A full desription of my research can be found on my lab website https://sites.brown.edu/stephanie-r-jones-lab/
My research integrates human brain imaging and computational neuroscience methods to study brain dynamics in health and disease. I work closely with animal neurophysiologist and clinicians to develop data constrained neural models that are functionally and translationally relevant. A main theme of my lab's research is to develop biophysically principled models of neural circuits that bridge the critical gap between human brain imaging signals (MEG/EEG) and their underlying cellular and network level generators. Current projects apply such interdisciplinary techniques to study the mechanisms and functions of neural dynamics, including brain rhythms, in healthy functions such as perception, attention and decision making, and in neural pathologies such as Parkinson's disease and Essential Tremor. We also study the impact of brain stimulation (DBS, tACS, TMS), and mind-body practices, on brain dynamics with an ultimate goal of improving treatments for neuropatholgy.
Diesburg DA, Wessel JR, Jones SR. "Biophysical Modeling of Frontocentral ERP Generation Links Circuit-Level Mechanisms of Action-Stopping to a Behavioral Race Model." Journal of Neuroscience, vol. 44, no. 20, 2024. |
Tolley N, Rodrigues PLC, Gramfort A, Jones SR. "Methods and considerations for estimating parameters in biophysically detailed neural models with simulation based inference." PLOS Computational Biology, vol. 20, no. 2, 2024, pp. e1011108. |
Zimmerman CS, Temereanca S, Daniels D, Penner C, Cannonier T, Jones SR, Kerr C. "A Randomized Controlled Pilot Trial Comparing Effects of Qigong and Exercise/Nutrition Training on Fatigue and Other Outcomes in Female Cancer Survivors." Integrative Cancer Therapies, vol. 22, 2023, pp. 15347354231162584. |
Moolchand P, Jones SR, Frank MJ. "Biophysical and Architectural Mechanisms of Subthalamic Theta under Response Conflict." Journal of Neuroscience, vol. 42, no. 22, 2022, pp. 4470-4487. |
Jas M, Jones SR, Hämäläinen MS. "Whole-head OPM-MEG enables noninvasive assessment of functional connectivity." Trends in Neurosciences, vol. 44, no. 7, 2021, pp. 510-512. |
Sahin M, Sweeney JA, Jones SR. "Editorial: Biomarkers to Enable Therapeutics Development in Neurodevelopmental Disorders." Frontiers in Integrative Neuroscience, vol. 14, 2020, pp. 616641. |
Neymotin, Samuel A, Daniels, Dylan S, Caldwell, Blake, McDougal, Robert A, Carnevale, Nicholas T, Jas, Mainak, Moore, Christopher I, Hines, Michael L, Hämäläinen, Matti, Jones, Stephanie R. "Human Neocortical Neurosolver (HNN), a new software tool for interpreting the cellular and network origin of human MEG/EEG data." eLife, vol. 9, 2020. |
Jones SR, Sliva DD. "Is Alpha Asymmetry a Byproduct or Cause of Spatial Attention? New Evidence Alpha Neurofeedback Controls Measures of Spatial Attention." Neuron, vol. 105, no. 3, 2020, pp. 404-406. |
Zandvakili A, Philip NS, Jones SR, Tyrka AR, Greenberg BD, Carpenter LL. "Use of machine learning in predicting clinical response to transcranial magnetic stimulation in comorbid posttraumatic stress disorder and major depression: A resting state electroencephalography study." Journal of Affective Disorders, vol. 252, 2019, pp. 47-54. |
Sliva, Danielle D., Black, Christopher J., Bowary, Paul, Agrawal, Uday, Santoyo, Juan F., Philip, Noah S., Greenberg, Benjamin D., Moore, Christopher I., Jones, Stephanie R. "A Prospective Study of the Impact of Transcranial Alternating Current Stimulation on EEG Correlates of Somatosensory Perception." Frontiers in Psychology, vol. 9, 2018, pp. 2117. |
Lee S, Asaad W, and Jones SR. "Computational modeling to improve treatments for Essential Tremor." Drug Discovery Today, 2017. |
Black CJ, Voights J, Agrawal U, Ladow M, Santoyo J, Moore CI, Jones SR. "Open Ephys. Electroencephalography: A modular, low-cost, open-source solution to human neural recordings." J. Neural Engineering, vol. 14, no. 3, 2017, pp. 035002. |
Shin, Hyeyoung, Law, Robert, Tsutsui, Shawn, Moore, Christopher I, Jones, Stephanie R. "The rate of transient beta frequency events predicts behavior across tasks and species." eLife, vol. 6, 2017. |
Shin H, Law R, Tsutsui S, Moore CI, Jones SR. "The rate of transient beta frequency events predicts behavior across tasks and species. eLife 6:e29086." eLife, vol. 6, no. e29086, 2017. |
Hwang, Kai, Ghuman, Avniel S., Manoach, Dara S., Jones, Stephanie R., Luna, Beatriz. "Frontal preparatory neural oscillations associated with cognitive control: A developmental study comparing young adults and adolescents." NeuroImage, vol. 136, 2016, pp. 139-148. |
Hershey DM, Ren X, Melnyk RA, Browne PJ, Ozyamak E, Jones SR, Chang MC, Hurley JH, Komeili A. "MamO Is a Repurposed Serine Protease that Promotes Magnetite Biomineralization through Direct Transition Metal Binding in Magnetotactic Bacteria." PLoS biology, vol. 14, no. 3, 2016, pp. e1002402. |
Sherman MA, Lee S, Law R, Haegens S, Thorn CA, Hämäläinen MS, Moore CI, Jones SR. "Neural mechanisms of transient neocortical beta rhythms: Converging evidence from humans, computational modeling, monkeys, and mice." Proceedings of the National Academy of Sciences, vol. 113, no. 33, 2016, pp. E4885-94. |
Jones SR. "When brain rhythms aren't 'rhythmic': implication for their mechanisms and meaning." Current opinion in neurobiology, vol. 40, 2016, pp. 72-80. |
Sacchet, M. D., LaPlante, R. A., Wan, Q., Pritchett, D. L., Lee, A. K. C., Hamalainen, M., Moore, C. I., Kerr, C. E., Jones, S. R. "Attention Drives Synchronization of Alpha and Beta Rhythms between Right Inferior Frontal and Primary Sensory Neocortex." Journal of Neuroscience, vol. 35, no. 5, 2015, pp. 2074-2082. |
Ahlfors, Seppo P., Jones, Stephanie R., Ahveninen, Jyrki, Hämäläinen, Matti S., Belliveau, John W., Bar, Moshe. "Direction of magnetoencephalography sources associated with feedback and feedforward contributions in a visual object recognition task." Neuroscience Letters, vol. 585, 2015, pp. 149-154. |
Hwang K, Ghuman AS, Manoach DS, Jones SR, Luna B. "Cortical neurodynamics of inhibitory control." Journal of Neuroscience, vol. 34, no. 29, 2014, pp. 9551-61. |
Lee S, Jones SR. "Distinguishing mechanisms of gamma frequency oscillations in human current source signals using a computational model of a laminar neocortical network." Frontiers in Human Neuroscience, vol. 7, 2013, pp. 869. |
Kerr CE, Sacchet MD, Lazar SW, Moore CI, Jones SR. "Mindfulness starts with the body: somatosensory attention and top-down modulation of cortical alpha rhythms in mindfulness meditation." Frontiers in Human Neuroscience, vol. 7, 2013, pp. 12. |
Siponen MI, Legrand P, Widdrat M, Jones SR, Zhang WJ, Chang MC, Faivre D, Arnoux P, Pignol D. "Structural insight into magnetochrome-mediated magnetite biomineralization." J. Geophys. Res., vol. 502, no. 7473, 2013, pp. 681-4. |
Carlén M, Meletis K, Siegle JH, Cardin JA, Futai K, Vierling-Claassen D, Rühlmann C, Jones SR, Deisseroth K, Sheng M, Moore CI, Tsai LH. "A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior." Molecular Psychiatry, vol. 17, no. 5, 2012, pp. 537-48. |
Wan Q, Kerr C, Pritchett D, Hämäläinen M, Moore C, Jones S. "Dynamics of dynamics within a single data acquisition session: variation in neocortical alpha oscillations in human MEG." PLoS ONE, vol. 6, no. 9, 2011, pp. e24941. |
Kerr CE, Jones SR, Wan Q, Pritchett DL, Wasserman RH, Wexler A, Villanueva JJ, Shaw JR, Lazar SW, Kaptchuk TJ, Littenberg R, Hämäläinen MS, Moore CI. "Effects of mindfulness meditation training on anticipatory alpha modulation in primary somatosensory cortex." Brain Research Bulletin, vol. 85, no. 3-4, 2011, pp. 96-103. |
Vierling-Claassen D, Cardin JA, Moore CI, Jones SR. "Computational modeling of distinct neocortical oscillations driven by cell-type selective optogenetic drive: separable resonant circuits controlled by low-threshold spiking and fast-spiking interneurons." Frontiers in Human Neuroscience, vol. 4, 2010, pp. 198. |
Jones SR, Kerr CE, Wan Q, Pritchett DL, Hämäläinen M, Moore CI. "Cued spatial attention drives functionally relevant modulation of the mu rhythm in primary somatosensory cortex." Journal of Neuroscience, vol. 30, no. 41, 2010, pp. 13760-5. |
Ziegler DA, Pritchett DL, Hosseini-Varnamkhasti P, Corkin S, Hämäläinen M, Moore CI, Jones SR. "Transformations in oscillatory activity and evoked responses in primary somatosensory cortex in middle age: a combined computational neural modeling and MEG study." NeuroImage, vol. 52, no. 3, 2010, pp. 897-912. |
Ziegler, DA, Wan, Q, Pritchett, DL, Kerr, CE, Corkin, S, Moore, CI, Jones, SR. "Age-related changes in neural dynamics during tactile detection." NeuroImage, vol. 47, 2009, pp. S131. |
Jones SR, Pritchett DL, Sikora MA, Stufflebeam SM, Hämäläinen M, Moore CI. "Quantitative analysis and biophysically realistic neural modeling of the MEG mu rhythm: rhythmogenesis and modulation of sensory-evoked responses." Journal of Neurophysiology, vol. 102, no. 6, 2009, pp. 3554-72. |
Boas DA, Jones SR, Devor A, Huppert TJ, Dale AM. "A vascular anatomical network model of the spatio-temporal response to brain activation." NeuroImage, vol. 40, no. 3, 2008, pp. 1116-29. |
Luo W, Jones SR, Yousaf MN. "Geometric control of stem cell differentiation rate on surfaces." Langmuir, vol. 24, no. 21, 2008, pp. 12129-33. |
Jones SR, Pritchett DL, Stufflebeam SM, Hämäläinen M, Moore CI. "Neural correlates of tactile detection: a combined magnetoencephalography and biophysically based computational modeling study." Journal of Neuroscience, vol. 27, no. 40, 2007, pp. 10751-64. |
Jones SR, Kopell N. "Local network parameters can affect inter-network phase lags in central pattern generators." Journal of Mathematical Biology, vol. 52, no. 1, 2006, pp. 115-40. |
Devor A, Ulbert I, Dunn AK, Narayanan SN, Jones SR, Andermann ML, Boas DA, Dale AM. "Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity." Proceedings of the National Academy of Sciences, vol. 102, no. 10, 2005, pp. 3822-7. |
Devor, Anna, Ulbert, Istvan, Dunn, Andrew K, Narayanan, Suresh N, Jones, Stephanie R, Andermann, Mark L, Boas, David A, Dale, Anders M. "Neuronal basis of optical imaging signals in sensory cortex." Journal of Cerebral Blood Flow & Metabolism, vol. 25, 2005, pp. S683-S683. |
Pinto DJ, Jones SR, Kaper TJ, Kopell N. "Analysis of state-dependent transitions in frequency and long-distance coordination in a model oscillatory cortical circuit." Journal of Computational Neuroscience, vol. 15, no. 2, 2003, pp. 283-98. |
Garabedian CE, Jones SR, Merzenich MM, Dale A, Moore CI. "Band-pass response properties of rat SI neurons." Journal of Neurophysiology, vol. 90, no. 3, 2003, pp. 1379-91. |
Jones SR, Mulloney B, Kaper TJ, Kopell N. "Coordination of cellular pattern-generating circuits that control limb movements: the sources of stable differences in intersegmental phases." Journal of Neuroscience, vol. 23, no. 8, 2003, pp. 3457-68. |
Kamei T, Jones SR, Chapman BM, MCGonigle KL, Dai G, Soares MJ. "The phosphatidylinositol 3-kinase/Akt signaling pathway modulates the endocrine differentiation of trophoblast cells." Molecular endocrinology (Baltimore, Md.), vol. 16, no. 7, 2002, pp. 1469-81. |
Jones SR, Pinto DJ, Kaper TJ, Kopell N. "Alpha-frequency rhythms desynchronize over long cortical distances: a modeling study." Journal of Computational Neuroscience, vol. 9, no. 3, 2000, pp. 271-91. |
Current Funding
Please see CV.
PUBLICATIONS
A full list of my publications can be found on google scholar: https://scholar.google.com/citations?hl=en&user=H2lcpR0AAAAJ&view_op=list_works&cstart=0&pagesize=20
2017
Shin H., Law R., Tsutsui S., Moore CI, Jones SR. (2017) The rate of transient beta frequency events predicts impaired function across tasks and species. bioRxiv doi: https://doi.org/10.1101/128769
Lee S, Asaad W, Jones SR (2017) Computational modeling to improve treatments for Essential Tremor. Drug Discovery Today. In Press
Black CJ, Voights J, Agrawal U, Ladow M, Santoyo J, Moore CI, Jones SR. (2017) Open Ephys. Electroencephalography: A modular, low-cost, open-source solution to human neural recordings. J. Neural Engineering. 14(3):035002
2016
Sherman M, Lee S, Law R, Haegens S, Thorn C, Hamalainen M, Moore CI, Jones SR. (2016) Neural mechanisms of transient neocortical beta rhythms: Converging evidence from humans, computational modeling, monkeys, and mice. Proc. Natl. Acad. Sci.; Epub.
Jones SR (2016) When brain rhythms aren’t ‘rhythmic’: implications for their mechanisms and meaning. Curr. Opin. Neurobiol.;. Epub.
Hwang K, Ghuman AS, Dara S. Manoach DS, Jones SR, Luna B. (2016) Frontal preparatory neural oscillations associated with cognitive control: A developmental study comparing young adults and adolescents. Adolescent immaturities in frontal preparatory neural oscillations associated with inhibitory control Neuroimage; 136:139-48.
Vierling-Claassen N and Jones SR. "Neural Rhythms". Chapter in Computational Neuroscience Textbook: From Neurons to Cognition: Computational Neuroscience MIT Press; Editor: M. Arbib. (In Press)
2015
Jones SR. “The Puzzle of Brain Rhythms”, contributed Path of Discovery Box, in Neuroscience: Exploring the Brain, 4th edition, by MF. Bear, BW. Connors, and M. Pardiso. (2015)
Black CJ, Voights J, Moore CI, Jones SR Open Ephys Electroencephalography: A Novel Method for Real-Time Recording during Transcranial Alternating Current Stimulation. Abstract. Proceedings of 2015 Neuromodulation Conference; Brain Stimulation (In Press).
Sacchet M, LaPlante R, Wan Q, Pritchett D, Lee A K-C, Hamalainen M, Moore CI, Kerr CE and Jones SR. Attention drives synchronization of alpha and beta rhythms between right inferior frontal and primary sensory cortex. J. Neurosci. (In Press)
Ahlfors SP, Jones SR, Ahveninen J, Hamalainen MS, Bar M Direction of magnetoencephalography sources associated with feedback and feedforward contributions in a visual object recognition task. Neurosci. Lett. 2015; 585:149-54
2014
Jones SR. "Local Field Potential: Relationship to Electroencephalography (EEG) and Magnetoencephalography (MEG)". Chapter in Encyclopedia of Computation Neuroscience.SpringerReference; Editors: Dieter Jaeger and Ranu Jung. Springer-Verlag Berlin Heidelberg. 2014
Hwang Kai, Ghuman Avniel S, Manoach Dara S, Jones SR. Luna B. Cortical neurodynamics of inhibitory control. J. Neurosci. 2014; 34(29):9551-61.
2013
Lee S and Jones SR. Distinguishing mechanisms of gamma frequency oscillations in human current source signals using a computational model of a laminar neocortical network. Frontiers in Human Neurosci. E pub. 2013
Kerr CE, Sacchet MD, Lazar SW, Moore CI, Jones SR. Mindfullness starts with the body: somatosensory attention and top-down modulation of cortical alpha rhythms in mindfulness mediation. Front Hum Neurosci 2013;7:17 Epub 2013 Feb 13
2011
Stephanie R. Jones. "Biophysically Principled Computational Neural Network Modeling of Magneto-/Electro- Encephalography Measured Human Brain Oscillations". Chapter in 'Neural Methods' Textbook.Springer Publishing; Editors: Fellin and Hallasa 2011
Kerr CE*, Jones SR*, Wan Q, Pritchett DL, Wasserman RH, Wexler A, Villanueva JJ, Shaw JR, Kaptchuk TJ, Littenberg R, Hamalainen MS, Moore CI. Effects of Mindfulness Meditation Training on Cortical Dyamics: A MEG Study of Alpha Rhythm Modulation in SI. Brain Research Bulletin. 2011 85(3-4):96-103. *Co-first author contributions.
Wan Q, Kerr CE, Pritchett D, Hamalainen M, Moore CI, Jones SR.Dynamics of Dynamics within a single data sessions: Variation in neocortical alpha oscillations. PLoSONE. 2011 6(9) 324941
Carlen M, Konstantinos M, Siegle JH, Cardin JA, Fatai F, Vierling-Claassen D, Ruhlmann C, Jones SR*, Deissertoth K, Sheng M, Moore CI, Tsai LH. A critical role for NMDAR parvalbumin interneurons for gamma rhythm induction and cognitive function. Molecular Psych. 2011 4/11. * Senior author contribution on computational neural modeling component
2010
Vierling-Claassen D, Cardin JA, Moore CI, Jones SR. Computational Modeling Of Distinct Neocortical Oscillations Driven By Cell-Type Selective Optogentic Drive: Separable Resonant Circuits Controlled By Low-Threshold Spiking And Fast-Spiking Interneurons. Frontiers in Human Neuroscience: Special Issue on Origin and Consequences of Rhythmic activity. 2010 Nov 22, 4:198
Jones SR*, Kerr CE*, Wan Q, Pritchett DL, Hamalainen MS, Moore CI. Cued Spatial Attention Drives Representation-Specific Modulation of The Alpha Rhythm in Primary Somatosensory Cortex. J. Neurosci. 2010;30(41):13760-5. *Co-first author contributions.
Ziegler DA, Pritchett DL, Hosseini-Varnamkhast P, Suzanne Corkin, H_m_l_inen MS, Moore CI, Jones SR. Transformations in Oscillatory Activity and Evoked Responses in Primary Somatosensory Cortex in Middle Age: A Combined Computational Neural Modeling and MEG Study. Neuroimage. 2010;52(3):897:912.
2009
Jones SR, Pritchett DL, Stufflebeam SM, Sikora M, Hamalainen MS, Moore CI. Quantitative Analysis and Biophysically-Realistic Modeling of the MEG Mu Rhythm: Rhythmogenesis and Modulation of Sensory Evoked Responses. J. Neurophys. 2009;102(6):3554-72.
2008
Boas DA, Jones SR, Devor A, Huppert TJ, Dunn AK, Dale AM. A vascular anatomical network model of the spatio-temporal response to brain activation. Neuroimage. 2008;40(3):1116-29.
2007
Jones SR, Pritchett DL, Stufflebeam SM, Hamalainen, M, Moore CI. Neural Correlates of Tactile Detection: A Combined MEG and Biophysically Based Computational Modeling Study. J. Neurosci. 2007;27(40):10751-10764.
2006
Jones SR, Kopell N. Local network parameters can affect inter-network phase lags in central pattern generators. Journal of Math Biology. 2006;52(1):115-40.
2005
Devor A, Ulbert I, Dunn AK, Narayanan SN, Jones SR, Andermann ML, Boas DA, Dale AM. Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity. Proc Natl Acad Sci U S A. 2005;102(10):3822-7.
2003
Pinto DJ, Jones SR, Kaper TJ, Kopell N. Analysis of state-dependent transitions in frequency and long-distance coordination in a model oscillatory cortical circuit. Journal of Computational Neurosci. 2003;15(2):283-98.
Garabedian CE, Jones SR*, Merzenich MM, Dale A, Moore CI. Band-pass response properties of rat SI neurons. Journal of Neurophysiology. 2003;90(3):1379-91. *First author contribution on computational neural modeling component
Jones SR, Mulloney B, Kaper TJ, Kopell N. Coordination of cellular pattern-generating circuits that control limb movements: the sources of stable differences in intersegmental phases. Journal of Neurosci. 2003;23(8):3457-68.
2000
Jones SR, Pinto DJ, Kaper TJ, Kopell N. Alpha-frequency rhythms desynchronize over long cortical distances: a modeling study. Journal of Computational Neurosci. 2000;9(3):271-91.
Year | Degree | Institution |
---|---|---|
2001 | PhD | Boston University |
1995 | MA | Boston College |
1993 | BA | Boston College |
1992 Pi Mu Epsilon, Mathematics Honor Fraternity
1993 Phi Beta Kappa, National Honor Society
1993 Alfred A. Bennet Mathematics Teaching Award, Boston College Mathematics Dept.
1993-1995 Dean’s Fellowship, Boston College Graduate School of Arts and Sciences
1995-2001 Graduate Fellow, Boston University Dept. of Math: PhD Dynamical Systems Theory
2001-2005 Post-doctoral Fellow, Massachusetts General Hospital (MGH): MEG/EEG Imaging
2008-2010 Claflin Distinguished Scholar Award, Massachusetts General Hospital
2005-2011 Instructor, Harvard Medical School
2005-2011 Assistant in Neuroscience, Massachusetts General Hospital
2010-2011 Massachusetts General Hospital ECOR Award
2011-2012 Scholars in Medicine Dr. Lynne Reid /Shore Fellowship, Harvard Medical School
2012-2013 Harvard Catalyst Advanced Imaging Award, Harvard Medical School
2012-2013 New Frontiers Fund Award, Brown Institute for Brain Science: PD/ET Research
2013-2014 New Frontiers Fund Award, Brown Institute for Brain Science: Pain Research
2013 Invited Panel Advisor, NIH sponsored “BRAIN” Initiative Workshop: Theory, Computation, Data
2014 Invited Panel Advisor, NSF sponsored “BRAIN” Initiative Workshop: Computational Theories
2014-2015 Brown University DEAN’s Emerging Areas of New Science Award: PD/ET Research
2014-2015 Advisory Board & Judge for NIH/Center for Advancing Innovation Brain Start-Up Challenge
2011-2013 Lecturer, Harvard Medical School
2011-2013 Associate Scientist in Newborn Medicine, Boston Children’s Hospital (BCH)
2011-2016 Assistant Research Professor, Dept. of Neuroscience, Brown University
2014-present Associate Editor MIT Press Journal Neural Computation
2015-present Lecturer, Dept. of Applied Mathematics, Brown University
2015-present NSF/NIH Panel Grant Reviewer: Collaborative Efforts in Computational Neuroscience
2016-present Computational Neuroscientist, CfNN, Providence Veteran’s Medical Center, RI
2016-present Associate Research Professor, Brown University, RI
Name | Title |
---|---|
Asaad, Wael | Sidney A. Fox and Dorothea Doctors Fox Professor of Ophthalmology and Visual Science, Professor of Neurosurgery, Professor of Neuroscience |
Connors, Barry | L. Herbert Ballou University Professor Emeritus of Neuroscience, Professor Emeritus of Medical Science, Professor of Neuroscience (Research) |
Frank, Michael | Edgar L. Marston Professor of Psychology, Professor of Brain Science |
Greenberg, Benjamin | Professor of Psychiatry and Human Behavior |
Moore, Christopher | Associate Director of the Carney Institute of Brain Science, Professor of Neuroscience, Professor of Brain Science |
APMA 2821V - Neural Dynamics: Theory and Modeling |
NEUR 1440 - Mechanisms and Meaning of Neural Dynamics |