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Edward V. Lally Professor of Medicine

Brown Affiliations

scholarly work

Khanna D, Furst DE, Hays RD, Lally EV, Clements PJ: Minimally important difference in diffuse systemic sclerosis – results from the D-Penicillamine study. Annals of Rheumatic Disease (in press).

Khanna D, Furst DE, Hays RD, Lally EV, Clements PJ: Minimally important difference in diffuse systemic sclerosis – results from the D-Penicillamine study. Annals of Rheumatic Disease (in press).

Tajirian AL, Malik MK, Robinson-Bostom L, Lally EV. Multicentric reticulohistiocytosis. 2006 (in press).

Orzano I, Lally EV: Development of polymyalgia rheumatica in patients with scleroderma: efficacy and safety of standard therapy with corticosteroids. Journal of Rheumatology 2006; 33: 1206-1207.

Falanga V, Lally EV, ACR 2006

Lieberman L, Orzano I, Passero M, Lally EV: Bronchiectasis in rheumatoid arthritis: report of 4 cases and literature review. Implications for management with biologic response modifiers. Seminars in Arthritis and Rheumatism 2006; 35: 379-387.

Hall HA, Lally EV, Kadmon D: Prevalence of anti-citrulline antibodies and rheumatoid factor in systemic sclerosis and systemic lupus erythematosus. Ann Rheum Dis 2005; 64(suppl III): 241.

Lally EV. Genetic aspects of osteoarthritis. Medicine & Health/Rhode Island, 87:210-212; July, 2004.

Michaels VM, Al y, Lally E: Mycobacterium marinum tenosynovitis: A report of 2 cases. Presened at RI Chapter, ACP Meeting, Warwick, RI, April 23, 2003.

Lally EV. Pathophysiology of rheumatoid arthritis. In Surgery of the Arthritic Hand and Wrist. Ed. A-P.C. Weiss and H. Hastings, Philadelphia, Lippincott Williams & Wilkins, 2002, p10-26.

DeMarco P, Weisman M, Lally EV, Clements PJ: Predictors and outcomes of scleroderma renal crisis: The higher dose vs. low-dose D-penicillamine in early diffuse systemic sclerosis trial. Arthritis and Rheumatism 46:2983-2989, 2002.

Furst DE, Clements PJ…Lally EV… Seibold JR: The effects of the ACR systemic sclerosis trial guidelines on the nature of systemic sclerosis patients entering a clinical trial. Rheumatology. 50:1-8, 2001

Furst DE, Clements PJ…Lally EV… Seibold JR: The effects of the ACR systemic sclerosis trial guidelines on the nature of systemic sclerosis patients entering a clinical trial. Rheumatology. 50:1-8, 2001

Said N, Zimmermann B, Lally EV: Rheumatoid arthritis (RA) and interstitial pulmonary (IPF): A family study. Arthritis and Rheumatism (Suppl) 44:5366, 2001.

Clements PJ, Wong WK, Lally EV, et al.: The disability index of the health assessment questionnaire is a predictor and correlate of outcome in the high-dose versus low-dose penicillamine in systemic sclerosis trial. Arthritis and Rheum 44:653-661, 2001.

Zimmermann BZ, Lally EV, Liu NYN: Infectious agents and the musculoskeletal system. In Textbook of Primary Care Medicine. Third Edition. Ed. J. Noble, St, Louis, Mosby, 2001, pp 1315-1325.

Clements PJ, Hurwitz EL,…Lally EV…Furst DE: Skin thickness score as a predictor and correlate of outcome in systemic sclerosis high-dose versus low-dose penicillamine trial. Arthritis and Rheumatism 43:2445-2454, 2000.

Clements PJ, Hurwitz EL,…Lally EV…Furst DE: Skin thickness score as a predictor and correlate of outcome in systemic sclerosis high-dose versus low-dose penicillamine trial. Arthritis and Rheumatism 43:2445-2454, 2000.

Lomotan ER, Zimmermann B, Lally EV: Crystal-mediated Articular Disease in the Elderly. Rheumatology and Musculoskeletal Medicine for Primary Care 1(4):19-28, 1999.

Clements PJ, Furst DE, …Lally EV… Seibold JR; High-dose versus low-dose D-penicillamine in early diffuse systemic sclerosis. Analysis of a two-year, double-blind, randomized, controlled clinical trial. Arthritis and Rheumatism 42:1194-1203, 1999.

Clements PJ, Wong WK…Lally EV…Seibold J: Correlates of the disability index of the health asessment questionnaire. A measure of functional impairment in systemic sclerosis. Arthritis and Rheumatism 42:2372-2380, 1999.

Clements PJ, Furst DE, …Lally EV… Seibold JR; High-dose versus low-dose D-penicillamine in early diffuse systemic sclerosis. Analysis of a two-year, double-blind, randomized, controlled clinical trial. Arthritis and Rheumatism 42:1194-1203, 1999.

Clements PJ, Wong WK…Lally EV…Seibold J: Correlates of the disability index of the health asessment questionnaire. A measure of functional impairment in systemic sclerosis. Arthritis and Rheumatism 42:2372-2380, 1999.

Coletta EM, Lally EV: Reference Guide-Osteoarthritis. 6th Edition. American Board of Family Practice 1998.

Vasudevan S, Weiss AP, Lally EV: Pathological diagnosis of rheumatoid disease in the absence of polyarthritis: A follow-up study. Arthritis Rheum (suppl) 40:5153, 1997.

Lee W, Zimmermann B, Lally EV: Relapse of polymyositis after prolonged remission. Journal of Rheumatology 24:1641-1644, 1997.

Vasudevan S, Weiss AP, Lally EV: Pathological diagnosis of rheumatoid disease in the absence of polyarthritis: A follow-up study. Presented at Northeast Region Meeting, American College of Rheumatology, Boston, MA, April 18, 1997.

Clements PJ, Wong WK,. ...Lally EV,... Abeles, M: High-dose (HI-DPA) vs.low-dose (LO-DPA) Penicillamine in early diffuse systemic sclerosis (SSc) trial: Analysis of trial. Arthritis Rheum (suppl) 40:5173, 1997.

Zimmermann B, Mikolich D, Lally EV: Septic sacroiliitis, Seminars in Arthritis and Rheumatism 26:592-604, 1996.

Vasudevan S, Zimmermann B, Lally EV: Treatment-resistant diffuse calcinosis in scleroderma. Journal of Clinical Rheumatology 2:227-229, 1996

Lee W, Zimmermann B, Lally EV: Relapse after prolonged remission in polymyositis: case report and literature review. Arthritis Rheum (suppl) 39:R25, 1996.

Zimmermann B, Lally EV: Infectious Disorders of the Spine. Seminars in Spine Surgery 7:177-186, 1995.

Stone P, Korn JH, North H, Lally EV, Miller LC, Tucker LB, Strongwater S, Snider GL, Franzblau. Crosslinked elastin and collagen degradation products in urine of patients with scleroderma. Arthritis and Rheumatism 38:517-524, 1995

Zimmermann B, Lally EV, Liu N: Infectious Agents and The Musculoskeletal System. In Textbook of Primary Care Medicine. Second Edition. Ed. J. Noble, St. Louis, Mosby, 1995, pp 1186-1199, 1995.

Clements P, Lachenbruch P, Seibold J, Lally EV, Furst D. Inter- and intra-observer variability of total skin thickness score (modified-Rodnan) in systemic sclerosis (SSc). Journal of Rheumatology 22:1281-1285, 1995

Stone PJ, Korn JH, Snider GL, Franzblau C, Miller LC, Tucker LB, Strongwater S, North H, Lally EV: Mature Elastin and collagen degradation products in urine of patients with scleroderma. Arthritis Rheum (suppl) 37:5264, 1994.

Clegg DO, Reading JC, Lally EV: Comparison of amino benzoate potassium and placebo in the treatment of scleroderma. Journal of Rheumatology 21:105-110, 1994.

Zimmermann B, Lally EV: Advances in the medical management of chronic arthritis. Rhode Island Medicine 77:10-15, 1994.

North HH, Zimmermann B, Lally EV: Long-term prospective evaluation of Raynaud's phenomenon and undifferentiated connective tissue disease: frequency of evolution and utility of autoantibody analysis. Arthritis Rheum (Suppl) 36:S132, 1993.

Clements PT, Lachenbruch, Lally EV, Furst DE: Skin thickness score in systemic sclerosis (SSc): An assessment of inter-observer variability in three independent studies. Journal of Rheumatology 29:1892-1892, 1993.

Cavacini LA, Kennel M, Lally EV, Posner MR, Quinn A: Human immunoglobulin production in immuno deficient mice: enhancement by immuno suppression of host and in vitro activation of human mononuclear cells. Clinical and Experimental Immunology 90:135-140, 1992.

Zimmermann B, Spiegel M, Lally EV: Cryptococcal meningitis in systemic lupus erythematosus. Seminars in Arthritis and Rheumatism 22:18-24, 1992.

Lally EV: Raynaud's phenomenon: Current Opinion in Rheumatology 4:825-836, 1992.

Lally EV, Marsella JM, Mojcik C, Bowden CJ, Posner M: Characterization of IgG autoantibodies which recognize T-cell surface antigens in systemic sclerosis. Arthritis Rheum (Suppl) 35:R47, 1992.

Mojcik C, Bowdin C, Posner M, Lally EV: Characterization of IgG anti-T-cell autoantibodies in systemic sclerosis. Arthritis Rheum (suppl) 34:R45, 1991.

Lally EV: Sexual and reproductive dysfunction in systemic sclerosis. Postgraduate Advances in Rheumatology 4 (12):1-7 1991.

Savin H, Zimmermann III B, Aaron RK, Libbey NP, Khorsand J, Alper JC, Lally EV: Seronegative symmetric polyarthritis in Sezary syndrome. The Journal of Rheumatology 18:464-467, 1991.

Zimmermann B, Crager K, Ho G, Lally EV: HLA-B27 in a family with seropositive rheumatoid arthritis (RA). Arthritis Rheum (suppl) 34:R48, 1991.

Stankiewicz AJ, Steiner M, Lally EV, Kaplan SR: Abnormally high level of C4b binding protein and deficiency of free fraction of protein S in a patient with systemic lupus erythematosus and recurrent thromboses. The Journal of Rheumatology 18:82-87, 1991.

Lally EV: Therapeutic application of monoclonal antibody therapy in rheumatic diseases. In Monoclonal Antibodies, Cytokines, and Arthritis. Mediators of Inflammation in Therapy. Ed. T. Kresina, New York, Marcel Dekker, 1991, p. 11-35.

Mojcik C, Bowdin C, Posner M, Lally EV: Characterization of IgG anti-T-cell autoantibodies in systemic sclerosis. Arthritis Rheum (suppl) 34:5109, 1991.

Barrach HJ, Chichester C, Chichester A, Matoney A, Srinivas G, Lally EV: Type II collagen reactive mouse and human monoclonal antibodies: evidence of poly-reactivity. Trans Orthop Res Soc 15:310, 1990.

Lally EV, Jimenez SA: Erectile failure in systemic sclerosis (letter). New England Journal of Medicine 22:1398-1399, 1990.

Varga J, Heiman-Patterson TD, Emery DL, Griffin R, Lally EV, Uitto JJ, Jimenez SA: Clinical spectrum of the systemic manifestations of the eosinophilia-myalgia syndrome. Seminars in Arthritis and Rheumatism 19:313-328, 1990.

Lally EV, Elboim HS, Tumber M Posner MR: High-Titered IgG antibodies against T-cell antigens in systemic sclerosis. Arthritis Rheum (suppl) 33:S157, 1990.

Lally EV, Elboim HS, Tumber M, Posner MR: High-titered IgG anti-T-cell antibodies in systemic sclerosis. Arthritis Rheum (Suppl) 33:R43, 1990.

Lally EV, Zimmermann B, Ho G, Kaplan SR: Urate-mediated inflammation in nodal osteoarthritis: clinical and roentgenographic correlations. Arthritis and Rheumatism 32:86-90, 1989.

Barrach HJ, Posner MR, Santos DJ, Nivens K, Lally EV, Chichester, CO: Characterization of human monoclonal antibodies: Subset of IgM-RF reactive with collagen type II. Trans Orthop Res Soc 14:60, 1989.

Posner MR, Barrach HJ, Elbomin HS, Nivens K, Santos DJ, Chichester CO, Lally EV: The generation of hybridomas secreting human monoclonal antibodies reactive with type II collagen. Hybridoma 8:187-197, 1989.

Lally EV: The use of methotrexate in the treatment of Reiter's syndrome, dermatomyositis-polymyositis and other connective tissue diseases. In The Treatment of Inflammatory Arthritis with Methotrexate. Ed. W. Wilke, New York, Marcel Dekker, 1989, p. 295-312.

Lally EV, Barrach HJ, Posner MR, Nivens K, Chichester CO: Characterization of polyreactive human monoclonal antibodies with anti-collagen and rheumatoid factor activity. Arthritis Rheum 32 (Suppl):R6, 1989.

Lally EV, Zimmermann B, Kaplan SR: Progressive systemic sclerosis with rapidly-progressive disease course (RP-PPS): Clinical and Laboratory analysis. Arthritis Rheum 32 (Suppl):R15, 1989.

Barrach HJ, Posner MR, Santos D, Nivens K, Lally EV, Chichester CO: The production of human monoclonal antibodies reactive with type II collagen. Presented at the Annual Meeting, Orthopaedic Research Society, Atlanta, GA, February 1-4, 1988.

Zimmermann B, Lally EV: Rheumatoid arthritis in the elderly. In Contemporary Geriatric Medicine Vol. 3 Ed. SR Gambert. New York, Plenum Medical Book Co., 1988, p. 211-218.

Varga J, Lally EV, Jimenez SA: Endocrinopathy and other visceral organ involvement in progressive systemic sclerosis. In Systemic Sclerosis: Scleroderma. Ed. MIV Jayson, CM Black, New York, John Wiley & sons, 1988, p. 267-278.

Grossman JAI, Barrall DT, Dennison A. Lally EV: Successful combined medical and surgical treatment of lower extremity sclerodermal ulcer. Annals of Plastic Surgery 20:582-585, 1988.

Lally EV, Jimenez SA, Kaplan SR: Progressive systemic sclerosis: Mode of presentation, rapidly progressive disease course and mortality based on an analysis of 91 patients. Seminars in Arthritis and Rheumatism 18:1-13, 1988.

Lally EV, Barrach HJ, Posner MR, Santos D, Nivens K, Chichester CO: Generation of human monoclonal antibodies against type II collagen. Clin Res 36:533A, 1988.

Zimmermann III B, Lally EV, Sharma SC, Levin W, Stroup R, Schoen FJ, Kpalan SR: Severe aortic stenosis in a young man with systemic lupus erythematosus and mucopolysaccharidosis Type II (Hunter's Syndrome). Clinical Cardiology 11:723-725, 1988.

Lally EV: Crystal-mediated disorders in the elderly. In Contemporary Geriatric Medicine Vol. 3 Ed. SR Gambert. New York, Plenum Medical Book Co., 1988, p. 198-211.

Lally EV, Jimenez SA: Vocal cord palsy in systemic sclerosis (letter). Journal of Rheumatology 15:1876, 1988.

Evans RB, Ettensohn DB, Estrup FF, Lally EV, Kaplan SR: Gold lung: Recent developments in pathogenesis, diagnosis and therapy. Seminars in Arthritis and Rheumatism 16:196-205, 1987.

Ingram GJ, Scher RK, Lally EV: Reflex sympathetic dystrophy following nail biopsy. Journal of the American Academy of Dermatology 16:253-256, 1987.

Lally EV, Crowley JP: An element of uncertainty: The clinical significance of zinc deficiency in rheumatoid arthritis. IM: Internal Medicine for the Specialist 8:98-197, 1987.

Lally EV, Bogaars HA, Zimmermann B, Kaplan SR: Diagnostic value of ANA Screening with HEpII cells and of ENA analysis in connective tissue diseases. Presented at the Annual Scientific Meeting, New England Rheumatism Society, Dedham, MA May 28, 1987.

Lally EV, Bogaars HA, Zimmermann B, Kaplan SR: Prospective evaluation of Raynaud's phenomenon (RP) and undifferentiated connective tissue disease (UCTD) using in vivo capillary microscopy (IVCM) and ANA analysis. Arthritis Rheum 30:S117, 1987.

Zimmermann B, Lally EV, Bogaars HA, Kaplan SR: Antinuclear antibodies (ANA's) in rheumatoid arthritis (RA): Clinical correlations. Arthritis Rheum 29:55, 1986.

Kaplan SR, Lally EV: Decision points in the management of rheumatoid arthritis. Parts I and II. Journal of Musculoskeletal Medicine 3:46-50, 1986.

Lally EV, Ho Jr. G, Kaplan SR: The clinical spectrum of gouty arthritis in women. Archives of Internal Medicine 146:2221-2225, 1986.

Lally EV, Bogaars HA, Kaplan SR: Sensitivity and specificity of "disease-specific" antibodies in scleroderma-spectrum disorders. Arthritis Rheum 29:54, 1986.

Malhotra CM, Lally EV, Buckley WM: Ossification of the plantar fascia and peroneus longus tendons in diffuse idiopathic skeletal hyperostosis (DISH). Journal of Rheumatology 13:215-218, 1986.

Lally EV, Bogaars HA, Kaplan SR: Detection of antinuclear antibodies in progressive systemic sclerosis (PSS) and scleroderma-spectrum disorders using a HEp II cell line: Sensitivity and specificity. Presented at the Annual Scientific Meeting, New England Rheumatism Society, Dedham, MA, May 3, 1985.

Scher RK, Tom DWK, Lally EV, Bogaars HA: The clinical significance of periodic acid-Schiff-positive deposits in cuticle-proximal nailfold biopsy specimens. Archives of Dermatology 121:1406-1409, 1985.

Lally EV, Ho, Jr. G: A review of methotrexate therapy in Reiter's disease. Seminars in Arthritis and Rheumatism 15:139-145, 1985.

Lally EV, Kaplan SR, Susset JG, Trebbin WM, Klutz WS, Cohen SI: Pathologic involvement of the urinary bladder in progressive systemic sclerosis. Journal of Rheumatology 12:778-781, 1985.

LaBresh KA, Lally EV, Sharma SC, Ho Jr. G: Two dimensional echocardiographic detection of preclinical aortic root abnormalities in rheumatoid variant diseases. American Journal of Medicine 78:908-912, 1985.

Lally EV, Friedman JH, Kaplan SR: Progressive myalgias and polyarthralgias in a patient with myoadenylate deaminase deficiency. Arthritis and Rheumatism 28:1298-1302, 1985.

Lally EV, Ho Jr. G, Kaplan SR: The clinical spectrum of gouty arthritis in women. Clin Res 33:778, 1985.

Scher RK, Tom DWK, Lally EV, Bogaars HA: Cuticle-proximal nailfold biopsy in patients with connective tissue disease: Specificity and clinical correlations. Presented at VI International Congress of Dermatologic Surgery, Rome, October 7, 1985.

Lally EV, Scher RK, Tom DWK, Bogaars HA: Specificity and clinical correlations of proximal nailfold biopsies in connective tissue disease. Arthritis Rheum 28:580, 1985.

Evans RB, Ettensohn DB, Appelbaum PA, Fawaz-Estrup F, Lally EV, Kaplan SR: Altered accessory cell function of alveolar macrophages (AlvMo) from patients with rheumatoid arthritis. Presented at Eastern Section Thoracic Society, September 26-29, 1985.

Lally EV, Ho Jr. G, Kaplan SR: Gouty Arthritis in Women. Clin Res 32:701A, 1984.

Lally EV, Jimenez SA, Kaplan SR: Progressive systemic sclerosis (PSS): Initial presentation and unusual clinical features in seventy-seven hospitalized patients. Clin Res 32:663A, 1984.

Lally EV, Klutz WS, Kaplan SR, Trebbin W, Cohen SI, Susset JG: Lower urinary tract involvement in progressive systemic sclerosis (PSS). Clin Res 32:663A, 1984.

Lally EV, Jimenez SA: Progressive systemic sclerosis: A comparison between patients with rapidly progressive and slowly progressive disease. Clin Res 31:157A, 1983.

Lally EV: High-dose corticosteroid therapy: Association with non-nflammatory synovial effusions. Arthritis and Rheumatism 26:1283-1287, 1983.

Lally EV, Buckley WM, Claster S: Diaphyseal bone infarctions in a patient with sickle cell trait. Journal of Rheumatology 10:813-816, 1983.

Lally EV, Kaplan SR: Update on Corticosteroid Therapy in the Rheumatic Diseases. Arlington, VA: Arthritis Information Clearinghouse 1983.

Ho G, Su EY, Lally EV, Melendez G, Guttell JF, Schmidt-Parker V, et al: Metabolic abnormalities and elastance of rheumatoid knees. Arthritis Rheum 25:S123, 1982.

Jimenez SA, Lally EV: Impotence in progressive systemic sclerosis (letter). Annals of Internal Medicine 96:125-126, 1982.

Lally EV: Synovial effusions during withdrawal from high-dose corticosteroid therapy (HDCST). Clin Res 30:653A, 1982.

Lally EV, Baker DG, Horwitz HM: Seronegative peripheral arthritis in B27-positive monozygotic twin sisters. Arthritis and Rheumatism 25:1490-1493, 1982.

Lally EV, Schmidt-Parker V, Kaplan SR: Acute gouty arthritis and systemic lupus erythematosus. Journal of Rheumatology 9:308-310, 1982.

Lally EV, Su EY, Ho G, Silvan KP, LaBresh KA: Echocardiographic assessment of aortic root size in patients with rheumatoid variant diseases. Arthritis Rheum 25:4152, 1982.

Lally EV: Characteristic synovial effusions during high-dose corticosteroid therapy. Arthritis Rheum 25:S104, 1982.

Lally EV, Jimenez SA: Impotence in progressive systemic sclerosis. Annals of Internal Medicine 95:150-153, 1981.

Jimenez SA, Lally EV: Disorders of collagen structure and metabolism. Bulletin on the Rheumatic Diseases 30:1016-1022, 1980.

Lally EV, Jimenez SA: Extraction and characterization of normal and pathologic human synovial membrane collagen. Arthritis Rheum 23:709, 1980.

OTHER PUBLICATIONS

Lally EV, Zimmermann B, Ho G, Kaplan SR: Urate-mediated inflammation in nodal osteoarthritis (NOA): Clinical and roentgenographic correlations. Arthritis Rheum (Accepted for publication.)

BOOK CHAPTERS AND REVIEWS

Ettensohn DB, Evans RB, Estrup F, Lally EV, Kaplan SR, Roberts Jr., NJ: Pulmonary immune properties in patients with rheumatoid arthritis (RA). Submitted to American Federation for Clinical Research.

Gazi H, Pope, J, Lally, EV, Seibold JR: Outcome measurements in scleroderma (submitted for publication).

research overview

Major areas of research interests are in the clinical arena.

1. Connective tissue disease including scleroderma and systemic lupus erythematosus (SLE, Lupus). I've had a long interest in SLE and Lupus both in terms of patient care as well as doing clinical studies of patients with these disorders.

2. The other is in osteoarthritis. I've been a consultant on the Osteoarthritis Initiative (Based at Memorial Hospital). I've been collaborating with a group in Orthopedic Surgery at Brown to develop an Osteoarthritis Center, which would be involved in the diagnosis, treatment, and research of osteoarthritis.

research statement

1. Establishment of a Scleroderma Registry for Rhode Island and Southern New England. Currently following about 70-80 patients with scleroderma and using the population base to investigate epidemiologic, clinical, laboratory, and therapeutic aspects of this disease.

2. Investigation of antibodies to Type II collagen peptides in osteoarthritis and rheumatoid arthritis using human monoclonal antibodies directed against Type II collagen peptides. (Roger Williams Medical Center and Rhode Island Hospital).

3. Pulmonary Hypertension in Scleroderma.

4. Fibrosis and Wound Healing

funded research

Kendall Anne-Asermely-Vars Scleroderma Research Fund