and E.M. Tansey,publ. by Wellcome Trust Centre for the History of Medicine, Aug 2005 ISBN 0-85484-103-2

Richardson PD. "Biomechanics of plaque rupture:progress, problems and new frontiers." Ann Biomed Engng 30: 524-536, 2002

Sobel JA, Forsberg A, Richardson PD, Laidlaw DH, Keefe DF, Pivkin I, Karniadakis GE. "Arterial flows seen in virtual reality." Biomedical Engineering: Recent Developments, Vossoughi J (ed). Proceedings 21st Southern Biomedical Engineering Conference, Sept 2002, pp.349-350. Biomed Res Foundation, Olney MD, 2002. ISBN 1-930636-01-6

Davies MJ, Treasure T, Richardson PD. "The pathogenesis of spontaneous arterial dissection." Heart 75: 434-435, 1996.

A sampling of earlier papers, 1996-1980:

Richardson PD. "Critical stresses in critical arteries", Challenges in Medicine - Symposium aus Anlass des 100. Geburstages von Ernst Jung, pp. 110-116, eds W. Siegenthaler und R. Haas, Publicationen der Jung-Stiftung fur Wissenschaft und Forschung, Georg Thieme, Stuttgart, 1996.

Davies MJ, Richardson PD, Woolf N, Katz DR, Mann J. "Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content" Brit Heart Jl 69:377-381, 1993

Lendon CL, Davies MJ, Richardson PD, Born GVR. "Testing of small connective tissue specimens for the determination of the mechanical behavior of atherosclerotic plaques" Jl Biomed Engng 15: 27-33, 1993

Burleigh MC, Briggs AD, Lendon CL, Davies MJ, Born GVR, Richardson PD. "Collagen types I and III, collagen content, GAGs and mechanical strength of human atherosclerotic plaque caps: span-wise variations" Atherosclerosis 96: 71-81, 1992

Lendon C, Born GVR, Davies MJ, Richardson PD. "Plaque fissure - the link between atherosclerosis and thrombosis" Nouv. Rev. Fr. Hematol. 34: 27-29, 1992

Lendon CL, Davies MJ, Born GVR, Richardson PD. "Atherosclerotic plaque caps are locally weakened when macrophage density is increased" Atherosclerosis, vol. 87, 87-90, 1991.

De Feyter PJ, Serrys PW, Davies MJ, Richardson P, Lubsen J, Oliver MF. "Quantitative coronary angiography to measure progression and regression of coronary atherosclerosis. Value, limitations and implications for clinical trials", Circulation 84: 412-423, 1991.

Richardson PD, Davies MJ, Born GVR. "Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques" The Lancet,ii, 941-944, October 21, 1989.

Richardson PD, Christo J. "Flow separation opposite a side branch" Proceedings 2nd Internat. Symposium on Biofluid Mechanics and Biorheology, June 25-28, 1989, Munich, W. Germany; Biofluid Mechanics: Blood Flow in Large Vessels, D. Liepsch (ed), pp. 275-283, Springer-Verlag, Munich, 1990.

Jandak J, Steiner M, Richardson PD. "Alpha-tocopherol, an effective inhibitor of platelet adhesion." Blood, vol.73, 141-149, Jan. 1989.

Richardson PD, Parhizgar A, Sasken HF, Chiu T-H, Aebischer P, Trudell LA, Galletti PM. "Tissue characterization by micromechanical testing of growths around bioresorbable implants" Progress in Artificial Organs-1985, Y. Nose, C. Kjellstrand and P. Ivanovich, Editors, pp. 1015-1019, ISAO Press, Cleveland, 1986.

Peterka JA, Richardson PD. "Effects of sound on local transport from a heated cylinder" Int. J. Heat Mass Trans 27: 1511-1523, 1984

Regnier CH, Kolsky H, Richardson PD, Ghoniem GM, Susset JG. "The elastic behavior of the urinary bladder" J. Biomechanics 16: 915-922, 1983

Galletti PM, Richardson PD, Trudell LA. "Oscillating blood flow enhances membrane plasmaphoresis" Trans Amer. Soc. Artif. Internal Organs 29: 279-282, 1983

Dario P, Richardson PD, Galletti PM. "Monitoring of prosthetic vascular grafts using piezoelectric polymer sensors" Trans. Amer. Soc. Artif. Internal Organs 29: 318-322, 1983

Richardson PD, Lazzara S. "Human blood oscillating axially in a tube" Biorheology 20: 317-326, 1983

Richardson PD, Kane RL, Aggarwal K. "Effects of drugs on adhesion of human platelets" Trans. Amer. Soc. Artif. Internal Organs 27: 203-207, 1981

Born GVR, Richardson PD. "Activation time of blood platelets" J. Membrane Biology 57: 87-90, 1980

Galletti PM, Richardson PD, Trudell LA, Panol G, Tanishita K, Accinelli D. "Development of an implantable booster lung" Trans. Amer. Soc. Artif. Internal Organs 26:573-576, 1980

Schmid-Schonbein H, Born GVR, Richardson PD, Rohling-Winkel J, Blasberg P, Cusack N, Wehmeyer A, Jungling E. "ADP release from cells subjected to high shear stresses" Chap 15 in Basic Aspects of Blood Trauma (H. Schmid-Schonbein and P. Teitel, eds) pp.322-340, Martinus Nijhoff, The Hague, 1979

de Vahl Davis G, Richardson PD. "Natural convection in a sound field giving large streaming Reynolds numbers" Int Jl Heat Mass Trans 16: 1245-1265, 1973

Galletti PM, Richardson PD, Snider MT, Friedman LI. "A standardized method for defining the overall in vivo performance of blood oxygenators" Amer Soc Artif Internal Organs 18: 359-368, 1972

Richardson PD, Snider MT, Galletti PM. "Oxygen transfer to blood in membrane lungs: correlation with and prediction from in vitro measurements" Amer Soc Artif Internal Organs 17: 323-329, 1971

Richardson PD. "Heat transfer from a circular cylinder by acoustic streaming" J. Fluid Mech 30: 337-355, 1967

Richardson PD. "Effects of sound and vibrations on heat transfer" Appl. Mechanics Rev. 20: 201-217, 1967

Richardson PD, Saunders OA. Studies of flow and heat transfer associated with a rotating disc. J. Mech. Engng. Sci. 5:336-342, 1963

research overview

Professor Richardson has biomedical engineering research interests with five main themes: adhesion, aggregation and disintegration of cells and cell groups, with applications in thrombosis and hemostasis; artificial organs, especially those designed for transport purposes such as artificial lungs and hybrid artificial pancreases; applications of ultrasound in detection and diagnosis, including intravascular usage, and corresponding image analysis; interaction of flow and blood vessel walls, especially for problems associated with atherosclerosis; design of devices and instruments with biomedical applications (where his research has led to patents).

research statement

Professor Richardson has biomedical engineering research interests with five main themes: adhesion, aggregation and disintegration of cells and cell groups, with applications in thrombosis and hemostasis artificial organs, especially those designed for transport purposes such as artificial lungs and hybrid artificial pancreases applications of ultrasound in detection and diagnosis, including intravascular usage, and corresponding image analysis interaction of flow and blood vessel walls, especially for problems associated with atherosclerosis design of devices and instruments with biomedical applications (where his research has led to patents). One current project illustrating a combination of the third and fourth themes is a study of the left anterior descending epicardial arteries in pigs which have been fed atherogenic diets, making comparisons between video-rate intravascular ultrasound images at various mean blood pressures (using image-analysis software custom-written at Brown), mechanical measurements of tissue obtained immediately at post-mortem, and histology of the vessel sections, with relevance to improvement of coronary angioplasty. Another current project involves computer-modeling of flow of thousands of blood platelets as they join a developing thrombus, under various conditions of flow, and incorporating time-varying physiological responses of the individual platelets. Professor Richardson also has engineering research interests which are not primarily biomedical, these having two main themes: (a) effects of oscillations, pulsations, sound and vibrations on flow fields, and corresponding heat and mass transfer (b) flows at branches of tubes and ducts, including cases where the flows are oscillatory or pulsatile

funded research

Sources of past research funding include:
US Air Force -
studies of heat transfer by convection, and especially the influence of sound and vibrations in free and forced convection, with both theory and experiment
NASA -
including very early computational studies on radiative transport on lunar surfaces with effects of cracks and powdery surfaces
National Science Foundation -
including separated flows, turbulence, and effects of high-intensity sound fields ... more recently, unsteady flows in branched tubes/arteries, thrombus formation, computer-based scientific visualization of flows
National Institutes of Health -
many years of experimental and theoretical studies of artificial organs, including membrane lungs and modalities for their acute and long-term use, hybrid artificial pancreas, permanent and bioresorbable vascular grafts, platelet adhesion, thrombus formation, implantable lungs, diagnostic ultrasound
industrial sources

Research funding handled external to Brown:
British Heart Foundation -
including the relation of atherosclerotic plaque pathology and rupture to lumenal pressure, tissue mechanical behavior, cellular and soft-tissue properties and behavior - the 'vulnerable plaque'
Ernst Jung Foundation

Current Support handled through Brown includes:

National Science Foundation, "Computational simulation, modeling, and visualization for understanding unsteady bioflows", $650,000, award period 10/1/04-9/30/09 - faculty colleagues Laidlaw, Karniadakis, Swartz

National Science Foundation, "A stochastic moecular dynamics method for multiscale modeling of blood platelet phenomena", $669,765, award period 7/1/05-6/30/08 - faculty colleagues Maxey, Karniadakis