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Fallon, Eleanor A, Biron-Girard, Bethany M, Chung, Chun-Shiang, Lomas-Neira, Joanne, Heffernan, Daithi S, Monaghan, Sean F, Ayala, Alfred.
"A novel role for coinhibitory receptors/checkpoint proteins in the immunopathology of sepsis." Journal of Leukocyte Biology, vol. 103, no. 6, 2018, pp. 1151-1164.
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Monaghan, Sean F., Banerjee, Debasree, Chung, Chun-Shiang, Lomas-Neira, Joanne, Cygan, Kamil J., Rhine, Christy L., Fairbrother, William G., Heffernan, Daithi S., Levy, Mitchell M., Cioffi, William G., Ayala, Alfred.
"Changes in the process of alternative RNA splicing results in soluble B and T lymphocyte attenuator with biological and clinical implications in critical illness." Molecular Medicine, vol. 24, no. 1, 2018, pp. 32.
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Chun TT, Chung CS, Fallon EA, Hutchins NA, Clarke E, Rossi AL, Cioffi WG, Heffernan DS, Ayala A.
"Group 2 Innate Lymphoid Cells (ILC2s) Are Key Mediators of the Inflammatory Response in Polymicrobial Sepsis." The American Journal of Pathology, vol. 188, no. 9, 2018, pp. 2097-2108.
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Biron, Bethany M., Chung, Chun-Shiang, Chen, Yaping, Wilson, Zachary, Fallon, Eleanor A., Reichner, Jonathan S., Ayala, Alfred.
"PAD4 Deficiency Leads to Decreased Organ Dysfunction and Improved Survival in a Dual Insult Model of Hemorrhagic Shock and Sepsis." The Journal of Immunology, vol. 200, no. 5, 2018, pp. ji1700639.
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Biron BM, Chung CS, O'Brien XM, Chen Y, Reichner JS, Ayala A.
"Cl-Amidine Prevents Histone 3 Citrullination and Neutrophil Extracellular Trap Formation, and Improves Survival in a Murine Sepsis Model." Journal of innate immunity, vol. 9, no. 1, 2017, pp. 22-32.
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Wu, Youping, Chung, Chun-Shiang.
"A Novel Role for Programmed Cell Death Receptor Ligand-1 (PD-L1) in Sepsis-Induced Intestinal Dysfunction." Molecular Medicine, vol. 22, no. 1, 2016, pp. 1.
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Cheng T, Bai J, Chung CS, Chen Y, Biron BM, Ayala A.
"Enhanced Innate Inflammation Induced by Anti-BTLA Antibody in Dual Insult Model of Hemorrhagic Shock/Sepsis." Shock, vol. 45, no. 1, 2016, pp. 40-9.
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Monaghan SF, Chung CS, Chen Y, Lomas-Neira J, Fairbrother WG, Heffernan DS, Cioffi WG, Ayala A.
"Soluble programmed cell death receptor-1 (sPD-1): a potential biomarker with anti-inflammatory properties in human and experimental acute respiratory distress syndrome (ARDS)." Journal of Translational Medicine, vol. 14, no. 1, 2016, pp. 312.
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Young, John S., Heffernan, Daithi S., Chung, Chun-Shiang, Kettenmann, Maude L., Young, Whitney A., Guillen, Valeria Sanabria, Cioffi, William G., Ayala, Alfred.
"Effect of PD-1: PD-L1 in Invariant Natural Killer T Cell Emigration and Chemotaxis Following Sepsis." SHOCK, vol. 45, no. 5, 2015, pp. 534-9.
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Tang L, Bai J, Chung CS, Lomas-Neira J, Chen Y, Huang X, Ayala A.
"PD-L1 Regulates the Tregs' Capacity to Repress Shock/Sepsis Induced Indirect Lung Injury (iALI) by Recruiting Phosphatase SHP-1." Shock, vol. 43, no. 1, 2015, pp. 47-54.
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Heffernan DS, Monaghan SF, Chung CS, Cioffi WG, Gravenstein S, Ayala A.
"A divergent response of innate regulatory T-cells to sepsis in humans: circulating invariant natural killer T-cells are preserved." Human immunology, vol. 75, no. 3, 2014, pp. 277-82.
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Huang X, Chen Y, Chung CS, Yuan Z, Monaghan SF, Wang F, Ayala A.
"Identification of B7-H1 as a novel mediator of the innate immune/proinflammatory response as well as a possible myeloid cell prognostic biomarker in sepsis." The Journal of Immunology, vol. 192, no. 3, 2014, pp. 1091-9.
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Lomas-Neira J, Venet F, Chung CS, Thakkar R, Heffernan D, Ayala A.
"Neutrophil-endothelial interactions mediate angiopoietin-2-associated pulmonary endothelial cell dysfunction in indirect acute lung injury in mice." American Journal of Respiratory Cell and Molecular Biology, vol. 50, no. 1, 2014, pp. 193-200.
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Ayala A, Elphick GF, Kim YS, Huang X, Carreira-Rosario A, Santos SC, Shubin NJ, Chen Y, Reichner J, Chung CS.
"Sepsis-induced potentiation of peritoneal macrophage migration is mitigated by programmed cell death receptor-1 gene deficiency." Journal of innate immunity, vol. 6, no. 3, 2014, pp. 325-38.
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Bai, J., Tang, L., Loma-Neira, J., Chen, Y., McLeish, K. R., Uriarte, S. M., Chung, C.-S., Ayala, A.
"TAT-SNAP-23 treatment inhibits the priming of neutrophil functions contributing to shock and/or sepsis-induced extra-pulmonary acute lung injury." Innate Immunity, vol. 21, no. 1, 2014, pp. 42-54.
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Heffernan DS, Monaghan SF, Thakkar RK, Tran ML, Chung CS, Gregory SH, Cioffi WG, Ayala A.
"Inflammatory mechanisms in sepsis: elevated invariant natural killer T-cell numbers in mouse and their modulatory effect on macrophage function." Shock, vol. 40, no. 2, 2013, pp. 122-8.
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Hutchins NA, Chung CS, Borgerding JN, Ayala CA, Ayala A.
"Kupffer cells protect liver sinusoidal endothelial cells from Fas-dependent apoptosis in sepsis by down-regulating gp130." The American Journal of Pathology, vol. 182, no. 3, 2013, pp. 742-54.
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Sun, Xiaolian, Guo, Shaojun, Chung, Chun-Shiang, Zhu, Wenlei, Sun, Shouheng.
"A Sensitive H 2 O 2 Assay Based on Dumbbell-like PtPd-Fe 3 O 4 Nanoparticles." Adv. Mater., vol. 25, no. 1, 2012, pp. 132-6.
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Monaghan SF, Thakkar RK, Heffernan DS, Huang X, Chung CS, Lomas-Neira J, Cioffi WG, Ayala A.
"Mechanisms of indirect acute lung injury: a novel role for the coinhibitory receptor, programmed death-1." Annals of Surgery, vol. 255, no. 1, 2012, pp. 158-64.
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Lomas-Neira J, Perl M, Venet F, Chung CS, Ayala A.
"The role and source of tumor necrosis factor-α in hemorrhage-induced priming for septic lung injury." Shock, vol. 37, no. 6, 2012, pp. 611-20.
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Thakkar RK, Chung CS, Chen Y, Monaghan SF, Lomas-Neira J, Heffernan DS, Cioffi WG, Ayala A.
"Local tissue expression of the cell death ligand, fas ligand, plays a central role in the development of extrapulmonary acute lung injury." Shock, vol. 36, no. 2, 2011, pp. 138-43.
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Venet F, Huang X, Chung CS, Chen Y, Ayala A.
"Plasmacytoid dendritic cells control lung inflammation and monocyte recruitment in indirect acute lung injury in mice." The American Journal of Pathology, vol. 176, no. 2, 2010, pp. 764-73.
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Perl M, Chung CS, Perl U, Thakkar R, Lomas-Neira J, Ayala A.
"Therapeutic accessibility of caspase-mediated cell death as a key pathomechanism in indirect acute lung injury." Critical care medicine, vol. 38, no. 4, 2010, pp. 1179-86.
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Venet F, Chung CS, Kherouf H, Geeraert A, Malcus C, Poitevin F, Bohé J, Lepape A, Ayala A, Monneret G.
"Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients." Intensive care medicine, vol. 35, no. 4, 2009, pp. 678-86.
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Huang X, Venet F, Wang YL, Lepape A, Yuan Z, Chen Y, Swan R, Kherouf H, Monneret G, Chung CS, Ayala A.
"PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis." Proceedings of the National Academy of Sciences, vol. 106, no. 15, 2009, pp. 6303-8.
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Hu CK, Venet F, Heffernan DS, Wang YL, Horner B, Huang X, Chung CS, Gregory SH, Ayala A.
"The role of hepatic invariant NKT cells in systemic/local inflammation and mortality during polymicrobial septic shock." The Journal of Immunology, vol. 182, no. 4, 2009, pp. 2467-75.
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Ayala A, Perl M, Venet F, Lomas-Neira J, Swan R, Chung CS.
"Apoptosis in sepsis: mechanisms, clinical impact and potential therapeutic targets." Current pharmaceutical design, vol. 14, no. 19, 2008, pp. 1853-9.
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Wesche-Soldato DE, Lomas-Neira J, Perl M, Chung CS, Ayala A.
"Hydrodynamic delivery of siRNA in a mouse model of sepsis." Methods in Molecular Biology, vol. 442, 2008, pp. 67-73.
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Venet F, Chung CS, Monneret G, Huang X, Horner B, Garber M, Ayala A.
"Regulatory T cell populations in sepsis and trauma." Journal of Leukocyte Biology, vol. 83, no. 3, 2008, pp. 523-35.
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Lomas-Neira J, Chung CS, Ayala A.
"RNA interference as a potential therapeutic treatment for inflammation associated lung injury." International journal of clinical and experimental medicine, vol. 1, no. 2, 2008, pp. 154-60.
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Perl M, Chung CS, Perl U, Biffl WL, Cioffi WG, Ayala A.
"Beneficial versus detrimental effects of neutrophils are determined by the nature of the insult." Journal of the American College of Surgeons, vol. 204, no. 5, 2007, pp. 840-52; discussion 852-3.
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Ayala A, Wesche-Soldato DE, Perl M, Lomas-Neira JL, Swan R, Chung CS.
"Blockade of apoptosis as a rational therapeutic strategy for the treatment of sepsis." Novartis Foundation symposium, vol. 280, 2007, pp. 37-49; discussion 49-52, 160-4.
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Huang X, Venet F, Chung CS, Lomas-Neira J, Ayala A.
"Changes in dendritic cell function in the immune response to sepsis. Cell- & tissue-based therapy." Expert opinion on biological therapy, vol. 7, no. 7, 2007, pp. 929-38.
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Perl M, Chung CS, Perl U, Lomas-Neira J, de Paepe M, Cioffi WG, Ayala A.
"Fas-induced pulmonary apoptosis and inflammation during indirect acute lung injury." Am J Respir Crit Care Med, vol. 176, no. 6, 2007, pp. 591-601.
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Swan R, Chung CS, Albina J, Cioffi W, Perl M, Ayala A.
"Polymicrobial sepsis enhances clearance of apoptotic immune cells by splenic macrophages." Surgery, vol. 142, no. 2, 2007, pp. 253-61.
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Chung CS, Chen Y, Grutkoski PS, Doughty L, Ayala A.
"SOCS-1 is a central mediator of steroid-increased thymocyte apoptosis and decreased survival following sepsis." Apoptosis : an international journal on programmed cell death, vol. 12, no. 7, 2007, pp. 1143-53.
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Wesche-Soldato DE, Swan RZ, Chung CS, Ayala A.
"The apoptotic pathway as a therapeutic target in sepsis." Current drug targets, vol. 8, no. 4, 2007, pp. 493-500.
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Wisnoski N, Chung CS, Chen Y, Huang X, Ayala A.
"The contribution of CD4+ CD25+ T-regulatory-cells to immune suppression in sepsis." Shock, vol. 27, no. 3, 2007, pp. 251-7.
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Perl M, Chung CS, Garber M, Huang X, Ayala A.
"Contribution of anti-inflammatory/immune suppressive processes to the pathology of sepsis." Frontiers in Bioscience, vol. 11, 2006, pp. 272-99.
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Chung CS, Watkins L, Funches A, Lomas-Neira J, Cioffi WG, Ayala A.
"Deficiency of gammadelta T lymphocytes contributes to mortality and immunosuppression in sepsis." American journal of physiology. Regulatory, integrative and comparative physiology, vol. 291, no. 5, 2006, pp. R1338-43.
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Perl M, Chung CS, Ayala A.
"Apoptosis." Critical care medicine, vol. 33, no. 12 Suppl, 2005, pp. S526-9.
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Wesche-Soldato DE, Chung CS, Lomas-Neira J, Doughty LA, Gregory SH, Ayala A.
"In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice." Blood, vol. 106, no. 7, 2005, pp. 2295-301.
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Wesche DE, Lomas-Neira JL, Perl M, Chung CS, Ayala A.
"Leukocyte apoptosis and its significance in sepsis and shock." Journal of Leukocyte Biology, vol. 78, no. 2, 2005, pp. 325-37.
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Song GY, Chung CS, Rhee RJ, Cioffi WG, Ayala A.
"Loss of signal transducer and activator of transduction 4 or 6 signaling contributes to immune cell morbidity and mortality in sepsis." Intensive care medicine, vol. 31, no. 11, 2005, pp. 1564-9.
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Lomas-Niera JL, Perl M, Chung CS, Ayala A.
"Shock and hemorrhage: an overview of animal models." Shock, vol. 24 Suppl 1, 2005, pp. 33-9.
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Wesche-Soldato DE, Lomas-Neira JL, Perl M, Jones L, Chung CS, Ayala A.
"The role and regulation of apoptosis in sepsis." Journal of Endotoxin Research, vol. 11, no. 6, 2005, pp. 375-82.
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Ding Y, Chung CS, Newton S, Chen Y, Carlton S, Albina JE, Ayala A.
"Polymicrobial sepsis induces divergent effects on splenic and peritoneal dendritic cell function in mice." Shock, vol. 22, no. 2, 2004, pp. 137-44.
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Grutkoski PS, Chen Y, Chung CS, Cioffi WG, Ayala A.
"Putative mechanism of hemorrhage-induced leukocyte hyporesponsiveness: induction of suppressor of cytokine signaling-3." The Journal of trauma, vol. 56, no. 4, 2004, pp. 742-7; discussion 747-8.
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Newton S, Ding Y, Chung CS, Chen Y, Lomas-Neira JL, Ayala A.
"Sepsis-induced changes in macrophage co-stimulatory molecule expression: CD86 as a regulator of anti-inflammatory IL-10 response." Surgical infections, vol. 5, no. 4, 2004, pp. 375-83.
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Lomas JL, Chung CS, Grutkoski PS, LeBlanc BW, Lavigne L, Reichner J, Gregory SH, Doughty LA, Cioffi WG, Ayala A.
"Differential effects of macrophage inflammatory chemokine-2 and keratinocyte-derived chemokine on hemorrhage-induced neutrophil priming for lung inflammation: assessment by adoptive cells transfer in mice." Shock, vol. 19, no. 4, 2003, pp. 358-65.
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Chung CS, Song GY, Lomas J, Simms HH, Chaudry IH, Ayala A.
"Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity." Journal of Leukocyte Biology, vol. 74, no. 3, 2003, pp. 344-51.
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Ayala A, Chung CS, Grutkoski PS, Song GY.
"Mechanisms of immune resolution." Critical care medicine, vol. 31, no. 8 Suppl, 2003, pp. S558-71.
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Ayala A, Lomas JL, Grutkoski PS, Chung CS.
"Pathological aspects of apoptosis in severe sepsis and shock?." The International Journal of Biochemistry & Cell Biology, vol. 35, no. 1, 2003, pp. 7-15.
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Ayala A, Ding Y, Rhee RJ, Doughty LA, Grutkoski PS, Chung CS.
"PATHOLOGICAL ASPECTS OF THE ANTI-INFLAMMATORY/IMMUNE SUPPRESSIVE RESPONSE IN SEPSIS AND SHOCK." Recent research developments in immunology, vol. 5, 2003, pp. 13-35.
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Song GY, Chung CS, Jarrar D, Cioffi WG, Ayala A.
"Mechanism of immune dysfunction in sepsis: inducible nitric oxide-meditated alterations in p38 MAPK activation." The Journal of trauma, vol. 53, no. 2, 2002, pp. 276-82; discussion 282-3.
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Joshi AR, Chung CS, Song GY, Lomas J, Priester RA, Ayala A.
"NF-kappaB activation has tissue-specific effects on immune cell apoptosis during polymicrobial sepsis." Shock, vol. 18, no. 4, 2002, pp. 380-6.
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