Francesca L. Beaudoin MD, MS, PhD is the Academic Dean of Brown's School of Public Health and a Professor of Epidemiology. Dr. Beaudoin is a board-certified emergency physician and clinical epidemiologist with expertise in opioid use disorders and pain. Her work primarily focuses on three substantive areas that intersect with different aspects of the opioid epidemic: (1) comparative effectiveness of opioids and analgesic alternatives, (2) pharmacologic and non-pharmacologic interventions for opioid use disorders (OUD), and (3) study of posttraumatic neuropsychiatric sequelae (trauma and its consequences being a major risk factor for substance use). More recently and in response to the pandemic, Dr. Beaudoin has engaged in research related to Long COVID. She is the PI/ MPI of multiple federal and private grant awards (e.g., R01DA054698, R01CE19001). Her work applies a wide range of epidemiologic principles in the design and analyses of randomized clinical trials, hybrid implementation-effectiveness studies, and prospective cohort designs. A key feature of Dr. Beaudoin's work is the use of administrative datasets and linkages to objectively measure health outcomes (e.g., opioid overdose) in addition to traditional patient-reported outcomes. She has been the PI or Site PI in more than 20 clinical trials alone. Much of Dr. Beaudoin's work has been conducted in emergency department (ED) settings, an opportune and oft underutilized place to make an impact on public health.
Dr. Beaudoin still practices as a physician and currently works with CODAC Behavioral Healthcare as part of the nation's latest mobile addiction treatment unit. Dr. Beaudoin has also written and implemented practice management policies for health care systems on pain management and opioid prescribing, and has served as a member of the Food and Drug Administration Anesthetic and Analgesic Drug Products Advisory Committee. She has partnered with small businesses to innovate new approaches to solving key public health problems such as the opioid epidemic and was the PI of a NIH STTR award to help develop and evaluate a mobile peer recovery support application. She collaborates with state stakeholders such as the Rhode Island Department of Health and the Governor’s Task Force on Opioid Overdoses and has served as a Senior Medical Advisor to the Institute for Clinical and Economic Review (ICER).
| Francis AK, Beaudoin FL, Naidjate SS, Berard-Collins C, Zullo AR. "Comparing Treatment Response Between Older and Younger Patients with Chronic Hepatitis C Virus Infection on Direct-acting Antiviral Agents." Rhode Island medical journal (2013), vol. 103, no. 5, 2020, pp. 35-40. |
| Naganathan S, Meehan-Coussee K, Pasichow S, Rybasack-Smith H, Binder W, Beaudoin F, Musits AN, Sutton E, Petrone G, Levine AC, Suner S. "From Concerts to COVID: Transforming the RI Convention Center into an Alternate Hospital Site in under a Month." Rhode Island medical journal (2013), vol. 103, no. 6, 2020, pp. 8-13. |
| Goldberg EM, Marks SJ, Merchant RC, Nagy JL, Aquilante JA Jr, Beaudoin FL. "How Accurately Do Older Adult Emergency Department Patients Recall Their Medications?." Academic Emergency Medicine, 2020. |
| Scotina AD, Beaudoin FL, Gutman R. "Matching estimators for causal effects of multiple treatments." Statistical methods in medical research, vol. 29, no. 4, 2020, pp. 962280219850858. |
| Scherzer CR, Ranney ML, Jain S, Bommaraju SP, Patena J, Langdon K, Nimaja E, Jennings E, Beaudoin FL. "Mobile Peer-Support for Opioid Use Disorders: Refinement of an Innovative Machine Learning Tool." Journal of psychiatry and brain science, vol. 5, no. 1, 2020. |
| Jacka B, Beaudoin F, Li Y, Nimaja E, Yedinak J, Samuels E, Marshall BDL. "Objective Outcome Measures in Randomized Clinical Trials of Interventions to Reduce Risk of Opioid Overdose Following Discharge From the Emergency Department: Utility of Administrative Data Linkage." Journal of Addiction Medicine, 2020. |
| Neylan TC, Kessler RC, Ressler KJ, Clifford G, Beaudoin FL, An X, Stevens JS, Zeng D, Linnstaedt SD, Germine LT, Sheikh S, Storrow AB, Punches BE, Mohiuddin K, Gentile NT, McGrath ME, van Rooij SJH, Haran JP, Peak DA, Domeier RM, Pearson C, Sanchez LD, Rathlev NK, Peacock WF, Bruce SE, Joormann J, Barch DM, Pizzagalli DA, Sheridan JF, Harte SE, Elliott JM, Hwang I, Petukhova MV, Sampson NA, Koenen KC, McLean SA. "Prior sleep problems and adverse post-traumatic neuropsychiatric sequelae (APNS) of motor vehicle collision in the AURORA study." Sleep, 2020. |
| McLean SA, Ressler K, Koenen KC, Neylan T, Germine L, Jovanovic T, Clifford GD, Zeng D, An X, Linnstaedt S, Beaudoin F, House S, Bollen KA, Musey P, Hendry P, Jones CW, Lewandowski C, Swor R, Datner E, Mohiuddin K, Stevens JS, Storrow A, Kurz MC, McGrath ME, Fermann GJ, Hudak LA, Gentile N, Chang AM, Peak DA, Pascual JL, Seamon MJ, Sergot P, Peacock WF, Diercks D, Sanchez LD, Rathlev N, Domeier R, Haran JP, Pearson C, Murty VP, Insel TR, Dagum P, Onnela JP, Bruce SE, Gaynes BN, Joormann J, Miller MW, Pietrzak RH, Buysse DJ, Pizzagalli DA, Rauch SL, Harte SE, Young LJ, Barch DM, Lebois LAM, van Rooij SJH, Luna B, Smoller JW, Dougherty RF, Pace TWW, Binder E, Sheridan JF, Elliott JM, Basu A, Fromer M, Parlikar T, Zaslavsky AM, Kessler R. "The AURORA Study: a longitudinal, multimodal library of brain biology and function after traumatic stress exposure." Molecular Psychiatry, vol. 25, no. 2, 2020, pp. 283-296. |
| Moretti, Katelyn, Marqués, Catalina González, Garbern, Stephanie, Mbanjumucyo, Gabin, Uwamahoro, Chantal, Beaudoin, Francesca L., Amanullah, Siraj, Gjelsvik, Annie, Aluisio, Adam R. "Transfusion, mortality and hemoglobin level: Associations among emergency department patients in Kigali, Rwanda." African Journal of Emergency Medicine, vol. 10, no. 2, 2020, pp. 68-73. |
| Moretti, Katelyn, Marqués, Catalina González, Garbern, Stephanie, Mbanjumucyo, Gabin, Uwamahoro, Chantal, Beaudoin, Francesca L., Amanullah, Siraj, Gjelsvik, Annie, Aluisio, Adam R. "Transfusion, mortality and hemoglobin level: Associations among emergency department patients in Kigali, Rwanda." African Journal of Emergency Medicine, vol. 10, no. 2, 2020, pp. 68-73. |
| Mauck MC, Linnstaedt SD, Bortsov A, Kurz M, Hendry PL, Lewandowski C, Velilla MA, Datner E, Pearson C, Domeier R, Fillingim RB, Beaudoin FL, Ting JP, McLean SA. "Vitamin D insufficiency increases risk of chronic pain among African Americans experiencing motor vehicle collision." PAIN, vol. 161, no. 2, 2020, pp. 274-280. |
| Bernstein MH, Magill M, Weiss AP, Kaptchuk TJ, Blease C, Kirsch I, Rich JD, Becker SJ, Mach S, Beaudoin FL. "Are Conditioned Open Placebos Feasible as an Adjunctive Treatment to Opioids? Results from a Single-Group Dose-Extender Pilot Study with Acute Pain Patients." Psychotherapy and Psychosomatics, vol. 88, no. 6, 2019, pp. 380-382. |
| Lawrence AC, Burke C, Brister J, Ferrante D, Beaudoin FL. "Evaluating the Impact of Hospital Closure on Local Emergency Department Operations." Rhode Island medical journal (2013), vol. 102, no. 5, 2019, pp. 37-42. |
| Goedel WC, Marshall BDL, Samuels EA, Brinkman MG, Dettor D, Langdon KJ, Mahoney LA, Merchant RC, Nizami T, O'Toole GA, Ramsey SE, Yedinak JL, Beaudoin FL. "Randomised clinical trial of an emergency department-based peer recovery support intervention to increase treatment uptake and reduce recurrent overdose among individuals at high risk for opioid overdose: study protocol for the navigator trial." BMJ Open, vol. 9, no. 11, 2019, pp. e032052. |
| Bernstein MH, Beaudoin FL, Magill M. "Response to FDA Commissioner's statement on Dsuvia approval." Addiction, vol. 114, no. 4, 2019, pp. 757-758. |
| Strauss DH, Santhanam DR, McLean SA, Beaudoin FL. "Study protocol for a randomised, double-blind, placebo-controlled clinical trial of duloxetine for the treatment and prevention of musculoskeletal pain: altering the transition from acute to chronic pain (ATTAC pain)." BMJ Open, vol. 9, no. 3, 2019, pp. e025002. |
| Beaudoin FL. "Combination of ibuprofen and acetaminophen is no different than low-dose opioid analgesic preparations in relieving short-term acute extremity pain." BMJ evidence-based medicine, 2018. |
| Madsen TE, McLean S, Zhai W, Linnstaedt S, Kurz MC, Swor R, Hendry P, Peak D, Lewandowski C, Pearson C, O'Neil B, Datner E, Lee D, Beaudoin F. "Gender Differences in Pain Experience and Treatment after Motor Vehicle Collisions: A Secondary Analysis of the CRASH Injury Study." Clinical Therapeutics, vol. 40, no. 2, 2018, pp. 204-213.e2. |
| Bernstein MH, Magill M, Beaudoin FL, Becker SJ, Rich JD. "Harnessing the placebo effect: a promising method for curbing the opioid crisis?." Addiction, vol. 113, no. 11, 2018, pp. 2144-2145. |
| Beaudoin FL, Rosellini AJ, Bortsov A, McLean SA. "Health care utilization following motor vehicle collision is poorly stratified by chronic pain risk: Lessons from the CRASH study." The American Journal of Emergency Medicine, 2018. |
| Michopoulos V, Maples-Keller J, Roger EI, Beaudoin FL, Sumner JA, Rothbaum BO, Hudak L, Gillespie CF, Kronish IM, McLean SA, Ressler KJ. "Nausea in the peri-traumatic period is associated with prospective risk for PTSD symptom development." Neuropsychopharmacology, 2018. |
| Zullo AR, Zhang T, Beaudoin FL, Lee Y, McConeghy KW, Kiel DP, Daiello LA, Mor V, Berry SD. "Pain Treatments After Hip Fracture Among Older Nursing Home Residents." Journal of the American Medical Directors Association, vol. 19, no. 2, 2018, pp. 174-176. |
| Beaudoin FL, Gutman R, Zhai W, Merchant RC, Clark MA, Bollen KA, Hendry P, Kurz MC, Lewandowski C, Pearson C, OʼNeil B, Datner E, Mitchell P, Domeier R, McLean SA. "Racial differences in presentations and predictors of acute pain after motor vehicle collision." PAIN, vol. 159, no. 6, 2018, pp. 1056-1063. |
| Beaudoin FL, Janicki A, Zhai W, Choo EK. "Trends in opioid prescribing before and after implementation of an emergency department opioid prescribing policy." The American Journal of Emergency Medicine, vol. 36, no. 2, 2018, pp. 329-331. |
| Haran JP, Wilsterman E, Zeoli T, Beaudoin FL, Tjia J, Hibberd PL. "Elderly patients are at increased risk for treatment failure in outpatient management of purulent skin infections." The American Journal of Emergency Medicine, vol. 35, no. 2, 2017, pp. 249-254. |
| "Opioid Prescribing by Emergency Physicians and Risk of Long-Term Use." New England Journal of Medicine, vol. 376, no. 19, 2017, pp. 1895-1896. |
| Beaudoin FL, Rich JD. "Opioid Prescribing by Emergency Physicians and Risk of Long-Term Use." New England Journal of Medicine, vol. 376, no. 19, 2017, pp. 1895-6. |
| Beaudoin FL, Gutman R, Merchant RC, Clark MA, Swor RA, Jones JS, Lee DC, Peak DA, Domeier RM, Rathlev NK, McLean SA. "Persistent pain after motor vehicle collision: comparative effectiveness of opioids vs nonsteroidal antiinflammatory drugs prescribed from the emergency department-a propensity matched analysis." PAIN, vol. 158, no. 2, 2016, pp. 1. |
| Beaudoin FL, Merchant RC, Clark MA. "Prevalence and Detection of Prescription Opioid Misuse and Prescription Opioid Use Disorder Among Emergency Department Patients 50 Years of Age and Older: Performance of the Prescription Drug Use Questionnaire, Patient Version." The American Journal of Geriatric Psychiatry, vol. 24, no. 8, 2016, pp. 627-36. |
| Henderson AW, Beaudoin FL, Mello MJ, Baird J. "Prevalence of Sedating Medication Use Among Older Drivers Presenting in the Emergency Department." Rhode Island medical journal (2013), vol. 99, no. 1, 2016, pp. 15-9. |
| Beaudoin FL, Banerjee GN, Mello MJ. "State-level and system-level opioid prescribing policies: The impact on provider practices and overdose deaths, a systematic review." Journal of opioid management, vol. 12, no. 2, 2016, pp. 109-18. |
| Henderson AW, Babu KM, Merchant RC, Beaudoin FL. "Prescription Opioid Use and Misuse Among Older Adult Rhode Island Hospital Emergency Department Patients." Rhode Island medical journal (2013), vol. 98, no. 3, 2015, pp. 28-31. |
| Beaudoin, Francesca L., Merchant, Roland C., Janicki, Adam, McKaig, Donald M., Babu, Kavita M. "Preventing Iatrogenic Overdose: A Review of In–Emergency Department Opioid-Related Adverse Drug Events and Medication Errors." Annals of Emergency Medicine, vol. 65, no. 4, 2015, pp. 423-431. |
| Beaudoin, Francesca L., Baird, Janette, Liu, Tao, Merchant, Roland C. "Sex Differences in Substance Use Among Adult Emergency Department Patients: Prevalence, Severity, and Need for Intervention." Academic Emergency Medicine, vol. 22, no. 11, 2015, pp. 1307-1315. |
| Choo EK, Beauchamp G, Beaudoin FL, Bernstein E, Bernstein J, Bernstein SL, Broderick KB, Cannon RD, D'Onofrio G, Greenberg MR, Hawk K, Hayes RB, Jacquet GA, Lippmann MJ, Rhodes KV, Watts SH, Boudreaux ED. "A research agenda for gender and substance use disorders in the emergency department." Academic Emergency Medicine, vol. 21, no. 12, 2014, pp. 1438-46. |
| Beaudoin, Francesca L., Lin, Charlie, Guan, Wentao, Merchant, Roland C. "Low-dose ketamine improves pain relief in patients receiving intravenous opioids for acute pain in the emergency department: results of a randomized, double-blind, clinical trial." Academic Emergency Medicine, vol. 21, no. 11, 2014, pp. 1193-202. |
| Swenson DW, Lourenco AP, Beaudoin FL, Grand DJ, Killelea AG, McGregor AJ. "Ovarian torsion: Case-control study comparing the sensitivity and specificity of ultrasonography and computed tomography for diagnosis in the emergency department." European Journal of Radiology, vol. 83, no. 4, 2014, pp. 733-8. |
| Beaudoin FL, Straube S, Lopez J, Mello MJ, Baird J. "Prescription opioid misuse among ED patients discharged with opioids." The American Journal of Emergency Medicine, vol. 32, no. 6, 2014, pp. 580-5. |
| Beaudoin FL, Haran JP, Liebmann O. "A comparison of ultrasound-guided three-in-one femoral nerve block versus parenteral opioids alone for analgesia in emergency department patients with hip fractures: a randomized controlled trial." Academic Emergency Medicine, vol. 20, no. 6, 2013, pp. 584-91. |
| Haran, John Patrick, Beaudoin, Francesca Lynn, Suner, Selim, Lu, Shan. "C-reactive protein as predictor of bacterial infection among patients with an influenza-like illness." The American Journal of Emergency Medicine, vol. 31, no. 1, 2013, pp. 137-44. |
| Beaudoin FL, Merchant RC, Lincoln J, Gardiner F, Liebmann O, Cohn J. "Bedside ultrasonography detects significant femoral vessel overlap: implications for central venous cannulation." CJEM, vol. 13, no. 4, 2011, pp. 245-50. |
| Beaudoin FL, Valente JH. "Delayed post-endoscopic retrograde cholangiopancreatography perforation presenting as scrotal subcutaneous emphysema." The Journal of Emergency Medicine, vol. 40, no. 1, 2011, pp. e15-7. |
| Leytin V, Beaudoin FL. "Reducing hip fractures in the elderly." Clinical interventions in aging, vol. 6, 2011, pp. 61-5. |
| Beaudoin FL, Nagdev A, Merchant RC, Becker BM. "Ultrasound-guided femoral nerve blocks in elderly patients with hip fractures." The American Journal of Emergency Medicine, vol. 28, no. 1, 2010, pp. 76-81. |
| Poissant SF, Beaudoin F, Huang J, Brodsky J, Lee DJ. "Impact of cochlear implantation on speech understanding, depression, and loneliness in the elderly." Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, vol. 37, no. 4, 2008, pp. 488-94. |
| Braun B, Sharoff C, Chipkin SR, Beaudoin F. "Effects of insulin resistance on substrate utilization during exercise in overweight women." Journal of Applied Physiology, vol. 97, no. 3, 2004, pp. 991-7. |
Ongoing Research Support
R01 CE003149 (Beaudoin & Baird) 9/1/19 – 8/31/22
CDC
Implementing Statewide Emergency Department Care Pathways for Addiction Recovery after Opioid Overdose
The goals of this study are to: (1) refine and test an implementation strategy that aims to improve the fidelity of ED post-overdose care as it relates to the state’s Levels of Care policy, and (2) to test the effectiveness of policy-driven ED-based post-overdose care.
Role: Co-Principal Investigator
R21 AG061632 (Zullo / Beaudoin) 8/1/19 – 4/30/21
NIH / Brown University
Opioid use in post-acute hip fracture care: prescribing patterns, effectiveness, and safety
Role: Co-Principal Investigator
Arnold Foundation Grant (Beaudoin / Marshall) 3/1/18 – 2/28/22
The Laura and John Arnold Foundation
ED-based behavioral interventions following opioid overdose: The impact of peer navigation on treatment engagement, relapse, and recovery (The Navigator Trial)
Role: Co-Principal Investigator
Cigna Foundation (Marshall) 1/1/20 - 12/31/20
Cigna Foundation / Brown University
Treating & Preventing Opioid Overdose through Emergency Room Peer Support Services
The main goal of this project is to boost patient enrollment on The Navigator Trial (Arnold Foundation).
Role: Co-Principal Investigator
U01 MH110925 (McLean, Kessler, Ressler, Koenen) 9/23/16 – 7/31/21
NIMH
Longitudinal Assessment of Post-Traumatic Syndromes (AURORA)
Examination of adverse neuropsychiatric sequelae (PTSD, chronic pain) following trauma.
Role: Co-Investigator
R34 DA045544 (Merchant) 6/1/18 – 5/31/21 (no cost ext.)
NIDA
Development and pilot testing of a persuasive health communication intervention for emergency department patients who decline rapid HIV/HCV screening
Role: Co-Investigator
Academic Assessment Award (Beaudoin / Sokolic) 4/1/20 – 3/31/21
Brown Physicians, Inc.
Low Dose Ketamine for Pain Management in Vasoocclusive Crisis of Sickle Cell Disease
This is ato determine the comparative efficacy of low doses of ketamine as an adjunct to opioids versus standard care (opioids alone) for the treatment of acute severe pain in patients presenting to ED with VOC.
Role: Co-Principal Investigator
UG1 DA015831 (D’Onofrio) 6/1/20 – 5/31/21
NIDA / Yale University Subcontract
The National Drug Abuse Treatment Clinical Trials Network
Clinical Trials Network: New England Node: CTN0099 ED-INNOVATION supplement
Emergency Department-INitiated bupreNOrphine and VAlidaTIOn Network Trial (ED-INNOVATION) (NIH HEAL Initiative)
Role: Co-Investigator
COVID-19 Research Seed Fund (Beaudoin, Hawrot, Ramratnam, Jay) 6/1/20 – 5/31/21
Brown University
The Brown COVID-19 Blood Biorepository
Role: Co-Principal Investigator
Johns Hopkins University (Shoham) 5/1/20 – 5/31/21
Convalescent Plasma to Stem Coronavirus: A Randomized Controlled Double Blinded Phase 2 Study Comparing the Efficacy and Safety of Human Coronavirus Immune Plasma versus control among Adults Exposed to COVID-19
Role: Sub-Investigator
Johns Hopkins University (Sullivan) 5/1/20 – 5/31/21
Convalescent Plasma to Limit Coronavirus Associated Complications: A Randomized, Double-Blind, Controlled, Phase 2 Study Comparing the Efficacy and Safety of Human Coronavirus Immune Plasma versus Control Plasma Among Outpatients with Symptomatic COVID-19
Role: Sub-Investigator
Completed Research Support (past 2 years)
R01 NR014782 (Merchant) 7/23/14 – 4/30/20 (no cost ext.)
NINR
Facilitating HIV/AIDS and HIV Testing Literacy for Emergency Department Patients
Role: Co-Investigator
P20 GM125507 (Rich) 9/1/18 – 3/31/20
NIGMS
COBRE Center on Opioids and Overdose - Project 1
Project: Informed opioid prescribing for acute musculoskeletal pain after motor vehicle collision: A support tool for assessing risks and benefits of analgesic medications before prescribing (STAAMP)
Role: Project Principal Investigator
U54 GM115677 (Padbury) 5/1/18 – 4/30/19 (no cost ext.)
NIGMS / Brown University
Advance-CTR Project: Altering the Transition from Acute to Chronic Pain (ATTAC Pain): a randomized clinical trial of duloxetine for the prevention of post-traumatic pain
Role: Project Principal Investigator
| Year | Degree | Institution |
|---|---|---|
| 2016 | PhD | Brown University |
| 2006 | MD | University of Massachusetts |
| 2002 | MS | University of Massachusetts, Amherst |
| 2000 | BS | University of Massachusetts, Amherst |
Barnett Fain Quality Award, Lifespan Health System, 2021
Physician of the Year, RI Chapter of the American College Emergency Physicians, 2020
Michael J. Mello Department Research Mentorship Award, 2019
Physician C.A.R.E Award, The Miriam Hospital, 2018
Clinical Excellence Award, Emergency Medicine, The Miriam Hospital, 2017
Dept of Emergency Medicine, Translational Research Impact Award, 2017
Top Peer Reviewer, Annals of Emergency Medicine, 2016- 2017
Society for Academic Emergency Medicine, Young Investigator Award, 2017
Dept of Emergency Medicine, Translational Research Impact Award, 2016
Top Peer Reviewer, Annals of Emergency Medicine, 2015, 2016
National Institutes of Health, Loan Repayment Award, 2014 - 2016
Best Scientific Presentation, Society for Academic Emergency Medicine, 2014
Fellow, American College of Emergency Physicians, 2013
Dean’s Excellence in Teaching Award – Alpert Medical School, 2012
Gregory D. Jay Research Award, 2010
Haffenreffer House Staff Excellence Award, 2010
Alpha Omega Alpha Medical Honor Society, 2006
Worcester District Medical Society Scholarship, 2006
| PHP 1680K - Introduction to Conducting Clinical Research |
| PHP 2090A - Research Grant Writing for Public Health-Part A |
| PHP 2950 - Doctoral Seminar in Public Health |
