Yen-Tsung HuangAssistant Professor of Epidemiology, Assistant Professor of Biostatistics
Dr. Huang is an Assistant Professor of Epidemiology and Biostatistics at Brown University. Dr. Huang earned a Doctor of Medicine degree from the National Taiwan University, Taiwan. Dr. Huang went to Harvard University for Master of Public Health in quantitative methods and Master of Science in biostatistics. Dr. Huang earned dual degree in Doctor of Science in Epidemiology and Biostatistics at Harvard in 2012. His research experience and goals focus on cancer genomics, statistical genetics, high-dimensional mediation analyses and genetic/molecular epidemiology of cancer.
YT Huang†, T Cai and E Kim. Integrative Genomic Testing of Cancer Survival Using Semiparametric Linear Transformation Models. Statistics in Medicine, accepted
YT Huang† and T Cai. Mediation Analysis for Survival Data using Semiparametric Probit Models. Biometrics 2016, published online, DOI: 10.1111/biom.12445
YT Huang† and WC Pan. Hypothesis Test of Mediation Effect in Causal Mediation Model with High-dimensional Continuous Mediators. Biometrics 2015, published online, DOI: 10.1111/biom.12421
YT Huang, L Liang, W Cookson, M Moffatt and X Lin. iGWAS: Integrative Genome-Wide Association Studies Using Mediation Analysis. Genetic Epidemiology 2015; 39: 347-356.
YT Huang†. Integrative Modeling of Multi-Platform Genomic Data under the Framework of Mediation Analysis. Statistics in Medicine 2015; 34: 162-178.
YT Huang†, T Hsu and DC Christiani. TEGS-CN: A Statistical Method for Pathway Analysis of Genome-Wide Copy Number Profile. Cancer Informatics 2014; Suppl 4:15-23.
YT Huang†. Integrative Modeling of Multi-Platform Genomic Data from Different Types of Genetic Association Studies. Biostatistics 2014; 15:587-602.
YT Huang†, TJ VanderWeele and X Lin. Joint Analysis of SNP and Gene Expression Data in Genetic Association Studies of Complex Diseases. Annals of Applied Statistics 2014; 8:352-376
YT Huang and X Lin. Gene Set Analyses Using Variance Component Tests. BMC Bioinformatics 2013; 14:210.
Genomics and molecular epidemiology
J Liu, HI Yang, MH Lee, CL Jen, HH Hu, SN Liu, LY Wang, SL You, YT Huang† and CJ Chen†. Alcohol Drinking Mediates the Association between Polymorphisms of ADH1B and ALDH2 and Hepatitis B related Hepatocellular Carcinoma. Cancer Epidemiology Biomarkers and Prevention, accepted
YT Huang, S Chu, E Loucks, CL Lin, C Eaton, S Buka and KT Kelsey. Epigenome-wide Profiling of DNA Methylation in Paired Samples of Adipose Tissue and Blood. Epigenetics, accepted
YT Huang†, JR Freeman, HI Yang, J Liu, MH Lee and CJ Chen. Mediation of Hepatitis B and C on Mortality. European Journal of Epidemiology, in press, DOI: 10.1007/s10654-016-0118-x
WC Pan, CD Wu, MJ Chen, YT Huang, CJ Chen, HJ Su and HI Yang. Fine Particle Pollution, Alanine Transaminase, and Liver Cancer: A Taiwanese Prospective Cohort Study (REVEAL-HBV). Journal of the National Cancer Institute, 2016; 108: djv341.
YT Huang†, HI Yang, J Liu, MH Lee, JR Freeman and CJ Chen†. Mediation Analysis of Hepatitis B and C in Relation to Hepatocellular Carcinoma Risk. Epidemiology 2016; 27: 14-20.
KP Chung, HT Chang, SC Lo, LY Chang, SY Lin, Cheng A, YT Huang, CC Chen, MR Lee, YJ Chen, HH Hou, CL Hsu, JS Jerng, CC Ho, MT Huang, CJ Yu and PC Yang. Severe Lymphopenia is Associated with Elevated Plasma Interleukin-15 Levels and Increased Mortality during Severe Sepsis. Shock 2015; 43: 569-575.
YT Huang*, JZJ Maccani*, N Hawley, R Wing, KT Kelsey and J McCaffrey. Epigenetics Patterns in Successful Weight Loss Maintainers: A Pilot Study. International Journal of Obesity 2015; 39: 865-868.
Y Song, YT Huang, Y Song, AL Hevener, K Ryckman, L Qi, ES LeBlanc, R Kazlauskaite, K Brennan, S Liu. Biological Mediations of the Effect of Low Birth Weight on Risk of Type 2 Diabetes in a Prospective Study of Multiethnic Women in the US. Diabetologia 2015; 58: 1220-1230.
YT Huang†, T Hsu, KT Kelsey and CL Lin. Integrative Analysis of microRNA, Gene Expression and Survival of Glioblastoma Multiforme. Genetic Epidemiology 2015; 39: 134-143.
Z Wang, S Choi, J Lee, SH Kim, YT Huang, F Chen, Y Zhao, X Lin, D Neuberg, J Kim and DC Christiani. Mitochondrial Variations in Non-Small Cell Lung Cancer Survival. Cancer Informatics 2015; 14 (Suppl 1): 1-9.
YC Hsu, HJ Ho, YT Huang, HH Wang, MS Wu, JT Lin and CY Wu. Association between Antiviral Treatment and Extrahepatic Outcomes in Patients with Hepatitis C Virus Infection. Gut 2015; 64: 495-503.
KH Chan, YT Huang, Q Meng, C Wu, A Reiner, EM Sobel, L Tinker, AJ Lusis, X Yang and S Liu. Shared Molecular Pathways and Gene Networks for Cardiovascular Disease and Type 2 Diabetes in Women Across Diverse Ethnicities. Circulation: Cardiovascular Genetics 2014; 7: 911-919.
A Smithǂ, YT Huang, M Eliot, EA Houseman, CJ Marsit, JK Wiencke and KT Kelsey. A Novel Approach to the Discovery of Survival Markers in Glioma Using a Joint Analysis of DNA Methylation and Gene Expression. Epigenetics 2014; 9:873-883. (ǂadvisee)
YC Hsu, JT Lin, HJ Ho, YH Kao, YT Huang, NW Hsiao, MS Wu, YY Liu, CY Wu. Antiviral Treatment for Hepatitis C Virus Infection Is Associated with Improved Renal and Cardiovascular Outcomes in Diabetic Patients. Hepatology 2014; 59:1293-1302.
KP Chung, YT Huang, YL Chang, CJ Yu, CH Yang, YC Chang, JY Shih, and PC Yang. Clinical Significance of TTF-1 in Advanced Lung Adenocarcinoma under EGFR Tyrosine Kinase Inhibitor Treatment.Chest 2012; 141:420-428.
YT Huang, X Lin, Y Liu, R McGovern, LR Chirieac, JC Wain, RS Heist, V Skaug, S Zienolddiny, A Haugen, L Su, EA Fox, KK Wong, and DC Christiani. Cigarette Smoking Increases Copy Number Alterations in Non-Small Cell Lung Cancer.Proceedings of the National Academy of Sciences 2011; 108:16345-16350.
YT Huang*, CL Jen*, HI Yang, MH Lee, J Su, SN Lu, UH Iloeje, and CJ Chen. Lifetime Risk and Gender Difference of Hepatocellular Carcinoma among Patients Affected with Chronic Hepatitis B and C.Journal of Clinical Oncology 2011; 29:3643-3650.
YT Huang, X Lin, LR Chirieac, R McGovern, JC Wain, RS Heist, V Skaug, S Zienolddiny, A Haugen, L Su, and DC Christiani. Impact on Disease Development, Genomic Location and Biological Function of Copy Number Alterations in Non-Small Cell Lung Cancer.PLoS One 2011; 6:e22961.
YT Huang, RS Heist, LR Chirieac, X Lin, V Skaug, S Zienolddiny, A Haugen, MC Wu, Z Wang, L Su, K Asomaning and DC Christiani. Genome-wide Analysis of Survival in Early Stage Non-Small Cell Lung Cancer.Journal of Clinical Oncology 2009; 27:2660-2667.
LM Sholl, AJ Iafrate, YP Chou, MT Wu, YG Goan, L Su, YT Huang, DC Christiani and LR Chirieac Validation of Chromogenic in situ Hybridization for Detection of EGFR Copy Number Amplification in Non-Small Cell Lung Carcinoma. Modern Pathology 2007; 20:1028-1035.
TL Pan, S Goto, R Lord, YC Huang, CM Huang, PW Wang, YC Lin, S Kawamoto, K Ono, PC Liao, CL Lin, CY Lai, HL Chang, CH Lan, TH Lee, YC Wang, ML Wu, B Jawan, YF Cheng, ST Chen, and CL Chen Proteome Analysis in Liver Transplantation. Transplant Proceedings 2001; 33:156.
Collaborative projects and others
CL Lin, AJ Taggart, KH Lim, Ferraris L, Cygan KJ, Creton RJ, YT Huang and WG Fairbrother. RNA Structure Replaces the Need for U2AF65 in Splicing. Genome Research, accepted
LX Qin and YT Huang. Sequencing Platform Modeling and Analysis (guest editorial). Cancer Informatics 2015; 14 (Suppl1): 55-56.
LX Qin, S Ma, YT Huang, H Zhang and H Cai. Array Platform Modeling and Analysis (guest editorial). Cancer Informatics 2014; 13 (Suppl 4): 91-93.
PL Kuo, H Lee, MA Bray, NA Geisse, YT Huang, WJ Adams, SP Sheehy and KK Parker. Myocyte Shape Regulates Lateral Registry of Sarcomeres and Contractility. American Journal of Pathology 2012; 181:2030-2037.
KP Chung, HT Chang, YT Huang, CH Liao, CC Ho, YS Chen, JS Jerng and CJ Yu. Central Venous Oxygen Saturation under Non-protocolized Resuscitation Is Not Related to Survival in Severe Sepsis or Septic Shock. Shock 2012; 38:584-591.
CL Lin, YT Huang and J Richter. Transient CPEB Dimerization and Translational Control. RNA 2012; 18:1050-1061.
I Alexandrov, M Ivshina, D Jung, R Friedline, H Ko, M Xu, B O'Sullivan-Murphy, R Bortell, YT Huang, F Urano, J Kim and J Richter. Cytoplasmic Polyadenylation Binding Protein Deficiency Stimulates PTEN and Stat3 mRNA Translation and Induces Hepatic Insulin Resistance. PLoS Genetics 2012; 8:e1002457.
YT Huang. Analysis of High-throughput Genomic Data: Methods and Applications, ScD Dissertation 2012, Harvard University.
(†corresponding author; *equal contribution)
Yen-Tsung Huang, MD, MPH, SM, ScD is an epidemiologist and statistical geneticist whose research is to build and employ a systematic approach to study cancer genomics by incorporating new biologic discoveries into statistical methodology. Genetic markers can now be easily collected on a genome-wide scale, yet remarkably little is known about how to integrate different genomic data in a knowledge-based way. Such a challenge necessitates the combination of hypothesis-driven and hypothesis-generating research. His solid training in medicine, epidemiology and statistics provides a rich foundation to develop new methods and discoveries in this challenging and exciting area.
Dr. Huang's research program has methodological, biologic and public health relevance. He develops and employs novel statistical methodologies to investigate the genetic etiology of complex diseases such as lung cancer, liver cancer and asthma and to elucidate how multiple genetic and environmental factors interact in disease causation. Although genome-wide association studies (GWAS) have become a popular approach to assess single nucleotide polymorphism (SNP) associated with complex diseases in human, they have not fully explored gene-environment and gene-gene interactions; they have not leveraged existing genomic annotation from diverse publicly-available knowledge bases; and most have not considered other 'omics measures, such as gene expression and DNA methylation data. Moreover, most of these limitations do not stem from limitations in high-throughput technology or basic biological knowledge but from the lack of statistical methodology. High-throughput data depend heavily on statistical analyses, but without new methodology, scientific questions are not optimally answered with existing statistical models. So, rather than compromising the scientific question to be answerable with existing statistical models, Dr. Huang's research starts with biological evidence and seeks to develop statistical methodologies that are most relevant to address the basic scientific question of interest.
5R03CA182937-2 (NIH/NCI) Project title: Integrative modeling of gene expression into GWAS of glioma, 2014/07/01-2016/06/30; Role: Principal Investigator (MPI)
1R01AG048825-01 (NIH/NIA) Project title: Identifying targets for reducing obesity caused by early life disadvantage, 2014/09/30-2016/04/30; Role: Co-Investigator
Salomon Research Award (Brown University) Project title: Gene-Environment and Gene-Gene Interactions in Cancer Survival, 2013/07/01-2014/12/31; Role: Principal Investigator
Salomon Research Award, Brown University (2013)
American Statistical Association Biometrics Section Byar Travel Award (2012)
RAB Poster Award, International Biometric Society, Eastern North American Region (2012)
Stellar Abstract Award, Program of Quantitative Genomics, Harvard University (2011)
Best Abstract Award, Dana-Farber/Harvard Cancer Center Lung Cancer Program Symposium (2010)
Best Student Poster (2008) and Honorable Mentions (2007, 2009) Faculty Council Poster Exhibit, Harvard University, School of Public Health
David H. Peipers Fellowship, Harvard University, School of Public Health (2007-2009)
Taiwanese Physicians Scholarship, Harvard University, School of Public Health (2005-2006)
Medical License of Clinical Practice in Taiwan (2003-present)
Kelsey, Karl Professor of Epidemiology, Professor of Pathology and Laboratory Medicine, Director of Center for Environmental Health and Technology