Principal Investigator: Surendra Sharma 15%
Polymorphisms in IL-10 Locus Predispose to Preterm Birth
Period: 09/01/2002-08/31/2007 $257,000/yr
The major goal of this project is to investigate the etiology of
Preterm births with a focus on the incidence in African American population.
These studies will focus on the immunogenetic role of IL-10 in this pregnancy disorder.
Principal Investigator: Jack Nassau (S. Sharma, Women & Infants Principal Investigator) 10%
Stress and Immunity in Pediatric Asthma
Period: 07/01/2002-06/30/2005 $260,000/yr
The major goal of this project is to investigate the effect of stress on the immune
function in pediatric asthma patients.
1 P20 RR018728-01
Principal Investigator: James Padbury (S. Sharma, Deputy Director) 5%
American Diabetes Association
Principal Investigator: Surendra Sharma 10%
Immune Programming of Gestational Diabetes (1-04-TLG-14)
Period: 01/01/2004-12/31/2007 $100,000/yr
The major goals of this project are to examine the mutually inclusive roles of
placental development, IL-10, and glucose in normal and GDM pregnancy providing
insights into the immune and cytokine programming of GDM.
Co-Investigator: Surendra Sharma 10%
Research on Scope & Causes of Stillbirth in the United States
Period: 09/26/2003-09/25/2008 $846,000
The major goals of the proposal are to establish a tissue bank for stillbirth deliveries
and to study the pathogenesis of stillbirth.
N0-1HD-2-3342, Sub-contract WSU05056, Perinatology Branch, NICHD, NIH and Detroit
PI: Surendra Sharma
Effect of Ascending Infections on BirthA Mouse Model
Period: 09/01/2005-08/31/2007 $79,000/year
This project focuses on establishing a mouse model to study the role of ascending
infections in the female genital tract on the incidence of preterm birth.
COBRE for Perinatal Biology
Period: 10/01/2003-09/30/2008 $1,570,000/yr
The major goals of this project are to increase our understanding of cardiopulmonary
development, immune programming of pregnancy, and help to develop strategies
for new therapeutic interventions by defining how several of these events impact
fetal and newborn development.
NIEHS Superfund Projects
Project Leader: Surendra Sharma
State-based Approach to Complex Exposures (PI: Kim Boekelhiede)
Sub Project: Genetic Stress and Toxicant-Induced Pregnancy Disruption
Period: 01/01/2005-12/31/2014 $219,592/yr
This project focuses on the influence of environmental toxicants on pregnancy
outcome in mice genetically disrupted at cytokine loci.