Wing, Edward

Edward Wing

Professor Emeritus of Medical Science

Overview

Dr. Wing, is a magna cum laude graduate of Williams College (BA in chemistry) and a cum laude alumnus of Harvard Medical School. He completed his internship and residency at the Peter Bent Brigham Hospital in Boston and an infectious diseases fellowship at Stanford University.
He began his career in academic medicine at the University of Pittsburgh, where in his twenty-one-year tenure he rose through the ranks to serve as chief of infectious diseases and interim chief of medicine. He became chair of Brown's Department of Medicine in 1998.
Dr. Wing's research interests, continuously funded by NIH for two-plus decades, are focused on the immune host defenses against intracellular pathogens. With strong clinical interests in infectious diseases, HIV, and international health, he oversees programs in the Dominican Republic, Kenya, India, Cambodia, Viet Nam, and Russia that provide direct care to hundreds of patients, as well as outstanding educational opportunities for Brown undergraduates, medical students, residents, fellows, and faculty

Research

Research Overview

Edward Wing's research interests are focused on the immune host defenses against intracellular pathogens such as Listeria monocytogenes and Mycobacterium tuberculosis. He also has a strong clinical interest in infectious diseases, HIV, and international health.

Research Statement

Edward Wing's research has been focused on the immnology of intracellular pathogens. Using a model of Listeria infection, he has described how T lymphocytes, cytokines, and other leukocytes combine to eliminate bacteria from the body and protect it from subsequent infections. His laboratory has been funded by the National Institutes of Health (NIH) since 1982. He and his colleague, Stephen Gregory, report the results of their research regularly at national and international scientific meetings. Dr. Wing also has published on a variety of clinical topics including Legionnaire's Disease, infections in immunocompromised hosts, and pneumonia.

Funded Research

Research Grants:

United States Public Health Service National Institutes of Health (NIH)

1983 - 86
National Institutes of Health RO1 CA33035
"Antitumor Activity of Colony Stimulating Factor"
$247,370 direct costs
Principal Investigator

1984 - 87
"Effect of Starvation on Monocytemacrophage Function"
National Institutes of Health RO1 AI20638
$287,316 direct costs
Principal Investigator

1987 - 94
"Host Defense Mechanisms in Listeria Infection"
National Institutes of Health RO1 AI24141
1987-1990 $318,291 direct costs
1991-1994 $660,273 direct costs
Principal Investigator

1994 - 97
"Factors Effecting Hepatocyte Resistance to Infection"
National Institutes of Health R01 DK44367
$664,589 direct costs
Co-Investigator; Principal Investigator - Stephen Gregory

1994 - 99
"Research Training in AIDS, STDs and Intracellular Pathogens"
National Institutes of Health T32 AI07333
$637,099 direct costs
Principal Investigator

2003 - 05
"Francisella Tularensis: Innate Resistance to Inhalation"
National Institutes of Health1 R21 AI055657-01
$308,000 (Federal Direct Costs $200,000, Federal FandA Costs $108,000)
Principal Investigator - Stephen Gregory

2006 - 11
"Neutrophil-macrophage interactions govern liver immunity"
National Institutes of Health R01 DK068097-02
$225,000/year direct costs (requested)
Co-Investigator; Principal Investigator - Stephen Gregory

Others

1980 - 82
"The Effect of Starvation on the Course of Bacterial and Protozoal Infections"
Health Research and Services Foundation (W-33)
$30,603 direct costs
Principal Investigator

1981 - 84
"Studies of Immune Function in Murine Models of Systemic Lupus Erythematosus and Other Mouse Strains: Effects of Nutritional Alterations and Prostaglandins"
Division of Chronic Disease Control, Pennsylvania Department of Health
$69,639 direct costs
Principal Investigator

1988 - 90
"Studies on the use of Clarithromycin in respiratory tract infections"
Abbott Laboratories
$20,000 direct costs
Principal Investigator

Scholarly Work

Gregory SH, Wing EJ: Neutrophil-Kupffer cell interaction: a critical component of host defenses to systemic bacterial infections. J of Leukocyte Biology, 72:239-248, 2002.

Wing EJ, Gregory SH: Listeria monocytogenes: Clinical and experimental update. J Infect Dis 185 (suppl 1): S18-24, 2002.

Calderwood SB, Mylonakis E, Hohmann E, Paliou M, Wing EJ: Listeriosis during pregnancy: A case series and review of 222 cases. Medicine, 81:260-69, 2002.

Gregory SH, Cousens LP, van Rooijen N, Dopp EA, Carlos TM, Wing EJ: Complementary adhesion molecules promote neutrophil-Kupffer cell interaction and the elimination of bacteria taken up by the liver. J Immunol 168:308-315, 2002.

Christopher K, Tammaro, D, Wing EJ: Early Scurvy complicating anorexia: a case report. South Med J 2002 Sep;95(9):1065-6

Gregory SH, van Rooijen N, Wing EJ: Neutrophil-Kupffer cell Interaction facilitates innate host defenses to systemic bacterial infections. American Association of Immunologists, New Orleans, LA, April 20-24,2002.

Cousens LP, Mott S, Wing EJ, Chau-Ching L, Gregory SH: CD8 T cells shift from perforin- to fas ligand-mediated cytolysis during primary listeriosis. 11th International Congress for Immunology, Stockholm, July 22-27, 2001.

Wing EJ: Listeriosis. Grand Rounds at Memorial Hospital of Rhode Island, January, 2001.

Wing EJ: Listeria: Hot dogs and CD8 cells. Grand Rounds at Dr. Jack Remington's Festschrift, Stanford School of Medicine, Palo Alto, CA, January 2001.

Background

Education and Training

Year	Degree	Institution
1971	MD	Harvard University
1967	BA	Williams College

Honors and Awards

1966 Phi Beta Kappa, Williams College
1983 Fellow, Infectious Diseases Society of America
2000 Fellow, American College of Physicians
2000 American Clinical and Climatological Association

Researchers@Brown