Dr. Alexey V. Fedulov has an MD in Internal Medicine and a PhD in Immunology/Allergy and Pathophysiology from St. Petersburg Pavlov Medical University. He completed his postdoctoral fellowship at Harvard School of Public Health and later became Assistant Professor at Harvard Medical School / Brigham and Women's Hospital. His research has been awarded with a K99/R00 Pathway to Independence Award from NIH. He has developed a program of independently funded experimental studies, trained fellows and students and taught Pathophysiology of Human Disease course for Harvard students in the Public Health programs.
He joined Brown and the RIH community in 2018 to expand his studies in epigenetics.
|Campion A, Smith KJ, Fedulov AV, Gregory DZ, Fan Y, Godleski JJ Identification of Foreign Particles in Human Tissues Using Raman Microscopy.. Analytical Chemistry. 2018; 90 (14) : 8362-8369.|
|Gregory DJ, Kobzik L, Yang Z, McGuire CC, Fedulov AV Transgenerational transmission of asthma risk after exposure to environmental particles during pregnancy.. AJP: Lung Cellular and Molecular Physiology. 2017; 313 (2) : L395-L405.|
|Zhang Y, Mikhaylova L, Kobzik L, Fedulov AV Estrogen-mediated impairment of macrophageal uptake of environmental TiO2 particles to explain inflammatory effect of TiO2 on airways during pregnancy.. Journal of immunotoxicology. 2015; 12 (1) : 81-91.|
|Lim R, Fedulov AV, Kobzik L Maternal stress during pregnancy increases neonatal allergy susceptibility: role of glucocorticoids.. AJP: Lung Cellular and Molecular Physiology. 2014; 307 (2) : L141-8.|
|Hu R, Pan W, Fedulov AV, Jester W, Jones MR, Weiss ST, Panettieri RA Jr, Tantisira K, Lu Q MicroRNA-10a controls airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway.. The FASEB Journal. 2014; 28 (5) : 2347-57.|
|Ysasi AB, Belle JM, Gibney BC, Fedulov AV, Wagner W, AkiraTsuda, Konerding MA, Mentzer SJ Effect of unilateral diaphragmatic paralysis on postpneumonectomy lung growth.. AJP: Lung Cellular and Molecular Physiology. 2013; 305 (6) : L439-45.|
|Mikhaylova L, Zhang Y, Kobzik L, Fedulov AV Link between epigenomic alterations and genome-wide aberrant transcriptional response to allergen in dendritic cells conveying maternal asthma risk.. PLoS ONE. 2013; 8 (8) : e70387.|
|Gregory DJ, Zhang Y, Kobzik L, Fedulov AV Specific transcriptional enhancement of inducible nitric oxide synthase by targeted promoter demethylation.. Epigenetics. 2013; 8 (11) : 1205-12.|
|Williams AS, Kasahara DI, Verbout NG, Fedulov AV, Zhu M, Si H, Wurmbrand AP, Hug C, Ranscht B, Shore SA Role of the adiponectin binding protein, T-cadherin (Cdh13), in allergic airways responses in mice.. PLoS ONE. 2012; 7 (7) : e41088.|
|Gregory DJ, Mikhaylova L, Fedulov AV Selective DNA demethylation by fusion of TDG with a sequence-specific DNA-binding domain.. Epigenetics. 2012; 7 (4) : 344-9.|
|Fedulov AV, Kobzik L Allergy risk is mediated by dendritic cells with congenital epigenetic changes.. American Journal of Respiratory Cell and Molecular Biology. 2011; 44 (3) : 285-92.|
|Zhu M, Liu PY, Kasahara DI, Williams AS, Verbout NG, Halayko AJ, Fedulov A, Shoji T, Williams ES, Noma K, Shore SA, Liao JK Role of Rho kinase isoforms in murine allergic airway responses.. European Respiratory Journal. 2011; 38 (4) : 841-50.|
|Lamoureux DP, Kobzik L, Fedulov AV Customized PCR-array analysis informed by gene-chip microarray and biological hypothesis reveals pathways involved in lung inflammatory response to titanium dioxide in pregnancy.. Journal of toxicology and environmental health. Part A. 2010; 73 (9) : 596-606.|
|Fedulov AV, Leme A, Yang Z, Dahl M, Lim R, Mariani TJ, Kobzik L Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility.. American Journal of Respiratory Cell and Molecular Biology. 2008; 38 (1) : 57-67.|
|Sigaud S, Goldsmith CA, Zhou H, Yang Z, Fedulov A, Imrich A, Kobzik L Air pollution particles diminish bacterial clearance in the primed lungs of mice.. Toxicology and Applied Pharmacology. 2007; 223 (1) : 1-9.|
|Fedulov AV, Leme AS, Kobzik L Duration of allergic susceptibility in maternal transmission of asthma risk.. American Journal of Reproductive Immunology. 2007; 58 (2) : 120-8.|
|Lim RH, Arredouani MS, Fedulov A, Kobzik L, Hubeau C Maternal allergic contact dermatitis causes increased asthma risk in offspring.. Respiratory research. 2007; 8 : 56.|
|Arredouani MS, Franco F, Imrich A, Fedulov A, Lu X, Perkins D, Soininen R, Tryggvason K, Shapiro SD, Kobzik L Scavenger Receptors SR-AI/II and MARCO limit pulmonary dendritic cell migration and allergic airway inflammation.. The Journal of Immunology. 2007; 178 (9) : 5912-20.|
|Fedulov A, Silverman E, Xiang Y, Leme A, Kobzik L Immunostimulatory CpG oligonucleotides abrogate allergic susceptibility in a murine model of maternal asthma transmission.. The Journal of Immunology. 2005; 175 (7) : 4292-300.|
|Fedulov AV, Ses TP, Gavrisheva NA, Rybakova MG, Vassilyeva JG, Tkachenko SB, Kallner A, MacMillan JC Serum TGF-beta 1 and TNF-alpha levels and cardiac fibrosis in experimental chronic renal failure.. Immunological investigations. 2005; 34 (2) : 143-52.|
|Emel'ianov AV, Zinakova MK, Krasnoshchekova OI, Sinitsina TM, Rudinskiĭ KA, Fedulov AV [Quality of life and characteristics of the external respiration function in patients with bronchial asthma].. Terapevticheskii arkhiv. 2001; 73 (12) : 63-5.|
|Emelyanov A, Fedoseev G, Abulimity A, Rudinski K, Fedoulov A, Karabanov A, Barnes PJ Elevated concentrations of exhaled hydrogen peroxide in asthmatic patients.. Chest. 2001; 120 (4) : 1136-9.|
|Emel'ianov AV, Shcherbak IG, Abulimiti A, Krasnoshchekova OI, Sinitsyna TM, Rudinskiĭ KA, Fedulov AV, Karabanov AV [Hydrogen peroxide--a marker for respiratory tract inflammation in patients with bronchial asthma].. Terapevticheskii arkhiv. 2000; 72 (12) : 27-30.|
Fedulov laboratory studies epigenetic regulation and develops molecular tools for epigenetic engineering.
Any cell in an organism includes all genes of that organism's genome. The difference in structure and function of cells results from epigenetic silencing of 'unnecessary genes' which occurs in great part by DNA methylation. Taking control of the epigenome is a novel and exciting biomedical challenge. Moreover, in disease the aberrant DNA methylation in key regulatory areas (e.g. promoters) can inhibit gene transcription. There is an increasing wealth of findings of abnormal DNA methylation in various pathologies. A major challenge is that no effective approach currently exists to gene-specifically demethylate a gene promoter, and little is known about DNA demethylation mechanisms. We develop fusion molecules of putative DNA demethylases with sequence-specific DNA binding domains and use these tools to re-activate or enhance the silenced intrinsic genes in cells. The method will be broadly applicable as experimental tool in epigenetics and may open avenues to novel classes of therapeutics.
Our models focus on inflammation, tissue repair and immune regulation with potential applications in lung disease (fibrosis, COPD, asthma) and in surgical research.
The Warren Alpert Medical School of Brown University.
Rhode Island Hospital. Department of Surgery, Divsion of Surgical Research.