My research combines multiple levels of computational modeling and experimental work to understand the neural mechanisms underlying reinforcement learning, decision making and cognitive control. We develop neural circuit and algorithmic models of systems-level interactions between multiple brain areas (primarily prefrontal cortex and basal ganglia and their modulation by dopamine). We test theoretical predictions of the models using various neuropsychological, pharmacological, genetic, and imaging techniques. Find out more at http://ski.clps.brown.edu
Cognitive, Linguistic, and Psychological Sciences
Robert J. and Nancy D. Carney Institute for Brain Science
| Ironside M, Amemori KI, McGrath CL, Pedersen ML, Kang MS, Amemori S, Frank MJ, Graybiel AM, Pizzagalli DA. "Approach-Avoidance Conflict in Major Depressive Disorder: Congruent Neural Findings in Humans and Nonhuman Primates." Biological Psychiatry, vol. 87, no. 5, 2020, pp. 399-408. |
| Westbrook A, van den Bosch R, Määttä JI, Hofmans L, Papadopetraki D, Cools R, Frank MJ. "Dopamine promotes cognitive effort by biasing the benefits versus costs of cognitive work." Science, vol. 367, no. 6484, 2020, pp. 1362-1366. |
| Franklin NT, Frank MJ. "Generalizing to generalize: Humans flexibly switch between compositional and conjunctive structures during reinforcement learning." PLOS Computational Biology, vol. 16, no. 4, 2020, pp. e1007720. |
| Browning M, Carter CS, Chatham C, Den Ouden H, Gillan CM, Baker JT, Chekroud AM, Cools R, Dayan P, Gold J, Goldstein RZ, Hartley CA, Kepecs A, Lawson RP, Mourao-Miranda J, Phillips ML, Pizzagalli DA, Powers A, Rindskopf D, Roiser JP, Schmack K, Schiller D, Sebold M, Stephan KE, Frank MJ, Huys Q, Paulus M. "Realizing the Clinical Potential of Computational Psychiatry: Report From the Banbury Center Meeting, February 2019." Biological Psychiatry, 2020. |
| Matar E, Shine JM, Gilat M, Ehgoetz Martens KA, Ward PB, Frank MJ, Moustafa AA, Naismith SL, Lewis SJG. "Identifying the neural correlates of doorway freezing in Parkinson's disease." Human Brain Mapping, vol. 40, no. 7, 2019, pp. 2055-2064. |
| Jang AI, Nassar MR, Dillon DG, Frank MJ. "Positive reward prediction errors during decision-making strengthen memory encoding." Nature Human Behaviour, vol. 3, no. 7, 2019, pp. 719-732. |
| Nassar MR, Bruckner R, Frank MJ. "Statistical context dictates the relationship between feedback-related EEG signals and learning." eLife, vol. 8, 2019. |
| Ritz H, Nassar MR, Frank MJ, Shenhav A. "A Control Theoretic Model of Adaptive Learning in Dynamic Environments." Journal of Cognitive Neuroscience, vol. 30, no. 10, 2018, pp. 1405-1421. |
| Franklin NT, Frank MJ. "Compositional clustering in task structure learning." PLOS Computational Biology, vol. 14, no. 4, 2018, pp. e1006116. |
| Jahfari S, Ridderinkhof KR, Collins AGE, Knapen T, Waldorp LJ, Frank MJ. "Cross-Task Contributions of Frontobasal Ganglia Circuitry in Response Inhibition and Conflict-Induced Slowing." Cerebral Cortex, 2018. |
| Kasanova, Zuzana, Ceccarini, Jenny, Frank, Michael J, van Amelsvoort, Thérèse, Booij, Jan, Heinzel, Alexander, Mottaghy, Felix M., Myin-Germeys, Inez. "Daily-life stress differentially impacts ventral striatal dopaminergic modulation of reward processing in first-degree relatives of individuals with psychosis." European Neuropsychopharmacology, vol. 28, no. 12, 2018, pp. 1314-1324. |
| Broadway, James M., Frank, Michael J., Cavanagh, James F. "Dopamine D2 agonist affects visuospatial working memory distractor interference depending on individual differences in baseline working memory span." Cognitive, Affective, & Behavioral Neuroscience, vol. 18, no. 3, 2018, pp. 509-520. |
| Hernaus D, Gold JM, Waltz JA, Frank MJ. "Impaired Expected Value Computations Coupled With Overreliance on Stimulus-Response Learning in Schizophrenia." Biological psychiatry. Cognitive neuroscience and neuroimaging, vol. 3, no. 11, 2018, pp. 916-926. |
| Patel SR, Herrington TM, Sheth SA, Mian M, Bick SK, Yang JC, Flaherty AW, Frank MJ, Widge AS, Dougherty D, Eskandar EN. "Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects." eLife, vol. 7, 2018. |
| Waltz JA, Xu Z, Brown EC, Ruiz RR, Frank MJ, Gold JM. "Motivational Deficits in Schizophrenia Are Associated With Reduced Differentiation Between Gain and Loss-Avoidance Feedback in the Striatum." Biological psychiatry. Cognitive neuroscience and neuroimaging, vol. 3, no. 3, 2018, pp. 239-247. |
| Collins, Anne G. E., Frank, Michael J. "Within- and across-trial dynamics of human EEG reveal cooperative interplay between reinforcement learning and working memory." Proceedings of the National Academy of Sciences, vol. 115, no. 10, 2018, pp. 2502-2507. |
| Maia, Tiago V., Frank, Michael J. "An Integrative Perspective on the Role of Dopamine in Schizophrenia." Biological Psychiatry, vol. 81, no. 1, 2017, pp. 52-66. |
| Collins, Anne G.E., Albrecht, Matthew A., Waltz, James A., Gold, James M., Frank, Michael J. "Interactions Among Working Memory, Reinforcement Learning, and Effort in Value-Based Choice: A New Paradigm and Selective Deficits in Schizophrenia." Biological Psychiatry, vol. 82, no. 6, 2017, pp. 431-439. |
| Schutte, Iris, Slagter, Heleen A., Collins, Anne G. E., Frank, Michael J., Kenemans, J. Leon. "Stimulus discriminability may bias value-based probabilistic learning." PLOS ONE, vol. 12, no. 5, 2017, pp. e0176205. |
| Kasanova Z, Ceccarini J, Frank MJ, Amelsvoort TV, Booij J, Heinzel A, Mottaghy F, Myin-Germeys I. "Striatal dopaminergic modulation of reinforcement learning predicts reward-oriented behavior in daily life." Biological Psychology, vol. 127, 2017, pp. 1-9. |
| Maia, Tiago V., Huys, Quentin J.M., Frank, Michael J. "Theory-Based Computational Psychiatry." Biological Psychiatry, vol. 82, no. 6, 2017, pp. 382-384. |
| Wiecki TV, Antoniades CA, Stevenson A, Kennard C, Borowsky B, Owen G, Leavitt B, Roos R, Durr A, Tabrizi SJ, Frank MJ. "A Computational Cognitive Biomarker for Early-Stage Huntington's Disease." PLoS ONE, vol. 11, no. 2, 2016, pp. e0148409. |
| Kayser, Andrew S., Op de Macks, Zdeňa, Dahl, Ronald E., Frank, Michael J. "A Neural Correlate of Strategic Exploration at the Onset of Adolescence." Journal of Cognitive Neuroscience, vol. 28, no. 2, 2016, pp. 199-209. |
| Stephan KE, Bach DR, Fletcher PC, Flint J, Frank MJ, Friston KJ, Heinz A, Huys QJ, Owen MJ, Binder EB, Dayan P, Johnstone EC, Meyer-Lindenberg A, Montague PR, Schnyder U, Wang XJ, Breakspear M. "Charting the landscape of priority problems in psychiatry, part 1: classification and diagnosis." The Lancet Psychiatry, vol. 3, no. 1, 2016, pp. 77-83. |
| Stephan KE, Binder EB, Breakspear M, Dayan P, Johnstone EC, Meyer-Lindenberg A, Schnyder U, Wang XJ, Bach DR, Fletcher PC, Flint J, Frank MJ, Heinz A, Huys QJ, Montague PR, Owen MJ, Friston KJ. "Charting the landscape of priority problems in psychiatry, part 2: pathogenesis and aetiology." The Lancet Psychiatry, vol. 3, no. 1, 2016, pp. 84-90. |
| Huys, Quentin J M, Maia, Tiago V, Frank, Michael J. "Computational psychiatry as a bridge from neuroscience to clinical applications." Nature Neuroscience, vol. 19, no. 3, 2016, pp. 404-413. |
| Moustafa, Ahmed A., Chakravarthy, Srinivasa, Phillips, Joseph R., Crouse, Jacob J., Gupta, Ankur, Frank, Michael J., Hall, Julie M., Jahanshahi, Marjan. "Interrelations between cognitive dysfunction and motor symptoms of Parkinson’s disease: behavioral and neural studies." Reviews in the Neurosciences, vol. 27, no. 5, 2016. |
| Collins AG, Frank MJ. "Motor Demands Constrain Cognitive Rule Structures." PLOS Computational Biology, vol. 12, no. 3, 2016, pp. e1004785. |
| Collins AG, Frank MJ. "Neural signature of hierarchically structured expectations predicts clustering and transfer of rule sets in reinforcement learning." Cognition, vol. 152, 2016, pp. 160-169. |
| Dowd EC, Frank MJ, Collins A, Gold JM, Barch DM. "Probabilistic Reinforcement Learning in Patients With Schizophrenia: Relationships to Anhedonia and Avolition." Biological psychiatry : cognitive neuroscience and neuroimaging, vol. 1, no. 5, 2016, pp. 460-473. |
| Albrecht MA, Waltz JA, Frank MJ, Gold JM. "Probability and magnitude evaluation in schizophrenia." Schizophrenia research. Cognition, vol. 5, 2016, pp. 41-46. |
| Albrecht MA, Waltz JA, Cavanagh JF, Frank MJ, Gold JM. "Reduction of Pavlovian Bias in Schizophrenia: Enhanced Effects in Clozapine-Administered Patients." PLoS ONE, vol. 11, no. 4, 2016, pp. e0152781. |
| Werchan, D. M., Collins, A. G. E., Frank, M. J., Amso, D. "Role of Prefrontal Cortex in Learning and Generalizing Hierarchical Rules in 8-Month-Old Infants." Journal of Neuroscience, vol. 36, no. 40, 2016, pp. 10314-10322. |
| Collins AG, Frank MJ. "Surprise! Dopamine signals mix action, value and error." Nature Neuroscience, vol. 19, no. 1, 2016, pp. 3-5. |
| Nassar MR, Frank MJ. "Taming the beast: extracting generalizable knowledge from computational models of cognition." Current opinion in behavioral sciences, vol. 11, 2016, pp. 49-54. |
| Pedersen ML, Frank MJ, Biele G. "The drift diffusion model as the choice rule in reinforcement learning." Psychonomic Bulletin & Review, 2016. |
| Doll BB, Bath KG, Daw ND, Frank MJ. "Variability in Dopamine Genes Dissociates Model-Based and Model-Free Reinforcement Learning." Journal of Neuroscience, vol. 36, no. 4, 2016, pp. 1211-22. |
| Werchan, D. M., Collins, A. G. E., Frank, M. J., Amso, D. "8-Month-Old Infants Spontaneously Learn and Generalize Hierarchical Rules." Psychological Science, vol. 26, no. 6, 2015, pp. 805-815. |
| Franklin NT, Frank MJ. "A cholinergic feedback circuit to regulate striatal population uncertainty and optimize reinforcement learning." eLife, vol. 4, 2015. |
| Solomon M, Ragland JD, Niendam TA, Lesh TA, Beck JS, Matter JC, Frank MJ, Carter CS. "Atypical Learning in Autism Spectrum Disorders: A Functional Magnetic Resonance Imaging Study of Transitive Inference." Journal of the American Academy of Child & Adolescent Psychiatry, vol. 54, no. 11, 2015, pp. 947-55. |
| Morris, Laurel S, Baek, Kwangyeol, Kundu, Prantik, Harrison, Neil A, Frank, Michael J, Voon, Valerie. "Biases in the Explore–Exploit Tradeoff in Addictions: The Role of Avoidance of Uncertainty." Neuropsychopharmacology, vol. 41, no. 4, 2015, pp. 940-948. |
| Gold, James M., Waltz, James A., Frank, Michael J. "Effort Cost Computation in Schizophrenia: A Commentary on the Recent Literature." Biological Psychiatry, vol. 78, no. 11, 2015, pp. 747-753. |
| Solomon, Marjorie, Frank, Michael J., Ragland, J. Daniel, Smith, Anne C., Niendam, Tara A., Lesh, Tyler A., Grayson, David S., Beck, Jonathan S., Matter, John C., Carter, Cameron S. "Feedback-Driven Trial-by-Trial Learning in Autism Spectrum Disorders." American Journal of Psychiatry, vol. 172, no. 2, 2015, pp. 173-181. |
| Frank, M. J., Gagne, C., Nyhus, E., Masters, S., Wiecki, T. V., Cavanagh, J. F., Badre, D. "fMRI and EEG predictors of dynamic decision parameters during human reinforcement learning." Journal of Neuroscience, vol. 35, no. 2, 2015, pp. 485-94. |
| Frank MJ, Badre D. "How cognitive theory guides neuroscience." Cognition, vol. 135, 2015, pp. 14-20. |
| Badre D, Frank MJ, Moore CI. "Interactionist Neuroscience." Neuron, vol. 88, no. 5, 2015, pp. 855-860. |
| Wiecki, T. V., Poland, J., Frank, M. J. "Model-Based Cognitive Neuroscience Approaches to Computational Psychiatry: Clustering and Classification." Clinical Psychological Science, vol. 3, no. 3, 2015, pp. 378-399. |
| Slagter, Heleen A., Georgopoulou, Katerina, Frank, Michael J. "Spontaneous eye blink rate predicts learning from negative, but not positive, outcomes." Neuropsychologia, vol. 71, 2015, pp. 126-132. |
| Cox, Sylvia M.L., Frank, Michael J., Larcher, Kevin, Fellows, Lesley K., Clark, Crystal A., Leyton, Marco, Dagher, Alain. "Striatal D1 and D2 signaling differentially predict learning from positive and negative outcomes." NeuroImage, vol. 109, 2015, pp. 95-101. |
| Collins, Anne G E, Frank, Michael J. "Surprise! Dopamine signals mix action, value and error." Nature Neuroscience, vol. 19, no. 1, 2015, pp. 3-5. |
| Cockburn J, Collins AG, Frank MJ. "A reinforcement learning mechanism responsible for the valuation of free choice." Neuron, vol. 83, no. 3, 2014, pp. 551-7. |
| Beeler, Jeff A., Frank, Michael J., McDaid, John, Alexander, Erin, Turkson, Susie, Bernardez Sarria, Maria Sol, McGehee, Daniel S., Zhuang, Xiaoxi. "A Role for Dopamine-Mediated Learning in the Pathophysiology and Treatment of Parkinson’s Disease." Cell Reports, vol. 8, no. 2, 2014, pp. 646. |
| Moustafa AA, Krishna R, Frank MJ, Eissa AM, Hewedi DH. "Cognitive correlates of psychosis in patients with Parkinson's disease." Cognitive Neuropsychiatry, vol. 19, no. 5, 2014, pp. 381-98. |
| Cavanagh, James F., Masters, Sean E., Bath, Kevin, Frank, Michael J. "Conflict acts as an implicit cost in reinforcement learning." Nature Communications, vol. 5, 2014, pp. 5394. |
| Chatham CH, Frank MJ, Badre D. "Corticostriatal output gating during selection from working memory." Neuron, vol. 81, no. 4, 2014, pp. 930-42. |
| Guitart-Masip M, Economides M, Huys QJ, Frank MJ, Chowdhury R, Duzel E, Dayan P, Dolan RJ. "Differential, but not opponent, effects of L -DOPA and citalopram on action learning with reward and punishment." Psychopharmacology, vol. 231, no. 5, 2014, pp. 955-66. |
| Kayser, Andrew S, Mitchell, Jennifer M, Weinstein, Dawn, Frank, Michael J. "Dopamine, Locus of Control, and the Exploration-Exploitation Tradeoff." Neuropsychopharmacology, vol. 40, no. 2, 2014, pp. 454-462. |
| Bell, Peter T., Gilat, Moran, O'Callaghan, Claire, Copland, David A., Frank, Michael J., Lewis, Simon J.G., Shine, James M. "Dopaminergic basis for impairments in functional connectivity across subdivisions of the striatum in Parkinson's disease." Human Brain Mapping, vol. 36, no. 4, 2014, pp. 1278-1291. |
| Cavanagh JF, Wiecki TV, Kochar A, Frank MJ. "Eye tracking and pupillometry are indicators of dissociable latent decision processes." Journal of Experimental Psychology: General, vol. 143, no. 4, 2014, pp. 1476-88. |
| Cavanagh JF, Frank MJ. "Frontal theta as a mechanism for cognitive control." Trends in Cognitive Sciences, vol. 18, no. 8, 2014, pp. 414-21. |
| Collins, A. G. E., Cavanagh, J. F., Frank, M. J. "Human EEG uncovers latent generalizable rule structure during learning." Journal of Neuroscience, vol. 34, no. 13, 2014, pp. 4677-85. |
| Collins AG, Frank MJ. "Opponent actor learning (OpAL): modeling interactive effects of striatal dopamine on reinforcement learning and choice incentive." Psychological Review, vol. 121, no. 3, 2014, pp. 337-66. |
| Doll, Bradley B., Waltz, James A., Cockburn, Jeffrey, Brown, Jaime K., Frank, Michael J., Gold, James M. "Reduced susceptibility to confirmation bias in schizophrenia." Cogn Affect Behav Neurosci, vol. 14, no. 2, 2014, pp. 715-728. |
| Cavanagh, James F., Sanguinetti, Joseph L., Allen, John J. B., Sherman, Scott J., Frank, Michael J. "The Subthalamic Nucleus Contributes to Post-error Slowing." Journal of Cognitive Neuroscience, vol. 26, no. 11, 2014, pp. 2637-2644. |
| Collins, A. G. E., Brown, J. K., Gold, J. M., Waltz, J. A., Frank, M. J. "Working Memory Contributions to Reinforcement Learning Impairments in Schizophrenia." Journal of Neuroscience, vol. 34, no. 41, 2014, pp. 13747-13756. |
| Wiecki TV, Frank MJ. "A computational model of inhibitory control in frontal cortex and basal ganglia." Psychological Review, vol. 120, no. 2, 2013, pp. 329-55. |
| Berghorst, Lisa H., Bogdan, Ryan, Frank, Michael J., Pizzagalli, Diego A. "Acute stress selectively reduces reward sensitivity." Frontiers in Human Neuroscience, vol. 7, 2013. |
| Collins AG, Frank MJ. "Cognitive control over learning: creating, clustering, and generalizing task-set structure." Psychological Review, vol. 120, no. 1, 2013, pp. 190-229. |
| Narayanan NS, Cavanagh JF, Frank MJ, Laubach M. "Common medial frontal mechanisms of adaptive control in humans and rodents." Nature Neuroscience, vol. 16, no. 12, 2013, pp. 1888-95. |
| Shine JM, Matar E, Ward PB, Frank MJ, Moustafa AA, Pearson M, Naismith SL, Lewis SJ. "Freezing of gait in Parkinson's disease is associated with functional decoupling between the cognitive control network and the basal ganglia." Brain, vol. 136, no. Pt 12, 2013, pp. 3671-81. |
| Cavanagh, J. F., Eisenberg, I., Guitart-Masip, M., Huys, Q., Frank, M. J. "Frontal theta overrides pavlovian learning biases." Journal of Neuroscience, vol. 33, no. 19, 2013, pp. 8541-8. |
| Wiecki, Thomas V., Sofer, Imri, Frank, Michael J. "HDDM: Hierarchical Bayesian estimation of the Drift-Diffusion Model in Python." Front. Neuroinform., vol. 7, 2013. |
| Brown JK, Waltz JA, Strauss GP, McMahon RP, Frank MJ, Gold JM. "Hypothetical decision making in schizophrenia: the role of expected value computation and "irrational" biases." Psychiatry Research, vol. 209, no. 2, 2013, pp. 142-9. |
| Gold JM, Strauss GP, Waltz JA, Robinson BM, Brown JK, Frank MJ. "Negative symptoms of schizophrenia are associated with abnormal effort-cost computations." Biological Psychiatry, vol. 74, no. 2, 2013, pp. 130-6. |
| Gold, Benjamin P., Frank, Michael J., Bogert, Brigitte, Brattico, Elvira. "Pleasurable music affects reinforcement learning according to the listener." Cogn Affect Behav Neurosci, vol. 4, 2013. |
| Cavanagh JF, Frank MJ. "Stop! Stay tuned for more information." Experimental Neurology, vol. 247, 2013, pp. 289-91. |
| Lighthall NR, Gorlick MA, Schoeke A, Frank MJ, Mather M. "Stress modulates reinforcement learning in younger and older adults." Psychology and aging, vol. 28, no. 1, 2013, pp. 35-46. |
| Shine, James M., Moustafa, Ahmed A., Matar, Elie, Frank, Michael J., Lewis, Simon J. G. "The role of frontostriatal impairment in freezing of gait in Parkinson's disease." Front. Syst. Neurosci., vol. 7, 2013. |
| Beeler JA, Frank MJ, McDaid J, Alexander E, Turkson S, Bernardez Sarria MS, McGehee DS, Zhuang X. "A role for dopamine-mediated learning in the pathophysiology and treatment of Parkinson's disease." Cell Reports, vol. 2, no. 6, 2012, pp. 1747-61. |
| Ragland JD, Cohen NJ, Cools R, Frank MJ, Hannula DE, Ranganath C. "CNTRICS imaging biomarkers final task selection: Long-term memory and reinforcement learning." Schizophrenia Bulletin, vol. 38, no. 1, 2012, pp. 62-72. |
| Cavanagh JF, Figueroa CM, Cohen MX, Frank MJ. "Frontal theta reflects uncertainty and unexpectedness during exploration and exploitation." Cerebral Cortex, vol. 22, no. 11, 2012, pp. 2575-86. |
| Collins, Anne G. E., Frank, Michael J. "How much of reinforcement learning is working memory, not reinforcement learning? A behavioral, computational, and neurogenetic analysis." European Journal of Neuroscience, vol. 35, no. 7, 2012, pp. 1024-1035. |
| Jahfari, S., Verbruggen, F., Frank, M. J., Waldorp, L. J., Colzato, L., Ridderinkhof, K. R., Forstmann, B. U. "How Preparation Changes the Need for Top-Down Control of the Basal Ganglia When Inhibiting Premature Actions." Journal of Neuroscience, vol. 32, no. 32, 2012, pp. 10870-10878. |
| Badre D, Frank MJ. "Mechanisms of Hierarchical Reinforcement Learning in Cortico-Striatal Circuits 2: Evidence from fMRI." Cerebral Cortex, vol. 22, no. 3, 2012, pp. 527-36. |
| Frank, M. J., Badre, D. "Mechanisms of hierarchical reinforcement learning in corticostriatal circuits 1: computational analysis." Cerebral Cortex, vol. 22, no. 3, 2012, pp. 509-526. |
| Gold JM, Waltz JA, Matveeva TM, Kasanova Z, Strauss GP, Herbener ES, Collins AG, Frank MJ. "Negative symptoms and the failure to represent the expected reward value of actions: behavioral and computational modeling evidence." Archives of General Psychiatry , vol. 69, no. 2, 2012, pp. 129-38. |
| Ratcliff R, Frank MJ. "Reinforcement-Based Decision Making in Corticostriatal Circuits: Mutual Constraints by Neurocomputational and Diffusion Models." Neural Computation, vol. 24, no. 5, 2012, pp. 1186-229. |
| Badre, David, Doll, Bradley B., Long, Nicole M., Frank, Michael J. "Rostrolateral Prefrontal Cortex and Individual Differences in Uncertainty-Driven Exploration." Neuron, vol. 73, no. 3, 2012, pp. 595-607. |
| Whitmer AJ, Frank MJ, Gotlib IH. "Sensitivity to reward and punishment in major depressive disorder: effects of rumination and of single versus multiple experiences." Cognition and Emotion, vol. 26, no. 8, 2012, pp. 1475-85. |
| Waltz JA, Frank MJ, Wiecki TV, Gold JM. "Altered probabilistic learning and response biases in schizophrenia: behavioral evidence and neurocomputational modeling." Neuropsychology, vol. 25, no. 1, 2011, pp. 86-97. |
| Frank MJ. "Computational models of motivated action selection in corticostriatal circuits." Current opinion in neurobiology, vol. 21, no. 3, 2011, pp. 381-6. |
| Strauss GP, Frank MJ, Waltz JA, Kasanova Z, Herbener ES, Gold JM. "Deficits in positive reinforcement learning and uncertainty-driven exploration are associated with distinct aspects of negative symptoms in schizophrenia." Biological Psychiatry, vol. 69, no. 5, 2011, pp. 424-31. |
| Doll, B. B., Hutchison, K. E., Frank, M. J. "Dopaminergic genes predict individual differences in susceptibility to confirmation bias." Journal of Neuroscience, vol. 31, no. 16, 2011, pp. 6188-98. |
| Maia TV, Frank MJ. "From reinforcement learning models to psychiatric and neurological disorders." Nature Neuroscience, vol. 14, no. 2, 2011, pp. 154-62. |
| Cavanagh, James F., Bismark, Andrew J., Frank, Michael J., Allen, John J. B. "Larger Error Signals in Major Depression are Associated with Better Avoidance Learning." Cogn Affect Behav Neurosci, vol. 2, 2011. |
| Frank MJ, Fossella JA. "Neurogenetics and pharmacology of learning, motivation, and cognition." Neuropsychopharmacology, vol. 36, no. 1, 2011, pp. 133-52. |
| Kasanova Z, Waltz JA, Strauss GP, Frank MJ, Gold JM. "Optimizing vs. matching: response strategy in a probabilistic learning task is associated with negative symptoms of schizophrenia." Schizophrenia research, vol. 127, no. 1-3, 2011, pp. 215-22. |
| Strauss GP, Robinson BM, Waltz JA, Frank MJ, Kasanova Z, Herbener ES, Gold JM. "Patients with schizophrenia demonstrate inconsistent preference judgments for affective and nonaffective stimuli." Schizophrenia Bulletin, vol. 37, no. 6, 2011, pp. 1295-304. |
| Solomon M, Smith AC, Frank MJ, Ly S, Carter CS. "Probabilistic reinforcement learning in adults with autism spectrum disorders." Autism Research, vol. 4, no. 2, 2011, pp. 109-20. |
| Wietzikoski, Evellyn Claudia, Boschen, Suelen Lúcio, Miyoshi, Edmar, Bortolanza, Mariza, dos Santos, Lucélia Mendes, Frank, Michael, Brandão, Marcus Lira, Winn, Philip, Da Cunha, Claudio. "Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses." Psychopharmacology, vol. 219, no. 1, 2011, pp. 159-169. |
| Cavanagh JF, Frank MJ, Allen JJ. "Social stress reactivity alters reward and punishment learning." Social Cognitive and Affective Neuroscience, vol. 6, no. 3, 2011, pp. 311-20. |
| Cavanagh JF, Wiecki TV, Cohen MX, Figueroa CM, Samanta J, Sherman SJ, Frank MJ. "Subthalamic nucleus stimulation reverses mediofrontal influence over decision threshold." Nature Neuroscience, vol. 14, no. 11, 2011, pp. 1462-7. |
| Solomon, Marjorie, Frank, Michael J., Smith, Anne C., Ly, Stanford, Carter, Cameron S. "Transitive inference in adults with autism spectrum disorders." Cogn Affect Behav Neurosci, vol. 11, no. 3, 2011, pp. 437-449. |
| Cavanagh JF, Gründler TO, Frank MJ, Allen JJ. "Altered cingulate sub-region activation accounts for task-related dissociation in ERN amplitude as a function of obsessive-compulsive symptoms." Neuropsychologia, vol. 48, no. 7, 2010, pp. 2098-109. |
| Samson, R. D., Frank, M. J., Fellous, Jean-Marc. "Computational models of reinforcement learning: the role of dopamine as a reward signal." Cogn Neurodyn, vol. 4, no. 2, 2010, pp. 91-105. |
| Robinson OJ, Frank MJ, Sahakian BJ, Cools R. "Dissociable responses to punishment in distinct striatal regions during reversal learning." NeuroImage, vol. 51, no. 4, 2010, pp. 1459-67. |
| Cavanagh JF, Frank MJ, Klein TJ, Allen JJ. "Frontal theta links prediction errors to behavioral adaptation in reinforcement learning." NeuroImage, vol. 49, no. 4, 2010, pp. 3198-209. |
| Hazy TE, Frank MJ, O'Reilly RC. "Neural mechanisms of acquired phasic dopamine responses in learning." Neuroscience & Biobehavioral Reviews, vol. 34, no. 5, 2010, pp. 701-20. |
| Wiecki TV, Frank MJ. "Neurocomputational models of motor and cognitive deficits in Parkinson's disease." Progress in brain research, vol. 183, 2010, pp. 275-97. |
| Frank, Michael J, Doll, Bradley B, Oas-Terpstra, Jen, Moreno, Francisco. "Prefrontal and striatal dopaminergic genes predict individual differences in exploration and exploitation." Nature Neuroscience, vol. 13, no. 5, 2010, pp. 649-649. |
| Chang LJ, Doll BB, van 't Wout M, Frank MJ, Sanfey AG. "Seeing is believing: trustworthiness as a dynamic belief." Cognitive Psychology, vol. 61, no. 2, 2010, pp. 87-105. |
| Wiecki TV, Riedinger K, von Ameln-Mayerhofer A, Schmidt WJ, Frank MJ. "A neurocomputational account of catalepsy sensitization induced by D2 receptor blockade in rats: context dependency, extinction, and renewal." Psychopharmacology, vol. 204, no. 2, 2009, pp. 265-77. |
| Chase, H. W., Frank, M. J., Michael, A., Bullmore, E. T., Sahakian, B. J., Robbins, T. W. "Approach and avoidance learning in patients with major depression and healthy controls: relation to anhedonia." Psychological Medicine, vol. 40, no. 03, 2009, pp. 433. |
| Ragland, J. D., Cools, R., Frank, M., Pizzagalli, D. A., Preston, A., Ranganath, C., Wagner, A. D. "CNTRICS Final Task Selection: Long-Term Memory." Schizophrenia Bulletin, vol. 35, no. 1, 2009, pp. 197-212. |
| Frank MJ, Surmeier DJ. "Do substantia nigra dopaminergic neurons differentiate between reward and punishment?." Journal of molecular cell biology, vol. 1, no. 1, 2009, pp. 15-6. |
| Frank MJ, Hutchison K. "Genetic contributions to avoidance-based decisions: striatal D2 receptor polymorphisms." Neuroscience, vol. 164, no. 1, 2009, pp. 131-40. |
| Doll BB, Jacobs WJ, Sanfey AG, Frank MJ. "Instructional control of reinforcement learning: a behavioral and neurocomputational investigation." Brain Research, vol. 1299, 2009, pp. 74-94. |
| Frank, Michael J., Cohen, Michael X., Sanfey, Alan G. "Multiple Systems in Decision Making: A Neurocomputational Perspective." Current Directions in Psychological Science, vol. 18, no. 2, 2009, pp. 73-77. |
| Cohen MX, Frank MJ. "Neurocomputational models of basal ganglia function in learning, memory and choice." Behavioural Brain Research, vol. 199, no. 1, 2009, pp. 141-56. |
| Frank MJ, Doll BB, Oas-Terpstra J, Moreno F. "Prefrontal and striatal dopaminergic genes predict individual differences in exploration and exploitation." Nature Neuroscience, vol. 12, no. 8, 2009, pp. 1062-8. |
| Chatham CH, Frank MJ, Munakata Y. "Pupillometric and behavioral markers of a developmental shift in the temporal dynamics of cognitive control." Proceedings of the National Academy of Sciences, vol. 106, no. 14, 2009, pp. 5529-33. |
| Daw ND, Frank MJ. "Reinforcement learning and higher level cognition: introduction to special issue." Cognition, vol. 113, no. 3, 2009, pp. 259-61. |
| Santesso DL, Evins AE, Frank MJ, Schetter EC, Bogdan R, Pizzagalli DA. "Single dose of a dopamine agonist impairs reinforcement learning in humans: evidence from event-related potentials and computational modeling of striatal-cortical function." Human Brain Mapping, vol. 30, no. 7, 2009, pp. 1963-76. |
| Frank, Michael J. "Slave to the striatal habit (Commentary on Tricomi et al. )." European Journal of Neuroscience, vol. 29, no. 11, 2009, pp. 2223-2224. |
| Cools, R., Frank, M. J., Gibbs, S. E., Miyakawa, A., Jagust, W., D'Esposito, M. "Striatal dopamine predicts outcome-specific reversal learning and its sensitivity to dopaminergic drug administration." Journal of Neuroscience, vol. 29, no. 5, 2009, pp. 1538-1543. |
| Gründler TO, Cavanagh JF, Figueroa CM, Frank MJ, Allen JJ. "Task-related dissociation in ERN amplitude as a function of obsessive-compulsive symptoms." Neuropsychologia, vol. 47, no. 8-9, 2009, pp. 1978-87. |
| Doll, B.B., Tsuchida, A., Fellows, L.K., Frank, M.J. "Ventromedial Prefrontal Cortex Lesions Impair Value Updating of Unchosen Stimuli in a Reversal Task." NeuroImage, vol. 47, 2009, pp. S138. |
| Moustafa AA, Sherman SJ, Frank MJ. "A dopaminergic basis for working memory, learning and attentional shifting in Parkinsonism." Neuropsychologia, vol. 46, no. 13, 2008, pp. 3144-56. |
| Moustafa, A. A., Cohen, M. X., Sherman, S. J., Frank, M. J. "A Role for Dopamine in Temporal Decision Making and Reward Maximization in Parkinsonism." Journal of Neuroscience, vol. 28, no. 47, 2008, pp. 12294-304. |
| Frank MJ, Kong L. "Learning to avoid in older age." Psychology and aging, vol. 23, no. 2, 2008, pp. 392-8. |
| Frank, Michael J, O'Reilly, Randall C, Curran, Tim. "Midazolam, hippocampal function, and transitive inference: Reply to Greene." Behavioral and Brain Functions, vol. 4, no. 1, 2008, pp. 5. |
| Frank MJ. "Schizophrenia: a computational reinforcement learning perspective." Schizophrenia Bulletin, vol. 34, no. 6, 2008, pp. 1008-11. |
| Pizzagalli DA, Evins AE, Schetter EC, Frank MJ, Pajtas PE, Santesso DL, Culhane M. "Single dose of a dopamine agonist impairs reinforcement learning in humans: behavioral evidence from a laboratory-based measure of reward responsiveness." Psychopharmacology, vol. 196, no. 2, 2008, pp. 221-32. |
| Gruendler, T.O.J., Cavanagh, J.F., Figueroa, C., Frank, M.J., Allen, J.J.B. "Task related dissociation in performance monitoring as a function of obsessive–compulsive symptoms." International Journal of Psychophysiology, vol. 69, no. 3, 2008, pp. 213. |
| FRANK, M. J., D'LAURO, C., CURRAN, T. "Cross-task individual differences in error processing: Neural, electrophysiological, and genetic components." Cogn Affect Behav Neurosci, vol. 7, no. 4, 2007, pp. 297-308. |
| Frank MJ, D'Lauro C, Curran T. "Cross-task individual differences in error processing: neural, electrophysiological, and genetic components." Cogn Affect Behav Neurosci, vol. 7, no. 4, 2007, pp. 297-308. |
| Frank MJ, Moustafa AA, Haughey HM, Curran T, Hutchison KE. "Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning." Proceedings of the National Academy of Sciences, vol. 104, no. 41, 2007, pp. 16311-6. |
| Frank, M. J., Samanta, J., Moustafa, A. A., Sherman, S. J. "Hold Your Horses: Impulsivity, Deep Brain Stimulation, and Medication in Parkinsonism." Science, vol. 318, no. 5854, 2007, pp. 1309-1312. |
| O'Reilly RC, Frank MJ, Hazy TE, Watz B. "PVLV: the primary value and learned value Pavlovian learning algorithm." Behavioral Neuroscience, vol. 121, no. 1, 2007, pp. 31-49. |
| Waltz JA, Frank MJ, Robinson BM, Gold JM. "Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striatal-cortical dysfunction." Biological Psychiatry, vol. 62, no. 7, 2007, pp. 756-64. |
| Frank MJ, Santamaria A, O'Reilly RC, Willcutt E. "Testing computational models of dopamine and noradrenaline dysfunction in attention deficit/hyperactivity disorder." Neuropsychopharmacology, vol. 32, no. 7, 2007, pp. 1583-99. |
| Hazy, T. E., Frank, M. J., O'Reilly, R. C. "Towards an executive without a homunculus: computational models of the prefrontal cortex/basal ganglia system." Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 362, no. 1485, 2007, pp. 1601-1613. |
| Aron, A. R., Behrens, T. E., Smith, S., Frank, M. J., Poldrack, R. A. "Triangulating a Cognitive Control Network Using Diffusion-Weighted Magnetic Resonance Imaging (MRI) and Functional MRI." Journal of Neuroscience, vol. 27, no. 14, 2007, pp. 3743-3752. |
| Frank, M. J., Scheres, A., Sherman, S. J. "Understanding decision-making deficits in neurological conditions: insights from models of natural action selection." Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 362, no. 1485, 2007, pp. 1641-1654. |
| Frank MJ, O'Reilly RC. "A mechanistic account of striatal dopamine function in human cognition: psychopharmacological studies with cabergoline and haloperidol." Behavioral Neuroscience, vol. 120, no. 3, 2006, pp. 497-517. |
| Frank MJ, Claus ED. "Anatomy of a decision: striato-orbitofrontal interactions in reinforcement learning, decision making, and reversal." Psychological Review, vol. 113, no. 2, 2006, pp. 300-26. |
| Hazy, T.E., Frank, M.J., O’Reilly, R.C. "Banishing the homunculus: Making working memory work." Neuroscience, vol. 139, no. 1, 2006, pp. 105-118. |
| Frank MJ. "Hold your horses: a dynamic computational role for the subthalamic nucleus in decision making." Neural Networks, vol. 19, no. 8, 2006, pp. 1120-36. |
| O'Reilly, Randall C., Frank, Michael J. "Making Working Memory Work: A Computational Model of Learning in the Prefrontal Cortex and Basal Ganglia." Neural Computation, vol. 18, no. 2, 2006, pp. 283-328. |
| Crystal, Howard A., Block, Jennifer, Frank, Michael J. "P1-147." Alzheimer's & Dementia, vol. 2, no. 3, 2006, pp. S139. |
| Frank, M. J., O'Reilly, R. C., Curran, T. "When Memory Fails, Intuition Reigns: Midazolam Enhances Implicit Inference in Humans." Psychological Science, vol. 17, no. 8, 2006, pp. 700-707. |
| Frank, Michael J. "Dynamic Dopamine Modulation in the Basal Ganglia: A Neurocomputational Account of Cognitive Deficits in Medicated and Nonmedicated Parkinsonism." Journal of Cognitive Neuroscience, vol. 17, no. 1, 2005, pp. 51-72. |
| Frank MJ, Woroch BS, Curran T. "Error-related negativity predicts reinforcement learning and conflict biases." Neuron, vol. 47, no. 4, 2005, pp. 495-501. |
| Frank, Michael J., Rudy, Jerry W., Levy, William B., O’Reilly, Randall C. "When logic fails: Implicit transitive inference in humans." Mem Cogn, vol. 33, no. 4, 2005, pp. 742-750. |
| Frank MJ, Rudy JW, Levy WB, O'Reilly RC. "When logic fails: implicit transitive inference in humans." Mem Cogn, vol. 33, no. 4, 2005, pp. 742-50. |
| Frank, M. J. "By Carrot or by Stick: Cognitive Reinforcement Learning in Parkinsonism." Science, vol. 306, no. 5703, 2004, pp. 1940-1943. |
| Atallah HE, Frank MJ, O'Reilly RC. "Hippocampus, cortex, and basal ganglia: insights from computational models of complementary learning systems." Neurobiology of learning and memory, vol. 82, no. 3, 2004, pp. 253-67. |
| Frank MJ, Rudy JW, O'Reilly RC. "Transitivity, flexibility, conjunctive representations, and the hippocampus. II. A computational analysis." Hippocampus, vol. 13, no. 3, 2003, pp. 341-54. |
Jaskir, A. & Frank, M.J. (2023). On the normative advantages of dopamine and striatal opponency for learning and choice. eLife, 12, e85107.
Rouhani, N., Niv, Y., Frank, M.J. & Schwabe, L. (2023). Multiple routes to enhanced memory for emotionally relevant events. Trends in Cognitive Sciences.
Rac-Lubashevsky, R., Cremer, A., Collins, A.G.E., Frank, M.J.*. & Schwabe, L.*. (2023). Neural index of reinforcement learning predicts improved stimulus-response retention under high working memory load. *co-senior authors. Journal of Neuroscience, 43(17), 3131–3143.
Scott, D.N. & Frank, M.J. (2023). Adaptive control of synaptic plasticity integrates micro- and macroscopic network function. Neuropsychopharmacology, 48, 121-144.
Liu, R.G. & Frank, M.J. (2022). Hierarchical clustering optimizes the tradeoff between compositionality and expressivity of task structures for flexible reinforcement learning. Artificial Intelligence, 312.
Fengler, A., Bera, K., Pedersen, M.L. & Frank, M.J. (2022). Beyond Drift Diffusion Models: Fitting a broad class of decision and RL models with HDDM. Journal of Cognitive Neuroscience, 34, 1780-1805.
Moolchand, P., Jones, S.R. & Frank, M.J. (2022). Biophysical and Architectural Mechanisms of Subthalamic Theta under Response Conflict. Journal of Neuroscience, 42, 4470-4487.
Calderon, C.B., Verguts, T. & Frank, M.J. (2022). Thunderstruck: The ACDC model of flexible sequences and rhythms in recurrent neural circuits. PLoS Computational Biology e1009854.
Hamid, A.A., Frank, M.J.*. & Moore, C.I.*. (2021). Wave-like dopamine dynamics as a mechanism for spatiotemporal credit assignment. *co-senior authors; alphabetical order. Cell, 184, 2733-2749.
Hitchcock, P.F., Fried, E.I. & Frank, M.J. (2022). Computational psychiatry needs time and context. Annual Reviews of Psychology, 73, 243-270.
Fengler, A., Govindarajan, L., Chen, T. & Frank, M.J. (2021). Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience. eLife, 10, e65074.
Rac-Lubashevsky, R. & Frank, M.J. (2021). Analogous computations in working memory input, output and motor gating: Electrophysiological and computational modeling evidence. PLoS Computational Biology, 17, e1008971.
Westbrook, J.A., Frank, M.J. & Cools, R. (2021). A mosaic of cost-benefit control over cortico-striatal circuitry. Trends in Cognitive Sciences, 25, 710-721.
Pedersen, M.L., Ironside, M., Amemori, K., McGrath, C.M., Kang, M.S., Graybiel, A.M., Pizzagalli, D.A. & Frank, M.J. (2021). Computational phenotyping of brain-behavior dynamics underlying approach-avoidance conflict in major depressive disorder. PLoS Computational Biology, 17(5),.
Geana, A., Barch, D.M., Gold, J.M., Carter, C.S., MacDonald, A.W., Ragland, J.D., Silverstein, S.M. & Frank, M.J. (2021). Using computational modelling to capture schizophrenia-specific reinforcement learning differences and their implications on patient classification. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.
Nassar, M.N., Waltz, J.A., Albrecht, M.A., Gold, J.M. & Frank, M.J. (2021). All or nothing belief updating in patients with schizophrenia reduces precision and flexibility of beliefs. Brain, 144, 1013-1029.
Lehnert, L., Littman, M.L. & Frank, M.J. (2020). Reward-predictive representations generalize across tasks in reinforcement learning. PLOS Computational Biology, 16(10), e1008317.
Westbrook, J., van den Bosch, R., Maatta, J.I., Hofmans, L., Papadopetraki, D., Cools, R.*. & Frank, M.J.*. (2020). Dopamine promotes cognitive effort by biasing the benefits versus costs of cognitive work. *co-senior authors. Science, 367, 1362-1366.
Franklin, N.T. & Frank, M.J. (2020). Generalizing to generalize: Humans flexibly switch between compositional and conjunctive structures during reinforcement learning. PLOS Computational Biology, 16, e1007720.
Pedersen, M.L. & Frank, M.J. (in press). Simultaneous hierarchical Bayesian parameter estimation for reinforcement learning and drift diffusion models: a tutorial and links to neural data. Computational Brain & Behavior.
Lamba, A., Frank, M.J. & FeldmanHall, O. (2020). Anxiety impedes adaptive social learning under uncertainty. Psychological Science.
Piray, P., Dezfouli, A., Heskes, T., Frank, M.J. & Daw, N.D. (2019). Hierarchical Bayesian inference for concurrent model fitting and comparison for group studies. PLoS Computational Biology.
Nassar, M.N., Bruckner, R. & Frank, M.J. (2019). Statistical context dictates the relationship between feedback-related EEG signals and learning. eLife, 8:e46975,.
Jang, A.I., Nassar, M.N., Dillon, D.G. & Frank, M.J. (2019). Positive reward prediction errors during decision making strengthen memory encoding. Nature Human Behaviour, 3.
Franklin, N.T. & Frank, M.J. (2018). Compositional clustering in task structure learning. PLOS Computational Biology, 14(4): e1006116,.
Collins, A.G.E. & Frank, M.J. (2018). Within- and across-trial dynamics of human EEG reveal cooperative interplay between reinforcement learning and working memory. Proceedings of the National Academy of Sciences, 115, 2502-2507.
Nassar, M.R., Helmers, J. & Frank, M.J. (2018). Chunking as a rational strategy for lossy data compression in visual working memory. Psychological Review, 125, 486-511.
Cavanagh, J.F., Bismark, A., Frank, M.J. & Allen, J.J.B. (2018). Multiple Dissociations between Comorbid Depression and Anxiety on Reward and Punishment Processing: Evidence from Computationally Informed EEG. Computational Psychiatry, 1, 1-17.
Swart, J.C., Frank, M.J., Maatta, J.I., Jensen, O., Cools, R. & den Ouden, H.E.M. (2018). Frontal network dynamics reflect neurocomputational mechanisms for reducing maladaptive biases in motivated action. PLoS Biology, 16:e2005959,.
Patel, S.R., Herrington, T., Sheth, S.A., Mian, M., Bick, S.K., Yang, J.C., Flaherty, A.W., Frank, M.J., Widge, A.S., Dougherty, D. & Eskandar, E.N. (2018). Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects. eLife, 7:e36460,.
Ritz, H., Nassar, M.R., Frank, M.J. & Shenhav, A. (2018). A control theoretic model of adaptive learning in dynamic environments. Journal of Cognitive Neuroscience, 30, 1405-1421.
Jahfari, S., Ridderinkhof, K.R., Collins, A.G.E., Knapen, T., Waldorp, L. & Frank, M.J. (2019). Cross-task contributions of frontobasal ganglia circuitry in response inhibition and conflict-induced slowing. Cerebral Cortex, 29, 1969-1983.
Hernaus, D., Gold, J.M., Waltz, J.A. & Frank, M.J. (2018). Impaired expected value computations coupled with overreliance on stimulus-response learning in schizophrenia. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.
Westbrook, J.A. & Frank, M.J. (2018). Dopamine and proximity in motivation and cognitive control. Current Opinion in Behavioral Sciences, 22, 28-34.
Maia, T.V., Huys, Q.J.M. & Frank, M.J. (2017). Theory-based computational psychiatry. Biological Psychiatry, 82, 382-384.
Collins, A.G.E., Albrecht, M., Waltz, J.A., Gold, J.M. & Frank, M.J. (2017). Interactions between working memory, reinforcement learning and effort in value-based choice: A new paradigm and selective deficits in schizophrenia. Biological Psychiatry, 82, 431-439.
Collins, A.G.E., Ciullo, B., Frank, M.J. & Badre, D. (2017). Working memory load strengthens reward prediction errors. Journal of Neuroscience, 37, 4332-4342.
Swart, J.C., Frobose, M.I., Cook, J.L., Geurts, D.E.M., Frank, M.J., Cools, R. & den Ouden, H.E.M. (2017). Catecholaminergic challenge uncovers distinct Pavlovian and instrumental mechanisms of motivated (in)action. eLife, 6:e22169,.
Frank, M.J. (2016). Computational Cognitive Neuroscience Approaches to Deconstructing Mental Function and Dysfunction. A.D. Redish & J.D. Gordon (Eds) Computational Psychiatry: New Perspectives on Mental Illness. Strüngmann Forum Reports, vol. 20, J. Lupp, series editor, 101-120, Cambridge, MA: MIT Press
Collins, A.G.E. & Frank, M.J. (2016). Neural signature of hierarchically structured expectations predicts clustering and transfer of rule sets in reinforcement learning. Cognition, 152, 160-169.
Maia, T.V. & Frank, M.J. (2017). An integrative perspective on the role of dopamine in schizophrenia. Biological Psychiatry, 81, 52-66.
Nassar, M.R. & Frank, M.J. (2016). Taming the beast: extracting generalizable knowledge from computational models of cognition. Current Opinion in Behavioral Sciences, 11, 49-54.
Huys, Q.J.M., Maia, T.V. & Frank, M.J. (2016). Computational psychiatry as a bridge from neuroscience to clinical applications. Nature Neuroscience, 19, 404-413.
Doll, B.B., Bath, K.G., Daw, N.D. & Frank, M.J. (2016). Variability in dopamine genes dissociates model-based and model-free reinforcement learning. Journal of Neuroscience, 36, 1211-1222.
Franklin, N.T. & Frank, M.J. (2015). A cholinergic feedback circuit to regulate striatal population uncertainty and optimize reinforcement learning. eLife, 4:e12029.
Badre, D., Frank, M.J. & Moore, C.I. (2015). Interactionist Neuroscience. Neuron, 88, 855-860.
Frank, M.J., Gagne, C., Nyhus, E., Masters, S., Wiecki, T.V., Cavanagh, J.F. & Badre, D. (2015). fMRI and EEG Predictors of Dynamic Decision Parameters during Human Reinforcement Learning. Journal of Neuroscience, 35, 484-494.
Wiecki, T.V., Poland, J.S. & Frank, M.J. (2015). Model-based cognitive neuroscience approaches to computational psychiatry: clustering and classification. Clinical Psychological Science, 3, 378-399.
Frank, M.J. & Badre, D. (2015). How cognitive theory guides neuroscience. Cognition, 135, 14-20.
Cavanagh, J.F., Masters, S.E., Bath, K. & Frank, M.J. (2014). Conflict acts as an implicit cost in reinforcement learning. Nature Communications, 5:5394,.
Collins, A.G.E., Brown., J., Gold, J., Waltz, J. & Frank, M.J. (2014). Working memory contributions to reinforcement learning in schizophrenia. Journal of Neuroscience, 34, 13747-13756.
Cockburn, J., Collins, A.G.E. & Frank, M.J. (2014). A reinforcement learning mechanism responsible for the valuation of free choice. Neuron, 83, 551-557.
Collins, A.G.E. & Frank, M.J. (2014). Opponent Actor Learning (OpAL): modeling interactive effects of striatal dopamine on reinforcement learning and choice incentive. Psychological Review, 121, 337-366.
Cavanagh, J.F. & Frank, M.J. (2014). Frontal theta as a mechanism for cognitive control. Trends in Cognitive Sciences, 18, 414-421.
Collins, A.G.E., Cavanagh, J.F. & Frank, M.J. (2014). Human EEG uncovers latent generalizable task-set structure during learning. Journal of Neuroscience, 34, 4677-4685.
Chatham, C., Frank, M.J. & Badre, D. (2014). Corticostriatal output gating during selection from working memory. Neuron, 81, 930-942.
Cavanagh, J.F., Wiecki, T.V., Kochar, A. & Frank, M.J. (2014). Eye tracking and pupillometry are indicators of dissociable latent decision processes. Journal of Experimental Psychology: General, 143, 1476-1488.
Wiecki, T.V., Sofer, I. & Frank, M.J. (2013). HDDM: Hierarchical Bayesian estimation of the Drift-Diffusion Model in Python. Frontiers of Neuroinformatics, 7, 1-10.
Narayanan, S.N., Cavanagh, J.F., Frank, M.J. & Laubach, M. (2013). Common medial frontal mechanisms of adaptive control in humans and rodents. Nature Neuroscience, 16, 1888-95.
Cavanagh, J.F., Eisenberg, I., Guitart-Masip, M., Huys, Q. & Frank, M.J. (2013). Frontal theta overrides Pavlovian learning biases. Journal of Neuroscience, 33, 8541-8548.
Collins, A.G.E. & Frank, M.J. (2013). Cognitive control over learning: Creating, clustering and generalizing task-set structure. Psychological Review, 120, 190-229.
Wiecki, T.V. & Frank, M.J. (2013). A computational model of inhibitory control in frontal cortex and basal ganglia. Psychological Review, 120, 329-355.
Badre, D., Doll, B.B., Long, N.M. & Frank, M.J. (2012). Rostrolateral prefrontal cortex and individual differences in uncertainty-driven exploration. Neuron, 73, 595-607.
Gold, J.M., Waltz, J.A., Matveeva, T.M., Kasanova, Z., Strauss, G.P., Herbener, E.S., Collins, A.G.E. & Frank, M.J. (2012). Negative symptoms and the failure to represent the expected reward value of actions: Behavioral and computational modeling evidence. Archives of General Psychiatry, 69, 129-138.
Frank, M.J. & Badre, D. (2012). Mechanisms of hierarchical reinforcement learning in corticostriatal circuits 1: Computational analysis. Cerebral Cortex, 22, 509-526
Frank, M.J. and Fossella, J. (2011) Neurogenetics and pharmacology of learning, motivation and cognition. Neuropsychopharmacology Reviews 36, 133-152.
Maia, T.V. and Frank, M.J. (2011). From reinforcement learning models to psychiatric and neurological disorders. Nature Neuroscience 14, 154-162.
Strauss, G.P., Frank, M.J., Waltz, J.A., Kasanova, Z., Herbener, E.S., Gold, J.M. (2011). Deficits in positive reinforcement learning and uncertainty-driven exploration are associated with distinct aspects of negative symptoms in schizophrenia. Biological Psychiatry 69, 424-31
Doll, B.B., Hutchison, K.E. & Frank, M.J. (2011). Dopaminergic genes predict individual differences in susceptibility to confirmation bias. Journal of Neuroscience 31, 6188-6198.
Cavanagh, J.F., Wiecki, T.V., Cohen, M.X., Figueroa, C.M., Samanta, J., Sherman, S.J. Frank, M.J. (2011). Subthalamic nucleus stimulation reverses mediofrontal influence over decision threshold. Nature Neuroscience 14, 1462-67.
Cavanagh, J., Frank, M.J., Klein, T.J., and Allen, J.J.B. (2010). Frontal theta links prediction errors to behavioral adaptation in reinforcement learning. NeuroImage 49, 3198-3209.
Wiecki, T.V., Riedinger, K., Meyerhofer, A., Schmidt, W.J. and Frank, M.J. (2009). A neurocomputational account of catalepsy sensitization induced by D2-receptor-blockade in rats: Context-dependency, extinction and renewal . Psychopharmacology 204(2):265-77.
Cohen, M.X. and Frank, M.J. (2009). Neurocomputational models of basal ganglia function in learning, memory and choice. Behavioural Brain Research 199:141-156.
Frank, M.J., Doll, B.B, Oas-Terpstra, J., and Moreno, F (2009). Prefrontal and striatal dopaminergic genes predict individual differences in exploration and exploitation. Nature Neuroscience
Doll, B.B., Jacobs, W.J. , Sanfey, A.G and Frank M.J. (2009). Instructional control of reinforcement learning: A behavioral and neurocomputational investigation. Brain Research
Moustafa, A.A., Cohen, M.X., Sherman, S.J. and Frank, M.J. (2008). A role for dopamine in temporal decision making and reward maximization in Parkinsonism. Journal of Neuroscience, 28, 12294-12304.
Frank, M.J., Santamaria, A., O'Reilly, R.C. and Willcutt, E. G. (2007). Testing computational models of dopamine and noradrenaline dysfunction in attention-deficit/hyperactivity disorder. Neuropsychopharmacology, 32, 1583-99.
Frank, M.J., Moustafa, A.A., Haughey, H.C., Curran, T. and Hutchison, K. (2007). Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning. Proceedings of the National Academy of Sciences, 104, 16311-16316.
Frank, M.J., Samanta, J., Moustafa, A.A. and Sherman, S.J. (2007). Hold your horses: Impulsivity, deep brain stimulation and medication in Parkinsonism. Science, 318, 1309-1312.
O'Reilly, R.C. and Frank, M.J. (2006). Making working memory work: A computational model of learning in the frontal cortex and basal ganglia. Neural Computation, 18, 283-328.
Frank, M.J., O'Reilly, R.C. and Curran, T. (2006). When memory fails, intuition reigns: Midazolam enhances implicit inference in humans. Psychological Science, 17, 700-707.
Frank, M.J. and Claus, E. (2006). Anatomy of a Decision: Striato-Orbitofrontal Interactions in Reinforcement Learning, Decision Making and Reversal. Psychological Review, 113, 300-326.
Frank, M.J. (2006). Hold your horses: A dynamic computational role for the subthalamic nucleus in decision making. Neural Networks, 19, 1120-1136
Frank, M.J. and O'Reilly, R.C. (2006). A mechanistic account of striatal dopamine function in cognition: Psychopharmacological studies with cabergoline and haloperidol. Behavioral Neuroscience, 120, 497-517.
Frank, M.J., Woroch, B.S. & Curran, T. (2005). Error related negativity predicts reinforcement learning and conflict biases. Neuron, 47, 495-501.
Frank, M.J. (2005). Dynamic dopamine modulation in the basal ganglia: A neurocomputational account of cognitive deficits in medicated and nonmedicated Parkinsonism. Journal of Cognitive Neuroscience, 17, 51-72.
Frank, M.J., Seeberger, L.C. and O'Reilly, R.C. (2004). By carrot or by stick: Cognitive reinforcement learning in Parkinsonism. Science, 306, 1940-3.
Frank, M.J., Rudy, J.W., & O'Reilly, R.C. (2003). Transitivity, flexibility, conjunctive representations and the hippocampus: II: A computational analysis. Hippocampus, 13, 341-354.
Frank, M. J., Loughry, B. & O'Reilly, R. C. (2001) Interactions between frontal cortex and basal ganglia in working memory: A computational model. Cognitive, Affective, and Behavioral Neuroscience, 1 137-160.
| Year | Degree | Institution |
|---|---|---|
| 2004 | PhD | University of Colorado at Boulder |
| 2000 | MS | University of Colorado at Boulder |
| 1997 | BS | Queen's University |
Troland Research Award, National Academy of Sciences, 2021
Kavli Fellow, 2016
Radboud Excellence Professorship, Radboud University, the Netherlands, 2015
Fellow, Association for Psychological Science, 2012
Cognitive Neuroscience Society Young Investigator Award, 2011
Janet T Spence Award for Transformative Early Career Contributions, APS, 2010
Neural Networks journal award for most cited article 2006-2010
D.G. Marquis Behavioral Neuroscience Award, best paper in Behavioral Neuroscience, 2006
Dozier Award for outstanding scholarly record, University of Colorado, 2004
| Director, Center for Computational Brain Science. 2020-Present |
| CLPS 1470 - Mechanisms of Motivated Decision Making |
| CLPS 1492 - Computational Cognitive Neuroscience |
