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Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MB, Clelland CD, Cohen AD, Crary JF, Dage JL, Diaz K, Frost B, Gan L, Goate AM, Golbe LI, Hansson O, Karch CM, Kolb HC, La Joie R, Lee SE, Matallana D, Miller BL, Onyike CU, Quiroz YT, Rexach JE, Rohrer JD, Rommel A, Sadri-Vakili G, Schindler SE, Schneider JA, Sperling RA, Teunissen CE, Weninger SC, Worley SL, Zheng H, Carrillo MC.
"Novel avenues of tau research." Alzheimer's & Dementia, vol. 20, no. 3, 2024, pp. 2240-2261.
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Zuniga G, Katsumura S, De Mange J, Ramirez P, Atrian F, Morita M, Frost B.
"Pathogenic tau induces an adaptive elevation in mRNA translation rate at early stages of disease." Aging Cell, 2024, pp. e14245.
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Frost, Bess, Dubnau, Josh.
"The Role of Retrotransposons and Endogenous Retroviruses in Age-Dependent Neurodegenerative Disorders." Annual Review of Neuroscience, 2024.
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Frost B.
"Alzheimer's disease and related tauopathies: disorders of disrupted neuronal identity." Trends in Neurosciences, vol. 46, no. 10, 2023, pp. 797-813.
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Miller HE, Montemayor D, Li J, Levy SA, Pawar R, Hartono S, Sharma K, Frost B, Chedin F, Bishop AJR.
"Exploration and analysis of R-loop mapping data with RLBase." Nucleic acids research, vol. 51, no. D1, 2023, pp. D1129-D1137.
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Beckmann A, Ramirez P, Gamez M, Gonzalez E, De Mange J, Bieniek KF, Ray WJ, Frost B.
"Moesin is an effector of tau-induced actin overstabilization, cell cycle activation, and neurotoxicity in Alzheimer's disease." iScience, vol. 26, no. 3, 2023, pp. 106152.
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Sohn C, Ma J, Ray WJ, Frost B.
"Pathogenic tau decreases nuclear tension in cultured neurons." Frontiers in aging, vol. 4, 2023, pp. 1058968.
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Ochoa E, Ramirez P, Gonzalez E, De Mange J, Ray WJ, Bieniek KF, Frost B.
"Pathogenic tau-induced transposable element-derived dsRNA drives neuroinflammation." Science Advances, vol. 9, no. 1, 2023, pp. eabq5423.
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Miller HE, Montemayor D, Levy S, Sharma K, Frost B, Bishop AJR.
"RLSuite: An Integrative R-Loop Bioinformatics Framework." Journal of bioinformatics and systems biology : Open access, vol. 6, no. 4, 2023, pp. 364-378.
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Zuniga G, Frost B.
"Selective neuronal vulnerability to deficits in RNA processing." Progress in neurobiology, vol. 229, 2023, pp. 102500.
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Zuniga G, Levy S, Ramirez P, De Mange J, Gonzalez E, Gamez M, Frost B.
"Tau-induced deficits in nonsense-mediated mRNA decay contribute to neurodegeneration." Alzheimer's & Dementia, vol. 19, no. 2, 2023, pp. 405-420.
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Sexton C, Snyder H, Beher D, Boxer AL, Brannelly P, Brion JP, Buée L, Cacace AM, Chételat G, Citron M, DeVos SL, Diaz K, Feldman HH, Frost B, Goate AM, Gold M, Hyman B, Johnson K, Karch CM, Kerwin DR, Koroshetz WJ, Litvan I, Morris HR, Mummery CJ, Mutamba J, Patterson MC, Quiroz YT, Rabinovici GD, Rommel A, Shulman MB, Toledo-Sherman LM, Weninger S, Wildsmith KR, Worley SL, Carrillo MC.
"Current directions in tau research: Highlights from Tau 2020." Alzheimer's & Dementia, vol. 18, no. 5, 2022, pp. 988-1007.
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Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, Whitney K, Dangoor DK, Walsh H, Marcora E, Hefti MM, Casella A, Sissoko CT, Kapoor M, Novikova G, Udine E, Wong G, Tang W, Bhangale T, Hunkapiller J, Ayalon G, Graham RR, Cherry JD, Cortes EP, Borukov VY, McKee AC, Stein TD, Vonsattel JP, Teich AF, Gearing M, Glass J, Troncoso JC, Frosch MP, Hyman BT, Dickson DW, Murray ME, Attems J, Flanagan ME, Mao Q, Mesulam MM, Weintraub S, Woltjer RL, Pham T, Kofler J, Schneider JA, Yu L, Purohit DP, Haroutunian V, Hof PR, Gandy S, Sano M, Beach TG, Poon W, Kawas CH, Corrada MM, Rissman RA, Metcalf J, Shuldberg S, Salehi B, Nelson PT, Trojanowski JQ, Lee EB, Wolk DA, McMillan CT, Keene CD, Latimer CS, Montine TJ, Kovacs GG, Lutz MI, Fischer P, Perrin RJ, Cairns NJ, Franklin EE, Cohen HT, Raj T, Cobos I, Frost B, Goate A, White Iii CL, Crary JF.
"Genome-wide association study and functional validation implicates JADE1 in tauopathy." Acta Neuropathologica, vol. 143, no. 1, 2022, pp. 33-53.
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Ramirez P, Zuniga G, Sun W, Beckmann A, Ochoa E, DeVos SL, Hyman B, Chiu G, Roy ER, Cao W, Orr M, Buggia-Prevot V, Ray WJ, Frost B.
"Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system." Progress in neurobiology, vol. 208, 2022, pp. 102181.
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Miller HE, Montemayor D, Abdul J, Vines A, Levy SA, Hartono SR, Sharma K, Frost B, Chédin F, Bishop AJR.
"Quality-controlled R-loop meta-analysis reveals the characteristics of R-loop consensus regions." Nucleic acids research, vol. 50, no. 13, 2022, pp. 7260-7286.
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Levy SA, Zuniga G, Gonzalez EM, Butler D, Temple S, Frost B.
"Tau(LUM), an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy." Cell reports methods, vol. 2, no. 9, 2022, pp. 100292.
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Dehkordi SK, Walker J, Sah E, Bennett E, Atrian F, Frost B, Woost B, Bennett RE, Orr TC, Zhou Y, Andhey PS, Colonna M, Sudmant PH, Xu P, Wang M, Zhang B, Zare H, Orr ME.
"Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology." Nature aging, vol. 1, no. 12, 2021, pp. 1107-1116.
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Mozolewski P, Jeziorek M, Schuster CM, Bading H, Frost B, Dobrowolski R.
"The role of nuclear Ca2+ in maintaining neuronal homeostasis and brain health." Journal of cell science, vol. 134, no. 8, 2021.
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Ochoa Thomas E, Zuniga G, Sun W, Frost B.
"Awakening the dark side: retrotransposon activation in neurodegenerative disorders." Current opinion in neurobiology, vol. 61, 2020, pp. 65-72.
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Lohr KM, Frost B, Scherzer C, Feany MB.
"Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model." Proceedings of the National Academy of Sciences, vol. 117, no. 52, 2020, pp. 33608-33618.
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Mahoney R, Ochoa Thomas E, Ramirez P, Miller HE, Beckmann A, Zuniga G, Dobrowolski R, Frost B.
"Pathogenic Tau Causes a Toxic Depletion of Nuclear Calcium." Cell Reports, vol. 32, no. 2, 2020, pp. 107900.
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Cornelison GL, Levy SA, Jenson T, Frost B.
"Tau-induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila." Aging Cell, vol. 18, no. 1, 2019, pp. e12847.
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Sun W, Samimi H, Gamez M, Zare H, Frost B.
"Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies." Nature Neuroscience, vol. 21, no. 8, 2018, pp. 1038-1048.
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Orr ME, Sullivan AC, Frost B.
"A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies." Trends in Pharmacological Sciences, vol. 38, no. 7, 2017, pp. 637-648.
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Frost B.
"Alzheimer's disease: An acquired neurodegenerative laminopathy." Nucleus, vol. 7, no. 3, 2016, pp. 275-83.
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Frost B, Bardai FH, Feany MB.
"Lamin Dysfunction Mediates Neurodegeneration in Tauopathies." Current Biology, vol. 26, no. 1, 2016, pp. 129-36.
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Sun W, Yan C, Frost B, Wang X, Hou C, Zeng M, Gao H, Kang Y, Liu J.
"Pomegranate extract decreases oxidative stress and alleviates mitochondrial impairment by activating AMPK-Nrf2 in hypothalamic paraventricular nucleus of spontaneously hypertensive rats." Scientific reports, vol. 6, 2016, pp. 34246.
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Frost B, Götz J, Feany MB.
"Connecting the dots between tau dysfunction and neurodegeneration." Trends in cell biology, vol. 25, no. 1, 2015, pp. 46-53.
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Merlo P, Frost B, Peng S, Yang YJ, Park PJ, Feany M.
"p53 prevents neurodegeneration by regulating synaptic genes." Proceedings of the National Academy of Sciences, vol. 111, no. 50, 2014, pp. 18055-60.
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Frost B, Hemberg M, Lewis J, Feany MB.
"Tau promotes neurodegeneration through global chromatin relaxation." Nature Neuroscience, vol. 17, no. 3, 2014, pp. 357-66.
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Frost B, Diamond MI.
"Prion-like mechanisms in neurodegenerative diseases." Nature Reviews Neuroscience, vol. 11, no. 3, 2010, pp. 155-9.
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Frost B, Ollesch J, Wille H, Diamond MI.
"Conformational diversity of wild-type Tau fibrils specified by templated conformation change." Journal of Biological Chemistry, vol. 284, no. 6, 2009, pp. 3546-51.
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Frost B, Jacks RL, Diamond MI.
"Propagation of tau misfolding from the outside to the inside of a cell." Journal of Biological Chemistry, vol. 284, no. 19, 2009, pp. 12845-52.
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Molecular Biology, Cell Biology and Biochemistry
Robert J. and Nancy D. Carney Institute for Brain Science
