We do fearless science to advance our understanding of genetic and non-genetic mechanisms that promote animal longevity. We also study how external signals that modulate aging regulate epigenetic changes and whether these conditions can be transmitted to subsequent generations.

Aging is considered a normal biological process. However, by itself is the principal risk factor for multiple chronic health conditions, including cancer, diabetes, and neurodegeneration. Several studies in model organisms, from yeast to monkeys, have contributed to our knowledge of how conserved genetic factors regulate the aging process. But there are also non-genetic factors playing an important role in lifespan. Indeed, studies in humans have estimated that the non-heritable genetic portion of lifespan regulation can reach up to 70%. This points out the importance of understanding how external and internal variations influence organismal physiology and whether these effects can be transgenerationally transmitted. To uncover these molecular mechanisms of aging, we use the power of functional genomics in Caenorhabditis elegans. We employ and develop cutting-edge techniques needed for each project. Current projects involve 1) regulation of longevity by epigenetic modifications (i.e., changes in histone post-translational modification patterns, DNA methylation, and chromatin remodeling), 2) molecular mechanisms that induce transgenerational benefits due to environmental interventions, and 3) inter-organ communication during aging. 

Yerby Postdoctoral Fellowship (2016-2018)

Aramont Postdoctoral Research Fellowship (2018-2019)

K99/R00 Pathway to Independence Award (2020-2025)

Trainer in the Brown University Molecular Biology, Cell Biology, and Biochemistry graduate program (MCBGP)