1979: MSc. in Physics at Moscow Institute of Physics and Technology, Russia. Advisor: Victor Gurfinkel, M.D., Dr.Sc.
1985: PhD, Biology and Biophysics at USSR Academy of Sciences, Moscow. Advisors: Dr. A. Malenkov and Dr. L. Radkevich.
1994-1996: Fellow in Physiology at UT Southwestern Medical Center, Dallas, TX. and Rockefeller University, New York, NY. Advisor: Donald Hilgemann, Ph.D.
| Kabakov AY, Roder K, Bronk P, Turan NN, Dhakal S, Zhong M, Lu Y, Zeltzer ZA, Najman-Licht YB, Karma A, Koren G. "E3 ubiquitin ligase rififylin has yin and yang effects on rabbit cardiac transient outward potassium currents (Ito) and corresponding channel proteins." Journal of Biological Chemistry, vol. 300, no. 3, 2024, pp. 105759. |
| Kabakov, A.Y., Sengun, E., Lu, Y., Roder, K., Bronk, P., Baggett, B.C., Turan, N.N., Moshal, K.S., Koren, G. "Corrigendum: Three-week-old rabbit ventricular cardiomyocytes as a novel system to study cardiac excitation and EC coupling." Frontiers in Physiology, vol. 14, 2023. |
| Baggett BC, Murphy KR, Sengun E, Mi E, Cao Y, Turan NN, Lu Y, Schofield L, Kim TY, Kabakov AY, Bronk P, Qu Z, Camelliti P, Dubielecka P, Terentyev D, Del Monte F, Choi BR, Sedivy J, Koren G. "Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart." eLife, vol. 12, 2023. |
| Kabakov, A.Y., Sengun, E., Lu, Y., Roder, K., Bronk, P., Baggett, B.C., Turan, N.N., Moshal, K.S., Koren, G. "Three-Week-Old Rabbit Ventricular Cardiomyocytes as a Novel System to Study Cardiac Excitation and EC Coupling." Frontiers in Physiology, vol. 12, 2021, pp. 672360. |
| Zhang Z, Shi G, Liu Y, Xing H, Kabakov AY, Zhao AS, Agbortoko V, Kim J, Singh AK, Koren G, Harrington EO, Sellke FW, Feng J. "Coronary endothelial dysfunction prevented by small-conductance calcium-activated potassium channel activator in mice and patients with diabetes." J Thorac Cardiovasc Surg, vol. 160, no. 6, 2020, pp. e263-e280. |
| Hwang, Jungmin, Kim, Tae Yun, Terentyev, Dmitry, Zhong, Mingwang, Kabakov, Anatoli Y., Bronk, Peter, Arunachalam, Karuppiah, Belardinelli, Luiz, Rajamani, Sridharan, Kunitomo, Yukiko, Pfeiffer, Zachary, Lu, Yichun, Peng, Xuwen, Odening, Katja E., Qu, Zhilin, Karma, Alain, Koren, Gideon, Choi, Bum-Rak. "Late I Na Blocker GS967 Supresses Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long QT Type 2." Circulation: Arrhythmia and Electrophysiology, vol. 13, no. 8, 2020. |
| Liu Y, Kabakov AY, Xie A, Shi G, Singh AK, Sodha NR, Ehsan A, Usheva A, Agbortoko V, Koren G, Dudley SC Jr, Sellke FW, Feng J. "Metabolic regulation of endothelial SK channels and human coronary microvascular function." International Journal of Cardiology, vol. 312, 2020, pp. 1-9. |
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Tae Yun Kim, Anatoli Kabakov, Radmila Terentyeva, Dmitry A Terentyev, YiChun Lu, Katja E Odening, Andras Varro, Zsuzsanna Bősze, Gideon Koren, Bum-Rak Choi.
"Mutations in KCNE1 Promote Cardiac Alternans in Long QT Syndrome Type 5 Rabbits." Biophysical Journal, vol. 118, no. 3, 2020, pp. 102a.
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| Turan, Nilüfer N., Moshal, Karni S., Roder, Karim, Baggett, Brett C., Kabakov, Anatoli Y., Dhakal, Saroj, Teramoto, Ryota, Chiang, David Yi-Eng, Zhong, Mingwang, Xie, An, Lu, Yichun, Dudley, Samuel C., MacRae, Calum A., Karma, Alain, Koren, Gideon. "The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2." Journal of Biological Chemistry, vol. 295, no. 52, 2020, pp. 18148-18159. |
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Anatoli Y Kabakov, Karim Roder, Karni S Moshal, YiChun Lu, Mingwang Zhong, Saroj Dhakal, Alain Karma, Gideon Koren.
"Ubiquitin Ligase Rififylin (RFFL) Has Yin-Yang Effects on Rabbit Cardiac Transient Outward (Ito) Potassium Channels." Biophysical Journal, vol. 118, no. 3, 2020, pp. 104a.
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Anatoli Y Kabakov, Karni Moshal, YiChun Lu, Karim Roder, Turan Nilufer, Weiyan Li, Kevin Murphy, Dmitry Terentyev, Gideon Koren.
"3-week-old rabbit cardiomyocytes (3wRbCM): A novel cellular model for studying cardiac excitation." Biophysical Journal, vol. 116, no. 3, 2019.
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| Moshal KS, Roder K, Kabakov AY, Werdich AA, Chiang DY, Turan NN, Xie A, Kim TY, Cooper LL, Lu Y, Zhong M, Li W, Terentyev D, Choi BR, Karma A, MacRae CA, Koren G. "LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor) Regulates Cardiac L-Type Calcium Channels by Modulating NEDD (Neural Precursor Cell Expressed Developmentally Downregulated Protein) 4-1 Ubiquitin Ligase." Circulation. Genomic and precision medicine, vol. 12, no. 9, 2019, pp. 407-420. |
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Karni S Moshal, Karim Roder, Anatoli Kabakov, Nilüfer N Turan, An Xie, Andreas A Werdich, Tae Yun Kim, Leroy L Cooper, Yichun Lu, Dmitry Terentyev, Bum‐Rak Choi, Calum A MacRae, Gideon Koren.
"LITAF regulates action potential duration by modulating NEDD4‐1‐mediated degradation of L‐type calcium channels." The FASEB Journal, vol. 33, no. S1, 2019, pp. 824.19-824.19.
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Karim Roder, Anatoli Kabakov, Karni S Moshal, An Xie, Nilüfer N Turan, Yichun Lu, Gideon Koren.
"Rififylin (RFFL), a Novel Regulator of Transient Outward (Ito) Potassium Channels." The FASEB Journal, vol. 33, no. S1, 2019, pp. 824.18-824.18.
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| Roder K, Kabakov A, Moshal KS, Murphy KR, Xie A, Dudley S, Turan NN, Lu Y, MacRae CA, Koren G. "Trafficking of the human ether-a-go-go-related gene (hERG) potassium channel is regulated by the ubiquitin ligase rififylin (RFFL)." Journal of Biological Chemistry, vol. 294, no. 1, 2019, pp. 351-360. |
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Kabakov, A. Y., Moshal, K., Lu, Y., Roder, K., Nilufer, T., Li, W., Murphy, K., Terentyev, D., Koren, G.
"Week-old rabbit cardiomyocytes
(3wRbCM): a novel cellular model for studying cardiac excitation." Biophysical Journal, vol. 116, no. 3, 2019, pp. 230a.
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Kim, T.Y., Kabakov, A., Terentyev, D., Terentieva, R., Arunachalam, K., Li, Y., Odening, K., Varro, A., Bosze, Z., Koren, G., Choi, B-R.
"Mutations in KCNE1 alters multiple K+ channels to cause APD instability and polymorphic ventricular tachycardia (PVT) in transgenic long QT syndrome type 5 rabbits." Circulation, vol. 138, 2018, pp. A16599.
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| Choi BR, Li W, Terentyev D, Kabakov AY, Zhong M, Rees CM, Terentyeva R, Kim TY, Qu Z, Peng X, Karma A, Koren G. "Transient Outward K+ Current (Ito) Underlies the Right Ventricular Initiation of Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long-QT Syndrome Type 1." Circulation: Arrhythmia and Electrophysiology, vol. 11, no. 6, 2018, pp. e005414. |
| Kabakov, Anatoli Y., Lisman, John E. "Catalytically Dead αCaMKII K42M Mutant Acts as a Dominant Negative in the Control of Synaptic Strength." PLOS ONE, vol. 10, no. 4, 2015, pp. e0123718. |
| Kabakov AY, Rosenberg PA. "GLT-1 Transport Stoichiometry Is Constant at Low and High Glutamate Concentrations when Chloride Is Substituted by Gluconate." PLoS ONE, vol. 10, no. 8, 2015, pp. e0136111. |
| Goodrich, Grant S., Kabakov, Anatoli Y., Hameed, Mustafa Q., Dhamne, Sameer C., Rosenberg, Paul A., Rotenberg, Alexander. "Ceftriaxone Treatment after Traumatic Brain Injury Restores Expression of the Glutamate Transporter, GLT-1, Reduces Regional Gliosis, and Reduces Post-Traumatic Seizures in the Rat." Journal of Neurotrauma, vol. 30, no. 16, 2013, pp. 1434-1441. |
| Kabakov, Anatoli Y., Muller, Paul A., Pascual-Leone, Alvaro, Jensen, Frances E., Rotenberg, Alexander. "Contribution of axonal orientation to pathway-dependent modulation of excitatory transmission by direct current stimulation in isolated rat hippocampus." Journal of Neurophysiology, vol. 107, no. 7, 2012, pp. 1881-1889. |
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Anatoli Y Kabakov, Paul Muller, Francis E Jensen, Alexander Rotenberg.
"Modulation of the Excitatory Synaptic Transmission in Isolated Rat Hippocampus by Direct Current Stimulation." Biophysical Journal, vol. 98, no. 3, 2010, pp. 142a.
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| Kabakov, Anatoli Y., Rosenberg, Paul A. "Evidence for change in current-flux coupling of GLT1 at high glutamate concentrations in rat primary forebrain neurons and GLT1a-expressing COS-7 cells." European Journal of Neuroscience, vol. 30, no. 2, 2009, pp. 186-195. |
| DeSilva, T. M., Kabakov, A. Y., Goldhoff, P. E., Volpe, J. J., Rosenberg, P. A. "Regulation of Glutamate Transport in Developing Rat Oligodendrocytes." Journal of Neuroscience, vol. 29, no. 24, 2009, pp. 7898-7908. |
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Kabakov AY, Rosenberg PA.
"The major glutamate transporter of the brain, GLT1, changes its stoichiometry at high concentrations of glutamate." Biophysical Journal, vol. 88, no. Jan 1, 2005, pp. 25A-25A.
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A.Y. Kabakov, M.T. Tosteson.
"Cell cycle dependence of osmo-regulated chloride current in NIH3T3 fibroblasts." Biophysical Journal, vol. 82, no. 1, 2002, pp. 243a.
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A.Y.Kabakov.
"Mathematical analysis of non steady-state kinetics or ligand regulated channels at ultrafast ligand concentration clamp." Biophysical Journal, vol. 78, no. 1, 2001, pp. 358a.
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A. Y. Kabakov.
"When does the depolarizing component of Na/K-pump activation dominate over three hyperpolarizing components?." Biophysical Journal, vol. 76, no. 1, 1999, pp. A453.
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| Kabakov AY. "Activation of KATP channels by Na/K pump in isolated cardiac myocytes and giant membrane patches." Biophysical Journal, vol. 75, no. 6, 1998, pp. 2858-67. |
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A.Y. Kabakov, R.L. Papke.
"Kinetics of BTMPS block of expressed muscle nAChR in outside-out patches: High resolution analysis of a slow process." Biophysical Journal, vol. 74, no. 2, 1998, pp. A89.
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| Kabakov AY, Karkanias NB, Lenox RH, Papke RL. "Synapse-specific accumulation of lithium in intracellular microdomains: a model for uncoupling coincidence detection in the brain." Synapse (New York, N.Y.), vol. 28, no. 4, 1998, pp. 271-9. |
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AY Kabakov, RL Papke.
"Ultra fast solution applications for prolonged gap-free recordings: Controlling a Burleigh piezo-electric positioner with Clampex7." Axobits, vol. 22, 1998, pp. 6-8.
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A.Y. Kabakov, N.B. Karkanias, R.L. Papke.
"Estimation of lithium diffusion in dendritic spine during activation of glutamate receptors." Biophysical Journal, vol. 72, no. 2, 1997, pp. A118.
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AY Kabakov, NB Karkanias, RL Papke.
"Estimation of lithium diffusion in dendritic spine during activation of glutamate receptors." Biophysical Journal, vol. 72, no. 2, 1997, pp. A118.
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A.Y. Kabakov, L.A. Radkevich.
"Membrane potential and mechanical properties of rat hepatocytes during toxic hepatitis." Biophysical Journal, vol. 70, no. 2, 1996, pp. WP196.
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| Lu CC, Kabakov A, Markin VS, Mager S, Frazier GA, Hilgemann DW. "Membrane transport mechanisms probed by capacitance measurements with megahertz voltage clamp." Proceedings of the National Academy of Sciences, vol. 92, no. 24, 1995, pp. 11220-4. |
| Kabakov AY, Hilgemann DW. "Modulation of Na+,Ca2+ exchange current by EGTA calcium buffering in giant cardiac membrane patches." Biochimica et biophysica acta, vol. 1240, no. 2, 1995, pp. 142-8. |
| Kabakov AYu. "The resting potential equations incorporating ionic pumps and osmotic concentration." Journal of Theoretical Biology, vol. 169, no. 1, 1994, pp. 51-64. |
| Kabakov AIu. "[The nature of pacemaker activity]." Biofizika, vol. 36, no. 4, 1991, pp. 632-9. |
| Kabakov AIu, Sarbash VI, Filimonov DA. "[Potassium transport in ischemia and anoxia of the perfused liver]." Biofizika, vol. 34, no. 2, 1989, pp. 295-6. |
| Kabakov AIu. "[Analysis of an equivalent electric circuit of the hepatocyte during stopping and restoration of the blood flow]." Biofizika, vol. 33, no. 5, 1988, pp. 828-33. |
| Kabakov AIu. "[Hyperpolarization of the cell membrane during Na,K-ATPase inactivation]." Biofizika, vol. 33, no. 2, 1988, pp. 297-302. |
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Radkevich, L.A., Kabakov, A.Iu., Malenkov, A.G.
"Investigation of hepatocyte membrane potential at different models of acute liver deficiency in order to optimize the model for rapid evaluation of liver protective agents." Biophyzika, no. 7601-V87, 1987, pp. 1-21.
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Bonashevskaya, T.I., Beljaeva, N.N., Kumpan, H.B., Kabakov, A.Y., Radkevich, L.A.
Methodical recommendations on bio-structural functional estimation of the processes of adaptation arisen under action of chemical factors of environment.. Moscow, Institute of general and occupational hygiene., 1987.
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"Transport and diffusion across cell membranes. Review of the book: Wilfred D. Stein; Academic Press, Inc., 1986." vol. B, 1987, pp. 4-7.
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| Bonashevskaia TI, Kabakov AIu, Suslova VM, Radkevich LA. "[Morphobiophysical parallels in assessing the hepatotropic action of nitrosodimethylamine]." Farmakologiia i toksikologiia, vol. 48, no. 4, 1985, pp. 103-5. |
| Radkevich LA, Kolotygina IM, Kabakov AIu. "[Stability of the membrane potential of mouse liver cells to damaging exposures]." Biofizika, vol. 30, no. 4, 1985, pp. 646-9. |
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Kabakov,A.Y.
"Electrophysiological and biomechanical characterization of rat hepatocytes in vivo during different pathological conditions." Ph.D. diploma, Institute for Biological Screening of Chemical Compounds, USSR Academy of Sciences, 1985, pp. 1-106.
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Malenkov, A.G., Radkevich, L.A., Kasatkina, N.N., Kolotygina, I.M., Kabakov, A.Y., Reznikova, M.M.
"The elaboration of express methods for evaluation of cancerogenic promoters and testing of substances on hepatotoxic and hepatoprotector activity." Reports of Institute for Biological Screening of Chemical Compounds., Moscow, Ministry of Medical Industry., 1985, pp. 1-91.
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Malenkov, A.G., Radkevich, L.A., Kasatkina, N.N., Kolotygina, I.M., Kabakov, A.Y., Komolev, I.B., Masalov, V.P.
"Comparative research of hepatotropic safety of pharmacologic drags on the basis of analysis of biophysical characteristics of membrane of hepatocytes." Reports of Institute for Biological Screening of Chemical Compounds., Moscow, Ministry of Medical Industry., 1984, pp. 1-139.
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Kabakov, A.Y.
"The electrogenesis of liver cells at different hypoxic states of the organ, and the body." The pharmacologic correction of oxygen dependent pathological states. The materials of All-Union Congress. , Moscow, Ministry of Medical Industry, 1984, pp. 14-15.
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| Radkevich LA, Kolotygina IM, Kabakov AIu. "[Membrane potential of the liver cells of high- and low-cancer mouse lines]." Ontogenez, vol. 13, no. 5, 1982, pp. 545-7. |
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Malenkov, A.G., Radkevich, L.A., Kasatkina, N.N., Kolotygina, I.M., Kabakov, A.Y., and Komolev, I.B.
"The elaboration of apparatus of parametric description of changes of biophysical homeostatic systems in ontogenesis." Reports of Institute for Biological Screening of Chemical Compounds, Moscow, Ministry of Medical Industry., 1982, pp. 1-52.
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Radkevich, L.A., Kolotygina, I.M., and Kabakov, A.Y.
"Stability of cell electrogenesis in liver as an indicator of effects of hepatotropic substances." Actual problems of estimation of pharmacologic activity of chemical compounds. The materials of All-Union Conference. , Moscow, Ministry of Medical Industry, 1981, pp. 146-147.
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Malenkov, A.G., Radkevich, L.A., Melikjanz, A.G., Kasatkina, N.N., Kolotygina, I.M., and Kabakov, A.Y.
"Research of mechanisms of morphogenesis and effects of biologically active substances on the morphogenesis." Reports of Institute for Biological Screening of Chemical Compounds., Moscow, Ministry of Medical Industry, 1980, pp. 1-38.
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Kabakov, A.Y.
"Automation of electrophysiological and biomechanical recordings." M.S. Diploma. Moscow Institute of Physics and Technology., 1979, pp. 1-33.
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| Year | Degree | Institution |
|---|---|---|
| 1985 | PhD | Russian Academy of Sciences |
| 1979 | BS | Moscow Institute of Physics and Technology |
| 1979 | MS | Moscow Institute of Physics and Technology |
| Postdoctoral Research Associate | Harvard Medical School, Department of cell biology | 1999-2001 | Boston, Massachusetts, USA |
| Postdoctoral Research Associate | University of Florida, Department of Pharmacology and Therapeutics | 1996-1999 | Gainesville, Florida, USA |
1988: Junior Scientist Award, Russian Academy of Sciences, Moscow, Russia
1993 : Biophysics of Membrane Transport Fellowship, University of Konstanz, Germany
1993: Junior Scientist Award, George Soros Foundation, USA
2005: William Randolph Hearst Award, USA
2007: William Randolph Hearst Award, USA
1995-present: Member of Biophysical Society
2001-2016: Member of Society for Neuroscience
| Assistant Professor of Medicine. Brown Medical School, 2016-2021 |
| Instructor of Neurology. Harvard Medical School, 2001-2011 |
1990-1993 Tutor of “Membrane Transport Biophysics” graduate program course, Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.
2003-2011 Tutor of “Human Nervous System and Behavior” course for 2nd year medical students, Department of Neurobiology, Harvard Medical School, Boston, MA.
2014-2016 Training of M.S. students in neuroscience and membrane transport biophysics, Volen National Center for Complex Systems, Neuroscience program, Brandeis University, Waltham, MA.
