Dr. Akhlaghi is a pharmaceutical scientist with expertise in clinical pharmacology, translational sciences, drug metabolism, pharmacogenomics and pharmacokinetic/pharmacodynamic (PKPD) modeling. Her research goal is to understand the sources of variability in drug disposition and effect with a long term goal of devising personalized therapy for existing or new pharmacological agents. She is proficient in design and implementation of clinical pharmacokinetic studies, quantification of drug concentration and metabolites using LC-MS/MS, analysis of pharmacokinetic studies by several standard and population pharmacokinetic modeling software and in vitro characterization of expression and activity of drug metabolism enzymes. The areas of research interest include the effect of diabetes mellitus on drug disposition, drug development in alcoholism and therapeutic drug monitoring of immunosuppressive agents in organ transplant recipients. In addition, she is the director of the graduate program in Pharmaceutics and Pharmacokinetics and Principal Investigator on two NIH grants.
| Rose KN, Barlock BJ, DaSilva NA, Johnson SL, Liu C, Ma H, Nelson R, Akhlaghi F, Seeram NP. "Anti-neuroinflammatory effects of a food-grade phenolic-enriched maple syrup extract in a mouse model of Alzheimer's disease." Nutritional neuroscience, 2019, pp. 1-10. |
| Adusumalli S, Jamwal R, Leggio L, Akhlaghi F. "Development and validation of an assay for a novel ghrelin receptor inverse agonist PF-5190457 and its major hydroxy metabolite (PF-6870961) by LC-MS/MS in human plasma." Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, vol. 1130-1131, 2019, pp. 121820. |
| Adusumalli S, Jamwal R, Obach RS, Ryder TF, Leggio L, Akhlaghi F. "Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach." Drug metabolism and disposition: the biological fate of chemicals, vol. 47, no. 8, 2019, pp. 874-882. |
| Farokhnia M, Deschaine SL, Sadighi A, Farinelli LA, Lee MR, Akhlaghi F, Leggio L. "A deeper insight into how GABA-B receptor agonism via baclofen may affect alcohol seeking and consumption: lessons learned from a human laboratory investigation." Molecular Psychiatry, 2018. |
| Valanejad L, Ghareeb M, Shiffka S, Nadolny C, Chen Y, Guo L, Verma R, You S, Akhlaghi F, Deng R. "Dysregulation of Δ<sup>4</sup>-3-oxosteroid 5β-reductase in diabetic patients: Implications and mechanisms." Molecular and cellular endocrinology, vol. 470, 2018, pp. 127-141. |
| Bouhlal, Sofia, Farokhnia, Mehdi, Lee, Mary R, Akhlaghi, Fatemeh, Leggio, Lorenzo. "Identifying and Characterizing Subpopulations of Heavy Alcohol Drinkers Via a Sucrose Preference Test: A Sweet Road to a Better Phenotypic Characterization?." Alcohol and Alcoholism, vol. 53, no. 5, 2018, pp. 560-569. |
| Bouhlal S, Farokhnia M, Lee MR, Akhlaghi F, Leggio L. "Identifying and Characterizing Subpopulations of Heavy Alcohol Drinkers Via a Sucrose Preference Test: A Sweet Road to a Better Phenotypic Characterization?." Alcohol and Alcoholism, vol. 53, no. 5, 2018, pp. 560-569. |
| Jamwal R, de la Monte SM, Ogasawara K, Adusumalli S, Barlock BB, Akhlaghi F. "Nonalcoholic Fatty Liver Disease and Diabetes Are Associated with Decreased CYP3A4 Protein Expression and Activity in Human Liver." Mol. Pharmaceutics, vol. 15, no. 7, 2018, pp. 2621-2632. |
| Lee MR, Scheidweiler KB, Diao XX, Akhlaghi F, Cummins A, Huestis MA, Leggio L, Averbeck BB. "Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: determination using a novel oxytocin assay." Molecular Psychiatry, vol. 23, no. 1, 2018, pp. 115-122. |
| Farokhnia M, Lee MR, Farinelli LA, Ramchandani VA, Akhlaghi F, Leggio L. "Pharmacological manipulation of the ghrelin system and alcohol hangover symptoms in heavy drinking individuals: Is there a link?." Pharmacology Biochemistry and Behavior, vol. 172, 2018, pp. 39-49. |
| Ghareeb, Mwlod, Gohh, Reginald Y., Akhlaghi, Fatemeh. "Tacrolimus Concentration in Saliva of Kidney Transplant Recipients: Factors Influencing the Relationship with Whole Blood Concentrations." Clinical Pharmacokinetics, vol. 57, no. 9, 2018, pp. 1199-1210. |
| Lee MR, Tapocik JD, Ghareeb M, Schwandt ML, Dias AA, Le AN, Cobbina E, Farinelli LA, Bouhlal S, Farokhnia M, Heilig M, Akhlaghi F, Leggio L. "The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: preclinical safety experiments and a phase 1b human laboratory study." Molecular Psychiatry, 2018. |
| Haass-Koffler CL, Akhlaghi F, Swift RM, Leggio L. "Altering ethanol pharmacokinetics to treat alcohol use disorder: Can you teach an old dog new tricks?." Journal of Psychopharmacology, vol. 31, no. 7, 2017, pp. 812-818. |
| Tang Q, Cai A, Bian K, Chen F, Delaney JC, Adusumalli S, Bach AC 2nd, Akhlaghi F, Cho BP, Li D. "Characterization of Byproducts from Chemical Syntheses of Oligonucleotides Containing 1-Methyladenine and 3-Methylcytosine." ACS omega, vol. 2, no. 11, 2017, pp. 8205-8212. |
| Jamwal R, Barlock BJ, Adusumalli S, Ogasawara K, Simons BL, Akhlaghi F. "Multiplex and Label-Free Relative Quantification Approach for Studying Protein Abundance of Drug Metabolizing Enzymes in Human Liver Microsomes Using SWATH-MS." Journal of Proteome Research, vol. 16, no. 11, 2017, pp. 4134-4143. |
| Cobbina E, Akhlaghi F. "Non-alcoholic fatty liver disease (NAFLD) - pathogenesis, classification, and effect on drug metabolizing enzymes and transporters." Drug metabolism reviews, vol. 49, no. 2, 2017, pp. 197-211. |
| Jamwal R, Topletz AR, Ramratnam B, Akhlaghi F. "Ultra-high performance liquid chromatography tandem mass-spectrometry for simple and simultaneous quantification of cannabinoids." Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, vol. 1048, 2017, pp. 10-18. |
| Akhlaghi F, Matson KL, Mohammadpour AH, Kelly M, Karimani A. "Clinical pharmacokinetics and pharmacodynamics of antihyperglycemic medications in children and adolescents with type 2 diabetes mellitus." Clinical pharmacokinetics, 2016. |
| Ghareeb M, Akhlaghi F. "Development and validation of a sensitive and selective LC-MS/MS method for determination of tacrolimus in oral fluids." Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, vol. 1038, 2016, pp. 136-141. |
| Ghareeb M, Akhlaghi F. "Alternative matrices for therapeutic drug monitoring of immunosuppressive agents using LC-MS/MS." Bioanalysis, vol. 7, no. 8, 2015, pp. 1037-58. |
| Ghareeb, Mwlod, Leggio, Lorenzo, El-Kattan, Ayman, Akhlaghi, Fatemeh. "Development and validation of an UPLC-MS/MS assay for quantitative analysis of the ghrelin receptor inverse agonist PF-5190457 in human or rat plasma and rat brain." Anal Bioanal Chem, vol. 407, no. 19, 2015, pp. 5603-5613. |
| Lin S, Henning AK, Akhlaghi F, Reisfield R, Vergara-Silva A, First MR. "Interleukin-2 receptor antagonist therapy leads to increased tacrolimus levels after kidney transplantation." Therapeutic drug monitoring, vol. 37, no. 2, 2015, pp. 206-13. |
| Robertsen I, Asberg A, Granseth T, Vethe NT, Akhlaghi F, Ghareeb M, Molden E, Reier-Nilsen M, Holdaas H, Midtvedt K. "More potent lipid-lowering effect by rosuvastatin compared with fluvastatin in everolimus-treated renal transplant recipients." Transplantation, vol. 97, no. 12, 2014, pp. 1266-71. |
| Ionita IA, Ogasawara K, Gohh RY, Akhlaghi F. "Pharmacokinetics of total and unbound prednisone and prednisolone in stable kidney transplant recipients with diabetes mellitus." Therapeutic drug monitoring, vol. 36, no. 4, 2014, pp. 448-55. |
| Chitnis SD, Ogasawara K, Schniedewind B, Gohh RY, Christians U, Akhlaghi F. "Concentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism." Xenobiotica; the fate of foreign compounds in biological systems, vol. 43, no. 7, 2013, pp. 641-9. |
| Mohammadpour AH, Akhlaghi F. "Future of cholesteryl ester transfer protein (CETP) inhibitors: a pharmacological perspective." Clinical pharmacokinetics, vol. 52, no. 8, 2013, pp. 615-26. |
| Dostalek M, Gohh RY, Akhlaghi F. "Inosine monophosphate dehydrogenase expression and activity are significantly lower in kidney transplant recipients with diabetes mellitus." Therapeutic drug monitoring, vol. 35, no. 3, 2013, pp. 374-83. |
| Ogasawara K, Chitnis SD, Gohh RY, Christians U, Akhlaghi F. "Multidrug resistance-associated protein 2 (MRP2/ABCC2) haplotypes significantly affect the pharmacokinetics of tacrolimus in kidney transplant recipients." Clinical pharmacokinetics, vol. 52, no. 9, 2013, pp. 751-62. |
| Patel CG, Ogasawara K, Akhlaghi F. "Mycophenolic acid glucuronide is transported by multidrug resistance-associated protein 2 and this transport is not inhibited by cyclosporine, tacrolimus or sirolimus." Xenobiotica; the fate of foreign compounds in biological systems, vol. 43, no. 3, 2013, pp. 229-35. |
| Macwan JS, Ionita IA, Akhlaghi F. "A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS)." Anal Bioanal Chem, vol. 402, no. 3, 2012, pp. 1217-27. |
| Dostalek M, Sam WJ, Paryani KR, Macwan JS, Gohh RY, Akhlaghi F. "Diabetes mellitus reduces the clearance of atorvastatin lactone: results of a population pharmacokinetic analysis in renal transplant recipients and in vitro studies using human liver microsomes." Clinical pharmacokinetics, vol. 51, no. 9, 2012, pp. 591-606. |
| Dostalek M, Akhlaghi F, Puzanovova M. "Effect of diabetes mellitus on pharmacokinetic and pharmacodynamic properties of drugs." Clinical pharmacokinetics, vol. 51, no. 8, 2012, pp. 481-99. |
| Longato L, Ripp K, Setshedi M, Dostalek M, Akhlaghi F, Branda M, Wands JR, de la Monte SM. "Insulin resistance, ceramide accumulation, and endoplasmic reticulum stress in human chronic alcohol-related liver disease." Oxidative medicine and cellular longevity, vol. 2012, 2012, pp. 479348. |
| Tsze DS, Steele DW, Machan JT, Akhlaghi F, Linakis JG. "Intranasal ketamine for procedural sedation in pediatric laceration repair: a preliminary report." Pediatric Emergency Care , vol. 28, no. 8, 2012, pp. 767-70. |
| Akhlaghi F, Dostalek M, Falck P, Mendonza AE, Amundsen R, Gohh RY, Asberg A. "The concentration of cyclosporine metabolites is significantly lower in kidney transplant recipients with diabetes mellitus." Therapeutic drug monitoring, vol. 34, no. 1, 2012, pp. 38-45. |
| Macwan JS, Ionita IA, Dostalek M, Akhlaghi F. "Development and validation of a sensitive, simple, and rapid method for simultaneous quantitation of atorvastatin and its acid and lactone metabolites by liquid chromatography-tandem mass spectrometry (LC-MS/MS)." Anal Bioanal Chem, vol. 400, no. 2, 2011, pp. 423-33. |
| Dostalek M, Court MH, Hazarika S, Akhlaghi F. "Diabetes mellitus reduces activity of human UDP-glucuronosyltransferase 2B7 in liver and kidney leading to decreased formation of mycophenolic acid acyl-glucuronide metabolite." Drug metabolism and disposition: the biological fate of chemicals, vol. 39, no. 3, 2011, pp. 448-55. |
| Bolin P Jr, Gohh R, Kandaswamy R, Shihab FS, Wiland A, Akhlaghi F, Melancon K. "Mycophenolic acid in kidney transplant patients with diabetes mellitus: does the formulation matter?." Transplantation reviews (Orlando, Fla.), vol. 25, no. 3, 2011, pp. 117-23. |
| Dostalek M, Court MH, Yan B, Akhlaghi F. "Significantly reduced cytochrome P450 3A4 expression and activity in liver from humans with diabetes mellitus." Journal of Cerebral Blood Flow & Metabolism, vol. 163, no. 5, 2011, pp. 937-47. |
| Hu, Susie, Akhlaghi, Fatemeh, Chitnis, Shripad, Chiu, Ritche, Go, Subil, Rout, Preeti, Steffes, Michael, Abbott, J. Dawn, Dworkin, Lance, Bostom, Andrew. "Comparison of plasma clearance of iodixanol during versus after angiography." American Journal of Kidney Diseases, vol. 56, no. 6, 2010, pp. 1219-20. |
| Dostalek M, Macwan JS, Chitnis SD, Ionita IA, Akhlaghi F. "Development and validation of a rapid and sensitive assay for simultaneous quantification of midazolam, 1'-hydroxymidazolam, and 4-hydroxymidazolam by liquid chromatography coupled to tandem mass-spectrometry." Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, vol. 878, no. 19, 2010, pp. 1629-33. |
| Narwal R, Akhlaghi F, Asberg A, Hermann M, Rosenbaum SE. "Development of a population pharmacokinetic model for atorvastatin acid and its lactone metabolite." Clinical pharmacokinetics, vol. 49, no. 10, 2010, pp. 693-702. |
| Pabla D, Akhlaghi F, Zia H. "Intestinal permeability enhancement of levothyroxine sodium by straight chain fatty acids studied in MDCK epithelial cell line." European Journal of Pharmaceutical Sciences, vol. 40, no. 5, 2010, pp. 466-72. |
| Ionita IA, Akhlaghi F. "Quantification of unbound prednisolone, prednisone, cortisol and cortisone in human plasma by ultrafiltration and direct injection into liquid chromatrography tandem mass spectrometry." Annals of clinical biochemistry, vol. 47, no. Pt 4, 2010, pp. 350-7. |
| Akhlaghi F, Gohh RY. "The level of ATP production in mitogen-stimulated CD4+ lymphocytes is independent of the time of ingestion of immunosuppressive agents." Therapeutic drug monitoring, vol. 32, no. 1, 2010, pp. 116-7. |
| Pabla D, Akhlaghi F, Zia H. "A comparative pH-dissolution profile study of selected commercial levothyroxine products using inductively coupled plasma mass spectrometry." European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, vol. 72, no. 1, 2009, pp. 105-10. |
| Ionita IA, Fast DM, Akhlaghi F. "Development of a sensitive and selective method for the quantitative analysis of cortisol, cortisone, prednisolone and prednisone in human plasma." Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, vol. 877, no. 8-9, 2009, pp. 765-72. |
| Sam WJ, Akhlaghi F, Rosenbaum SE. "Population pharmacokinetics of mycophenolic acid and its 2 glucuronidated metabolites in kidney transplant recipients." Journal of clinical pharmacology, vol. 49, no. 2, 2009, pp. 185-95. |
| Teasdale ME, Liu J, Wallace J, Akhlaghi F, Rowley DC. "Secondary metabolites produced by the marine bacterium Halobacillus salinus that inhibit quorum sensing-controlled phenotypes in gram-negative bacteria." Applied and Environmental Microbiology, vol. 75, no. 3, 2009, pp. 567-72. |
| Mendonza AE, Gohh RY, Akhlaghi F. "Blood and plasma pharmacokinetics of ciclosporin in diabetic kidney transplant recipients." Clinical pharmacokinetics, vol. 47, no. 11, 2008, pp. 733-42. |
| Falck P, Asberg A, Guldseth H, Bremer S, Akhlaghi F, Reubsaet JL, Pfeffer P, Hartmann A, Midtvedt K. "Declining intracellular T-lymphocyte concentration of cyclosporine a precedes acute rejection in kidney transplant recipients." Transplantation, vol. 85, no. 2, 2008, pp. 179-84. |
| Chitnis SD, Akhlaghi F. "Development and validation of an HPLC-UV method for iodixanol quantification in human plasma." Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, vol. 869, no. 1-2, 2008, pp. 133-7. |
| Pabla D, Akhlaghi F, Ahmed A, Zia H. "Development and validation of an inductively coupled plasma mass spectrometry method for quantification of levothyroxine in dissolution studies." Rapid Communications in Mass Spectrometry, vol. 22, no. 7, 2008, pp. 993-6. |
| Plante, Troilus, Harris, Darcy, Savitt, Julie, Akhlaghi, Fatemeh, Monti, James, Jay, Gregory D. "Carboxyhemoglobin Monitored by Bedside Continuous CO-Oximetry." The Journal of trauma, vol. 63, no. 5, 2007, pp. 1187-1190. |
| Patel CG, Harmon M, Gohh RY, Akhlaghi F. "Concentrations of mycophenolic acid and glucuronide metabolites under concomitant therapy with cyclosporine or tacrolimus." Therapeutic drug monitoring, vol. 29, no. 1, 2007, pp. 87-95. |
| Patel CG, Richman K, Yang D, Yan B, Gohh RY, Akhlaghi F. "Effect of diabetes mellitus on mycophenolate sodium pharmacokinetics and inosine monophosphate dehydrogenase activity in stable kidney transplant recipients." Therapeutic drug monitoring, vol. 29, no. 6, 2007, pp. 735-42. |
| Mendonza AE, Zahir H, Gohh RY, Akhlaghi F. "Tacrolimus in diabetic kidney transplant recipients: pharmacokinetics and application of a limited sampling strategy." Therapeutic drug monitoring, vol. 29, no. 4, 2007, pp. 391-8. |
| Mendonza AE, Gohh RY, Akhlaghi F. "Analysis of mycophenolic acid in saliva using liquid chromatography tandem mass spectrometry." Therapeutic drug monitoring, vol. 28, no. 3, 2006, pp. 402-6. |
| Shi D, Yang J, Yang D, LeCluyse EL, Black C, You L, Akhlaghi F, Yan B. "Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel." The Journal of pharmacology and experimental therapeutics, vol. 319, no. 3, 2006, pp. 1477-84. |
| Zahir H, Keogh AM, Akhlaghi F. "Apparent clearance of sirolimus in heart transplant recipients: impact of primary diagnosis and serum lipids." Therapeutic drug monitoring, vol. 28, no. 5, 2006, pp. 614-22. |
| Zahir H, Keogh A, Akhlaghi F. "Apparent clearance of sirolimus in heart transplant recipients: impact of primary diagnosis and serum lipids." Therapeutic drug monitoring, vol. 28, no. 6, 2006, pp. 818-26. |
| Patel CG, Akhlaghi F. "High-performance liquid chromatography method for the determination of mycophenolic acid and its acyl and phenol glucuronide metabolites in human plasma." Therapeutic drug monitoring, vol. 28, no. 1, 2006, pp. 116-22. |
| Akhlaghi F, Patel CG, Zuniga XP, Halilovic J, Preis IS, Gohh RY. "Pharmacokinetics of mycophenolic acid and metabolites in diabetic kidney transplant recipients." Therapeutic drug monitoring, vol. 28, no. 1, 2006, pp. 95-101. |
| Akhlaghi F, Gonzalez L, Trull AK. "Association between cyclosporine concentrations at 2 hours post-dose and clinical outcomes in de novo lung transplant recipients." The Journal of Heart and Lung Transplantation, vol. 24, no. 12, 2005, pp. 2120-8. |
| Soman RS, Zahir H, Akhlaghi F. "Development and validation of an HPLC-UV method for determination of iohexol in human plasma." Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, vol. 816, no. 1-2, 2005, pp. 339-43. |
| Zahir H, McLachlan AJ, Nelson A, McCaughan G, Gleeson M, Akhlaghi F. "Population pharmacokinetic estimation of tacrolimus apparent clearance in adult liver transplant recipients." Therapeutic drug monitoring, vol. 27, no. 4, 2005, pp. 422-30. |
| Rosenbaum SE, Baheti G, Trull AK, Akhlaghi F. "Population pharmacokinetics of cyclosporine in cardiopulmonary transplant recipients." Therapeutic drug monitoring, vol. 27, no. 2, 2005, pp. 116-22. |
| Mendonza A, Gohh R, Akhlaghi F. "Determination of cyclosporine in saliva using liquid chromatography-tandem mass spectrometry." Therapeutic drug monitoring, vol. 26, no. 5, 2004, pp. 569-75. |
| Patel CG, Mendonza AE, Akhlaghi F, Majid O, Trull AK, Lee T, Holt DW. "Determination of total mycophenolic acid and its glucuronide metabolite using liquid chromatography with ultraviolet detection and unbound mycophenolic acid using tandem mass spectrometry." Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, vol. 813, no. 1-2, 2004, pp. 287-94. |
| Trull AK, Akhlaghi F, Charman SC, Endenberg S, Majid O, Cornelissen J, Steel L, Parameshwar J, Wallwork J, Large S. "Immunosuppression, eotaxin and the diagnostic changes in eosinophils that precede early acute heart allograft rejection." Transplant immunology, vol. 12, no. 2, 2004, pp. 159-66. |
| Ray JE, Keogh AM, McLachlan AJ, Akhlaghi F. "Cyclosporin C(2) and C(0) concentration monitoring in stable, long-term heart transplant recipients receiving metabolic inhibitors." The Journal of Heart and Lung Transplantation, vol. 22, no. 7, 2003, pp. 715-22. |
| Akhlaghi F, Trull AK. "Distribution of cyclosporin in organ transplant recipients." Clinical pharmacokinetics, vol. 41, no. 9, 2002, pp. 615-37. |
| Akhlaghi F, Jackson CH, Parameshwar J, Sharples LD, Trull AK. "Risk factors for the development and progression of dyslipidemia after heart transplantation." Transplantation, vol. 73, no. 8, 2002, pp. 1258-64. |
| Trull AK, Charman SC, Endenburg S, Akhlaghi F, Majid O, Cornelissen J, Sharples LD, Steel LA, Parameshwar J, Wallwork J. "Eotaxin and prednisolone concentrations regulate the mobilisation of peripheral blood eosinophils preceding heart allograft rejection." The Journal of Heart and Lung Transplantation, vol. 20, no. 2, 2001, pp. 161. |
| Akhlaghi F, Keogh AM, McLachlan AJ, Kaan A. "Pharmacokinetics of cyclosporine in heart transplant recipients receiving metabolic inhibitors." The Journal of Heart and Lung Transplantation, vol. 20, no. 4, 2001, pp. 431-8. |
| Majid O, Akhlaghi F, Lee T, Holt DW, Trull A. "Simultaneous determination of plasma prednisolone, prednisone, and cortisol levels by high-performance liquid chromatography." Therapeutic drug monitoring, vol. 23, no. 2, 2001, pp. 163-8. |
| Trull AK, Steel LA, Sharples LD, Akhlaghi F, Parameshwar J, Cary N, Wallwork J, Large S. "Randomized trial of blood eosinophil count monitoring as a guide to corticosteroid dosage adjustment after heart transplantation." Transplantation, vol. 70, no. 5, 2000, pp. 802-9. |
| Akhlaghi F, Ashley J, Keogh A, Brown K. "Cyclosporine plasma unbound fraction in heart and lung transplantation recipients." Therapeutic drug monitoring, vol. 21, no. 1, 1999, pp. 8-16. |
| Akhlaghi F, Keogh AM, Brown KF. "Unbound cyclosporine and allograft rejection after heart transplantation." Transplantation, vol. 67, no. 1, 1999, pp. 54-9. |
| Akhlaghi F, Ashley JJ, Keogh AM, Brown KF. "Indirect estimation of the unbound fraction of cyclosporine in plasma." Therapeutic drug monitoring, vol. 20, no. 3, 1998, pp. 301-8. |
| Akhlaghi F, McLachlan AJ, Keogh AM, Brown KF. "Effect of simvastatin on cyclosporine unbound fraction and apparent blood clearance in heart transplant recipients." British journal of clinical pharmacology, vol. 44, no. 6, 1997, pp. 537-42. |
Professor and Ernest Mario Distinguished Chair in Pharmaceutics, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island
Adjunct Professor, Department of Medicine, Brown University
