Dr. Mantsounga’s research focuses on the uncoupling IL-1beta/VEGF-A signaling axis in inflammatory arteriogenesis and in the context of aging which could lead to a better understanding of reduced VEGF-A and VEGF-A-mediated downstream signaling pathway while IL-1beta expression is increased in Type 2 diabetes mouse model. Dr. Mantsounga also investigates the impairment of inflammatory angiogenesis/arteriogenesis in the context of advanced aging which could be a result of the VEGF-A isoforms switch.
Dr. Chris Mantsounga is appointed as Assistant Professor of Medicine (Research) at Brown University Warren Alpert Medical School and affiliate to Ocean State Research Institute (OSRI) at Providence VA Medical Center (PVAMC). Dr. Mantsounga graduated from the University of Paris V Descartes at Paris (France) where he obtained his Ph.D. in Cardiovascular Pathology. He did his postdoctoral fellowship in the Dr. Morrison’s Laboratory at the Rhode Island Hospital and PVAMC. His basic sciences research interests include mechanisms of immune-mediated vascular remodeling focusing on areas where immune cells direct the biologic processes of angiogenesis/arteriogenesis and vascular calcification in diabetic state and age-related defects.
Dr. Mantsounga has approximated 12 years’ experience and expertise in cellular and molecular mechanisms involved in inflammation, new arterial and capillary growth in both tumors and ischemic injury models. Dr. Mantsounga has contributed as first or co-author in high impact journals, including original and review articles (Cells reports 2022; Angiogenesis 2018; Diabetes 2012 etc).
Dr. Mantsounga’s research has been supported and awarded by the French National Research ministry; the CardioPulmonary Vascular Biology COBRE Project Leader as well as the American Heart Association Career Development Award as a PI.
CPVB COBRE Research Project Leader
American Heart Association Career Development Award
