Expertise/Certifications: Transfusion Medicine, International Health Research
Office number: 401-444-7375
(Lab Customer Service: 401-793-4242)
Christian Nixon received his MD/PhD from Brown University in 2008. He completed residencies in clinical and anatomic pathology at University of California at San Francisco and Yale Medical School respectively, and a blood bank fellowship in the Joint Program in Transfusion Medicine at Harvard Medical School. After completing residency/fellowship in 2014, he joined the faculty at Brown University in the Department of Pathology and Laboratory Medicine and serves as an attending physician on the Transfusion Medicine and Coagulation Service at Rhode Island Hospital.
|Nixon CP Plasmodium falciparum gametocyte transit through the cutaneous microvasculature: A new target for malaria transmission blocking vaccines? . Human Vaccines & Immunotherapeutics. 2016;|
|Nixon, Christian P., Sweeney, Joseph D. Discriminating different causes of transfusion-associated pulmonary edema. Transfusion. 2015; 55 (8) : 1825-1828.|
|Fine, Antonella B., Sweeney, Joseph D., Nixon, Christian P., Knoll, Bettina M. Transfusion-transmitted anaplasmosis from a leukoreduced platelet pool. Transfusion. 2015; 56 (3) : 699-704.|
|Raj DK, Nixon CP, Nixon CE, Dvorin JD, DiPetrillo CG, Pond-Tor S, Wu HW, Jolly G, Pischel L, Lu A, Michelow IC, Cheng L, Conteh S, McDonald EA, Absalon S, Holte SE, Friedman JF, Fried M, Duffy PE, Kurtis JD Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection.. Science. 2014; 344 (6186) : 871-7.|
|Nixon CP, Nixon CE, Arsyad DS, Chand K, Yudhaputri FA, Sumarto W, Wangsamuda S, Asih PB, Marantina SS, Wahid I, Han G, Friedman JF, Bangs MJ, Syafruddin D, Baird JK Distance to Anopheles sundaicus larval habitats dominant among risk factors for parasitemia in meso-endemic Southwest Sumba, Indonesia.. Pathogens and global health. 2014; 108 (8) : 369-80.|
|Syafruddin D, Bangs MJ, Sidik D, Elyazar I, Asih PB, Chan K, Nurleila S, Nixon C, Hendarto J, Wahid I, Ishak H, Bøgh C, Grieco JP, Achee NL, Baird JK Impact of a spatial repellent on malaria incidence in two villages in Sumba, Indonesia. american journal of tropical medicine and hygiene. 2014; 91 (6) : 1079-87.|
|Nixon CP, Friedman J, Treanor K, Knopf PM, Duffy PE, Kurtis JD Antibodies to rhoptry-associated membrane antigen predict resistance to Plasmodium falciparum.. Journal of Infectious Diseases. 2005; 192 (5) : 861-9.|
|Solomon JS, Nixon CP, McGarvey ST, Acosta LP, Manalo D, Kurtis JD Expression, purification, and human antibody response to a 67 kDa vaccine candidate for schistosomiasis japonica.. Protein expression and purification. 2004; 36 (2) : 226-31.|
|Leenstra T, ter Kuile FO, Kariuki SK, Nixon CP, Oloo AJ, Kager PA, Kurtis JD Dehydroepiandrosterone sulfate levels associated with decreased malaria parasite density and increased hemoglobin concentration in pubertal girls from western Kenya.. Journal of Infectious Diseases. 2003; 188 (2) : 297-304.|
|Montano MA, Nixon CP, Ndung'u T, Bussmann H, Novitsky VA, Dickman D, Essex M Elevated tumor necrosis factor-alpha activation of human immunodeficiency virus type 1 subtype C in Southern Africa is associated with an NF-kappaB enhancer gain-of-function.. Journal of Infectious Diseases. 2000; 181 (1) : 76-81.|
We focus on the functional significance of antibody targeted cellular and complement responses to a novel pediatric malaria vaccine candidate that was discovered here at Brown in the Center for International Health Research. Elucidating the roles of cellular effector mechanisms to this vaccine target will help to guide ongoing immune-epidemiology studies and ultimately vaccine trials. As a second aim, the Nixon Laboratory will focus on identifying novel vaccine targets against the transmissible form of the malaria parasite, the gametocyte, while it still resides within the human host. Novel vaccine candidates that target this stage will ultimately be incorporated into a multi-stage vaccine that target the liver and blood stage of malaria.