Dr. Asaad is Director of Functional and Epilepsy Neurosurgery at Rhode Island Hospital and Vice Chair for Research in the Department of Neurosurgery. His research work focuses on neurophysiology and neuromodulation in both human and animal subjects.
Dr. Asaad received his undergraduate degree from Amherst College, and then earned a PhD in Systems Neuroscience from MIT, followed by an MD from Yale University. He completed a general surgery internship and neurosurgical residency at the Massachusetts General Hospital / Harvard Medical School. He joined Brown University in 2011.
His lab seeks to improve our understanding of the basic neural circuit mechanisms of learning, memory and decision-making, and to apply this knowledge to alleviate the cognitive, affective, and motor sequelae of human neurological illness and injury.
His clinical interests include functional neurosurgery (including deep brain stimulation and focused ultrasound), epilepsy surgery (including intracranial monitoring, laser ablation, and responsive neurostimulation), and psychiatric neurosurgery.
| Pagnier GJ, Asaad WF, Frank MJ. "Double dissociation of dopamine and subthalamic nucleus stimulation on effortful cost/benefit decision making." Current Biology, 2024. |
| Abdulrazeq, Hael, Kimata, Anna R, Blum, Andrew, Malik, Athar N, Asaad, Wael F. "Exploring the Role of the Pulvinar Nucleus of the Thalamus in Occipital Lobe Epilepsy: A Case Report." Cureus, 2024. |
| Abdulrazeq, Hael F., Kimata, Anna R., Shao, Belinda, Svokos, Konstantina, Ayub, Neishay, Nie, Duyu, Asaad, Wael F. "Laser amygdalohippocampotomy reduces contralateral hippocampal sub-clinical activity in bitemporal epilepsy: A case illustration of responsive neurostimulator ambulatory recordings." Epilepsy & Behavior Reports, vol. 25, 2024, pp. 100636. |
| Abdulrazeq, Hael F., Kimata, Anna R., Shao, Belinda, Svokos, Konstantina, Ayub, Neishay, Nie, Duyu, Asaad, Wael F. "Laser amygdalohippocampotomy reduces contralateral hippocampal sub-clinical activity in bitemporal epilepsy: A case illustration of responsive neurostimulator ambulatory recordings." Epilepsy & Behavior Reports, vol. 25, 2024, pp. 100636. |
| Mirza, Fatima N., Tang, Oliver Y., Connolly, Ian D., Abdulrazeq, Hael A., Lim, Rachel K., Roye, G. Dean, Priebe, Cedric, Chandler, Cheryl, Libby, Tiffany J., Groff, Michael W., Shin, John H., Telfeian, Albert E., Doberstein, Curtis E., Asaad, Wael F., Gokaslan, Ziya L., Zou, James, Ali, Rohaid. "Using ChatGPT to Facilitate Truly Informed Medical Consent." NEJM AI, vol. 1, no. 2, 2024. |
| Fields, Madeline C., Eka, Onome, Schreckinger, Cristina, Dugan, Patricia, Asaad, Wael F., Blum, Andrew S., Bullinger, Katie, Willie, Jon T., Burdette, David E., Anderson, Christopher, Quraishi, Imran H., Gerrard, Jason, Singh, Anuradha, Lee, Kyusang, Yoo, Jiyeoun, Ghatan, Saadi, Panov, Fedor, Marcuse, Lara V. "A multicenter retrospective study of patients treated in the thalamus with responsive neurostimulation." Frontiers in Neurology, vol. 14, 2023. |
| Alarie, Michaela E., Provenza, Nicole R., Herron, Jeffrey A., Asaad, Wael F. "Automated artifact injection into sensing-capable brain modulation devices for neural-behavioral synchronization and the influence of device state." Brain Stimulation, vol. 16, no. 5, 2023, pp. 1358-1360. |
| Lauro, Peter M, Lee, Shane, Amaya, Daniel E, Liu, David D, Akbar, Umer, Asaad, Wael F. "Concurrent decoding of distinct neurophysiological fingerprints of tremor and bradykinesia in Parkinson’s disease." eLife, vol. 12, 2023. |
| Ali, Rohaid, Tang, Oliver Y., Connolly, Ian D., Abdulrazeq, Hael F., Mirza, Fatima N., Lim, Rachel K., Johnston, Benjamin R., Groff, Michael W., Williamson, Theresa, Svokos, Konstantina, Libby, Tiffany J., Shin, John H., Gokaslan, Ziya L., Doberstein, Curtis E., Zou, James, Asaad, Wael F. "Demographic Representation in 3 Leading Artificial Intelligence Text-to-Image Generators." JAMA Surgery, 2023. |
| McLaughlin NCR, Magnotti JF, Banks GP, Nanda P, Hoexter MQ, Lopes AC, Batistuzzo MC, Asaad WF, Stewart C, Paulo D, Noren G, Greenberg BD, Malloy P, Salloway S, Correia S, Pathak Y, Sheehan J, Marsland R, Gorgulho A, De Salles A, Miguel EC, Rasmussen SA, Sheth SA. "Gamma knife capsulotomy for intractable OCD: Neuroimage analysis of lesion size, location, and clinical response." Translational psychiatry, vol. 13, no. 1, 2023, pp. 134. |
| Tang, Oliver Y., Ali, Rohaid, Connolly, Ian D., Fridley, Jared S., Zadnik Sullivan, Patricia L., Cielo, Deus, Oyelese, Adetokunbo A., Doberstein, Curtis E., Telfeian, Albert E., Gokaslan, Ziya L., Shin, John H., Asaad, Wael F. "Letter: The Urgency of Neurosurgical Leadership in the Era of Artificial Intelligence." Neurosurgery, vol. 93, no. 3, 2023, pp. e69-e70. |
| Ali R, Tang OY, Connolly ID, Zadnik Sullivan PL, Shin JH, Fridley JS, Asaad WF, Cielo D, Oyelese AA, Doberstein CE, Gokaslan ZL, Telfeian AE. "Performance of ChatGPT and GPT-4 on Neurosurgery Written Board Examinations." Neurosurgery, vol. 93, no. 6, 2023, pp. 1353-1365. |
| Ali, Rohaid, Tang, Oliver Y., Connolly, Ian D., Fridley, Jared S., Shin, John H., Zadnik Sullivan, Patricia L., Cielo, Deus, Oyelese, Adetokunbo A., Doberstein, Curtis E., Telfeian, Albert E., Gokaslan, Ziya L., Asaad, Wael F. "Performance of ChatGPT, GPT-4, and Google Bard on a Neurosurgery Oral Boards Preparation Question Bank." Neurosurgery, vol. 93, no. 5, 2023, pp. 1090-1098. |
| Zheng, Bryan, Abdulrazeq, Hael, Shao, Belinda, Liu, David D., Leary, Owen, Lauro, Peter M., Bartolini, Luca, Blum, Andrew S., Asaad, Wael F. "Seizure and anatomical outcomes of repeat laser amygdalohippocampotomy for temporal lobe epilepsy: A single-institution case series." Epilepsy & Behavior, vol. 146, 2023, pp. 109365. |
| Zheng, Bryan, Liu, David D., Theyel, Brian B, Abdulrazeq, Hael, Kimata, Anna R., Lauro, Peter M, Asaad, Wael F. "Thalamic neuromodulation in epilepsy: A primer for emerging circuit-based therapies." Expert Review of Neurotherapeutics, vol. 23, no. 2, 2023, pp. 123-140. |
| Kimata, Anna R., Zheng, Bryan, Watanabe, Takeo, Asaad, Wael F. "The temporal cost of deploying attention limits accurate target identification in rapid serial visual presentation." Scientific Reports, vol. 13, no. 1, 2023. |
| Zheng, Bryan, Hsieh, Ben, Rex, Nathaniel, Lauro, Peter M., Collins, Scott A., Blum, Andrew S., Roth, Julie L., Ayub, Neishay, Asaad, Wael F. "A hierarchical anatomical framework and workflow for organizing stereotactic encephalography in epilepsy." Human Brain Mapping, 2022. |
| Ganga, Arjun, Leary, Owen P., Sastry, Rahul A., Asaad, Wael F., Svokos, Konstantina A., Oyelese, Adetokunbo A., Mermel, Leonard A. "Antibiotic prophylaxis in penetrating traumatic brain injury: analysis of a single-center series and systematic review of the literature." Acta Neurochirurgica, vol. 165, no. 2, 2022, pp. 303-313. |
| Phillips RK, Aghagoli G, Blum AS, Asaad WF. "Bilateral thalamic responsive neurostimulation for multifocal, bilateral frontotemporal epilepsy: illustrative case." Journal of Neurosurgery: Case Lessons, vol. 3, no. 12, 2022. |
| Walek KW, Leary OP, Sastry R, Asaad WF, Walsh JM, Horoho J, Mermel LA. "Risk factors and outcomes associated with external ventricular drain infections." Infection Control & Hospital Epidemiology, 2022, pp. 1-8. |
| Shao, Belinda, Zheng, Bryan, Liu, David D., Anderson, Matthew N., Svokos, Konstantina, Bartolini, Luca, Asaad, Wael F. "Seizure freedom after laser amygdalohippocampotomy guided by bilateral responsive neurostimulation in pediatric epilepsy: illustrative case." Journal of Neurosurgery: Case Lessons, vol. 4, no. 9, 2022. |
| Tang, Oliver Y., Shao, Belinda, Kimata, Anna R., Sastry, Rahul A., Wu, Joshua, Asaad, Wael F. "The Impact of Frailty on Traumatic Brain Injury Outcomes: An Analysis of 691 821 Nationwide Cases." Neurosurgery, vol. 91, no. 5, 2022, pp. 808-820. |
| Barrios-Anderson A, McLaughlin NCR, Patrick MT, Marsland R, Noren G, Asaad WF, Greenberg BD, Rasmussen S. "The Patient Lived-Experience of Ventral Capsulotomy for Obsessive-Compulsive Disorder: An Interpretive Phenomenological Analysis of Neuroablative Psychiatric Neurosurgery." Frontiers in Integrative Neuroscience, vol. 16, 2022, pp. 802617. |
| Reznik ME, Kalagara R, Moody S, Drake J, Margolis SA, Cizginer S, Mahta A, Rao SS, Stretz C, Wendell LC, Thompson BB, Asaad WF, Furie KL, Jones RN, Daiello LA. "Common biomarkers of physiologic stress and associations with delirium in patients with intracerebral hemorrhage." Journal of Critical Care, vol. 64, 2021, pp. 62-67. |
| Walek KW, Leary OP, Sastry R, Asaad WF, Walsh JM, Mermel L. "Decreasing External Ventricular Drain Infection Rates in the Neurocritical Care Unit: 12-Year Longitudinal Experience at a Single Institution." World Neurosurgery, vol. 150, 2021, pp. e89-e101. |
| Shao B, Tang OY, Leary OP, Abdulrazeq H, Sastry RA, Brown S, Wilson IB, Asaad WF, Gokaslan ZL. "Demand for Essential Nonambulatory Neurosurgical Care Decreased While Acuity of Care Increased During the Coronavirus Disease 2019 (COVID-19) Surge." World Neurosurgery, vol. 151, 2021, pp. e523-e532. |
| Targum SD, Fosdick L, Drake KE, Rosenberg PB, Burke AD, Wolk DA, Foote KD, Asaad WF, Sabbagh M, Smith GS, Lozano AM, Lyketsos CG. "Effect of Age on Clinical Trial Outcome in Participants with Probable Alzheimer's Disease." Journal of Alzheimer's disease : JAD, 2021. |
| McLaughlin NCR, Lauro PM, Patrick MT, Pucci FG, Barrios-Anderson A, Greenberg BD, Rasmussen SA, Asaad WF. "Magnetic Resonance Imaging-Guided Laser Thermal Ventral Capsulotomy for Intractable Obsessive-Compulsive Disorder." Neurosurgery, vol. 88, no. 6, 2021, pp. 1128-1135. |
| Aghagoli G, Gallo Marin B, Katchur NJ, Chaves-Sell F, Asaad WF, Murphy SA. "Neurological Involvement in COVID-19 and Potential Mechanisms: A Review." Neurocritical Care, vol. 34, no. 3, 2021, pp. 1062-1071. |
| Asaad, Wael. "Neurosurgery and the Pursuit of Fundamental Neuroscience." Surviving Neurosurgery, 2021, pp. 357-363. |
| Lauro PM, Lee S, Akbar U, Asaad WF. "Subthalamic-Cortical Network Reorganization during Parkinson's Tremor." Journal of Neuroscience, vol. 41, no. 47, 2021, pp. 9844-9858. |
| Liu DD, Lauro PM, Phillips RK 3rd, Leary OP, Zheng B, Roth JL, Blum AS, Segar DJ, Asaad WF. "Two-trajectory laser amygdalohippocampotomy: Anatomic modeling and initial seizure outcomes." Epilepsia, vol. 62, no. 10, 2021, pp. 2344-2356. |
| Reznik ME, Drake J, Margolis SA, Moody S, Murray K, Costa S, Mahta A, Wendell LC, Thompson BB, Rao SS, Barrett AM, Boukrina O, Daiello LA, Asaad WF, Furie KL, Jones RN. "Deconstructing Poststroke Delirium in a Prospective Cohort of Patients With Intracerebral Hemorrhage." Critical care medicine, vol. 48, no. 1, 2020, pp. 111-118. |
| Asaad, Wael F., McLaughlin, Nicole C. R. "LITT for Intractable Psychiatric Disease." Laser Interstitial Thermal Therapy in Neurosurgery, 2020, pp. 119-126. |
| Sanderson, John B., Yu, James H., Liu, David D, Amaya, Daniel, Lauro, Peter M., D'Abreu, Anelyssa, Akbar, Umer, Lee, Shane, Asaad, Wael F. "Multi-Dimensional, Short-Timescale Quantification of Parkinson's Disease and Essential Tremor Motor Dysfunction." Frontiers in Neurology, vol. 11, 2020, pp. 886. |
| Wu E, Marthi S, Asaad WF. "Predictors of Mortality in Traumatic Intracranial Hemorrhage: A National Trauma Data Bank Study." Frontiers in Neurology, vol. 11, 2020, pp. 587587. |
| Ahn M, Lee S, Lauro PM, Schaeffer EL, Akbar U, Asaad WF. "Rapid motor fluctuations reveal short-timescale neurophysiological biomarkers of Parkinson's disease." Journal of Neural Engineering, vol. 17, no. 4, 2020, pp. 046042. |
| Asaad, Wael F., Lauro, Peter M., Lee, Shane. "The Design of Clinical Studies for Neuromodulation." Stereotactic and Functional Neurosurgery, 2020, pp. 523-540. |
| Reznik ME, Moody S, Murray K, Costa S, Grory BM, Madsen TE, Mahta A, Wendell LC, Thompson BB, Rao SS, Stretz C, Sheth KN, Hwang DY, Zahuranec DB, Schrag M, Daiello LA, Asaad WF, Jones RN, Furie KL. "The impact of delirium on withdrawal of life-sustaining treatment after intracerebral hemorrhage." Neurology, vol. 95, no. 20, 2020, pp. e2727-e2735. |
| Powers AY, Pinto MB, Tang OY, Chen JS, Doberstein C, Asaad WF. "Predicting mortality in traumatic intracranial hemorrhage." Journal of Neurosurgery, vol. 132, no. 2, 2019, pp. 552-559. |
| Schaeffer EL, Liu DY, Guerin J, Ahn M, Lee S, Asaad WF. "A low-cost solution for quantification of movement during DBS surgery." Journal of Neuroscience Methods, vol. 303, 2018, pp. 136-145. |
| Carnevale JA, Segar DJ, Powers AY, Shah M, Doberstein C, Drapcho B, Morrison JF, Williams JR, Collins S, Monteiro K, Asaad WF. "Blossoming contusions: identifying factors contributing to the expansion of traumatic intracerebral hemorrhage." Journal of Neurosurgery, vol. 129, no. 5, 2018, pp. 1305-1316. |
| Lauro PM, Lee S, Ahn M, Barborica A, Asaad WF. "DBStar: An Open-Source Tool Kit for Imaging Analysis with Patient-Customized Deep Brain Stimulation Platforms." Stereotactic and Functional Neurosurgery, vol. 96, no. 1, 2018, pp. 13-21. |
| Leoutsakos JS, Yan H, Anderson WS, Asaad WF, Baltuch G, Burke A, Chakravarty MM, Drake KE, Foote KD, Fosdick L, Giacobbe P, Mari Z, McAndrews MP, Munro CA, Oh ES, Okun MS, Pendergrass JC, Ponce FA, Rosenberg PB, Sabbagh MN, Salloway S, Tang-Wai DF, Targum SD, Wolk D, Lozano AM, Smith GS, Lyketsos CG. "Deep Brain Stimulation Targeting the Fornix for Mild Alzheimer Dementia (the ADvance Trial): A Two Year Follow-up Including Results of Delayed Activation." Journal of Alzheimer's disease : JAD, vol. 64, no. 2, 2018, pp. 597-606. |
| Powers AY, Pinto MB, Aldridge AM, Tang OY, Chen JS, Berube RL, Doberstein C, Fox JM, Carnevale JA, Asaad WF. "Factors associated with the progression of conservatively managed acute traumatic subdural hemorrhage." Journal of Critical Care, vol. 48, 2018, pp. 243-250. |
| Bayer AD, Blum AS, Asaad WF, Roth J, Toms SA, Deck GM. "Fighting Fire with Fire: Surgical Options for Patients with Drug-Resistant Epilepsy." Rhode Island medical journal (2013), vol. 101, no. 2, 2018, pp. 37-40. |
| Lee JJ, Segar DJ, Morrison JF, Mangham WM, Lee S, Asaad WF. "Subdural hematoma as a major determinant of short-term outcomes in traumatic brain injury." Journal of Neurosurgery, vol. 128, no. 1, 2018, pp. 236-249. |
| Akbar U, Asaad WF. "A Comprehensive Approach to Deep Brain Stimulation for Movement Disorders." Rhode Island medical journal (2013), vol. 100, no. 6, 2017, pp. 30-33. |
| Golebiowski D, van der Bom IMJ, Kwon CS, Miller AD, Petrosky K, Bradbury AM, Maitland S, Kühn AL, Bishop N, Curran E, Silva N, GuhaSarkar D, Westmoreland SV, Martin DR, Gounis MJ, Asaad WF, Sena-Esteves M. "Direct Intracranial Injection of AAVrh8 Encoding Monkey β-N-Acetylhexosaminidase Causes Neurotoxicity in the Primate Brain." Human gene therapy, vol. 28, no. 6, 2017, pp. 510-522. |
| Asaad WF, Lauro PM, Perge JA, Eskandar EN. "Prefrontal Neurons Encode a Solution to the Credit-Assignment Problem." Journal of Neuroscience, vol. 37, no. 29, 2017, pp. 6995-7007. |
| Carnevale JA, Ahmedli N, Morrison JF, Asaad WF, Klinge P, Telfeian A. "T-Connector Modification for Reducing Recurrent Distal Shunt Failure: Report of 2 Cases." Operative neurosurgery (Hagerstown, Md.), vol. 13, no. 6, 2017, pp. E33-E36. |
| Carnevale J, Segar DJ, Drapcho B, Doberstein C, Morrison JF, Asaad W. "326 Cerebral Contusions: Catalysts and Counteractants." Neurosurgery, vol. 63, no. CN_suppl_1, 2016, pp. 195. |
| Lozano AM, Fosdick L, Chakravarty MM, Leoutsakos JM, Munro C, Oh E, Drake KE, Lyman CH, Rosenberg PB, Anderson WS, Tang-Wai DF, Pendergrass JC, Salloway S, Asaad WF, Ponce FA, Burke A, Sabbagh M, Wolk DA, Baltuch G, Okun MS, Foote KD, McAndrews MP, Giacobbe P, Targum SD, Lyketsos CG, Smith GS. "A Phase II Study of Fornix Deep Brain Stimulation in Mild Alzheimer's Disease." Journal of Alzheimer's disease : JAD, vol. 54, no. 2, 2016, pp. 777-87. |
| Ponce FA, Asaad WF, Foote KD, Anderson WS, Rees Cosgrove G, Baltuch GH, Beasley K, Reymers DE, Oh ES, Targum SD, Smith GS, Lyketsos CG, Lozano AM, for The ADvance Research Group. "Bilateral deep brain stimulation of the fornix for Alzheimer's disease: surgical safety in the ADvance trial." Journal of Neurosurgery, vol. 125, no. 1, 2016, pp. 75-84. |
| Lee S, Asaad WF, Jones SR. "Computational modeling to improve treatments for essential tremor." Drug Discovery Today: Disease Models, vol. 19, 2016, pp. 19-25. |
| Cabot, Richard C., Rosenberg, Eric S., Harris, Nancy Lee, Shepard, Jo-Anne O., Cort, Alice M., Ebeling, Sally H., McDonald, Emily K., Gupta, Rajiv, Vavvas, Demetrios, Asaad, Wael F. "Case 15-2015." New England Journal of Medicine, vol. 372, no. 20, 2015, pp. 1945-1952. |
| Xinyi Deng, Faghih RT, Barbieri R, Paulk AC, Asaad WF, Brown EN, Dougherty DD, Widge AS, Eskandar EN, Eden UT. "Estimating a dynamic state to relate neural spiking activity to behavioral signals during cognitive tasks." 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, vol. 2015, 2015, pp. 7808-13. |
| Girgis, Fady, Walcott, Brian P., Kwon, Churl-Su, Sheth, Sameer A., Asaad, Wael, Nahed, Brian V., Eskandar, Emad N., Coumans, Jean-Valery. "The Absence of Fever or Leukocytosis Does Not Exclude Infection Following Cranioplasty." The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, vol. 42, no. 04, 2015, pp. 255-259. |
| Lee, Jonathan J., Segar, David J., Asaad, Wael F. "Comprehensive Assessment of Isolated Traumatic Subarachnoid Hemorrhage." Journal of Neurotrauma, vol. 31, no. 7, 2014, pp. 595-609. |
| Williams, John R., Aghion, Daniel M., Doberstein, Curtis E., Cosgrove, G. Rees, Asaad, Wael F. "Penetrating Brain Injury after Suicide Attempt with Speargun: Case Study and Review of Literature." Frontiers in Neurology, vol. 5, 2014. |
| Srinivasan, Lakshminarayan, Asaad, Wael F., Ginat, Daniel T., Gale, John T., Dougherty, Darin D., Williams, Ziv M., Sejnowski, Terrence J., Eskandar, Emad N. "Action Initiation in the Human Dorsal Anterior Cingulate Cortex." PLoS ONE, vol. 8, no. 2, 2013, pp. e55247. |
| Walcott, Brian P., Kwon, Churl-Su, Sheth, Sameer A., Fehnel, Corey R., Koffie, Robert M., Asaad, Wael F., Nahed, Brian V., Coumans, Jean-Valery. "Predictors of cranioplasty complications in stroke and trauma patients." Journal of Neurosurgery, vol. 118, no. 4, 2013, pp. 757-762. |
| Patel, Shaun R, Sheth, Sameer A, Martinez-Rubio, Clarissa, Mian, Matthew K, Asaad, Wael F, Gerrard, Jason L, Kwon, Churl-Su, Dougherty, Darin D, Flaherty, Alice W, Greenberg, Benjamin D, Gale, John T, Williams, Ziv M, Eskandar, Emad N. "Studying task-related activity of individual neurons in the human brain." Nat Protoc, vol. 8, no. 5, 2013, pp. 949-957. |
| Walcott, Brian P., Nahed, Brian V., Sheth, Sameer A., Yanamadala, Vijay, Caracci, James R., Asaad, Wael F. "Bilateral Hemicraniectomy in Non-Penetrating Traumatic Brain Injury." Journal of Neurotrauma, vol. 29, no. 10, 2012, pp. 1879-1885. |
| Asaad, W. F., Santhanam, N., McClellan, S., Freedman, D. J. "High-performance execution of psychophysical tasks with complex visual stimuli in MATLAB." Journal of Neurophysiology, vol. 109, no. 1, 2012, pp. 249-260. |
| Sheth, Sameer A., Mian, Matthew K., Patel, Shaun R., Asaad, Wael F., Williams, Ziv M., Dougherty, Darin D., Bush, George, Eskandar, Emad N. "Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation." Nature, vol. 488, no. 7410, 2012, pp. 218-221. |
| Walcott, Brian P., Kuklina, Elena V., Nahed, Brian V., George, Mary G., Kahle, Kristopher T., Simard, J. Marc, Asaad, Wael F., Coumans, Jean-Valery C. E. "Craniectomy for Malignant Cerebral Infarction: Prevalence and Outcomes in US Hospitals." PLoS ONE, vol. 6, no. 12, 2011, pp. e29193. |
| Asaad, W. F., Eskandar, E. N. "Encoding of Both Positive and Negative Reward Prediction Errors by Neurons of the Primate Lateral Prefrontal Cortex and Caudate Nucleus." Journal of Neuroscience, vol. 31, no. 49, 2011, pp. 17772-17787. |
| Hanak, Brian W., Walcott, Brian P., Codd, Patrick J., Jones, Pamela S., Nahed, Brian V., Butler, William E., Asaad, Wael F. "Fourth ventricular neurocystercercosis presenting with acute hydrocephalus." Journal of Clinical Neuroscience, vol. 18, no. 6, 2011, pp. 867-869. |
| Stapleton, Christopher J., Walcott, Brian P., Linskey, Katy R., Kahle, Kristopher T., Nahed, Brian V., Asaad, Wael F. "Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activity." Journal of Clinical Neuroscience, vol. 18, no. 6, 2011, pp. 857-860. |
| Walcott, Brian P., Kahle, Kristopher T., Nahed, Brian V., Coumans, Jean-Valery C. E., Asaad, Wael F. "The use of intra-operative blood gas analysis in the investigation of suspected iatrogenic vascular injury." European Spine Journal, vol. 21, no. S4, 2011, pp. 492-494. |
| Asaad, Wael F., Walcott, Brian P., Nahed, Brian V., Ogilvy, Christopher S. "Operative management of brainstem cavernous malformations." Neurosurgical focus, vol. 29, no. 3, 2010, pp. E10. |
| Asaad, Wael, Eskandar, Emad N. "Prefrontal and Caudate Neurons Solve the Temporal Credit Assignment Problem." Neurosurgery, vol. 65, no. 2, 2009, pp. 421. |
| Ben-Haim, Sharona, Asaad, Wael F., Gale, John T., Eskandar, Emad N. "RISK FACTORS FOR HEMORRHAGE DURING MICROELECTRODE-GUIDED DEEP BRAIN STIMULATION AND THE INTRODUCTION OF AN IMPROVED MICROELECTRODE DESIGN." Neurosurgery, vol. 64, no. 4, 2009, pp. 754-763. |
| Asaad, Wael F., Eskandar, Emad N. "A flexible software tool for temporally-precise behavioral control in Matlab." Journal of Neuroscience Methods, vol. 174, no. 2, 2008, pp. 245-258. |
| Asaad, Wael F., Eskandar, Emad N. "Achieving behavioral control with millisecond resolution in a high-level programming environment." Journal of Neuroscience Methods, vol. 173, no. 2, 2008, pp. 235-240. |
| Shields, Donald C., Asaad, Wael, Eskandar, Emad N., Jain, Felipe A., Cosgrove, G. Rees, Flaherty, Alice W., Cassem, Edwin H., Price, Bruce H., Rauch, Scott L., Dougherty, Darin D. "Prospective Assessment of Stereotactic Ablative Surgery for Intractable Major Depression." Biological Psychiatry, vol. 64, no. 6, 2008, pp. 449-454. |
| Asaad, Wael, Eskandar, Emad. "The movers and shakers of deep brain stimulation." Nature Medicine, vol. 14, no. 1, 2008, pp. 17-19. |
| Fusi, Stefano, Asaad, Wael F., Miller, Earl K., Wang, Xiao-Jing. "A Neural Circuit Model of Flexible Sensorimotor Mapping: Learning and Forgetting on Multiple Timescales." Neuron, vol. 54, no. 2, 2007, pp. 319-333. |
| Asaad WF, Rainer G, Miller EK. "Task-specific neural activity in the primate prefrontal cortex." Journal of Neurophysiology, vol. 84, no. 1, 2000, pp. 451-9. |
| Kim WK, Choi YB, Rayudu PV, Das P, Asaad W, Arnelle DR, Stamler JS, Lipton SA. "Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO-." Neuron, vol. 24, no. 2, 1999, pp. 461-9. |
| Rainer G, Asaad WF, Miller EK. "Memory fields of neurons in the primate prefrontal cortex." Proceedings of the National Academy of Sciences, vol. 95, no. 25, 1998, pp. 15008-13. |
| Asaad WF, Rainer G, Miller EK. "Neural activity in the primate prefrontal cortex during associative learning." Neuron, vol. 21, no. 6, 1998, pp. 1399-407. |
| Rainer G, Asaad WF, Miller EK. "Selective representation of relevant information by neurons in the primate prefrontal cortex." Nature, vol. 393, no. 6685, 1998, pp. 577-9. |
| Wilson HR, Wilkinson F, Asaad W. "Concentric orientation summation in human form vision." Vision research, vol. 37, no. 17, 1997, pp. 2325-30. |
Our lab is interested in how cortical and subcortical systems give rise to complex, adaptive behavior as well as how neural activity in those systems contributes to pathology in movement disorders, epilepsy and psychiatric disease. We combine rigorous behavioral analysis with multi-electrode neuronal recordings and neurostimulation in human and nonhuman subjects, in the operative, peri-operative, and laboratory settings. We aim to advance neuromodulation by improving our understanding of the neurophysiological and behavioral biomarkers of disease, and to develop circuit-based, neuromodulation methods to foster or augment learning to improve recovery from neurologic illness or injury.
| Year | Degree | Institution |
|---|---|---|
| 2003 | MD | Yale University |
| 2001 | PhD | Massachusetts Institute of Technology |
| 1993 | BA | Amherst College |
| Research Fellow | Massachusetts General Hospital, neurosurgery | 2006-2008 | Boston, MA, USA |
| Resident | Massachusetts General Hospital, neurosurgery | 2004-2010 | |
| Intern | Massachusetts General Hospital, general surgery | 2003-2004 | |
| Post-Doctoral Fellow | Massachusetts Institute of Technology, Systems Neuroscience | 2001-2003 | Cambridge, MA |
1993 James Olds Neuroscience Prize, Amherst College
2000 Walle Nauta Award “for excellence in graduate teaching” M.I.T.
2000 McDonnell-Pew Post-Doctoral Fellowship in Cognitive Neuroscience
2001 Lindsley Prize, Society for Neuroscience
2007 Tosteson Fellowship, Massachusetts Biomedical Research Council
2012 Young Clinician Investigator Award, AANS / NREF
2014 Doris Duke Clinical Scientist Development Award
2017 Dean's Excellence in Teaching Award (Brown University Alpert Medical School)
2020 Dean's Excellence in Teaching Award (Brown University Alpert Medical School)
2021 Hasbro Children's Hospital "Brite Lites" Award
| Name | Title |
|---|---|
| Akbar, Umer | Associate Professor of Neurology |
| Ayub, Neishay | Assistant Professor of Neurology |
| Bartolini, Luca | Assistant Professor of Pediatrics, Assistant Professor of Neurosurgery, Assistant Professor of Neurology |
| Blum, Andrew | Professor of Neurology |
| Borton, David | Associate Professor of Engineering, Associate Professor of Neurosurgery, Associate Professor of Brain Science |
| Frank, Michael | Edgar L. Marston Professor of Psychology, Professor of Brain Science |
| Greenberg, Benjamin | Professor of Psychiatry and Human Behavior |
| Jones, Stephanie | Professor of Neuroscience |
| Lee, Shane | Assistant Professor of Neurosurgery (Research) |
| Malik, Athar | Samuel I. Kennison, M.D. and Bertha S. Kennison Assistant Professor of Clinical Neuroscience, Assistant Professor of Neurosurgery |
| McLaughlin, Nicole | Associate Professor of Psychiatry and Human Behavior |
| Moore, Christopher | Associate Director of the Carney Institute of Brain Science, Professor of Neuroscience, Professor of Brain Science |
| Nurmikko, Arto | L. Herbert Ballou University Professor of Engineering, Professor of Physics |
| Rasmussen, Steven | Professor of Psychiatry and Human Behavior |
| Roth, Julie | Associate Professor of Neurology, Associate Professor of Medical Science |
| Serre, Thomas | Thomas J. Watson, Sr. Professor of Science and Professor of Computer Science., Professor of Computer Science |
| Sherif, Mohamed | Assistant Professor of Psychiatry and Human Behavior |
Society for Neuroscience
American Association of Neurological Surgeons
Congress of Neurological Surgeons
American Society for Stereotactic and Functional Neurosurgery
American Epilepsy Society
| Fellow of the American Association of Neurological Surgeons | 2016- |
| Associate Director, Neurosurgery Residency Training Program. Rhode Island Hospital, 2022- |
| Vice Chair, Research. Rhode Island Hospital, 2022- |
| Member, Bioengineering of Vision and Neuroscience Technologies (BNVT) study section, NIH. 2020-2024 |
| Director of Functional and Epilepsy Neurosurgery. Rhode Island Hospital, 2016- |
Lecturer, Brain Sciences Block for First Year Medical Students
Trainer, Neuroscience Graduate Program
Trainer, Biomedical Engineering Graduate Program
