Douglas C. Moore Clinical Assistant Professor of Orthopaedics

Doug joined the department in 1994 as Co-Director of the Hand Research Lab in the Division of Orthopaedic Research. In 1985 he received his M.S. in Biomedical Engineering from the University of California, Davis graduating Phi Kappa Phi. He was previously employed as a Senior Research Analyst in Ann Arbor, Michigan and as a Research Engineer in 1992, conducted clinically-oriented orthopaedic biomechanic research at the University of Michigan.

Brown Affiliations

scholarly work

Moore DC, LeBlanc CW, Muller R, Crisco JJ, Ehrlich MG: Physiologic weight-bearing increases new vessel formation during distraction osteogenesis: a micro-tomographic imaging study. In press at the Journal of Orthopaedic Research (12/02)

Valdes M, Keeping H, Robertson A, Appel AJ, McGough R, Moore DC, Palumbo M, Lucas P, Ehrlich MG: Vascularization of a DBM carrier mass in the lumbar posterolateral fusion rabbit model. Accepted for presentation at the 47th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, February 2003.

Crisco JJ, Marai GE, Laidlaw DH, Moore DC, Akelman E: Kinematic and mechanical changes in the distal radioulnar joint (DRUJ) of patients with malunited distal radius fractures. Accepted for presentation at the 47th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, February 2003.

Valdes M, Keeping H, Robertson A, Appel AJ, McGough R, Moore DC, Palumbo M, Lucas P, Ehrlich MG: Vascularization of a DBM Carrier Mass in the Lumbar posterolateral Fusion Rabbit Model. Accepted for presentation at World Spine II: The Second Interdisciplinary Congress on Spine Care, Chicago, IL, August 2003.

Valdes M, Keeping H, Robertson A, Appel AJ, McGough R, Moore DC, Palumbo M, Lucas P, Ehrlich MG: Enhancing Posterolateral Spinal Fusion with rhBMP-6 Exposed Osteoprogenitor Cells. Accepted for presentation at World Spine II: The Second Interdisciplinary Congress on Spine Care, Chicago, IL, August 2003.

Moore DC, LeBlanc CW, Müller R, Crisco JJ, Ehrlich MG: Physiologic weight-bearing increases new vessel formation during distraction osteogenesis: A micro-tomographic imaging study. Journal of Orthopaedic Research- 21: 489-96, 2003.

Schiller JR, Moore DC, Sheikh S, Keeping H, Ehrlich MG: Increased distraction rate decreases expression of angiogenic and osteogenic growth factors in distraction osteogenesis. Accepted for presentation at the Annual Meeting of the Pediatric Orthopaedic Society of North America. Amelia Island, FL, May 2003.

Valdes M, Keeping H, Robertson A, Appel AJ, Moore DC, Palumbo M, Lucas P, Ehrlich MG: Enhancing posterolateral spinal fusion with rhBMP-6 exposed osteoprogenitor cells. Accetted for presentation at the 47th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, February 2003. Received Young Investigator Award at RIH Reseacrh Celebration, November 2002. Finalist forYoung Investigator Award at ORS, February 2003.

Moore DC, Pedrozo HA, Crisco JJ, Ehrich MG: Porcine small intestine submucosa (SIS) does not heal segmental bone defects. 28th Annual Meeting of the Society for Biomaterials, Tampa, FL, April, 2002.

Marai GE, Laidlaw DH, Demiralp C, Grimm CM, Crisco JJ, Moore DC, Akelman E: Contact areas and ligament lengths are abnormal in patients with malunited distal radius fracture despite normal radioulnar kinematics. IV World Congress of Biomechanics, Calgary, Alberta, August 4-9, 2002.

Crisco JJ, Moore DC, Panjabi MM: Strain rate sensitivity of ligaments diminishes at traumatic loading rates. IV World Congress of Biomechanics, Calgary, Alberta, August 4-9, 2002.

Pacicca DM, Moore DC, Ehrlich MG: The effect of weight-bearing on consolidation of the regenerate zone in a rat model of distraction osteogenesis. J Pediatr Orthop 22(5):652-659, 2002.

Crisco JJ, Moore DC, McGovern RD: Impact mechanics of the rabbit MCL. Journal of Biomechanics, 35:1379-1385, 2002.

Moore DC, Hogan KA, Crisco JJ, Akelman E, DaSilva MF, Weiss A-PC: 3-D in vivo kinematics of the distal radioulnar joint in malunited distal radius fractures. Journal of Hand Surgery, 27A(2):233-242, 2002.

Moore DC, Pedrozo HA, Crisco JJ, Ehrich MG: Evaluation of porcine small intestine submucosa (SIS) for treating segmental bone defects. 48th Annual Meeting of the Orthopaedic Research Society, Dallas, TX, February, 2002.

Moore DC, Ehrlich MG: The Effect of Weight-Bearing on Healing in a Rat Model of Distraction Osteogenesis. 47th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, February, 2001.

Dennsion DG, Moore DC, Crisco JJ, Weiss A-PC: A spiral intramedullary nail for fixation of diaphyseal metacarpal fractures: mechanical comparison of a spiral intramedullary nail versus Kirschner wire. Adrian E. Flatt Residents and Fellows Conference, Baltimore, MD, October, 2001.

Ehrlich MG, Moore DC, LeBlanc CW, M¸ller R, Crisco JJ: Weight-bearing increases new vessel formation in distraction osteogenesis. Annual Meeting of the Pediatric Orthopaedic Society of North America. Cancun, Mexico, May 2001.

Radomisli TE, Moore DC, Barrach HJ, Keeping HS, Ehrlich MG: Weight-bearing alters the expression of collagen Types I and II, BMP 2,4 and osteocalcin in the early stages of distraction osteogenesis. Journal of Orthopaedic Research, 19:1049-1056, 2001.

Moore DC, Staebler MP, Crisco JJ, Greenwald RM, Akelman E, Weiss A-PC: Wrist Guards Reduce Impact-Generated Bone Strain in the Distal Radius. 46th Annual Meeting of the Orthopaedic Research Society, Orlando, FL, March, 2000.

Moore DC, Hogan KA, Crisco JJ, Akelman E, DaSilva MF, Weiss A-PC: 3-D In Vivo Kinematics of the Distal Radioulnar Joint in Malunited Distal Radius Fractures. 46th Annual Meeting of the Orthopaedic Research Society, Orlando, FL, March, 2000.

Moore DC, LeBlanc CW, M¸ller R, Crisco JJ, Ehrlich MG: The Effect of Weight-Bearing on the Vasculature in Distraction Osteogenesis as Assessed by Micro-Tomographic Imaging. 46th Annual Meeting of the Orthopaedic Research Society, Orlando, FL, March 2000.

Belanger MJ, Moore DC, McAllister SC, Ehrlich MG: The Mechanical Properties of Rat ACL are Independent of Serum Estrogen Level. 46th Annual Meeting of the Orthopaedic Research Society, Orlando, FL, March 2000.

Moore DC, Crisco JJ, Ehrlich MG: Bridging Segmental Defects in Long Bones with Intramedullary Tubes and Periosteal Sleeves Made from Small Intestine Submucosa. 3rd SIS Symposium, Orlando, FL, November, 2000.

Moore DC, Belanger MJ, Hulstyn M, Fadale PD, McGovern RD, Labradour DP, Crisco JJ: The effect of tubularization on the mechanical properties of patellar tendon grafts for ACL reconstruction. American Journal of Knee Surgery, 13(4):211-217, 2000.

Lifrak JT, Moore DC, Muirhead WR, Fadale PD, Hulstyn MJ: Enhanced Repair of Goat Meniscal Defects Using Procine Small Intestine Submucosa (SIS). 3rd SIS Symposium, Orlando, FL, November, 2000.

Eberson CP, Hogan KA, Moore DC, Ehrlich MG: The Effect of Low Intensity Ultrasound on Consolidation of Regenerate Bone in a Rat Model of Distraction Osteogenesis. 46th Annual Meeting of the Orthopaedic Research Society, Orlando, FL, March, 2000.

Pacicca DM, Moore DC, McGovern RD, Crisco JJ, Ehrlich MG: The effect of weight-bearing on consolidation of the regenerate zone in a rat model of distraction osteogenesis. 45th Annual Meeting of the Orthopaedic Research Society, Anaheim, California, 1999.

Moore DC, McGovern RD, Crisco JJ, Infantolino CE, McAllister SC, Akelman E, Weiss A-PC: Metacarpophalangeal mechanics after silicone joint replacement. 45th Annual Meeting of the Orthopaedic Research Society, Anaheim, California, 1999.

Belanger MJ, McGovern RD, Fadale PD, Hulstyn MJ, Crisco JJ, Moore DC, Ehrlich MG: Menstrual Cycle, Exercise, and Knee Laxity. Annual Meeting of the American Orthopaedic Society for Sports Medicine, Traverse City, Michigan, June 1999.

Weiss A-PC, Moore DC, Akelman E, Crisco JJ: Metacarpophalangeal mechanics after silicone joint replacement. 54th Annual Meeting, American Society of the Hand, Boston, MA. September 2-4, 1999.

Moore DC, Hogan KA, DaSilva MF, Akelman E, Weiss A-PC, Crisco JJ: 3-D in vivo kinematics of the distal radioulnar joint in malunited distal radius fractures. 54th Annual Meeting, American Society of the Hand, Boston, MA. September 2-4, 1999.

Staebler MP, Moore DC, Akelman E, McGovern RD, Crisco JJ, Fadale PD, Weiss A-PC: The effect of wrist guards on bone strain in the distal forearm. American Journal of Sports Medicine, 27(4):500-506, 1999.

Farley FA, Tseng KF, Moore DC: Torsional stiffness of three spine constructs for thoracic scoliosis. Journal of Spinal Disorders, 12(2):120-125, 1999.

Crisco JJ, McGovern RD, Moore DC: Failure displacement of rabbit medial collateral ligament is constant over a wide range of loading rates. 45th Annual Meeting of the Orthopaedic Research Society, Anaheim, California, 1999.

Belanger MJ, McGovern RD, Fadale PD, Hulstyn MJ, Crisco JJ, Natarajan RJ, Moore DC, Ehrlich MG: Effects of menstrual cycle and exersize on knee laxity in female athletes. 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, 1998.

Crisco JJ, Moore DC, McGovern RD: The effects of impact loading on the mechanical properties of the rabbit MCL. 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, 1998.

Weiss A-PC, Thompson NL, Babu KM, Hulsizer DL, Barnum MJ, Moore DC: Factors in the survival of replanted extremities: TGF-_ isoform and receptor expression in ischemia/reperfusion. 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, 1998.

Staebler MP, Moore DC, Akelman E, Weiss A-PC, Fadale P, Crisco JJ: The effect of wrist guards on distal radius bone strain. 24th Annual Meeting of the American Orthopaedic Society for Sports Medicine, Vancouver, British Columbia, 1998.

Shin SS, Moore DC, McGovern RD, Weiss A-PC: Scapholunate ligament reconstruction using a bone-retinaculum-bone autograft: A biomechanical and histological study. Journal of Hand Surgery, 23A(2):216-221, 1998.

Staebler MP, Akelman E, McGovern RD, Crisco JJ, Fadale PD, Weiss A-PC, Moore DC: Wrist guards reduce bone strain in the distal radius. 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, 1998.

Radomisli TE, Ehrlich MG, Moore DC, Keeping HS, Barrach HJ, Medina MM, Labrador DP: Earliest molecular biologic and immunohistochemical manifestations of bone formation under the effect of weight bearing in distraction osteogenesis--a preliminary report. 43rd Annual Meeting of the Orthopaedic Research Society, San Francisco, California, 1997.

Voss LA, Rosenberg JN, Weiss A-PC, Akelman E, Moore DC: Early recovery of peripheral nerve injury after intermittent and continuous crush injury. 43rd Annual Meeting of the Orthopaedic Research Society, San Francisco, California, 1997.

Crisco JJ, Moore DC, McGovern RD: Impact mechanics of the rabbit MCL. American Society of Biomechanics, Clemson, South Carolina, 1997.

Moore DC, Frankenburg EP, Goulet JA, Goldstein SA: Hip screw augmentation with an in situ-setting calcium phosphate cement. Journal of Orthopaedic Trauma, 11(8):557-583, 1997.

Moore DC, Maitra RS, Farjo L, Graziano GP, Goldstein SA: Restoration of pedicle screw fixation with an in situ-setting calcium phosphate cement. Spine, 22(15):1696-1705, 1997.

Moore DC, Matthews LS. Impulse loading of the femoral neck during antegrade intramedullary nailing. 63rd Annual Meeting of the American Academy of Orthopaedic Surgeons, Atlanta Georgia, 1996.

Weiss A-PC, Blanks RH, Glowacki KA, Sachar K, Moore DC, Khawaja MS, Koch RB, Thompson NL: TGF- _ expression in extremity replant reperfusion injury. 42nd Annual Meeting of the Orthopaedic Research Society, Atlanta Georgia, 1996.

Blanks RH, Platt JC, Valentini R F, Alford JW, Moore DC, Rosenberg JN, Akelman E, Weiss A-PC: Early recovery of peripheral nerve crush injury induced by nerve growth factor. 42nd Annual Meeting of the Orthopaedic Research Society, Atlanta, Georgia, 1996.

DaSilva MF, Moore DC, Weiss A-PC, Akelman E, Sikirica M: Innervation of the palmar aponeurosis and transverse carpal ligament: implications for surgical treatment. 63rd Annual Meeting of the American Academy of Orthopaedic Surgeons, Atlanta, Georgia, 1996.

DaSilva MF, Moore DC, Weiss A-PC, Akelman E, Sikirica M: Anatomy of the palmer cutaneous branch of the median nerve: clinical significance. Journal of Hand Surgery, 21A(4):639-643, 1996.

Hilibrand AS, Moore DC, Graziano GP: The role of pediculolaminar fixation in compromised pedicle bone. Spine, 21(4):445-451, 1996.

Abate J, Hulstyn M, Fadale PD, Labradour DP, Moore DC, Crisco JJ: The effect of tubularization on patellar tendon grafts used for ACL reconstructions. 22nd Annual Meeting of the American Orthopaedic Society for Sports Medicine. Lake Buena Vista, Florida, 1996.

Tseng K-F, Farley FA, Moore DC, Goldstein SA: "Biomechanical evaluation of spine instrumentation constructs." Transactions of the Orthopaedic Research Society, 20:665, 1995, and Orthopaedic Transactions (in press) (Same as "Torsion stiffness of three spine constructs for scoliosis." FA Farley et al.)

Tseng K-F, Farley FA, Moore DC, Goldstein SA: Biomechanical evaluation of spine instrumentation constructs. Orthopaedic Research Society, Orlando, Florida, 1995. (Same as Torsion stiffness of three spine constructs for scoliosis. FA Farley et al.)

Glowacki KA, Alford JW, Moore DC, Crisco JJ, Weiss A-PC: Ulnar variance and lunotriquetral mechanics. International Hand and Wrist Biomechanics Symposium, San Francisco, California, 1995.

Farley FA, Tseng K-F, Moore DC, Hensinger RN, Goldstein SA, Herring JA, Ashman RD: Torsion stiffness of three spine constructs for scoliosis. American Academy of Orthopaedic Surgeons, Orlando, Florida, 1995.

Rouleau JP, Palmer ML, Hollister SJ, Moore DC, Huiskes R: Development of a local homogenization model of the trabecular bone - cement interface. Orthopaedic Research Society, Orlando, Florida, 1995.

Hilibrand AS, Moore DC, Graziano GP: "The effects of a supralaminar hook on pedicle screw fixation." Transactions of the Orthopaedic Research Society, 20:660, 1995, and Orthopaedic Transactions (in press)

Moore DC, Germiller JA, Grady-Benson JC, Matthews LS, Goldstein SA: "Comparison of the cement mantle in proximally-restricted and conventionally-cemented femoral stems: cement pressure distributions and mantle morphology." Transactions of the Orthopaedic Research Society, 19:814, 1994, and Orthopaedic Transactions (in press)

Moore DC, Germiller JA, Grady-Benson JC, Matthews LS, Goldstein SA: Comparison of the cement mantle in proximally-restricted and conventionally-cemented femoral stems: cement pressure distributions and mantle morphology. Orthopaedic Research Society, New Orleans, Louisiana, 1994.

Hilibrand AS, Moore DC, Graziano GP: The effects of a supralaminar hook on pedicle screw fixation. Scoliosis Research Society, Portland, Oregon, 1994, American Academy of Orthopaedic Surgeons, Orlando, Florida, 1995 and Orthopaedic Research Society, Orlando, Florida, 1995.

Goldstein SA, Moore DC, Frankenburg EP, Goulet JA, Graziano GP: Fixation enhancement and defect filling with a new, bioresorbable, osteoconductive calcium phosphate cement. Mid-America Orthopaedic Association, Hamilton, Bermuda, 1994.

Moore DC, Frankenburg EP, Goulet JA: "Hip screw augmentation with an in situ-setting calcium phosphate ceramic: an in vitro biomechanical analysis." Transactions of the Orthopaedic Research Society, 18:570, 1993, and Orthopaedic Transactions 17(3): 811, 1993.

Moore DC, Frankenburg EP, Goulet JA, Graziano GP, Maitra RS, Farjo LA, Goldstein SA: Fixation enhancement with a new, in situ-setting calcium phosphate cement. 10th European Conference on Biomaterials, Davos, Switzerland, 1993.

Moore DC, Graziano GP, Maitra RS, Farjo LA, Goldstein SA: Calcium phosphate cement vs. PMMA for the augmentation of transpedicular screws. Scoliosis Research Society, Dublin, Ireland, 1993 and American Academy of Orthopaedic Surgeons, New Orleans, Louisiana, 1994.

Moore DC, Graziano GP, Maitra RS, Farjo LA, Goldstein SA: Calcium phosphate cement vs. PMMA for the augmentation of transpedicular screws. Scoliosis Research Society, Dublin, Ireland, 1993, North American Spine Society, San Diego, California, 1993, and American Academy of Orthopaedic Surgeons, New Orleans, Louisiana, 1994.

Moore DC, Frankenburg EP, Goulet JA, Goldstein SA: Hip screw augmentation with an in situ-setting calcium phosphate ceramic: an in vitro biomechanical analysis. Orthopaedic Research Society, San Francisco, California, 1993.

Grundel RE, Chapman MW, Yee T, Moore DC: Autogenic bone marrow and porous biphasic calcium phosphate ceramic for segmental bone defects in the canine ulna. Clinical Orthopaedics and Related Research, 266:244-258, 1991.

Moore DC, Chapman MW, Manske DJ: The evaluation of a new, biphasic, calcium phosphate ceramic for use in grafting long bone diaphyseal defects. The Journal of Orthopaedic Research, 5:356-365, 1987.

Moore DC, Manske DJ, Chapman MW: The evaluation of a new, biphasic calcium-phosphate ceramic for use in grafting long bone diaphyseal defects. Orthopaedic Research Society, New Orleans, Louisiana, 1986.

Moore DC, Chapman MW, Manske DJ: "The evaluation of a new, biphasic, calcium phosphate ceramic for use in grafting long bone diaphyseal defects." Transactions of the Orthopaedic Research Society, 11:68, 1986, and Orthopaedic Transactions 10(2):246, 1986.

Moore DC, Chapman MW, Manske DJ: "The evaluation of a new, biphasic, calcium phosphate ceramic for use in grafting long bone diaphyseal defects." Transactions of the Society for Biomaterials, in Conjunction with the Seventeenth International Biomaterials Symposium, 8: 160, 1985.

Moore DC, Manske DJ, Chapman MW: The evaluation of a new, biphasic calcium-phosphate ceramic for use in grafting long bone diaphyseal defects. Society for Biomaterials, San Diego, California, 1985.

Vasseur PB, Moore DC, Brown SA: Stability of the canine shoulder joint: an in vitro analysis. American Journal of Veterinary Research, 43(2):352-355, 1982.

Eberson CP, Hogan K, Moore DC, Ehrlich MG: The effect of low intensity ultrasound stimulation on consolidation of the regenerat zone in a rat model of distraction osteogenesis. Accepted for publication in the Journal of Pediatric Orthopaedics (4/02)

Belanger MJ, McGovern RD, Moore DC, Fadale PD, Hulstyn MJ, Crisco JJ, Ehrlich MG: Association between menstrual cycle and knee laxity in female athletes. Submitted to the American Journal of Sports Medicine

Weiss A-PC, Infantolino CE, Moore DC, Crisco JJ, McGovern RD, Akelman E: Mechanics of metacarpophalangeal joint replacements in finger flexion and extension. Provisionally accepted for publication in the Journal of Hand Surgery

Moore DC, Pedrozzo HA, Crisco JJ, Ehrlich MG: The evaluation of porcine small intestine submucosa (SIS) as a graft material for treating segmental bone defects. Submitted to the Journal of Orthopaedic Research (12/02)

Note: Received Aircast Award for Basic Science Research

Jarrell D, Crisco JJ, Moore DC, McGovern RD: Coating of stainless steel bone cutting devices enhances functional performance. J23rd Annual Meeting of the Society for Biomaterials, New Orleans, Louisiana, USA

research overview

Douglas Moore conducts orthopaedic basic science research in collaboration with engineering and orthopaedic clinical faculty.

funded research

Research Support

Abnormal in vivo Carpal Kinematics - $2,561,320.00
PI: Crisco JJ. Co-Invest: Wolfe SW, Laidlaw DH, Weiss A-PC, Akelman E, Moore DC. National Institutes of Health, Bethesda, MD (4/1/01 - 2/28/06)

Intraarticular Injection of Capsaicin for Long-Term Pain Relief - $173,318.02
PIs: Moore DC, Ehrlich MG. AlgoRx, Inc. (9/1/02-12/31/03)

Tissue Engineered Ligament - $25,798.00
PI: Moore DC. Co-Invest: Crisco JJ. Tissue Regeneration, Inc. (4/1/01-3/31/02)

The Effect of Lateral Bending Stress on the Fatigue Life of the Anatomically Neutral Neuflex Metacarpophalangeal (MCP) Joint Prosthesis - $9,500.00
PI: Weiss A-PC. Co-Invest: Alsheik NH, Moore DC, Crisco JJ. The Indiana Hand Center Research Foundation, Indianapolis, IN

DePuy SIS in Segmental Bone Defects - $34,641.95
PI: Moore DC. Co-Invest: JJ Crisco, MG Ehrlich. DePuy Orthopaedics, Warsaw, IN (12/1/99-3/1/01)

DePuy SIS in Meniscal Defects - $24,176.00
PI: Moore DC. Co-Invest: Fadale PD, Hulstyn MJ. DePuy Orthopaedics, Warsaw, IN (12/15/99-12/31/00)

DePuy/DuPont Silicone Metacarpophalangeal Joint Replacement - $49,599.00
PI: Crisco JJ. Co-Invest: Moore DC, Weiss A-PC, Akelman E. DePuy/DuPont Orthopaedics, Newark, DE (8/1/97-8/1/98)

Contact Area Measurements in a Prototype Total Knee Prosthesis - $3,590.00
PI: Moore DC. Soma Research, Inc., Corte Madera, CA (4/1/96-4/1/98)

3-D In Vivo Kinematics of the Distal Radioulnar Joint in Malunited Distal Radius Fractures - $9,960.00
PIs: Moore DC, DaSilva M. Co-Invest: Akelman E, Crisco JJ, Weiss, A-PC. Riordan-Brand Research Grant (7/1/97-7/1/98)

Interference Screw Fixation in a Bovine Model of ACL Repair - 6,203.13
PI: Moore DC. Co-Invest: Abate J, Crisco JJ, Fadale PD. Arthrex, Inc., Naples, FL (7/1/96-7/1/97)