Carl Saab is a PhD Neuroscientist studying neurological disorders. He obtained his PhD in 2001 from the University of Texas Medical Branch mapping pain pathways in the CNS (thesis advisor WD Willis). He then completed his postdoctoral fellowship in the laboratory of Stephen Waxman at Yale studying sodium channelopathies in pain and multiple sclerosis. Currently, Carl is Professor (Research) at Brown University & Rhode Island Hospital, Departments of Neurosurgery & Neuroscience, where his lab studies brain mechanisms of pain in animals and humans.
| Saab CY, Barrett LF. "Thalamic Bursts and the Epic Pain Model." Frontiers in computational neuroscience, vol. 10, 2017, pp. 147. |
| LeBlanc BW, Cross B, Smith KA, Roach C, Xia J, Chao YC, Levitt J, Koyama S, Moore CI, Saab CY. "Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior." Scientific reports, vol. 7, no. 1, 2017, pp. 2482. |
| Levitt J, Choo HJ, Smith KA, LeBlanc BW, Saab CY. "Electroencephalographic frontal synchrony and caudal asynchrony during painful hand immersion in cold water." Brain Research Bulletin, vol. 130, 2016, pp. 75-80. |
| LeBlanc BW, Bowary PM, Chao YC, Lii TR, Saab CY. "Electroencephalographic signatures of pain and analgesia in rats." PAIN, vol. 157, no. 10, 2016, pp. 2330-40. |
| "T-type calcium channel blocker Z944 restores cortical synchrony and thalamocortical connectivity in a rat model of neuropathic pain." 2016. |
| LeBlanc BW, Lii TR, Huang JJ, Chao YC, Bowary PM, Cross BS, Lee MS, Vera-Portocarrero LP, Saab CY. "T-type calcium channel blocker Z944 restores cortical synchrony and thalamocortical connectivity in a rat model of neuropathic pain." PAIN, vol. 157, no. 1, 2016, pp. 255-63. |
| LeBlanc, Brian W., Lii, Theresa R., Silverman, Andrew E., Alleyne, Robert T., Saab, Carl Y. "Cortical theta is increased while thalamocortical coherence is decreased in rat models of acute and chronic pain." PAIN, vol. 155, no. 4, 2014, pp. 773-782. |
| Lii, T., LeBlanc, B., Saab, C. "Altered connectivity between the thalamus and somatosensory cortex during chronic pain." The Journal of Pain, vol. 14, no. 4, 2013, pp. S44. |
| Shields, Shannon D., Cheng, Xiaoyang, Gasser, Andreas, Saab, Carl Y., Tyrrell, Lynda, Eastman, Emmanuella M., Iwata, Masashi, Zwinger, Pamela J., Black, Joel A., Dib-Hajj, Sulayman D., Waxman, Stephen G. "A channelopathy contributes to cerebellar dysfunction in a model of multiple sclerosis." Annals of neurology, vol. 71, no. 2, 2012, pp. 186-194. |
| Wang, Jing, Saab, Carl, Al-Chaer, Elie D. "Mo1845 P2×7 Receptors Facilitate Visceral Hypersensitivity Through Activation of Spinal Cord Microglia." Gastroenterology, vol. 142, no. 5, 2012, pp. S-698. |
| Saab, Carl Y. "Pain-related changes in the brain: diagnostic and therapeutic potentials." Trends in Neurosciences, vol. 35, no. 10, 2012, pp. 629-637. |
| "Pain-related changes in the brain: diagnostic and therapeutic potentials." 2012. |
| Saab, Carl. "Visualizing the Complex Brain Dynamics of Chronic Pain." Journal of Neuroimmune Pharmacology, vol. 8, no. 3, 2012, pp. 510-517. |
| Iwata, Masashi, LeBlanc, Brian W., Kadasi, Laith M., Zerah, Michele L., Cosgrove, Rees G., Saab, Carl Y. "High-frequency stimulation in the ventral posterolateral thalamus reverses electrophysiologic changes and hyperalgesia in a rat model of peripheral neuropathic pain." PAIN, vol. 152, no. 11, 2011, pp. 2505-2513. |
| LeBlanc, Brian W., Zerah, Michele L., Kadasi, Laith M., Chai, Noori, Saab, Carl Y. "Minocycline injection in the ventral posterolateral thalamus reverses microglial reactivity and thermal hyperalgesia secondary to sciatic neuropathy." Neuroscience Letters, vol. 498, no. 2, 2011, pp. 138-142. |
| LeBlanc, B.W., Iwata, M., Mallon, A.P., Rupasinghe, C.N., Goebel, D.J., Marshall, J., Spaller, M.R., Saab, C.Y. "A cyclic peptide targeted against PSD-95 blocks central sensitization and attenuates thermal hyperalgesia." Neuroscience, vol. 167, no. 2, 2010, pp. 490-500. |
| Chang, Yu-Wen, Tan, Andrew, Saab, Carl, Waxman, Stephen. "Unilateral Focal Burn Injury Is Followed by Long-Lasting Bilateral Allodynia and Neuronal Hyperexcitability in Spinal Cord Dorsal Horn." The Journal of Pain, vol. 11, no. 2, 2010, pp. 119-130. |
| Saab, Carl Y., Hains, Bryan C. "Remote neuroimmune signaling: a long-range mechanism of nociceptive network plasticity." Trends in Neurosciences, vol. 32, no. 2, 2009, pp. 110-117. |
| Saab, Carl Y., Shamaa, Farah, El Sabban, Marwan E., Safieh-Garabedian, Bared, Jabbur, Suhayl J., Saadé, Nayef E. "Transient increase in cytokines and nerve growth factor in the rat dorsal root ganglia after nerve lesion and peripheral inflammation." Journal of neuroimmunology, vol. 208, no. 1-2, 2009, pp. 94-103. |
| Shaw, S.K., Owolabi, S.A., Bagley, J., Morin, N., Cheng, E., LeBlanc, B.W., Kim, M., Harty, P., Waxman, S.G., Saab, C.Y. "Activated polymorphonuclear cells promote injury and excitability of dorsal root ganglia neurons." Experimental Neurology, vol. 210, no. 2, 2008, pp. 286-294. |
| Saab, Carl Y., Waxman, Stephen G., Hains, Bryan C. "Alarm or curse? The pain of neuroinflammation." Brain Research Reviews, vol. 58, no. 1, 2008, pp. 226-235. |
| MORIN, N, OWOLABI, S, HARTY, M, PAPA, E, TRACYJR, T, SHAW, S, KIM, M, SAAB, C. "Neutrophils invade lumbar dorsal root ganglia after chronic constriction injury of the sciatic nerve." Journal of neuroimmunology, vol. 184, no. 1-2, 2007, pp. 164-171. |
| Hains, B. C. "Alterations in Burst Firing of Thalamic VPL Neurons and Reversal by Nav1.3 Antisense After Spinal Cord Injury." Journal of Neurophysiology, vol. 95, no. 6, 2006, pp. 3343-3352. |
| Owolabi, Samuel A., Saab, Carl Y. "Fractalkine and minocycline alter neuronal activity in the spinal cord dorsal horn." FEBS Letters, vol. 580, no. 18, 2006, pp. 4306-4310. |
| Black, J. A., Liu, S., Hains, B. C., Saab, C. Y., Waxman, S. G. "Long-term protection of central axons with phenytoin in monophasic and chronic-relapsing EAE." Brain, vol. 129, no. 12, 2006, pp. 3196-3208. |
| Saab, Carl Y., Wang, Jing, Gu, Chunping, Garner, Kirsten N., Al-Chaer, Elie D. "Microglia: a newly discovered role in visceral hypersensitivity?." NGB, vol. 2, no. 04, 2006, pp. 271. |
| Saab CY, Wang J, Gu C, Garner KN, Al-Chaer ED. "Microglia: a newly discovered role in visceral hypersensitivity?." NGB, vol. 2, no. 4, 2006, pp. 271-7. |
| Hains, B. C. "Changes in electrophysiological properties and sodium channel Nav1.3 expression in thalamic neurons after spinal cord injury." Brain, vol. 128, no. 10, 2005, pp. 2359-2371. |
| Saab, CarlY., Craner, MatthewJ., Kataoka, Yuko, Waxman, StephenG. "Abnormal Purkinje cell activity in vivo in experimental allergic encephalomyelitis." Exp Brain Res, vol. 158, no. 1, 2004. |
| Hains BC, Saab CY, Klein JP, Craner MJ, Waxman SG. "Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury." Journal of Neuroscience, vol. 24, no. 20, 2004, pp. 4832-9. |
| Saab, Carl Y., Waxman, Stephen G. "Potentiation of sural nerve A?? action potential after neurogenic inflammation." Neuroreport, vol. 15, no. 11, 2004, pp. 1773-1777. |
| Saab CY, Waxman SG. "Potentiation of sural nerve Abeta action potential after neurogenic inflammation." Neuroreport, vol. 15, no. 11, 2004, pp. 1773-7. |
| Hains, Bryan C., Saab, Carl Y., Lo, Albert C., Waxman, Stephen G. "Sodium channel blockade with phenytoin protects spinal cord axons, enhances axonal conduction, and improves functional motor recovery after contusion SCI." Experimental Neurology, vol. 188, no. 2, 2004, pp. 365-377. |
| Saab, Carl Y., Park, Young C., Al-Chaer, Elie D. "Thalamic modulation of visceral nociceptive processing in adult rats with neonatal colon irritation." Brain Research, vol. 1008, no. 2, 2004, pp. 186-192. |
| Saab CY, Cummins TR, Waxman SG. "GTP gamma S increases Nav1.8 current in small-diameter dorsal root ganglia neurons." Exp Brain Res, vol. 152, no. 4, 2003, pp. 415-9. |
| Lo AC, Saab CY, Black JA, Waxman SG. "Phenytoin protects spinal cord axons and preserves axonal conduction and neurological function in a model of neuroinflammation in vivo." Journal of Neurophysiology, vol. 90, no. 5, 2003, pp. 3566-71. |
| Saab CY, Willis WD. "The cerebellum: organization, functions and its role in nociception." Brain research. Brain research reviews, vol. 42, no. 1, 2003, pp. 85-95. |
| Hains BC, Klein JP, Saab CY, Craner MJ, Black JA, Waxman SG. "Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury." Journal of Neuroscience, vol. 23, no. 26, 2003, pp. 8881-92. |
| Saab CY, Willis WD. "Cerebellar stimulation modulates the intensity of a visceral nociceptive reflex in the rat." Exp Brain Res, vol. 146, no. 1, 2002, pp. 117-21. |
| Saab CY, Cummins TR, Dib-Hajj SD, Waxman SG. "Molecular determinant of Na(v)1.8 sodium channel resistance to the venom from the scorpion Leiurus quinquestriatus hebraeus." Neuroscience Letters, vol. 331, no. 2, 2002, pp. 79-82. |
| Saab CY, Garcia-Nicas E, Willis WD. "Stimulation in the rat fastigial nucleus enhances the responses of neurons in the dorsal column nuclei to innocuous stimuli." Neuroscience Letters, vol. 327, no. 1, 2002, pp. 17-20. |
| Saab CY, Kawasaki M, Al-Chaer ED, Willis WD. "Cerebellar cortical stimulation increases spinal visceral nociceptive responses." Journal of Neurophysiology, vol. 85, no. 6, 2001, pp. 2359-63. |
| Saab CY, Willis WD. "Nociceptive visceral stimulation modulates the activity of cerebellar Purkinje cells." Exp Brain Res, vol. 140, no. 1, 2001, pp. 122-6. |
| Saadé NE, Kafrouni AI, Saab CY, Atweh SF, Jabbur SJ. "Chronic thalamotomy increases pain-related behavior in rats." PAIN, vol. 83, no. 3, 1999, pp. 401-9. |
| Burton AW, Lee DH, Saab C, Chung JM. "Preemptive intrathecal ketamine injection produces a long-lasting decrease in neuropathic pain behaviors in a rat model." Regional anesthesia and pain medicine, vol. 24, no. 3, 1999, pp. 208-13. |
1. LeBlanc B.W., Iwata M., Mallon A.P., Rupasinghe C.N., Goebel D.J., Marshall J., Spaller M.R., Saab C.Y. A Cyclic Peptide Targeted against PSD-95 blocks central sensitization and attenuates thermal hyperalgesia. Neurosci 167:490-500, 2010.
2. Saab C.Y. and Hains B.C. Remote neuroimmune signaling: a long-range mechanism of nociceptive network plasticity. TINS 32:110-7, 2009.
3. Shaw S.K., Owolabi S.A., Bagley J., Morin N., Cheng E., LeBlanc B.W., Kim M., Harty P., Waxman S.G. and Saab C.Y. Activated polymorphonuclear cells promote injury and excitability of dorsal root ganglia neurons. Exp Neurol 210(2):286-94, 2008 (COVER).
4. Saab C.Y., Wang J., Gu C., Garner K.N. and Al-Chaer E.D. Microglia: A newly discovered role in visceral hypersensitivity. Neuron Glia Biol 2:1-7, 2007.
7. Hains B.C., Saab C.Y. and Waxman S.G. Alterations in burst firing of thalamic VPL neurons and reversal by Nav1.3 antisense after spinal cord injury. J Neurophysiol 95:3343-3352, 2006.
5. Black J.A., Liu S., Hains B.C., Saab C.Y. and Waxman S.G. Long-term neuroprotection of central axons with phenytoin in monophasic and chronic-relapsing murine EAE. Brain 129:3196-208, 2006.
6. Owolabi S.A. and Saab C.Y. Fractalkine and minocycline alter neuronal activity in the spinal cord dorsal horn. FEBS Lett 580:4306-10, 2006.
8. Hains B.C.*, Saab C.Y.* and Waxman S.G. Changes in electrophysiologic properties and sodium channel Nav1.3 expression in thalamic neurons after spinal cord injury. Brain 128: 2359-71, 2005 (* equal contribution).
9. Hains B.C., Saab C.Y., Klein J.P., Craner M.J., Black J.A. and Waxman S.G. Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury. J Neurosci 24: 4832-4839, 2004.
10. Lo A.C., Saab C.Y., Black J.O. and Waxman S.G. Phenytoin protects spinal cord axons and preserves neurological function in experimental allergic encephalomyelitis. J Neurophysiol 90: 3566-3571, 2003.
| Year | Degree | Institution |
|---|---|---|
| 2001 | PhD | University of Texas Medical Branch |
| 1997 | MS | American University of Beirut |
| 1994 | BS | American University of Beirut |
| Postdoctoral Fellow | Yale University, neurology | 2001-2004 | New Haven, CT |
| Name | Title |
|---|---|
| Greenberg, Benjamin | Professor of Psychiatry and Human Behavior |
| Jones, Stephanie | Professor of Neuroscience |
| Kauer, Julie | Adjunct Professor of Molecular Pharmacology, Physiology and Biotechnology |
| Moore, Christopher | Associate Director of the Carney Institute of Brain Science, Professor of Neuroscience, Professor of Brain Science |
| Research Associate II. Rhode Island Hospital, 2010-Present |
| Research Associate I. Rhode Island Hospital, 2004-2010 |
