Brajesh Kumar Singh
Brajesh Kumar Singh
Senior Research Scientist of Pathology and Laboratory Medicine
Overview
Brajesh K Singh, PhD, DABT, is a Senior Research Scientist in the Department of Pathology and Laboratory Medicine at Brown University’s Center for International Health Research. His research focuses on malaria parasite biology, malaria vaccine development, and antimalarial drug discovery, with an emphasis on Plasmodium falciparum and severe malaria.
Dr. Singh’s current research involves identifying and characterizing novel antigens and therapeutic targets associated with severe malaria and evaluating their potential for vaccine development. He also investigates novel antimalarial compounds, including their potency, mechanisms of action, parasite-stage specificity, and potential for further preclinical development.
Prior to joining Brown University, Dr. Singh conducted postdoctoral research at the National Institutes of Health, Hebrew University of Jerusalem, and the Weizmann Institute of Science. At NIH, his research focused on ubiquitination in malaria parasites and the role of a P. falciparum RING finger E3 ubiquitin ligase in parasite development and responses to antimalarial drugs. At Hebrew University, he investigated gene regulation and alternative splicing in P. falciparum using CRISPR/Cas9-based genetic approaches, including studies of PfSR1 and parasite responses to DNA damage and artemisinin exposure.
Dr. Singh received his PhD in biochemical and molecular mechanisms of heavy metal-induced neurotoxicity from CSIR-Indian Institute of Toxicology Research and Jamia Hamdard, India. His interdisciplinary research experience spans molecular parasitology, drug response, vaccine target discovery, neuro toxicity in context of Parkinson's disease, and molecular mechanisms of disease.
