| Murthy D, Attri KS, Shukla SK, Thakur R, Chaika NV, He C, Wang D, Jha K, Dasgupta A, King RJ, Mulder SE, Souchek J, Gebregiworgis T, Rai V, Patel R, Hu T, Rana S, Kollala SS, Pacheco C, Grandgenett PM, Yu F, Kumar V, Lazenby AJ, Black AR, Ulhannan S, Jain A, Edil BH, Klinkebiel DL, Powers R, Natarajan A, Hollingsworth MA, Mehla K, Ly Q, Chaudhary S, Hwang RF, Wellen KE, Singh PK. "Author Correction: Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis." Nature Cell Biology, vol. 26, no. 5, 2024, pp. 840. |
| Murthy D, Attri KS, Shukla SK, Thakur R, Chaika NV, He C, Wang D, Jha K, Dasgupta A, King RJ, Mulder SE, Souchek J, Gebregiworgis T, Rai V, Patel R, Hu T, Rana S, Kollala SS, Pacheco C, Grandgenett PM, Yu F, Kumar V, Lazenby AJ, Black AR, Ulhannan S, Jain A, Edil BH, Klinkebiel DL, Powers R, Natarajan A, Hollingsworth MA, Mehla K, Ly Q, Chaudhary S, Hwang RF, Wellen KE, Singh PK. "Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis." Nature Cell Biology, vol. 26, no. 4, 2024, pp. 613-627. |
| Murthy D, Dutta D, Attri KS, Samanta T, Yang S, Jung KH, Latario SG, Putluri V, Huang S, Putluri N, Park JH, Kaipparettu BA. "CD24 negativity reprograms mitochondrial metabolism to PPARα and NF-κB-driven fatty acid β-oxidation in triple-negative breast cancer." Cancer Letters, vol. 587, 2024, pp. 216724. |
| Murthy D, Attri KS, Suresh V, Rajacharya GH, Valenzuela CA, Thakur R, Zhao J, Shukla SK, Chaika NV, LaBreck D, Rao CV, Hollingsworth MA, Mehla K, Singh PK. "The MUC1-HIF-1α signaling axis regulates pancreatic cancer pathogenesis through polyamine metabolism remodeling." Proceedings of the National Academy of Sciences, vol. 121, no. 14, 2024, pp. e2315509121. |
| He C, Wang D, Shukla SK, Hu T, Thakur R, Fu X, King RJ, Kollala SS, Attri KS, Murthy D, Chaika NV, Fujii Y, Gonzalez D, Pacheco CG, Qiu Y, Singh PK, Locasale JW, Mehla K. "Vitamin B6 Competition in the Tumor Microenvironment Hampers Antitumor Functions of NK Cells." Cancer Discovery, vol. 14, no. 1, 2024, pp. 176-193. |
| Murthy D, Attri KS. "PTGES Expression Is Associated with Metabolic and Immune Reprogramming in Pancreatic Ductal Adenocarcinoma." International Journal of Molecular Sciences, vol. 24, no. 8, 2023. |
| King RJ, Shukla SK, He C, Vernucci E, Thakur R, Attri KS, Dasgupta A, Chaika NV, Mulder SE, Abrego J, Murthy D, Gunda V, Pacheco CG, Grandgenett PM, Lazenby AJ, Hollingsworth MA, Yu F, Mehla K, Singh PK. "CD73 induces GM-CSF/MDSC-mediated suppression of T cells to accelerate pancreatic cancer pathogenesis." Oncogene, vol. 41, no. 7, 2022, pp. 971-982. |
| Chatterjee A, Sakallioglu IT, Murthy D, Kosmacek EA, Singh PK, McDonald JT, Powers R, Oberley-Deegan RE. "MnTE-2-PyP protects fibroblast mitochondria from hyperglycemia and radiation exposure." Redox biology, vol. 52, 2022, pp. 102301. |
| Sultan F, Basu R, Murthy D, Kochar M, Attri KS, Aggarwal A, Kumari P, Dnyane P, Tanwar J, Motiani RK, Singh A, Gadgil C, Bhavesh NS, Singh PK, Natarajan VT, Gokhale RS. "Temporal analysis of melanogenesis identifies fatty acid metabolism as key skin pigment regulator." PLoS biology, vol. 20, no. 5, 2022, pp. e3001634. |
| Hu T, Shukla SK, Vernucci E, He C, Wang D, King RJ, Jha K, Siddhanta K, Mullen NJ, Attri KS, Murthy D, Chaika NV, Thakur R, Mulder SE, Pacheco CG, Fu X, High RR, Yu F, Lazenby A, Steegborn C, Lan P, Mehla K, Rotili D, Chaudhary S, Valente S, Tafani M, Mai A, Auwerx J, Verdin E, Tuveson D, Singh PK. "Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression." Gastroenterology, vol. 161, no. 5, 2021, pp. 1584-1600. |
| Zhu, Yuxiang, Murthy, Divya, Kollala, Sai Sundeep, Kosmacek, Elizabeth A., Chatterjee, Arpita, McDowell, Joshua A., Singh, Pankaj K., Oberley-Deegan, Rebecca E. "The central role of NADPH depletion in MnTE-2-PyP-induced prostate cancer cell growth inhibition." Advances in Redox Research, vol. 3, 2021, pp. 100025. |
| Mulder SE, Dasgupta A, King RJ, Abrego J, Attri KS, Murthy D, Shukla SK, Singh PK. "JNK signaling contributes to skeletal muscle wasting and protein turnover in pancreatic cancer cachexia." Cancer Letters, vol. 491, 2020, pp. 70-77. |
| Dasgupta A, Shukla SK, Vernucci E, King RJ, Abrego J, Mulder SE, Mullen NJ, Graves G, Buettner K, Thakur R, Murthy D, Attri KS, Wang D, Chaika NV, Pacheco CG, Rai I, Engle DD, Grandgenett PM, Punsoni M, Reames BN, Teoh-Fitzgerald M, Oberley-Deegan R, Yu F, Klute KA, Hollingsworth MA, Zimmerman MC, Mehla K, Sadoshima J, Tuveson DA, Singh PK. "SIRT1-NOX4 signaling axis regulates cancer cachexia." Journal of Experimental Medicine, vol. 217, no. 7, 2020. |
| Murthy D, Vernucci E, Goode G, Abrego J, Singh PK. "Evaluating the Metabolic Impact of Hypoxia on Pancreatic Cancer Cells." Methods in Molecular Biology, vol. 1742, 2018, pp. 81-93. |
| Murthy D, Attri KS, Singh PK. "Phosphoinositide 3-Kinase Signaling Pathway in Pancreatic Ductal Adenocarcinoma Progression, Pathogenesis, and Therapeutics." Frontiers in Physiology, vol. 9, 2018, pp. 335. |
| Ramkumar A, Murthy D, Raja DA, Singh A, Krishnan A, Khanna S, Vats A, Thukral L, Sharma P, Sivasubbu S, Rani R, Natarajan VT, Gokhale RS. "Classical autophagy proteins LC3B and ATG4B facilitate melanosome movement on cytoskeletal tracks." Autophagy, vol. 13, no. 8, 2017, pp. 1331-1347. |
| Abrego J, Gunda V, Vernucci E, Shukla SK, King RJ, Dasgupta A, Goode G, Murthy D, Yu F, Singh PK. "GOT1-mediated anaplerotic glutamine metabolism regulates chronic acidosis stress in pancreatic cancer cells." Cancer Letters, vol. 400, 2017, pp. 37-46. |
| Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Matés JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK. "MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer." Cancer Cell, vol. 32, no. 1, 2017, pp. 71-87.e7. |
| Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Matés JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK. "MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer." Cancer Cell, vol. 32, no. 3, 2017, pp. 392. |
| Attri KS, Murthy D, Singh PK. "Racial disparity in metabolic regulation of cancer." Frontiers in bioscience (Landmark edition), vol. 22, no. 8, 2017, pp. 1221-1246. |
| Thukral L, Sengupta D, Ramkumar A, Murthy D, Agrawal N, Gokhale RS. "The Molecular Mechanism Underlying Recruitment and Insertion of Lipid-Anchored LC3 Protein into Membranes." Biophysical Journal, vol. 109, no. 10, 2015, pp. 2067-78. |
| Murthy D, Attri KS, Gokhale RS. "Network, nodes and nexus: systems approach to multitarget therapeutics." Current opinion in biotechnology, vol. 24, no. 6, 2013, pp. 1129-36. |
| Year | Degree | Institution |
|---|---|---|
| 2016 | PhD | Council Of Scientific And Industrial Research–Institute Of Genomics And Integrative Biology |
| 2010 | MSc | Maharaja Sayajirao University of Baroda |
| 2008 | BSc | University of Delhi |
| Postdoctoral Research Associate | University of Nebraska Medical Center, cancer biology | 2016-2020 |
CSIR-Travel Award 2014
Immunology Foundation Award 2014
CSIR- Senior Research Fellowship 2011-14
CSIR- Junior Research Fellowship 2009-10
Dr. V. V. Modi Gold medal in M.Sc. Biotechnology (2007-09) 2009
Department of Biotechnology Fellowship 2007-2009
| Assistant Professor (Research). Brown University, 2024-Present |
| Research Associate. Baylor College of Medicine, 2022-2024 |
| Research Instructor. University of Nebraska Medical Center, 2020-2022 |
