Creton, Robbert

Robbert J Creton

Professor of Medical Science (Research), Professor of Pathology and Laboratory Medicine (Research)

Overview

Robbert Creton received his B.S. in Biology (1990) and Ph.D. in Developmental Biology (1994) from the University of Utrecht in the Netherlands. He completed his post-doctoral training in developmental physiology at the Marine Biological Laboratory in Woods Hole, Massachusetts, and was appointed as an investigator at Women & Infants Hospital of Rhode Island. In 2002, Robbert Creton joined Brown University, where he continued his studies on brain development and visually-guided behavior using zebrafish as a model system. He is the director of the Leduc Bioimaging Facility, which provides equipent and training dedicated to high-resolution imaging in the life sciences.

Brown Affiliations

Research Areas

On the Web

Zebrafish at Brown

Leduc Bioimaging Facility

Creton Lab in the News (Research Features)

Publications Visualize it

Tucker Edmister S, Ibrahim R, Kakodkar R, Kreiling JA, Creton R. "A zebrafish model for calcineurin-dependent brain function." Behavioural Brain Research, vol. 416, 2022, pp. 113544.

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Tucker Edmister S, Del Rosario Hernández T, Ibrahim R, Brown CA, Gore SV, Kakodkar R, Kreiling JA, Creton R. "Novel use of FDA-approved drugs identified by cluster analysis of behavioral profiles." Scientific reports, vol. 12, no. 1, 2022, pp. 6120.

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Ranasinghe P, Thorn RJ, Creton R, Lee CM. "Enantioselective Toxicity Effects of 2,2',3,5',6-Pentachloro Biphenyl (PCB-95) on Developing Brains in Zebrafish Larvae." Bulletin of environmental contamination and toxicology, vol. 107, no. 2, 2021, pp. 351-360.

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Thorn RJ, Dombroski A, Eller K, Dominguez-Gonzalez TM, Clift DE, Baek P, Seto RJ, Kahn ES, Tucker SK, Colwill RM, Sello JK, Creton R. "Analysis of vertebrate vision in a 384-well imaging system." Scientific reports, vol. 9, no. 1, 2019, pp. 13989.

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Richendrfer H, Creton R. "Cluster analysis profiling of behaviors in zebrafish larvae treated with antidepressants and pesticides." Neurotoxicology and Teratology, 2017.

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Thorn RJ, Clift DE, Ojo O, Colwill RM, Creton R. "The loss and recovery of vertebrate vision examined in microplates." PLoS ONE, vol. 12, no. 8, 2017, pp. e0183414.

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Holloway MP, DeNardo BD, Phornphutkul C, Nguyen K, Davis C, Jackson C, Richendrfer H, Creton R, Altura RA. "An asymptomatic mutation complicating severe chemotherapy-induced peripheral neuropathy (CIPN): a case for personalised medicine and a zebrafish model of CIPN." NPJ genomic medicine, vol. 1, 2016, pp. 16016.

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Gonzalez, Sarah T., Remick, Dylan, Creton, Robbert, Colwill, Ruth M. "Effects of embryonic exposure to polychlorinated biphenyls (PCBs) on anxiety-related behaviors in larval zebrafish." Neurotoxicology, vol. 53, 2016, pp. 93-101.

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Gonzalez ST, Remick D, Creton R, Colwill RM. "Effects of embryonic exposure to polychlorinated biphenyls (PCBs) on anxiety-related behaviors in larval zebrafish." Neurotoxicology, vol. 53, 2016, pp. 93-101.

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Lovato, Ava K., Creton, Robbert, Colwill, Ruth M. "Effects of embryonic exposure to polychlorinated biphenyls (PCBs) on larval zebrafish behavior." Neurotoxicology and Teratology, vol. 53, 2016, pp. 1-10.

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Lovato AK, Creton R, Colwill RM. "Effects of embryonic exposure to polychlorinated biphenyls (PCBs) on larval zebrafish behavior." Neurotoxicology and Teratology, vol. 53, 2016, pp. 1-10.

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Mallick, Emily M., Bergeron, Audrey C., Jones, Stephen K., Newman, Zachary R., Brothers, Kimberly M., Creton, Robbert, Wheeler, Robert T., Bennett, Richard J. "Phenotypic Plasticity Regulates Candida albicans Interactions and Virulence in the Vertebrate Host." Frontiers in microbiology, vol. 7, 2016, pp. 780.

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Richendrfer H, Creton R. "Chlorpyrifos and malathion have opposite effects on behaviors and brain size that are not correlated to changes in AChE activity." Neurotoxicology, vol. 49, 2015, pp. 50-8.

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Clift, Danielle E., Thorn, Robert J., Passarelli, Emily A., Kapoor, Mrinal, LoPiccolo, Mary K., Richendrfer, Holly A., Colwill, Ruth M., Creton, Robbert. "Effects of embryonic cyclosporine exposures on brain development and behavior." Behavioural Brain Research, vol. 282, 2015, pp. 117-124.

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Lin CL, Taggart AJ, Lim KH, Ferraris L, Cygan KJ, Creton R, Huang YT, Fairbrother WG. "RNA structure replaces the need for U2AF2 in splicing." Genome Research, vol. 26, no. 1, 2015, pp. 12-23.

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Clift, Danielle, Richendrfer, Holly, Thorn, Robert J., Colwill, Ruth M., Creton, Robbert. "High-Throughput Analysis of Behavior in Zebrafish Larvae: Effects of Feeding." Zebrafish, vol. 11, no. 5, 2014, pp. 455-461.

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O'Neale A, Ellis J, Creton R, Colwill RM. "Single stimulus learning in zebrafish larvae." Neurobiology of learning and memory, vol. 108, 2014, pp. 145-54.

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Richendrfer, Holly, Créton, Robbert. "Automated High-throughput Behavioral Analyses in Zebrafish Larvae." Journal of Visualized Experiments, no. 77, 2013.

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Richendrfer, Holly, Pelkowski, Sean D., Colwill, Ruth M., Créton, Robbert. "Developmental sub-chronic exposure to chlorpyrifos reduces anxiety-related behavior in zebrafish larvae." Neurotoxicology and Teratology, vol. 34, no. 4, 2012, pp. 458-465.

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Richendrfer H, Pelkowski SD, Colwill RM, Creton R. "On the edge: pharmacological evidence for anxiety-related behavior in zebrafish larvae." Behavioural Brain Research, vol. 228, no. 1, 2012, pp. 99-106.

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Pelkowski SD, Kapoor M, Richendrfer HA, Wang X, Colwill RM, Creton R. "A novel high-throughput imaging system for automated analyses of avoidance behavior in zebrafish larvae." Behavioural Brain Research, vol. 223, no. 1, 2011, pp. 135-44.

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Colwill RM, Creton R. "Imaging escape and avoidance behavior in zebrafish larvae." Reviews in the Neurosciences, vol. 22, no. 1, 2011, pp. 63-73.

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Colwill RM, Creton R. "Locomotor behaviors in zebrafish (Danio rerio) larvae." Behavioural processes, vol. 86, no. 2, 2011, pp. 222-9.

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Créton, Robbert, Wessel, Gary M. "The passing of a major wave: Lionel F. Jaffe (December 28, 1927 - April 27, 2011)." Mol. Reprod. Dev., vol. 78, no. 6, 2011, pp. Fm i-Fm i.

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Creton R. "Automated analysis of behavior in zebrafish larvae." Behavioural Brain Research, vol. 203, no. 1, 2009, pp. 127-36.

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Kreiling JA, Balantac ZL, Crawford AR, Ren Y, Toure J, Zchut S, Kochilas L, Creton R. "Suppression of the endoplasmic reticulum calcium pump during zebrafish gastrulation affects left-right asymmetry of the heart and brain." Mechanisms of development, vol. 125, no. 5-6, 2008, pp. 396-410.

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Kreiling JA, Prabhat, Williams G, Creton R. "Analysis of Kupffer's vesicle in zebrafish embryos using a cave automated virtual environment." Developmental dynamics : an official publication of the American Association of Anatomists, vol. 236, no. 7, 2007, pp. 1963-9.

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Kreiling JA, Creton R, Reinisch C. "Early embryonic exposure to polychlorinated biphenyls disrupts heat-shock protein 70 cognate expression in zebrafish." Journal of toxicology and environmental health. Part A, vol. 70, no. 12, 2007, pp. 1005-1013.

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Creton R. "The calcium pump of the endoplasmic reticulum plays a role in midline signaling during early zebrafish development." Brain research. Developmental brain research, vol. 151, no. 1-2, 2004, pp. 33-41.

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Wong, Julian L., Créton, Robbert, Wessel, Gary M. "The oxidative burst at fertilization is dependent upon activation of the dual oxidase Udx1." Developmental Cell, vol. 7, no. 6, 2004, pp. 801-14.

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Research

Research Overview

Research in the Creton laboratory is focused on brain development and behavior, using zebrafish as a model system. The studies aim to provide a better understanding of basic biological mechanisms and to contribute to the prevention and treatment of various human disorders, including visual impairment, developmental brain disorders and Alzheimer’s disease.

Research Statement

The Creton laboratory found that modulation of calcium signaling during embryonic development causes a randomization of left-right asymmetry in the heart and brain. As part of these studies, an imaging system was built for automated analyses of asymmetric behaviors. However, it quickly became clear that this imaging system could be used for a broad range of research projects that go beyond the studies on left-right asymmetry.

Project 1. Automated analyses of behavior in response to visual stimuli

This NIH-funded project (R01 EY024562) is focused on the automated analysis of behavior in response to visual stimuli using zebrafish as a model system. The studies will contribute to a better basic understanding of behaviors that are influenced by visual stimuli and will provide high-throughput tools to evaluate novel treatments of blindness and low vision.

Project 2. Regulation of behavior by calcineurin signaling pathways

This project is focused on the regulation of behavior by Calcineurin signaling pathways. The obtained results will provide a better basic understanding of neural Calcineurin signaling and may lead to the identification of novel treatments for neural dysfunction in Down syndrome and Alzheimer’s disease.

Project 3. Tools for automated analyses of vertebrate behavior in microplates

This project is focused on the further development of tools for automated analyses of vertebrate behavior in microplates. The developed methodologies will be used to examine functional changes in the neural, digestive and muscular systems. The studies will lead to a better understanding of the basic biological processes that influence behavior and will provide novel tools for disease prevention and treatment.

Collaborative research projects

The developed imaging system has been used in collaboration with Dr. Ruth Colwill to study effects of developmental PCB exposures; Dr. Holly Richendrfer to study effects of developmental pesticide exposures; Dr. Rachel Altura to study chemotherapy-induced peripheral neuropathy; and Dr. Jason Sello to discover novel antidotes to treat drug overdoses.

Funded Research

NIH / Office of the Director, S10 OD023461. Project period: 04/15/2017 - 04/14/2018. Project title: “SEM for serial block-face imaging”. Role on project: Principal Investigator.

Brown University Core Research Facility (CRF) Infrastructure Program. Project period: 7/12/17 - 6/30/18. Project title: “Confocal microscope”. Role on project: Principal Investigator

NIH / NEI, R01 EY024562. Project period: 09/01/2015 – 08/31/2019. Project title: Automated analyses of behavior in response to visual stimuli. Role on project: Principal Investigator.

NIH / NIEHS, P42 ES013660. Project period: 09/30/2015 - 03/31/2020. Project title: Superfund Research Program: “Toxicant Exposures in Rhode Island: Past, Present, and Future”. Role on project: Core leader of the Molecular Pathology Core.

NIH R01 HD060647 03/01/2010 - 01/31/16
Brain defects induced by embryonic exposure to modulators of calcium signaling. The goal of this project is to better understand the basic mechanisms by which modulators of calcium signaling affect brain development. R. Creton is the PI on this project.

NIH F32 ES021342 09/03/2012 - 08/31/2015
The effects of organophosphates on anxiety-related behavior and neurodevelopment. R. Creton serves as a mentor on this project.

NIH P42 ES013660 04/01/09 - 03/31/15
Reuse in RI: A State-based Approach to Complex Exposures. R.Creton is the core leader of the Molecular Pathology Core.

NSF IBN-0421654 08/01/04 - 07/31/07
Calcium signaling in the developing zebrafish brain. The goal of this project is to better understand the mechanisms regulating brain regionalization during early embryonic development, using zebrafish embryos as a model system. R. Creton is the PI on this project.

The Rhode Island Foundation 01/25/05 - 12/31/06
The role of HDACs in zebrafish heart development. The goal of this project is to determine the presence and role of histone deacetylases in cardiac development. R. Creton is the PI on this project.

Scholarly Work

Publications: http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40509348/?sort=date&direction=descending

Background

Education and Training

Year	Degree	Institution
1994	PhD	Utrecht University
1990	BS	Utrecht University

Honors and Awards

1993 Spiegel fellow
1995 NATO fellow

Affiliations Visualize it

Collaborators

Name	Title
Altura, Rachel	Adjunct Associate Professor of Pediatrics
Colwill, Ruth	Professor of Cognitive and Psychological Sciences
Sello, Jason	Adjunct Professor of Chemistry

Affiliations

Society for Developmental Biology, member, 2003-present

Society for Neuroscience, member, 2003-present

Brown Institute for Brain Science, 2010-present

Brown University Superfund Research Program, 2012-present

Researchers@Brown

Researchers@Brown

Robbert J Creton

Professor of Medical Science (Research), Professor of Pathology and Laboratory Medicine (Research)

Overview

Brown Affiliations

Research Areas

On the Web

Publications Visualize it

Research

Research Overview

Research Statement

Funded Research

Scholarly Work

Background

Education and Training

Honors and Awards

Affiliations Visualize it

Collaborators

Affiliations

Teaching