Agnes B. Kane, M.D., Ph.D. is Professor of Pathology and Laboratory Medicine at Brown University where she has pursued research on fiber toxicology and nanotoxicology with funding from the National Institute of Environmental Health Sciences, US EPA, and NSF. She is board-certified in anatomic pathology and has studied murine models of asbestos-induced disease. She has served as scientific advisor and invited participant in workshops on fiber toxicology and nanotechnology for NIOSH, US EPA, NAS, IOM, NTP, and ILO. She has participated in three IARC Working Groups on the Evaluation of Carcinogenic Risks to Humans. She is the Director of the Training Program in Environmental Pathology at Brown University, now in its 27th year of funding from the National Institute of Environmental Health Sciences.
|Gray, Evan P., Browning, Cynthia L., Wang, Mengjing, Gion, Kyle D., Chao, Eric Y., Koski, Kristie J., Kane, Agnes B., Hurt, Robert H. Biodissolution and cellular response to MoO3 nanoribbons and a new framework for early hazard screening for 2D materials. Environmental Science: Nano/Environmental Science: Nano. 2018; 5 (11) : 2545-2559.|
|Rodd, April L., Messier, Norma J., Vaslet, Charles A., Kane, Agnes B. A 3D fish liver model for aquatic toxicology: Morphological changes and Cyp1a induction in PLHC-1 microtissues after repeated benzo(a)pyrene exposures. Aquatic Toxicology/Aquatic Toxicology. 2017; 186 : 134-144.|
|Wang, Zhongying, Zhu, Wenpeng, Qiu, Yang, Yi, Xin, von dem Bussche, Annette, Kane, Agnes, Gao, Huajian, Koski, Kristie, Hurt, Robert Biological and environmental interactions of emerging two-dimensional nanomaterials. Chem. Soc. Rev./Chem. Soc. Rev.. 2016; 45 (6) : 1750-1780.|
|Zhu, Wenpeng, von dem Bussche, Annette, Yi, Xin, Qiu, Yang, Wang, Zhongying, Weston, Paula, Hurt, Robert H., Kane, Agnes B., Gao, Huajian Nanomechanical mechanism for lipid bilayer damage induced by carbon nanotubes confined in intracellular vesicles. Proceedings of the National Academy of Sciences/Proceedings of the National Academy of Sciences. 2016; 113 (44) : 12374-12379.|
|Qiu, Yang, Wang, Zhongying, Owens, Alisa C. E., Kulaots, Indrek, Chen, Yantao, Kane, Agnes B., Hurt, Robert H. Antioxidant chemistry of graphene-based materials and its role in oxidation protection technology. Nanoscale/Nanoscale. 2014; 6 (20) : 11744-11755.|
|Rodd AL, Creighton MA, Vaslet CA, Rangel-Mendez JR, Hurt RH, Kane AB Effects of Surface-Engineered Nanoparticle-Based Dispersants for Marine Oil Spills on the Model Organism Artemia franciscana.. Environmental Science & Technology. 2014; 48 (11) : 6419-27.|
|Nel AE, Nasser E, Godwin H, Avery D, Bahadori T, Bergeson L, Beryt E, Bonner JC, Boverhof D, Carter J, Castranova V, Deshazo JR, Hussain SM, Kane AB, Klaessig F, Kuempel E, Lafranconi M, Landsiedel R, Malloy T, Miller MB, Morris J, Moss K, Oberdorster G, Pinkerton K, Pleus RC, Shatkin JA, Thomas R, Tolaymat T, Wang A, Wong J A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment.. ACS Nano. 2013; 7 (8) : 6422-33.|
|Wang Z, von dem Bussche A, Kabadi PK, Kane AB, Hurt RH Biological and environmental transformations of copper-based nanomaterials.. ACS Nano. 2013; 7 (10) : 8715-27.|
|Li, Y., Yuan, H., von dem Bussche, A., Creighton, M., Hurt, R. H., Kane, A. B., Gao, H. Graphene microsheets enter cells through spontaneous membrane penetration at edge asperities and corner sites. Proceedings of the National Academy of Sciences. 2013; 110 (30) : 12295-12300.|
|Creighton, Megan A., Rangel-Mendez, J. Rene, Huang, Jiaxing, Kane, Agnes B., Hurt, Robert H. Graphene-Induced Adsorptive and Optical Artifacts During In Vitro Toxicology Assays. Small/Small. 2013; 9 (11) : 1921-1927.|
|Chen Y, Guo F, Jachak A, Kim SP, Datta D, Liu J, Kulaots I, Vaslet C, Jang HD, Huang J, Kane A, Shenoy VB, Hurt RH Aerosol synthesis of cargo-filled graphene nanosacks.. Nano Letters/Nano Letters. 2012; 12 (4) : 1996-2002.|
|Jachak, Ashish C., Creighton, Megan, Qiu, Yang, Kane, Agnes B., Hurt, Robert H. Biological interactions and safety of graphene materials. MRS Bull./MRS Bull.. 2012; 37 (12) : 1307-1313.|
|Sanchez VC, Jachak A, Hurt RH, Kane AB Biological interactions of graphene-family nanomaterials: an interdisciplinary review.. Chem. Res. Toxicol./Chemical Research in Toxicology. 2012; 25 (1) : 15-34.|
|Liu, Jingyu, Wang, Zhongying, Liu, Frances D., Kane, Agnes B., Hurt, Robert H. Chemical Transformations of Nanosilver in Biological Environments. ACS Nano/ACS Nano. 2012; 6 (11) : 9887-99.|
|Sanchez, Vanesa C, Weston, Paula, Yan, Aihui, Hurt, Robert H, Kane, Agnes B A 3-dimensional in vitro model of epithelioid granulomas induced by high aspect ratio nanomaterials.. Particle and Fibre Toxicology/Particle and Fibre Toxicology. 2011; 8 (1) : 17.|
|Liu X, Sen S, Liu J, Kulaots I, Geohegan D, Kane A, Puretzky AA, Rouleau CM, More KL, Palmore GT, Hurt RH Antioxidant Deactivation on Graphenic Nanocarbon Surfaces. Small/Small. 2011; 7 (19) : 2775-2785.|
|Pietruska JR, Liu X, Smith A, McNeil K, Weston P, Zhitkovich A, Hurt R, Kane AB Bioavailability, Intracellular Mobilization of Nickel, and HIF-1 Activation in Human Lung Epithelial Cells Exposed to Metallic Nickel and Nickel Oxide Nanoparticles. Toxicological Sciences/Toxicological Sciences. 2011; 124 (1) : 138-148.|
|Shi X, von dem Bussche A, Hurt RH, Kane AB, Gao H Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation.. Nature Nanotech/Nature Nanotech. 2011; 6 (11) : 714-719.|
|Broaddus VC, Everitt JI, Black B, Kane AB Non-neoplastic and neoplastic pleural endpoints following fiber exposure.. Journal of toxicology and environmental health. Part B, Critical reviews. 2011; 14 (1-4) : 153-78.|
|Liu X, Hurt RH, Kane AB Biodurability of single-walled carbon nanotubes depends on surface functionalization. Carbon/Carbon. 2010; 48 (7) : 1961-1969.|
|Sarin, Love, Sanchez, Vanesa C., Yan, Aihui, Kane, Agnes B., Hurt, Robert H. Cancer Therapeutics: Selenium-Carbon Bifunctional Nanoparticles for the Treatment of Malignant Mesothelioma (Adv. Mater. 45/2010). Adv. Mater./Adv. Mater.. 2010; 22 (45) : 5072-5072.|
|Miselis NR, Lau BW, Wu Z, Kane AB Kinetics of host cell recruitment during dissemination of diffuse malignant peritoneal mesothelioma.. Cancer Microenvironment. 2010; 4 (1) : 39-50.|
|Lau BW, Kane AB SDF1/CXCL12 is involved in recruitment of stem-like progenitor cells to orthotopic murine malignant mesothelioma spheroids.. Anticancer research. 2010; 30 (6) : 2153-60.|
|Sarin L, Sanchez VC, Yan A, Kane AB, Hurt RH Selenium-Carbon Bifunctional Nanoparticles for the Treatment of Malignant Mesothelioma. Adv. Mater./Adv. Mater.. 2010; 22 (45) : 5207-5211.|
|Pietruska JR, Johnston T, Zhitkovich A, Kane AB XRCC1 deficiency sensitizes human lung epithelial cells to genotoxicity by crocidolite asbestos and Libby amphibole.. Environ Health Perspect. 2010; 118 (12) : 1707-13.|
|Altomare DA, Menges CW, Pei J, Zhang L, Skele-Stump KL, Carbone M, Kane AB, Testa JR Activated TNF-alpha/NF-kappaB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice.. Proceedings of the National Academy of Sciences. 2009; 106 (9) : 3420-5.|
|Sanchez VC, Pietruska JR, Miselis NR, Hurt RH, Kane AB Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos?. WIREs Nanomed Nanobiotechnol/Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 2009; 1 (5) : 511-529.|
|Hoover, Elizabeth, Phil Brown, Mara Averick, Robert Hurt, and Agnes Kane. Teaching Small and Thinking Large: Effects of Including Social and Ethical Implications in an Interdisciplinary Nanotechnology Course.. Journal of Nano Education/Journal of Nano Education. 2009; 1 (1) : 86-95.|
|Guo, Lin, Von Dem Bussche, Annette, Buechner, Michelle, Yan, Aihui, Kane, Agnes B., Hurt, Robert H. Adsorption of essential micronutrients by carbon nanotubes and the implications for nanotoxicity testing.. Small/Small. 2008; 4 (6) : 721-7.|
|Kane AB, Hurt RH Nanotoxicology: the asbestos analogy revisited.. Nature Nanotech. 2008; 3 (7) : 378-9.|
|Liu, Xinyuan, Guo, Lin, Morris, Daniel, Kane, Agnes B., Hurt, Robert H. Targeted removal of bioavailable metal as a detoxification strategy for carbon nanotubes. Carbon/Carbon. 2008; 46 (3) : 489-500.|
|Miselis NR, Wu ZJ, Van Rooijen N, Kane AB Targeting tumor-associated macrophages in an orthotopic murine model of diffuse malignant mesothelioma.. Molecular Cancer Therapeutics. 2008; 7 (4) : 788-99.|
|Guo, Lin, Liu, Xin Yuan, Sanchez, Vanesa, Vaslet, Charles, Kane, Agnes B., Hurt, Robert H. A Window of Opportunity: Designing Carbon Nanomaterials for Environmental Safety and Health. Materials Science Forum/Materials Science Forum. 2007; 544-545 : 511-516.|
|Liu, X., Gurel, V., Morris, D., Murray, D. W., Zhitkovich, A., Kane, A. B., Hurt, R. H. Bioavailability of Nickel in Single-Wall Carbon Nanotubes. Adv. Mater./Adv. Mater.. 2007; 19 (19) : 2790-2796.|
|Guo, Lin, Morris, Daniel G., Liu, Xinyuan, Vaslet, Charles, Hurt, Robert H., Kane, Agnes B. Iron Bioavailability and Redox Activity in Diverse Carbon Nanotube Samples. Chemistry of Materials/Chemistry of Materials. 2007; 19 (14) : 3472-3478.|
|Pietruska JR, Kane AB SV40 oncoproteins enhance asbestos-induced DNA double-strand breaks and abrogate senescence in murine mesothelial cells.. Cancer Research. 2007; 67 (8) : 3637-45.|
|Yan, Aihui, Von Dem Bussche, Annette, Kane, Agnes B., Hurt, Robert H. Tocopheryl polyethylene glycol succinate as a safe, antioxidant surfactant for processing carbon nanotubes and fullerenes. Carbon/Carbon. 2007; 45 (13) : 2463-2470.|
|Altomare, D.A., Skele, K.L., Vaslet, C.A., Messier, N., Henderson, I., Kane, A.B., Testa, J.R. 19 Loss of functional Arf predisposes mice to asbestos-induced mesothelioma. Lung Cancer/Lung Cancer. 2006; 54 : S5.|
|Sanchez, V.C., Weston, P., Liu, X., Hurt, R.H., Kane, A.B. 213 Asbestos in the past, nanomaterials in the future?. Lung Cancer/Lung Cancer. 2006; 54 : S52.|
|Lau, B.W., Yan, A., Weissman, B.S., Kulaots, I., Yang, N.Y.C., Kane, A., Hurt, R. 229 Biocompatible, hydrophilic, supramolecular carbon nanoparticles for cell delivery. Lung Cancer/Lung Cancer. 2006; 54 : S55-S56.|
|Pietruska, J.R., Kane, A.B. 23 SV40 oncoproteins and p53 deficiency impair stress-induced mesothelial cell senescence. Lung Cancer/Lung Cancer. 2006; 54 : S6.|
|Kane AB Animal models of malignant mesothelioma.. Inhalation toxicology. 2006; 18 (12) : 1001-4.|
|Yan, A., Lau, B. W., Weissman, B. S., Külaots, I., Yang, N. Y. C., Kane, A. B., Hurt, R. H. Biocompatible, Hydrophilic, Supramolecular Carbon Nanoparticles for Cell Delivery. Adv. Mater./Adv. Mater.. 2006; 18 (18) : 2373-2378.|
|Hurt, Robert H., Monthioux, Marc, Kane, Agnes Toxicology of carbon nanomaterials: Status, trends, and perspectives on the special issue. Carbon/Carbon. 2006; 44 (6) : 1028-1033.|
|Altomare DA, Vaslet CA, Skele KL, De Rienzo A, Devarajan K, Jhanwar SC, McClatchey AI, Kane AB, Testa JR A mouse model recapitulating molecular features of human mesothelioma.. Cancer Research. 2005; 65 (18) : 8090-5.|
|Altomare DA, You H, Xiao GH, Ramos-Nino ME, Skele KL, De Rienzo A, Jhanwar SC, Mossman BT, Kane AB, Testa JR Human and mouse mesotheliomas exhibit elevated AKT/PKB activity, which can be targeted pharmacologically to inhibit tumor cell growth.. Oncogene. 2005; 24 (40) : 6080-9.|
|Bernstein D, Castranova V, Donaldson K, Fubini B, Hadley J, Hesterberg T, Kane A, Lai D, McConnell EE, Muhle H, Oberdorster G, Olin S, Warheit DB, ILSI Risk Science Institute Working Group Testing of fibrous particles: short-term assays and strategies.. Inhalation toxicology. 2005; 17 (10) : 497-537.|
|Yuan ZL, Guan YJ, Wang L, Wei W, Kane AB, Chin YE Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells.. Molecular and Cellular Biology. 2004; 24 (21) : 9390-400.|
|Kane AB Asbestos bodies: clues to the mechanism of asbestos toxicity?. Human Pathology. 2003; 34 (8) : 735-6.|
|Cordier Kellerman L, Valeyrie L, Fernandez N, Opolon P, Sabourin JC, Maubec E, Le Roy P, Kane A, Legrand A, Abina MA, Descamps V, Haddada H Regression of AK7 malignant mesothelioma established in immunocompetent mice following intratumoral gene transfer of interferon gamma.. Cancer gene therapy. 2003; 10 (6) : 481-90.|
|Vaslet CA, Messier NJ, Kane AB Accelerated progression of asbestos-induced mesotheliomas in heterozygous p53+/- mice.. Toxicological Sciences. 2002; 68 (2) : 331-8.|
|Yano N, Habib NA, Fadden KJ, Yamashita H, Mitry R, Jauregui H, Kane A, Endoh M, Rifai A Profiling the adult human liver transcriptome: analysis by cDNA array hybridization.. Journal of Hepatology. 2001; 35 (2) : 178-86.|
|Yano N, Endoh M, Fadden K, Yamashita H, Kane A, Sakai H, Rifai A Comprehensive gene expression profile of the adult human renal cortex: analysis by cDNA array hybridization.. Kidney International. 2000; 57 (4) : 1452-9.|
|Goodglick LA, Vaslet CA, Messier NJ, Kane AB Growth factor responses and protooncogene expression of murine mesothelial cell lines derived from asbestos-induced mesotheliomas.. Toxicologic Pathology. 1997; 25 (6) : 565-73.|
|Macdonald JL, Kane AB Mesothelial cell proliferation and biopersistence of wollastonite and crocidolite asbestos fibers.. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1997; 38 (2) : 173-83.|
|Marsella JM, Liu BL, Vaslet CA, Kane AB Susceptibility of p53-deficient mice to induction of mesothelioma by crocidolite asbestos fibers.. Environ Health Perspect. 1997; 105 Suppl 5 : 1069-72.|
|Kane AB Mechanisms of mineral fibre carcinogenesis.. IARC scientific publications. 1996; (140) : 11-34.|
|Cistulli CA, Sorger T, Marsella JM, Vaslet CA, Kane AB Spontaneous p53 mutation in murine mesothelial cells: increased sensitivity to DNA damage induced by asbestos and ionizing radiation.. Toxicology and Applied Pharmacology. 1996; 141 (1) : 264-71.|
|Kane AB Redefining cell death.. The American Journal of Pathology. 1995; 146 (1) : 1-2.|
|Moyer VD, Cistulli CA, Vaslet CA, Kane AB Oxygen radicals and asbestos carcinogenesis.. Environ Health Perspect. 1994; 102 Suppl 10 : 131-6.|
|Branchaud RM, Garant LJ, Kane AB Pathogenesis of mesothelial reactions to asbestos fibers. Monocyte recruitment and macrophage activation.. Pathobiology : journal of immunopathology, molecular and cellular biology. 1993; 61 (3-4) : 154-63.|
|Abeshaus DB, Epstein LC, Kane AB, Monteiro LA The status of women in medicine at the Brown University School of Medicine.. Rhode Island medicine. 1993; 76 (7) : 337-9.|
|Kane AB Animal models of mesothelioma induced by mineral fibers: implications for human risk assessment.. Progress in clinical and biological research. 1992; 374 : 37-50.|
|Kane AB Environmental pathology: the pathologist's responsibility?. Human Pathology. 1992; 23 (10) : 1093-4.|
|Gleva GF, Goodglick LA, Kane AB Altered calcium homeostasis in irreversibly injured P388D1 macrophages.. The American Journal of Pathology. 1990; 137 (1) : 43-57.|
|Goodglick LA, Kane AB Cytotoxicity of long and short crocidolite asbestos fibers in vitro and in vivo.. Cancer Research. 1990; 50 (16) : 5153-63.|
|Goodglick LA, Pietras LA, Kane AB Evaluation of the causal relationship between crocidolite asbestos-induced lipid peroxidation and toxicity to macrophages.. The American review of respiratory disease. 1989; 139 (5) : 1265-73.|
|Branchaud RM, MacDonald JL, Kane AB Induction of angiogenesis by intraperitoneal injection of asbestos fibers.. The FASEB Journal. 1989; 3 (6) : 1747-52.|
|Dobson ME, Stern RO, Kane AB Selective purine release from P388D1 macrophages injured by silica.. Journal of cellular physiology. 1988; 135 (2) : 244-52.|
|Moalli PA, MacDonald JL, Goodglick LA, Kane AB Acute injury and regeneration of the mesothelium in response to asbestos fibers.. The American Journal of Pathology. 1987; 128 (3) : 426-45.|
|Macdonald JL, Kane AB Identification of asbestos fibers within single cells.. Laboratory investigation; a journal of technical methods and pathology. 1986; 55 (2) : 177-85.|
|Goodglick LA, Kane AB Role of reactive oxygen metabolites in crocidolite asbestos toxicity to mouse macrophages.. Cancer Research. 1986; 46 (11) : 5558-66.|
|Kane AB, Petrovich DR, Stern RO, Farber JL ATP depletion and loss of cell integrity in anoxic hepatocytes and silica-treated P388D1 macrophages.. The American journal of physiology. 1985; 249 (3 Pt 1) : C256-66.|
|Russo MA, Kane AB, Farber JL Ultrastruct pathology of phalloidin-intoxicated hepatocytes in the presence and absence of extracellular calcium.. The American Journal of Pathology. 1982; 109 (2) : 133-44.|
|Kane AB, Bols NC A study of metabolic cooperation with rat peritoneal macrophages.. Journal of cellular physiology. 1980; 102 (3) : 385-93.|
|Kane AB, Stanton RP, Raymond EG, Dobson ME, Knafelc ME, Farber JL Dissociation of intracellular lysosomal rupture from the cell death caused by silica.. The Journal of cell biology. 1980; 87 (3 Pt 1) : 643-51.|
Ongoing Research Support
P42 ES013660 Boekelheide (PI) 04/18/05-06/30/15 (no cost extension) NIH/NIEHS
Superfund Basic Research Program – Reuse in RI: A State-based Approach to Complex Exposures
This program has 8 research projects and 6 cores.
Role: Leader of Research Project 2 and the Training Core. The goal of Project 2 is to explore mechanisms of toxicity and genotoxicity of metallic nanoparticles and carbon nanotubes containing nickel.
T32 ES007272 Kane (PI) 07/01/02-06/30/17 NIH/NIEHS
Training in Environmental Pathology
The major goal of this training grant is to prepare our predoctoral and postdoctoral trainees for research careers in environment pathology and toxicology.
P200A090076 Hurt (PI), Kane (Co-PI) 08/15/09-08/14/15
US Department of Education
DOE: GAANN-Interdisciplinary Training in Applications and Implications of Nanotechnology
The goal of this training grant is to develop, administer, and evaluate a new interdisciplinary Ph.D. training program in nanotechnology, nanotoxicology, and nanomedicine.
CBET 1344097 Hurt (PI), Kane (Co-PI) 11/01/13-/10/31/16
INSPIRE Track1: Computational Design for the Safe Development of High-Aspect Ratio Nanomaterials
The goal of this grant it to identify the fundamental design rules that will allow the safe development of high-aspect ratio nanomaterials.
MA-2014-01684 Boekelheide (PI), Kane and Morgan (Co-I) 11/26/14-11/25/15
Developing fit-for-purpose predictive biology platforms for in vitro toxicity testing
This research agreement between Brown University and Unilever support the further development and validation of unique 3-dimensional in vitro predictive biology platforms for toxicity testing.
Completed Research Support
RD-833862201 Hurt (PI) Kane (Co-PI) 08/01/08-07/31/11
Bioavailability, Environmental Transformation, and Detoxification of Core/Shell Nanomaterials
The goal of this grant was to develop and validate chemical screening assays for bioavailability assessment, data on environmental degradation, and toxicant release throughout product lifecycle. Practical protocols for material detoxification were developed.
RO1 ES016178 Kane (PI), Hurt (Co-PI) 09/20/07-05/31/12
Chemical, Structural, and Superstructural Determinants of Nanocarbon Toxicity
The goal of this grant was to determine the properties of nanomaterials responsible for production of lung granulomas and fibrosis.
100028-D NIH Grand Opportunity Grant (RC2)
Elder and Oberdorster (Co-PIs), Kane (Brown U. PI) 09/30/09-09/29/12
University of Rochester (National Institute of Health)
Hazard Assessment and Risk Estimation of Inhaled Nanomaterials
The goal of this grant is to address long-term consequences associated with human occupational exposures to engineered nanomaterials.
ECCS – 1057547 Hurt (PI), Kane and Pennell (Co-PIs) 09/01/10-08/31/13 NSF
Exposure Pathways, Dissolution Kinetics, and Fate of Nanosilver in the Environment
The goal of this grant was to assess fate, transport, and bioaccumulation of silver nanoparticles in the aquatic environment.
CBET 1132446 Hurt (PI), Kane (Co-PI) 07/01/11 – 06/30/14
Cellular and Biomolecular Interactions of Graphene-Family Nanomaterials
This interdisciplinary research project will characterize adsorption of micronutrients to a panel of well-characterized graphene-family materials and their interactions with macrophages as initial target cells using generation of reactive oxygen species and GSH depletion as endpoints.
Gulf of Mexico Research Initiative John (PI) 10/01/11 – 09/30/14
Kane and Hurt (Co-PIs, subcontract to Brown University)
The Science and Technology of Dispersants as Relevant to Deep Sea Oil Releases
The Brown subcontract will develop novel particle-based alternatives to chemical dispersants and evaluate their potential toxicity to marine organisms.
Qiu Y, Wang Z, Owens AC, Kulaots I, Chen Y, Kane AB, Hurt RH: Antioxidant chemistry of graphene-based materials and its role in oxidation protection technology. Nanoscale 6(20): 11744-55 (2014).
Grosse Y, Loomis D, Guyton KZ, Lauby-Secretan B, El Ghissassi F, Douvard V, Benbrahim-Tallaa L, Guha N, Scoccianti C, Mattock H, Straif K; International Agency for Research on Cancer Monograph Working Group and Kane AB, Debia M, Dion C, Moller P, Savolainen K, Canu IG, Jaurand MC, Comba P, Fubini B, Kobayashi N, Morimoto Y, Tsuda H, Yu IJ, Vermeulen R, Bugge MD, Bateso TF, Kuempel ED, Morgan DL, Pinkerton KE, Sargent LM, Stayner L: Carcinogenicity of fluoro-edenite, silicon carbide fibres and whiskers, and carbon nanotubes. Lancet Oncol. 15(13): 1427-8 (2014).
Rodd AL, Creighton MA, Vaslet CA, Rangel-Mendez JR, Hurt RH, Kane AB: Effects of surface-engineered nanparticle-based dispersants for marine oil spills on the model organism Artemia franciscana. Environ Sci Technol. 48: 6419-6427 (2014).
Wang Z, von dem Bussche A, Kabadi PK, Kane AB, Hurt RH: Biological and environmental transformations of copper-based nanomaterials. ACS Nano. 7: 8715-8727 (2013).
Nel AE, Nasser E, Godwin H, Avery D, Bahadori T, Bergeson L, Beryt E, Bonner JC, Boverhof D, Carter J, Castranova V, Deshazo JR, Hussain SM, Kane AB, Klaessig F, Kuempel E, Lafranconi M, Landsiedel R, Malloy T, Miller MB, Morris J, Moss K, Oberdorster G, Pinkerton K, pleus RC, Shatkin JA, Thomas R, Tolaymat T, Wang A and Wong J: A muti-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment. ACS Nano. 7:6422-6433 (2013).
Li Y, Yuan H, von dem Bussche A, Creighton M, Hurt RH, Kane AB, Gao H: Graphene microsheets enter cells through spontaneous membrane penetration at edge asperities and corner sites. Proc Natl Acad Sci U S A 110:12295-12300 (2013).
Creighton M, Rangel-Mendez R, Huang J, Kane AB, Hurt RH: Graphene induced adsorptive and optical artifacts during in vitro toxicology assays . Small 9:1921-1927 (2013).
Sanchez VC, Jachak A, Hurt RH, Kane AB: Biological interactions of graphene-family nanomaterials: an interdisciplinary review. Chem Res Toxicol. 25:15-34 (2012).
Liu J, Wang Z, Liu FD, Kane AB, Hurt RH: Chemical transformations of nanosilver in biological environments. ACS Nano. 6:9887-9899 (2012).
Jachak A, Creighton M, Qui Y, Kane AB, Hurt RH: Biological interactions and safety of graphene materials. MRS Bulletin 37:1307-1313 (2012).
Chen Y, Guo F, Jachak A, Kim SP, Datta D, Liu J, Vaslet C, Jang HD, Huang J, Kane A, Shenoy VB, and Hurt RH: Aerosol synthesis of cargo-filled graphene nanosacks. Nano Lett. 12: 1996-2002 (2012).
Sanchez VC, Jachak A, Hurt RH and Kane AB: Biological interactions of graphene-family nanomaterials: An interdisciplinary review. Chem. Res. Toxicol. 25:15-34 (2012).
Sanchez VC, Weston P, Yan A, Hurt RH, and Kane AB: A 3-dimensional in vitro model of epithelioid granulomas induced by high aspect ratio nanomaterials. Part Fibre Toxicol, 8, 17 (2011).
Liu X, Sen, S Liu, J Kulaots, I, Geohegan, D. Kane A, Puretzky, A, Rouleau, C, More, K, Palmore, G, and Hurt, R: (2011) Antioxidant deactivation on graphenic nanocarbon surfaces. Small 7: 2775-2785 (2011).
Shi X, von dem Bussche A, Hurt RH, Kane AB and Gao H: Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation. Nat. Nanotechnol. 6: 714-719 (2011).
Pietruska JR, Liu X, Smith A, McNeil K, Weston P, Zhitkovich A, Hurt R and Kane AB: Bioavailability, intracellular mobilization of nickel, and HIF-1α activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles. Toxicol. Sci. 124:138-148 (2011)
Broaddus VC, Everitt JI, Black B, Kane AB: Non-Neoplastic and neoplastic pleural endpoints following fiber exposure, J. Toxicol. Environ. Health, Part B Crit. Rev. 14: 153-178 (2011)
Liu X, Hurt RH, Kane AB. Biodurability of single-walled carbon nanotubes depends on surface functionalization. Carbon 48: 1961-1969 (2010).
Sarin L, Sanchez VC, Yan A, Kane AB and Hurt RH: Selenium-carbon bifunctional nanoparticles for the treatment of malignant mesothelioma. Advanced Materials. 10: 5207-5211 (2010)
Pietruska JR, Johnston T, Zhitkovich A, Kane AB: XRCC1 deficiency sensitizes human lung epithelial cells to genotoxicity by crocidolite asbestos and Libby amphibole. Environ. Health Perspect.118: 1707-1713 (2010)
Straif K, Benbrahim-Tallaa L, Baan R, Grosse Y, Secretan B, El Ghissassi F, Bouvard V, Guha N, Freeman C, Galichet L, Cogliano V: A review of human carcinogens - part C:metals, arsenic, dusts, and fibres. WHO International Agency for Research on Cancer Monograph Working Group. Lancet Oncol. 10:453-454 (2009).
Altomare DA, Menges CW, Pei J, Zhang L, Skele-Stump KL, Carbon M, Kane AB, Testa JR: Activated TNF-alpha/NF-kappaB signaling via down-regulation of fas-assocaited factor 1 in asbestos-induced mesothelioma from Arf knockout mice. Proc Natl Acad Sci U S A. 106:3420-3425 (2009).
Sanchez, VC, Pietruska JR, Miselis NR, Hurt RH, and Kane AB: Biopersistence and potential adverse health impacts of fibrous nanomaterials; what have we learned from asbestos? Wiley Interdiscip Rev, Nanomed Nanobiotechnol 1: 511-529 (2009)
Liu X, Guo L, Morris D, Kane AB, Hurt, RH: Targeted removal of bioavailable metal as a detoxification strategy for carbon nanotubes. Carbon 46: 489-500 (2008).
Miselis N, Wu Z, Van Rooijen N, Kane AB: Targeting tumor-associated macrophages in an orthotopic murine model of diffuse malignant mesotheliomas. Mol. Cancer Ther. 7:788-799 (2008).
Guo L, von dem Bussche A, Buechner M, Kane AB, Hurt RH: Adsorption of essential micronutrients by carbon nanotubes and its implications for nanotoxicitiy testing. Small 4:721-727 (2008).
Kane AB and Hurt RH: Nanotoxicology: The asbestos analogy revisited. Nat. Nanotech. 3: 378-379 (2008).
Hoover E, Brown P, Averick M, Kane AB and Hurt R: Teaching small and thinking large: Effects of including social and ethical implications in an interdisciplinary nanotechnology course. J. of Nano Education 1: 1-10 (2008).
Guo L., Liu X., Sanchez V., Vaslet C., Kane AB., and Hurt RH: A window of opportunity: designing carbon nanomaterials for environmental safety and health. Mater. Sci. Forum 544/545:511-516 (2007).
Guo L., Morris DG., Liu X., Vaslet C., Hurt RH., Kane AB: Iron bioavailability and redox activity in diverse carbon nanotubes samples. Chem. Mater. 19:3472-78 (2007).
Pietruska JR and Kane AB: SV40 oncoproteins enhance asbestos-induced DNA double-strand breaks and abrogate senescence in murine mesothelial cells. Cancer Res. 67:3637-45 (2007).
Yan A, von dem Bussche, A, Kane AB, Hurt RH: Tocopheryl polyethylene glycol succinate as a safe, antioxidant surfactant for processing carbon nanotubes and fullerenes. Carbon 45:2463- 70 (2007).
Yan A, Lau BW, Weissman B, Kulaots I, Yang NYC, Kane AB and Hurt RH: Biocompatible, hydrophilic, supramolecular carbon nanoparticles for cell delivery. Advanced Materials. 18:2373-2378 (2006).
Kane AB: Animal models of malignant mesothelioma. Inhalation Toxicol. 18: 1001-1004 (2006).
Hurt RH, Monthioux M and Kane A: Toxicology of carbon nanomaterials: Status, trends, and perspectives on the special issue. Carbon 44:1028-1033 (2006).
Liu X., Gurel V., Morris D., Murray, D., Zhitkovich A., Kane AB., Hurt R.H. Bioavailability of nickel in single-wall carbon nanotubes. Advanced Materials 19:2790-96 (2006).
Altomare DA, Vaslet CA, Skele KL, DeRienzo A, Devarajan K, Jhanwar SC, McClatchey AI, Kane AB and Testa JR: A mouse model recapitulating molecular features of human mesothelioma. Cancer Res 65:8090-8095 (2005).
35. Altomare DA, Ramos-Nino ME, Xiao G-H, Wang HQ, Skele KL, DeRienzo AD, Mossman BT, Kane AB and Testa JR: The AKT/PKB pathway is frequently activated in human murine mesotheliomas and can be targeted to inhibit mesothelioma cell growth. Oncogene 24: 6080-6089 (2005).
Vaslet, Charles A., Messier, Norma J., and Kane, Agnes B. Accelerated progression of asbestos-induced mesotheliomas in heterozygous p53 +/- mice. Toxicological Sciences 68: 331-338 (2002).
Kane, Agnes B. Oncogenes and tumor suppressor genes in the carcinogenicity of fibers and particles. Inhalation Toxicology 12: 133-140 (2000).
Goodglick LA, Vaslet CA, Messier NJ and Kane AB, Growth factor responses and protooncogene expression of murine mesothelial cell lines. Toxicologic Pathology 25:565-573 (1997).
Macdonald JL and Kane AB. Mesothelial cell proliferation and biopersistence of wollastonite and crocidolite asbestos fibers. Fundam. Appl. Toxicol. 38:173-183 (1997).
Goodglick LA and Kane AB: Cytotoxicity of long and short crocidolite asbestos fibers in vitro and in vivo. Cancer Res. 50:5153-5163 (1990).
Moalli PA, Macdonald JL, Goodglick LA and Kane AB: Acute injury and regeneration of the mesothelium in response to asbestos fibers. Am. J. Path. 128:426-445 (1987).
Goodglick LA and Kane AB: The role of reactive oxygen metabolites in crocidolite asbestos toxicity to macrophages. Cancer Res. 46:5558-5566 (1986).
|postdoctoral associate||Karolinska Institute, Cell biology||1976-1977||Stockholm, Sweden|
|Gao, Huajian||Walter H. Annenberg Professor of Engineering|