Amit Basu Associate Professor of Chemistry

B.A., Reed College, 1992 (Advisor – Patrick McDougal)
Ph.D., University of llinois at Urbana-Champaign, 1996 (Advisor – Peter Beak)
Post-doctoral training, Princeton University 1996-1999 (Advisor – Daniel Kahne)

Brown Affiliations

Research Areas

scholarly work

Galactan synthesis in a single step via oligomerization of monosaccharides M. Dräger and A. Basu Beilstein J. Org. Chem. 2014, 10, 2658–2663.

Anti-bacterial glycosyl triazoles – Identification of an N-acetyl glucosamine derivative with bacteriostatic activity against Bacillus H. Kuhn, D. Gutelius, E. Black, C. Nadolny, A. Basu, and C. Reid Med. Chem. Commun. 2014, 5, 1213-1217.

A rapid, inexpensive, and semi-quantitative method for determining pollen tube extension using fluorescence E. Hartman, C. Levy, D. M. Kern, M. Johnson, and A. Basu Plant Methods 2014, 10:3

End-Labeled Amino Terminated Monotelechelic Glycopolymers Generated by ROMP and Cu(I)-Catalyzed Azide – Alkyne Cycloaddition R. Okoth and A. Basu, Beilstein J. Org. Chem. 2013, 9, 608-612.

Participation of Myelin Glycosphingolipids, Galactosylceramide and Sulfatide, in Glycosynapses between Oligodendrocyte or Myelin Membranes J. M. Boggs, W. Gao, J. Zhao, H. Park, Y. Liu, and A. Basu. FEBS Letters. 2010, In press –doi: 10.1016/j.febslet.2009.11.074

Probing the lactose•GM3 carbohydrate‐carbohydrate interaction with glycodendrimers. N. Seah, P.V. Santacroce and A. Basu. Org. Lett. 2009, 11, 559562.

Core Functionalization of Hollow Polymer Nanocapsules. X. Liu and A. Basu. J. Am. Chem. Soc. 2009, 131, 5718‐5719.

Reagentless functionalization of gold nanoparticles via a 3 + 2 Huisgen cycloaddition. J. Coll. Interfac. Sci. 2008, 318, 140‐144. W. Limapichat and A. Basu.

Carbohydrate‐carbohydrate interactions. N. Seah and A. Basu. Encyclopedia of Chemical Biology. John Wiley & Sons. 2008 Ed. T. Begley.

Cross‐linked polynorbornene‐coated gold nanoparticles – Dependence of particle stability on cross‐linking position and cross‐linker structure. X. Liu and A. Basu. Langmuir, 2008, 24, 11169‐11174.

Colorimetric Sensing and Biosensing using Functionalized Conjugated Polymers. A. Basu. Molecular Recognition Using Polymers. John Wiley & Sons. 2008 Ed. V. Rotello & S. Thayumanavan.

Two Polymerizable Derivatives of 2,2'‐Azino‐bis(3 ethylbenzthiazoline‐6‐sulfonic acid). J. Fei, A. Basu, F. Xue, G. T. R. Palmore. Org. Lett. 2006; 8, 3‐6.

Olefin Metathesis on Nanostructures. Liu, X. and Basu, A. J. Organomet. Chem. 2006, 691, 5148‐5154. (Invited Submission, Special Issue on Alkene Metathesis)

Model Systems. Basu, A. and Schneider. J. Curr. Opin. Chem. Biol. 2006, 10, 527–528.

Glycosidase Inhibition by 1‐Glycosyl‐4‐Phenyl Triazoles. L. L. Rossi and A. Basu. Bioorg. Med. Chem. Lett. 2005, 15, 3596‐3599.

Synthesis of the glycosphingolipid β‐galactosyl ceramide and analogs via olefin cross metathesis. A. N. Rai and A. Basu. J. Org. Chem. 2005, 70, 8228‐8230.

Lipopolysaccharide identification with functionalized polydiacetylene liposome sensors. M. Rangin and A. Basu. J. Am. Chem. Soc. 2004, 126, 5038‐5039.

Sphingolipid synthesis via olefin cross metathesis: Preparation of a differentially protected building block and application to the synthesis of D‐erythro‐ceramide. A. N. Rai and A. Basu. Org Lett. 2004, 6, 2861‐2863.

Studies of the Carbohydrate‐Carbohydrate Interaction Between Lactose and GM3 using Langmuir Monolayers and Glycolipid Micelles. P. V. Santacroce and A. Basu. Glycoconjugate J. 2004. 21, 89‐95. (Invited Submission, Special Issue on Carbohydrate‐Carbohydrate Interactions)

3‐Methoxycarbonyl‐5‐nitrophenyl boronic acid: High affinity diol recognition at neutral pH. H. R. Mulla, N. J. Agard and A. Basu. Bioorg. Med. Chem. Lett. 2004, 14, 25‐27.

Probing Specificity in Carbohydrate‐Carbohydrate Interactions with Micelles and Langmuir Monolayers. P. V. Santacroce and A. Basu. Angew. Chem. Int. Ed. Engl. 2003, 42, 95‐98.

A Rapid and Efficient Method for para‐Methoxybenzyl Ether Formation with Lanthanum Triflate. A. N. Rai and A. Basu. Tetrahedron. Lett. 2003, 44, 2267‐2269.

Configurational Stability and Stereoinformation Transfer in the Reactions of Enantioenriched Organolithium Reagents. A. Basu and S. Thayumanavan. Angew. Chem. Int. Ed. Engl. 2002, 41, 716‐738.

research overview

Our group is interested in questions that lie at the interface of chemistry, biology, and materials science. Research in the group includes –glycochemistry and glycobiology; synthesis and application of novel polymers and nanomaterials; development of new sensors and diagnostic agents. Current foci include the glcyochemistry of the plant cell wall and the development of small molecules that interfere with bacterial cell wall dynamics and can serve as leads for new antibiotics.