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Satyan Kalkunte Instructor in Pediatrics (Research)

A focus of Dr. Kalkunte's research in collaboration with Dr. Sharma has been to develop in vitro and animal models for preeclampsia, understand mechanisms for target development, and to screen potential molecules that can prevent the onset of disease. Using patient's serum as a "blueprint", Dr. Kalkunte has established novel in vitro and in vivo models for preeclampsia. Using proteomic approaches to identify causative factors in serum, Dr. Kalkunte's work has contributed to identification of dysregulated transthyretin that suggest that preeclampsia is likely disorder of protein misfolding and amyloidogenic aggregates. In addition, Dr. Kalkunte's work has contributed to the understanding of the role of hCG, Tregs, heme, angiogenesis, and complement factors in preeclampsia. His complementary work on enviormental toxicants in preterm birth and polyhydramnios is well appreciated. Together, his long-term goal is to propel translational therapeutics and diagnostic tools from bench to bedside and pursue developmental origins of chronic disease.

Research Areas

scholarly work

Kalkunte S, Neubeck S, Norris W, Kostadinov S, Hoang DV, Ahmed A, Shaikh Z, Padbury JP, Berg G, Olofsson A, Markert U, Sharma S. Transthyretin is dysregulated in preeclampsia and its native form prevents the onset of disease in mice. Am. J.Pathol. 2013;. doi: 10.1016/j.ajpath.2013.07.022

Lai Z, Kalkunte S, Sharma S. A critical role of IL-10 in limiting hypoxia-induced preeclampsia-like disease in mice. Hypertension. 57(3),505-14, 2011.

Kalkunte S, Norris W, Friedman J, Lai Z, Kurtis K, Lim K, Boij R, Padbury J, Matthiesen L, Sharma S. Sera from preeclampsia patients elicits symptoms of human disease in mice and provides a basis for an in vitro predictive assay. Am J Pathol 177, 2387-2398, 2010

Tewari N, Kalkunte S, Murray DM, Sharma S. The water channel aquaporin 1 is a novel molecular target of polychlorinated biphenyls for in utero anomalies. J Biol Chem 284 (22),15224-32, 2009

Saulnier Sholler GL, Brard L, Straub JA, Dorf L, Illeyne S, Koto K, Kalkunte S, Bosenberg M, Ashikaga T, Nishi R.Nifurtimox induces apoptosis of neuroblastoma cells in vitro and in vivo.J Pediatr Hematol Oncol. ;31(3):187-93,2009

Kalkunte S, Mselle TF, Norris WE, Wira CR, Sentman CL, Sharma S. VEGF C facilitates immune tolerance and endovascular activity of human uterine NK cells at the maternal-fetal interface. J Immunol 182 (7), 4085-92, 2009

Kalkunte S, Lai Z, Tewari N, Chichester CO, Romero R, Padbury J, Sharma S. In-vitro and in-vivo evidence for lack of endovascular remodeling by third trimester trophoblasts. Placenta. 29, 871-878, 2008

Kalkunte S, Singh AP, Chaves FC et al. Antidepressant and anti-stress activity of GC-MS characterized lipophillic extracts of Ginkgo biloba leaves. Phytother Res. 21(11), 1061-65, 2007

Lange TS, Singh RK, Kim KK, Zou Y, Kalkunte SS, Sholler GL, Swamy N, Brard L.Anti-proliferative and pro-apoptotic properties of 3-bromoacetoxy calcidiol in high-risk neuroblastoma.Chem Biol Drug Des.;70(4):302-10, 2007

Saulnier Sholler GL, Kalkunte S, Greenlaw C, McCarten K, Forman E Antitumor activity of nifurtimox observed in a patient with neuroblastoma.J Pediatr Hematol Oncol. 28(10):693-5, 2006

Satyan KS, Swamy N, Dizon DS, Singh R, Granai CO, Brard L.Phenethyl isothiocyanate (PEITC) inhibits growth of ovarian cancer cells by inducing apoptosis: role of caspase and MAPK activation. Gynecol Oncol. 103(1):261-70,2006

Kalkunte S, Brard L, Granai CO, Swamy N. Inhibition of angiogenesis by vitamin D-binding protein: characterization of anti-endothelial activity of DBP-maf.Angiogenesis. 8(4):349-60,2005

Satyan KS, Jaiswal AK, Ghosal S, Bhattacharya SK. Anxiolytic activity of Ginkgolic Acid – conjugates from Indian Ginkgo biloba Linn.Psychopharmacology, 136 (2), 148-152, 1998

Bhattacharya SK, Satyan KS, Ramanathan M.Experimental methods for evaluation of psychotropic agents in rodents: II-Antidepressants.Indian J Exp Biol. 37(2):117-23,1999. Review

Satyan KS, Jaiswal AK, Ghosal S, Bhattacharya SK. Effect of Ginkgolic acid conjugates on the brain monoamines and metabolites in rats. Biogenic Amines 13(2), 143–151, 1997

Bhattacharya SK, Satyan KS.Experimental methods for evaluation of psychotropic agents in rodents: I--Anti-anxiety agents.Indian J Exp Biol. 35(6):565-75, 1997.Review

Bhattacharya SK, Satyan KS, Ghosal S.Antioxidant activity of glycowithanolides from Withania somnifera.Indian J Exp Biol. 35(3):236-9,1997

Bhattacharya SK, Satyan KS, Chakrabarti A.Anxiogenic action of caffeine: an experimental study in rats.J Psychopharmacol. 11(3):219-24, 1997

Jaiswal AK, Upadhyay SN, Satyan KS,Bhattacharya SK. Behavioral effects of prenatal and postnatal under nutrition in rats. Ind J Exp Biol 34, 1216–1219, 1996

Satyan KS, Rai A, Jaiswal AK, Acharya SB, Bhattacharya SK. Isatin, a putative anxiogenic endocoid, induces memory dysfunction in rats.Ind J Exp Biol. 33(8):576-9,1995

research overview

A focus of Dr. Kalkunte's research has been to develop in vitro and animal models for preeclampsia, understand mechanisms for target development, and to screen potential molecules that can prevent the onset of disease. His recent work suggests that preeclampsia is a disorder of protein misfolding and amyloidogenic aggregates. Apart from translational therapeutics and diagnostics, his long-term research interest is to understand factors influencing the developmental origins of chronic disease

funded research

NIH-National Center for Research Resources (5P20RR018728-10) & National Institute of General Medical Sciences (8 P20 GM103537-10)-PI: James Padbury
Lead Investigator Pilot Project I: Satyan Kalkunte, COBRE for Perinatal Biology
Period: 08/01/2011-07/31/13
The major goals of this project is to develop in vivo models of preeclampsia, understand the interplay of angiogenesis, apoptosis, and immunology at the maternal-fetal interface that can lead to identification of causative biomarkers and potential targets. This would further help develop strategies for new therapeutic interventions by defining how several of these events impact fetal and newborn development.