I am currently serving as director of molecular imaging in the department of diagnostic imaging at RIH. I have been involved in the field of Image-guided Thermal Ablation (IGTA) for treatment of solid tumors. I have recently discovered and developed materials known as Thermal Accelerants that augment microwave energy from a distance normally unattainable by a single applicator: the source of microwave energy. Performance of this novel material is very effective in ablation sculpting, and expected to reduce the local tumor recurrence.
My research interest has been treating cancer by either non- or minimally invasive methods using microwave, radiofrequency, laser, and ultrasound as an energy source.
I am a medicinal chemist by training and have over 20 years of academic and pharmaceutical R&D experience that encompasses from a small molecule drug design to drug delivery.
William K. C. Park, David R. Mills, Sierin Lim, Barindra Sana, Victoria E. Frank, Brendan M. Kenyon, Grayson L. Baird, Kate E. Brilliant, Edward G. Walsh, Damian E. Dupuy
A Ferritin-Based Nanoconjugate MRI Contrast Agent Targeting Necl-5 as a Tumor Specific Marker: A Potential Thermal Accelerant for Microwave Ablation.
2017; : 100660H-1-9.
William K. C. Park, Aaron W P Maxwell; Victoria E. Frank, Michael P. Primmer, Scott A. Collins, Damian E. Dupuy
A Novel Thermal Accelerant for Augmentation of Microwave Energy during Image-guided Tumor Ablation.
2017; : 1006602-9.
|William Keun Chan Park; Aaron Wilhelm Palmer Maxwell; Victoria Elizabeth Frank; Michael Patrick Primmer; Scott Andrew Collins; Grayson Luderman Baird; Damian Edward Dupuy Evaluation of A Novel Thermal Accelerant (TA) for Augmentation of Microwave Energy during Image-guided Tumor Ablation.. Theranostics. 2017; 7 (4) : 1026-1035.|
|Edward G. Walsh, David R. Mills, Sierin Lim, Barindra Sana, Kate E. Brilliant, William K.C. Park MRI Contrast Demonstration Of Antigen Specific-Targeting With An Iron-Based Ferritin Construct. Journal of Nanoparticle Research. 2013; 15 (1)|
|Park WK, Kennedy RM, Larsen SD, Miller S, Roth BD, Song Y, Steinbaugh BA, Sun K, Tait BD, Kowala MC, Trivedi BK, Auerbach B, Askew V, Dillon L, Hanselman JC, Lin Z, Lu GH, Robertson A, Sekerke C Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors.. Bioorganic & Medicinal Chemistry Letters. 2008; 18 (3) : 1151-6.|
|Jeffrey A. Pfefferkorn, Chulho Choi, Scott D. Larsen, Bruce Auerbach, Richard Hutchings, William Park, Valerie Askew, Lisa Dillon, Jeffrey C. Hanselman, Zhiwu Lin, Gina H. Lu, Andrew Robertson, Catherine Sekerke, Melissa S. Harris, Alexander Pavlovsky, Graeme Bainbridge, Nicole Caspers, Mark Kowala, and Bradley D. Tait Pyrazoles as Hepatoselective HMG-CoA Reductase Inhibitors: Discovery of (3R,5R)-7-[2-(4-Fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic Acid (PF-3052334) as a Candidate for the Treatment of Hypercholesterolemia. Journal of Medicinal Chemistry. 2008; 51 : 31.|
|Pfefferkorn JA, Choi C, Larsen SD, Auerbach B, Hutchings R, Park W, Askew V, Dillon L, Hanselman JC, Lin Z, Lu GH, Robertson A, Sekerke C, Harris MS, Pavlovsky A, Bainbridge G, Caspers N, Kowala M, Tait BD Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia.. Journal of medicinal chemistry. 2008; 51 (1) : 31-45.|
|Kimmich RD, Park WK Chemical libraries towards protein kinase inhibitors.. Combinatorial chemistry & high throughput screening. 2003; 6 (7) : 661-72.|
|Tsai CY, Park WK, Weitz-Schmidt G, Ernst B, Wong CH Synthesis of sialyl Lewis X mimetics using the Ugi four-component reaction.. Bioorganic & Medicinal Chemistry Letters. 1998; 8 (17) : 2333-8.|
Roy, Rene; Park, William, K. C.; Zanini, Diana; Foxall, Carrol; Srivastava, Om P.
Dendritic 3'-sulfo-LewisX-(Glc) as potent L- and E-selectin antagonists.
Carbohydrate Letters. 1997; 2 (4) : 259-266.
|Park, William K. C.; Auer, Manfred; Jaksche, Herbert; Wong, Chi-Huey Rapid Combinatorial Synthesis of Amino Glycoside Antibiotic Mimetics: Use of a Polyethylene Glycol-Linked Amine and a Neamine-Derived Aldehyde in Multiple Component Condensation as a Strategy for the Discovery of New Inhibitors of the HIV RNA Rev Responsive Element. Journal of the American Chemical Society. 1996; 118 (42) : 10150-10155.|
Park, W. K. C.; Meunier, S. J.; Zanini, D.; Roy, R.
Chemoselective deprotection of thioacetates with hydrazinium acetate.
Carbohydrate Letters. 1995; 1 (3) : 179-184.
Zanini, D.; Park, W. K. C.; Meunier, S. J.; Wu, Q.; Aravind, S.; Kratzer, B.; Roy, R.
Syntheses and biological properties of glycodendrimers. .
Polymeric Materials Science and Engineering. 1995; 73 : 82-3.
|Roy, Rene; Park, William K. C.; Wu, Qingquan; Wang, Sho-Nong Synthesis of hyper-branched dendritic lactosides. Tetrahedron Letters. 1995; 36 (25) : 4377-80.|
|Zanini, Diana; Park, William K. C.; Roy, Rene Synthesis of novel dendritic glycosides. Tetrahedron Letters. 1995; 36 (41) : 7383-6.|
|Aravind, Sivasubramanian; Park, William K. C.;Brochu, Stephane; Roy, Rene Single step syntheses of lactosylated clusters by telomerizations. Tetrahedron Letters. 1994; 35 (42) : 7739-7742.|
|Tarkka, Richard M.; Park, William K. C.; Liu, Ping; Buncel, Erwin; Hoz, Shmaryahu. Solvent independent transition-state structures. Part III. Sulfonyl transfer reactions. . Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry . 1994; 12 : 2439-2444.|
|Park WK, Aravind S, Romanowska A, Renaud J, Roy R Syntheses of clustered lactosides by telomerization.. Methods in enzymology. 1994; 242 : 294-304.|
|Gordon, Robert D.; Park, William K. C. The 353-nm 1nπ* transition of 4H-pyran-4-one and a deuterated derivative. Canadian Journal of Chemistry. 1993; 71 (10) : 1672-1675.|
Rhode Island Hostpital, Lifespan
|Director of Molecular Imaging/ Research Associate. 2011-2017|