B.A., Reed College, 1992 (Advisor Patrick McDougal)
Ph.D., University of llinois at Urbana-Champaign, 1996 (Advisor Peter Beak)
Post-doctoral training, Princeton University 1996-1999 (Advisor Daniel Kahne)
| Nayyab S, O'Connor M, Brewster J, Gravier J, Jamieson M, Magno E, Miller RD, Phelan D, Roohani K, Williard P, Basu A, Reid CW. "Diamide Inhibitors of the Bacillus subtilis N-Acetylglucosaminidase LytG That Exhibit Antibacterial Activity." ACS infectious diseases, vol. 3, no. 6, 2017, pp. 421-427. |
| Okoth, Ronald, Basu, Amit. "Glycopolymers Prepared by Ring-Opening Metathesis Polymerization Followed by Glycoconjugation Using a Triazole-Forming “Click” Reaction." Methods in Molecular Biology, 2016, pp. 29-37. |
| Kuhn H, Gutelius D, Black E, Nadolny C, Basu A, Reid C. "Anti-bacterial glycosyl triazoles - Identification of an N-acetylglucosamine derivative with bacteriostatic activity against Bacillus." MedChemComm, vol. 5, no. 8, 2014, pp. 1213-1217. |
| Dräger, Marius, Basu, Amit. "Galactan synthesis in a single step via oligomerization of monosaccharides." Beilstein J. Org. Chem., vol. 10, 2014, pp. 2658-2663. |
| Okoth, Ronald, Basu, Amit. "End-labeled amino terminated monotelechelic glycopolymers generated by ROMP and Cu(I)-catalyzed azide–alkyne cycloaddition." Beilstein J. Org. Chem., vol. 9, 2013, pp. 608-612. |
| Zhao, Jingsha, Liu, Yuanfang, Park, Hyun-Joo, Boggs, Joan M., Basu, Amit. "Carbohydrate-Coated Fluorescent Silica Nanoparticles as Probes for the Galactose/3-Sulfogalactose Carbohydrate–Carbohydrate Interaction Using Model Systems and Cellular Binding Studies." Bioconjugate Chem., vol. 23, no. 6, 2012, pp. 1166-1173. |
| Boggs, Joan M., Gao, Wen, Zhao, Jingsha, Park, Hyun-Joo, Liu, Yuanfang, Basu, Amit. "Participation of galactosylceramide and sulfatide in glycosynapses between oligodendrocyte or myelin membranes." FEBS Letters, vol. 584, no. 9, 2010, pp. 1771-1778. |
| Wang, Yaqi, Gildersleeve, Jeffrey C., Basu, Amit, Zimmt, Matthew B. "Photo- and Biophysical Studies of Lectin-Conjugated Fluorescent Nanoparticles: Reduced Sensitivity in High Density Assays †." The Journal of Physical Chemistry B, vol. 114, no. 45, 2010, pp. 14487-14494. |
| Liu, Xiang, Basu, Amit. "Core Functionalization of Hollow Polymer Nanocapsules." J. Am. Chem. Soc., vol. 131, no. 16, 2009, pp. 5718-5719. |
| Seah, Nicole, Santacroce, Paul V., Basu, Amit. "Probing the Lactose·GM3 Carbohydrate−Carbohydrate Interaction with Glycodendrimers." Organic Letters, vol. 11, no. 3, 2009, pp. 559-562. |
| Liu, Xiang, Basu, Amit. "Cross-Linked Polynorbornene-Coated Gold Nanoparticles: Dependence of Particle Stability on Cross-Linking Position and Cross-Linker Structure." Langmuir, vol. 24, no. 19, 2008, pp. 11169-11174. |
| Limapichat, Walrati, Basu, Amit. "Reagentless functionalization of gold nanoparticles via a 3 + 2 Huisgen cycloaddition." Journal of Colloid and Interface Science, vol. 318, no. 1, 2008, pp. 140-144. |
| Park YS, Yum EK, Basu A, Beak P. "Dynamic thermodynamic resolution: solvent effects, mechanism, and an asymmetric 3,4,5-substituted benzazepine synthesis." Organic Letters, vol. 8, no. 13, 2006, pp. 2667-70. |
| BASU, A, SCHNEIDER, J. "Model systems." Current opinion in chemical biology, vol. 10, no. 6, 2006, pp. 527-528. |
| Liu, Xiang, Basu, Amit. "Olefin metathesis on nanostructures." Journal of Organometallic Chemistry, vol. 691, no. 24-25, 2006, pp. 5148-5154. |
| Fei, Jiangfeng, Basu, Amit, Xue, Fengtian, Palmore, G. Tayhas R. "Two Polymerizable Derivatives of 2,2‘-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid)." Organic Letters, vol. 8, no. 1, 2006, pp. 3-6. |
| Rossi, Lauren L., Basu, Amit. "Glycosidase inhibition by 1-glycosyl-4-phenyl triazoles." Bioorganic & Medicinal Chemistry Letters, vol. 15, no. 15, 2005, pp. 3596-3599. |
| Rai, Anand Narain, Basu, Amit. "Synthesis of the Glycosphingolipid β-Galactosyl Ceramide and Analogues via Olefin Cross Metathesis." J. Org. Chem., vol. 70, no. 20, 2005, pp. 8228-8230. |
| Mulla, Hormuzd R., Agard, Nicholas J., Basu, Amit. "3-Methoxycarbonyl-5-nitrophenyl boronic acid: high affinity diol recognition at neutral pH." Bioorganic & Medicinal Chemistry Letters, vol. 14, no. 1, 2004, pp. 25-27. |
| Mulla HR, Agard NJ, Basu A. "3-Methoxycarbonyl-5-nitrophenyl boronic acid: high affinity diol recognition at neutral pH." Bioorganic & Medicinal Chemistry Letters, vol. 14, no. 1, 2004, pp. 25-7. |
| Rangin, Marianne, Basu, Amit. "Lipopolysaccharide Identification with Functionalized Polydiacetylene Liposome Sensors." J. Am. Chem. Soc., vol. 126, no. 16, 2004, pp. 5038-5039. |
| Rai, Anand Narain, Basu, Amit. "Sphingolipid Synthesis via Olefin Cross Metathesis: Preparation of a Differentially Protected Building Block and Application to the Synthesis of d - e rythro -Ceramide." Organic Letters, vol. 6, no. 17, 2004, pp. 2861-2863. |
| Santacroce, Paul V., Basu, Amit. "Studies of the carbohydrate-carbohydrate interaction between lactose and GM 3 using Langmuir monolayers and glycolipid micelles." Glycoconj J, vol. 21, no. 3/4, 2004, pp. 89-95. |
| Basu A, Kahne D. "Overcoming degeneracy in carbohydrate recognition." Angew. Chem. Int. Ed. Engl., vol. 42, no. 22, 2003, pp. 2504-6. |
| Santacroce PV, Basu A. "Probing specificity in carbohydrate-carbohydrate interactions with micelles and Langmuir monolayers." Angew. Chem. Int. Ed. Engl., vol. 42, no. 1, 2003, pp. 95-8. |
| Basu A, Thayumanavan S. "Configurational stability and transfer of stereochemical information in the reactions of enantioenriched organolithium reagents." Angew. Chem. Int. Ed. Engl., vol. 41, no. 5, 2002, pp. 717-38. |
Our group is interested in questions that lie at the interface of chemistry, biology, and materials science. Research in the group includes glycochemistry and glycobiology; synthesis and application of novel polymers and nanomaterials; development of new sensors and diagnostic agents. Current foci include the glcyochemistry of the plant cell wall and the development of small molecules that interfere with bacterial cell wall dynamics and can serve as leads for new antibiotics.
Galactan synthesis in a single step via oligomerization of monosaccharides M. Dräger and A. Basu Beilstein J. Org. Chem. 2014, 10, 2658–2663.
Anti-bacterial glycosyl triazoles – Identification of an N-acetyl glucosamine derivative with bacteriostatic activity against Bacillus H. Kuhn, D. Gutelius, E. Black, C. Nadolny, A. Basu, and C. Reid Med. Chem. Commun. 2014, 5, 1213-1217.
A rapid, inexpensive, and semi-quantitative method for determining pollen tube extension using fluorescence E. Hartman, C. Levy, D. M. Kern, M. Johnson, and A. Basu Plant Methods 2014, 10:3
End-Labeled Amino Terminated Monotelechelic Glycopolymers Generated by ROMP and Cu(I)-Catalyzed Azide – Alkyne Cycloaddition R. Okoth and A. Basu, Beilstein J. Org. Chem. 2013, 9, 608-612.
Participation of Myelin Glycosphingolipids, Galactosylceramide and Sulfatide, in Glycosynapses between Oligodendrocyte or Myelin Membranes J. M. Boggs, W. Gao, J. Zhao, H. Park, Y. Liu, and A. Basu. FEBS Letters. 2010, In press –doi: 10.1016/j.febslet.2009.11.074
Probing the lactose•GM3 carbohydrate‐carbohydrate interaction with glycodendrimers. N. Seah, P.V. Santacroce and A. Basu. Org. Lett. 2009, 11, 559562.
Core Functionalization of Hollow Polymer Nanocapsules. X. Liu and A. Basu. J. Am. Chem. Soc. 2009, 131, 5718‐5719.
Reagentless functionalization of gold nanoparticles via a 3 + 2 Huisgen cycloaddition. J. Coll. Interfac. Sci. 2008, 318, 140‐144. W. Limapichat and A. Basu.
Carbohydrate‐carbohydrate interactions. N. Seah and A. Basu. Encyclopedia of Chemical Biology. John Wiley & Sons. 2008 Ed. T. Begley.
Cross‐linked polynorbornene‐coated gold nanoparticles – Dependence of particle stability on cross‐linking position and cross‐linker structure. X. Liu and A. Basu. Langmuir, 2008, 24, 11169‐11174.
Colorimetric Sensing and Biosensing using Functionalized Conjugated Polymers. A. Basu. Molecular Recognition Using Polymers. John Wiley & Sons. 2008 Ed. V. Rotello & S. Thayumanavan.
Two Polymerizable Derivatives of 2,2'‐Azino‐bis(3 ethylbenzthiazoline‐6‐sulfonic acid). J. Fei, A. Basu, F. Xue, G. T. R. Palmore. Org. Lett. 2006; 8, 3‐6.
Olefin Metathesis on Nanostructures. Liu, X. and Basu, A. J. Organomet. Chem. 2006, 691, 5148‐5154. (Invited Submission, Special Issue on Alkene Metathesis)
Model Systems. Basu, A. and Schneider. J. Curr. Opin. Chem. Biol. 2006, 10, 527–528.
Glycosidase Inhibition by 1‐Glycosyl‐4‐Phenyl Triazoles. L. L. Rossi and A. Basu. Bioorg. Med. Chem. Lett. 2005, 15, 3596‐3599.
Synthesis of the glycosphingolipid β‐galactosyl ceramide and analogs via olefin cross metathesis. A. N. Rai and A. Basu. J. Org. Chem. 2005, 70, 8228‐8230.
Lipopolysaccharide identification with functionalized polydiacetylene liposome sensors. M. Rangin and A. Basu. J. Am. Chem. Soc. 2004, 126, 5038‐5039.
Sphingolipid synthesis via olefin cross metathesis: Preparation of a differentially protected building block and application to the synthesis of D‐erythro‐ceramide. A. N. Rai and A. Basu. Org Lett. 2004, 6, 2861‐2863.
Studies of the Carbohydrate‐Carbohydrate Interaction Between Lactose and GM3 using Langmuir Monolayers and Glycolipid Micelles. P. V. Santacroce and A. Basu. Glycoconjugate J. 2004. 21, 89‐95. (Invited Submission, Special Issue on Carbohydrate‐Carbohydrate Interactions)
3‐Methoxycarbonyl‐5‐nitrophenyl boronic acid: High affinity diol recognition at neutral pH. H. R. Mulla, N. J. Agard and A. Basu. Bioorg. Med. Chem. Lett. 2004, 14, 25‐27.
Probing Specificity in Carbohydrate‐Carbohydrate Interactions with Micelles and Langmuir Monolayers. P. V. Santacroce and A. Basu. Angew. Chem. Int. Ed. Engl. 2003, 42, 95‐98.
A Rapid and Efficient Method for para‐Methoxybenzyl Ether Formation with Lanthanum Triflate. A. N. Rai and A. Basu. Tetrahedron. Lett. 2003, 44, 2267‐2269.
Configurational Stability and Stereoinformation Transfer in the Reactions of Enantioenriched Organolithium Reagents. A. Basu and S. Thayumanavan. Angew. Chem. Int. Ed. Engl. 2002, 41, 716‐738.
| Year | Degree | Institution |
|---|---|---|
| 1996 | PhD | University of Illinois at Urbana-Champaign |
| 1992 | BA | Reed College |
RC Fuson Research Award, 1995
Department of Education/Chevron Graduate Fellowship, 1994-1995
Research Innovation Award, 2001-2006
National Science Foundation (NSF) Faculty Early CAREER Award, 2002-2006
Mizutani Award in Glycoscience 2005
Karen T Romer Advising Prize 2014
| CHEM 0360 - Organic Chemistry |
| CHEM 0910 - The Language of Chemistry |
| CHEM 1450 - Advanced Organic Chemistry |
| CHEM 2410 - Organic Mechanisms |
| CHEM 2410 - Physical Organic Chemistry |
| CHEM 2420 - Organic Reactions |
| CHEM 2430 - Synthetic Organic Chemistry |
