Dr. Francois Luks is the J. Murray Beardsley Professor of Pediatric Surgery and Professor of Surgery, Pediatrics and Obstetrics &Gynecology at the Warren Alpert Medical School of Brown University. He is Chief of the Division of Pediatric Surgery and Pediatric Surgeon-in-Chief at Hasbro Children's/Rhode Island Hospital. He is Co-Director of the Fetal Treatment Program of New England and Director of the Brown Program in Fetal Medicine . From 2005 to 2017, he was Course Director for the Multidisciplinary Fetal Medicine Course (BIOL 6505), a pre-clinical seminar taught to PLME and medical students. He has authored or co-authored over 170 peer-reviewed publications and book chapters, and over 200 abstracts. His research interests include fetal development and fetal surgery, and in particular the etiology of Twin-to-twin Transfusion Syndrome. He is a past president of the International Fetal Medicine and Surgery Society (IFMSS). He was the site Principal Investigator for the first randomized study on endoscopic fetal surgery for this syndrome; the Brown Fetal Treatment Program was the only North-American center participating in the study. The Program is a founding member of the North American Fetal Treatment Network (NAFTNet).
Since 2012, he has led a one-day workshop on medical illustration for 1st year medical students, as part of the Integrated Medical Arts and Humanities program. He is director of the preclinical elective The Physician as Medical Illustrator (BIOL 6527).
In 2017, the first full-semester course in medical illustration was offered to PLME and other Brown undergraduate students, in collaboration with the Rhode Island School of Design: Introduction to Medical Illustration (PLME 0400).
In his book, MedSpeak Illuminated: The art and practice of medical illustration (Kent State University Press, 2022), he explores the different aspects of visual communication in medicine and science.
| Tindal EW, Willis M, Recinos Soto A, Coyle MG, Herzlinger M, Luks FI, Renaud EJ. "How many tests does it take? Minimizing preoperative testing prior to surgical placement of gastrostomy tubes in children." Nutrition in Clinical Practice, vol. 38, no. 2, 2023, pp. 434-441. |
| Joshi D, Stellon M, Antony K, Beninati M, Luks FI, Puricelli M, Lobeck IN. "Indications, Resource Allocation and Outcomes Associated with EXIT Procedures - A North American Fetal Therapy Network (NAFTNet) Survey." Fetal diagnosis and therapy, 2023. |
| Joshi D, Stellon M, Antony K, Beninati M, Luks FI, Puricelli M, Lobeck IN. "Indications, Resource Allocation and Outcomes Associated with EXIT Procedures - A North American Fetal Therapy Network (NAFTNet) Survey." Fetal diagnosis and therapy, 2023. |
| Baschat AA, Blackwell SB, Chatterjee D, Cummings JJ, Emery SP, Hirose S, Hollier LM, Johnson A, Kilpatrick SJ, Luks FI, Menard MK, McCullough LB, Moldenhauer JS, Moon-Grady AJ, Mychaliska GB, Narvey M, Norton ME, Rollins MD, Skarsgard ED, Tsao K, Warner BB, Wilpers A, Ryan G. "Care Levels for Fetal Therapy Centers." Obstetrics and gynecology, vol. 139, no. 6, 2022, pp. 1027-1042. |
| Francois I. Luks. MedSpeak Illuminated: The Art and Practice of Medical Illustration. Kent State University Press, 2022. |
| Luks FI, Collins S, Xia J, Cao SA, Rios M. "Combination of volume-rendering 3D surface modeling and medical illustration to capture the living fetus." Prenat Diagn, vol. 41, no. 1, 2021, pp. 79-88. |
| Akuchie, Chinonso, Renaud, Elizabeth J., Watson-Smith, Debra, Carr, Stephen R., Luks, Francois I. "Minimizing Individual Learning Curves in a Mature Endoscopic Fetal Surgery Program." Fetal Diagnosis and Therapy, vol. 47, no. 12, 2020, pp. 918-926. |
| Akuchie C, Renaud EJ, Watson-Smith D, Carr SR, Luks FI. "Minimizing Individual Learning Curves in a Mature Endoscopic Fetal Surgery Program." Fetal diagnosis and therapy, vol. 47, no. 12, 2020, pp. 918-926. |
| Novotny J, Miller WR, Luks FI, Merck D, Collins S, Laidlaw DH. "Towards Placental Surface Vasculature Exploration in Virtual Reality." IEEE Comput. Grap. Appl., vol. 40, no. 1, 2020, pp. 28-39. |
| Monteagudo J, Dickinson CM, Wakeley M, Mangray S, Wills HE, Luks FI. "Proximity to the Diaphragm Predicts the Presence of Rhabdomyomatous Dysplasia in Congenital Pulmonary Airway Malformations." European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, vol. 29, no. 1, 2019, pp. 49-52. |
| Dickinson CM, Vidri RJ, Smith AD, Wills HE, Luks FI. "Can time to healing in pediatric blunt splenic injury be predicted?." Pediatric surgery international, vol. 34, no. 11, 2018, pp. 1195-1200. |
| Berman L, Jackson J, Miller K, Kowalski R, Kolm P, Luks FI. "Expert surgical consensus for prenatal counseling using the Delphi method." Journal of Pediatric Surgery, vol. 53, no. 8, 2018, pp. 1592-1599. |
| De Paepe, Monique E., Mao, Quanfu, Chu, Sharon, Zhang, Yuqi, Luks, François I. "Clinicoplacental correlates of amniocyte vacuolization in association with gastroschisis." Placenta, vol. 57, 2017, pp. 87-93. |
| Dickinson CM, Coppersmith NA, Luks FI. "Early Predictors of Abscess Development after Perforated Pediatric Appendicitis." Surgical infections, vol. 18, no. 8, 2017, pp. 886-889. |
| Moon-Grady AJ, Baschat A, Cass D, Choolani M, Copel JA, Crombleholme TM, Deprest J, Emery SP, Evans MI, Luks FI, Norton ME, Ryan G, Tsao K, Welch R, Harrison M. "Fetal Treatment 2017: The Evolution of Fetal Therapy Centers - A Joint Opinion from the International Fetal Medicine and Surgical Society (IFMSS) and the North American Fetal Therapy Network (NAFTNet)." Fetal diagnosis and therapy, vol. 42, no. 4, 2017, pp. 241-248. |
| De Paepe, Monique E, V Benny, Merline Kocheekkaran, Priolo, Lauren, Luks, Francois I, Shapiro, Svetlana. "Florid Intussusceptive-like Microvascular Dysangiogenesis in a Preterm Lung." Pediatric and Developmental Pathology, vol. 20, no. 5, 2017, pp. 432-439. |
| Moise KJ Jr, Moldenhauer JS, Bennett KA, Goodnight W, Luks FI, Emery SP, Tsao K, Moon-Grady AJ, Moore RC, Treadwell MC, Vlastos EJ, Wetjen NM. "Current Selection Criteria and Perioperative Therapy Used for Fetal Myelomeningocele Surgery." Obstetrics and gynecology, vol. 127, no. 3, 2016, pp. 593-7. |
| Berman L, Kabre R, Kazak A, Hicks B, Luks F. "Exposure to prenatal consultation during pediatric surgery residency: Implications for training." Journal of Pediatric Surgery, vol. 51, no. 1, 2016, pp. 131-6. |
| Hartwich, Joseph, Luks, Francois I., Watson-Smith, Debra, Kurkchubasche, Arlet G., Muratore, Christopher S., Wills, Hale E., Tracy, Thomas F. "Nonoperative treatment of acute appendicitis in children: A feasibility study." Journal of Pediatric Surgery, vol. 51, no. 1, 2016, pp. 111-6. |
| Emery SP, Hasley SK, Catov JM, Miller RS, Moon-Grady AJ, Baschat AA, Johnson A, Lim FY, Gagnon AL, O'Shaughnessy RW, Ozcan T, Luks FI, North American Fetal Therapy Network. "North American Fetal Therapy Network: intervention vs expectant management for stage I twin-twin transfusion syndrome." American Journal of Obstetrics and Gynecology, vol. 215, no. 3, 2016, pp. 346.e1-7. |
| Chau DB, Ciullo SS, Watson-Smith D, Chun TH, Kurkchubasche AG, Luks FI. "Patient-centered outcomes research in appendicitis in children: Bridging the knowledge gap." Journal of Pediatric Surgery, vol. 51, no. 1, 2016, pp. 117-121. |
| Petersen SG, Gibbons KS, Luks FI, Lewi L, Diemert A, Hecher K, Dickinson JE, Stirnemann JJ, Ville Y, Devlieger R, Gardener G, Deprest JA. "The Impact of Entry Technique and Access Diameter on Prelabour Rupture of Membranes Following Primary Fetoscopic Laser Treatment for Twin-Twin Transfusion Syndrome." Fetal diagnosis and therapy, vol. 40, no. 2, 2016, pp. 100-9. |
| Luks, Francois I., Johnson, Anthony, Polzin, William J. "Innovation in Maternal–Fetal Therapy." Obstetrics and gynecology, vol. 125, no. 3, 2015, pp. 649-652. |
| Fallon EA, Ha AY, Merck DL, Ciullo SS, Luks FI. "Interactive Instrument-Driven Image Display in Laparoscopic Surgery." Journal of Laparoendoscopic & Advanced Surgical Techniques, 2015. |
| De Paepe, M.E., Shapiro, S., Young, L.E., Luks, F.I. "Placental weight, birth weight and fetal:placental weight ratio in dichorionic and monochorionic twin gestations in function of gestational age, cord insertion type and placental partition." Placenta, vol. 36, no. 2, 2015, pp. 213-220. |
| Luks, F. I. "Re: Fetal intervention for severe lower urinary tract obstruction: a multicenter case-control study comparing fetal cystoscopy with vesicoamniotic shunting. R. Ruano, N. Sananes, H. Sangi-Haghpeykar, S. Hernandez-Ruano, R. Moog, F. Becmeur, A. Zaloszyc, A." Ultrasound Obstet Gynecol, vol. 45, no. 4, 2015, pp. 375-376. |
| Johnson A, Luks FI. "A cautionary note on new fetal interventions." Obstetrics and gynecology, vol. 124, no. 2 Pt 2 Suppl 1, 2014, pp. 411-2. |
| Liou KT, George P, Baruch JM, Luks FI. "Clinical sketches: teaching medical illustration to medical students." Medical education, vol. 48, no. 5, 2014, pp. 525. |
| Maggio, Lindsay, Carr, Stephen R., Watson-Smith, Debra, O'Brien, Barbara M., Lopes, Vrishali, Muratore, Christopher S., Luks, Francois I. "Iatrogenic Preterm Premature Rupture of Membranes after Fetoscopic Laser Ablative Surgery." Fetal diagnosis and therapy, vol. 38, no. 1, 2014, pp. 29-34. |
| Duron VP, Day KM, Steigman SA, Aidlen JT, Luks FI. "Maintaining low transfusion and angioembolization rates in the age of nonoperative management of pediatric blunt splenic injury." The American Surgeon, vol. 80, no. 11, 2014, pp. 1159-63. |
| Duron VD, Watson-Smith D, Benzuly SE, Muratore CS, O'Brien BM, Carr SR, Luks FI. "Maternal and fetal safety of fluid-restrictive general anesthesia for endoscopic fetal surgery in monochorionic twin gestations." Journal of clinical anesthesia, vol. 26, no. 3, 2014, pp. 184-90. |
| Bates MF, Khander A, Steigman SA, Tracy TF Jr, Luks FI. "Use of white blood cell count and negative appendectomy rate." Pediatrics, vol. 133, no. 1, 2014, pp. e39-44. |
| Marsit CJ, Koestler DC, Watson-Smith D, Boney CM, Padbury JF, Luks F. "Developmental genes targeted for epigenetic variation between twin-twin transfusion syndrome children." Clinical Epigenetics, vol. 5, no. 1, 2013, pp. 18. |
| Hui L, Wick HC, Moise KJ Jr, Johnson A, Luks F, Haeri S, Johnson KL, Bianchi DW. "Global gene expression analysis of amniotic fluid cell-free RNA from recipient twins with twin-twin transfusion syndrome." Prenat Diagn, vol. 33, no. 9, 2013, pp. 873-83. |
| Skupski DW, Luks FI, Papanna R, Walker M, Bebbington M, Ryan G, O'Shaughnessy R, Moldenhauer J, Bahtiyar O, North American Fetal Therapy Network (NAFTNet). "Laser ablation of placental anastomoses in twin-to-twin transfusion syndrome: preoperative predictors of death by recursive partitioning." Prenat Diagn, vol. 33, no. 3, 2013, pp. 279-83. |
| De Paepe ME, Luks FI. "What-and why-the pathologist should know about twin-to-twin transfusion syndrome." Pediatric and Developmental Pathology, vol. 16, no. 4, 2013, pp. 237-51. |
| Luks FI, Aidlen JT. "Enhanced image display to improve laparoscopic surgery: new and future developments." Expert review of medical devices, vol. 9, no. 6, 2012, pp. 551-3. |
| Thakkar RK, Steigman SA, Aidlen JT, Luks FI. "Individualized image display improves performance in laparoscopic surgery." Journal of Laparoendoscopic & Advanced Surgical Techniques, vol. 22, no. 10, 2012, pp. 1010-3. |
| Kowitt B, Tucker R, Watson-Smith D, Muratore CS, O'Brien BM, Vohr BR, Carr SR, Luks FI. "Long-term morbidity after fetal endoscopic surgery for severe twin-to-twin transfusion syndrome." Journal of Pediatric Surgery, vol. 47, no. 1, 2012, pp. 51-6. |
| Aidlen JT, Luks FI. "Management of pediatric splenic injury: we agree, more or less: comment on "less is more"." Archives of surgery (Chicago, Ill. : 1960), vol. 147, no. 5, 2012, pp. 441-2. |
| De Paepe ME, Shapiro S, Hanley LC, Chu S, Luks FI. "Correlation between cord insertion type and superficial choriovasculature in diamniotic-monochorionic twin placentas." Placenta, vol. 32, no. 11, 2011, pp. 901-5. |
| Narsule CK, Kahle EJ, Kim DS, Anderson AC, Luks FI. "Effect of delay in presentation on rate of perforation in children with appendicitis." The American Journal of Emergency Medicine, vol. 29, no. 8, 2011, pp. 890-3. |
| Lombardo ML, Watson-Smith DJ, Muratore CS, Carr SR, O'Brien BM, Luks FI. "Laser ablation of placental vessels in twin-to-twin transfusion syndrome: a paradigm for endoscopic fetal surgery." Journal of Laparoendoscopic & Advanced Surgical Techniques, vol. 21, no. 9, 2011, pp. 869-72. |
| Luks FI. "New and/or improved aspects of fetal surgery." Prenat Diagn, vol. 31, no. 3, 2011, pp. 252-8. |
| Luks FI. "Blast injuries--and the pivotal role of trauma surgeons." Acta chirurgica Belgica, vol. 110, no. 5, 2010, pp. 517-20. |
| Abodeely AA, Cheah YL, Ryder BA, Aidlen JT, Luks FI. "Eliminating the effects of paradoxic imaging during laparoscopic surgery." Journal of Laparoendoscopic & Advanced Surgical Techniques, vol. 20, no. 1, 2010, pp. 31-4. |
| O'Brien BM, Feltovich HM, Carr SR, Luks FI. "Feto-fetal transfusion syndrome in monochorionic quadruplets." Obstetrics and gynecology, vol. 115, no. 2 Pt 2, 2010, pp. 470-2. |
| Ahmed S, Luks FI, O'Brien BM, Muratore CS, Carr SR. "Influence of experience, case load, and stage distribution on outcome of endoscopic laser surgery for TTTS--a review." Prenat Diagn, vol. 30, no. 4, 2010, pp. 314-9. |
| De Paepe ME, Shapiro S, Young L, Luks FI. "Placental characteristics of selective birth weight discordance in diamniotic-monochorionic twin gestations." Placenta, vol. 31, no. 5, 2010, pp. 380-6. |
| De Paepe ME, Shapiro S, Greco D, Luks VL, Abellar RG, Luks CH, Luks FI. "Placental markers of twin-to-twin transfusion syndrome in diamniotic-monochorionic twins: A morphometric analysis of deep artery-to-vein anastomoses." Placenta, vol. 31, no. 4, 2010, pp. 269-76. |
| Skupski DW, Luks FI, Walker M, Papanna R, Bebbington M, Ryan G, O'Shaughnessy R, Moldenhauer J, Bahtiyar O, North American Fetal Therapy Network (NAFTNet). "Preoperative predictors of death in twin-to-twin transfusion syndrome treated with laser ablation of placental anastomoses." American Journal of Obstetrics and Gynecology, vol. 203, no. 4, 2010, pp. 388.e1-388.e11. |
| Curran S, McMurdy JW, Carr SR, Muratore CS, O'Brien BM, Crawford GP, Luks FI. "Reflectance spectrometry for real-time hemoglobin determination of placental vessels during endoscopic laser surgery for twin-to-twin transfusion syndrome." Journal of Pediatric Surgery, vol. 45, no. 1, 2010, pp. 59-64. |
| Deprest JA, Flake AW, Gratacos E, Ville Y, Hecher K, Nicolaides K, Johnson MP, Luks FI, Adzick NS, Harrison MR. "The making of fetal surgery." Prenat Diagn, vol. 30, no. 7, 2010, pp. 653-67. |
| Martin AE, Chen JY, Muratore CS, Mayo-Smith WW, Luks FI. "Dual localization technique for thoracoscopic resection of lung lesions in children." Journal of Laparoendoscopic & Advanced Surgical Techniques, vol. 19 Suppl 1, 2009, pp. S161-4. |
| Muratore CS, Luks FI, Zhou Y, Harty M, Reichner J, Tracy TF. "Endotoxin alters early fetal lung morphogenesis." Journal of Surgical Research, vol. 155, no. 2, 2009, pp. 225-30. |
| Aidlen JT, Glick S, Silverman K, Silverman HF, Luks FI. "Head-motion-controlled video goggles: preliminary concept for an interactive laparoscopic image display (i-LID)." Journal of Laparoendoscopic & Advanced Surgical Techniques, vol. 19, no. 4, 2009, pp. 595-8. |
| Luks FI. "NIH takes lead on interdisciplinary fetal therapy research." AAP News, vol. 30, no. 11, 2009, pp. 15. |
| Prendergast CJ, Ryder BA, Abodeely A, Muratore CS, Crawford GP, Luks FI. "Surgical performance with head-mounted displays in laparoscopic surgery." Journal of Laparoendoscopic & Advanced Surgical Techniques, vol. 19 Suppl 1, 2009, pp. S237-40. |
| Muratore CS, Carr SR, Lewi L, Delieger R, Carpenter M, Jani J, Deprest JA, Luks FI. "Survival after laser surgery for twin-to-twin transfusion syndrome: when are they out of the woods?." Journal of Pediatric Surgery, vol. 44, no. 1, 2009, pp. 66-9; discussion 70. |
| Luks FI, Carr SR, Muratore CS, O'Brien BM, Tracy TF. "The pediatric surgeons' contribution to in utero treatment of twin-to-twin transfusion syndrome." Annals of Surgery, vol. 250, no. 3, 2009, pp. 456-62. |
| Martin AE, Khan A, Kim DS, Muratore CS, Luks FI. "The use of intraabdominal tissue expanders as a primary strategy for closure of giant omphaloceles." Journal of Pediatric Surgery, vol. 44, no. 1, 2009, pp. 178-82. |
| De Paepe ME, Gundavarapu S, Tantravahi U, Pepperell JR, Haley SA, Luks FI, Mao Q. "Fas-ligand-induced apoptosis of respiratory epithelial cells causes disruption of postcanalicular alveolar development." The American Journal of Pathology, vol. 173, no. 1, 2008, pp. 42-56. |
| Luks FI, Carr SR, O'Brien BM, Muratore CS. "Power and interpretation of a randomized study on the treatment of severe twin-to-twin transfusion syndrome." American Journal of Obstetrics and Gynecology, vol. 198, no. 5, 2008, pp. 607; author reply 607-8. |
| Mao Q, Gundavarapu S, Patel C, Tsai A, Luks FI, De Paepe ME. "The Fas system confers protection against alveolar disruption in hyperoxia-exposed newborn mice." American Journal of Respiratory Cell and Molecular Biology, vol. 39, no. 6, 2008, pp. 717-29. |
| Tan TW, Kim DS, Wallach MT, Mangray S, Luks FI. "Thoracoscopic resection of a giant thymolipoma in a 4-year-old girl." Journal of Laparoendoscopic & Advanced Surgical Techniques, vol. 18, no. 6, 2008, pp. 903-5. |
| Young JY, Kim DS, Muratore CS, Kurkchubasche AG, Tracy TF Jr, Luks FI. "High incidence of postoperative bowel obstruction in newborns and infants." Journal of Pediatric Surgery, vol. 42, no. 6, 2007, pp. 962-5; discussion 965. |
| Muratore, Christopher S., Ryder, Beth A., Luks, Francois I. "Image display in endoscopic surgery." Journal of the Society for Information Display, vol. 15, no. 6, 2007, pp. 349. |
| Kwon A, Sorrells DL Jr, Kurkchubasche AG, Cassese JA, Tracy TF Jr, Luks FI. "Isolated computed tomography diagnosis of pulmonary contusion does not correlate with increased morbidity." Journal of Pediatric Surgery, vol. 41, no. 1, 2006, pp. 78-82; discussion 78-82. |
| Truitt AK, Carr SR, Cassese J, Kurkchubasche AG, Tracy TF Jr, Luks FI. "Perinatal management of congenital cystic lung lesions in the age of minimally invasive surgery." Journal of Pediatric Surgery, vol. 41, no. 5, 2006, pp. 893-6. |
| Chang J, Tracy TF Jr, Carr SR, Sorrells DL Jr, Luks FI. "Port insertion and removal techniques to minimize premature rupture of the membranes in endoscopic fetal surgery." Journal of Pediatric Surgery, vol. 41, no. 5, 2006, pp. 905-9. |
| Sholler GL, Luks F, Mangray S, Meech SJ. "Advanced small cell carcinoma of the ovary in a pediatric patient with long-term survival and review of the literature." Journal of Pediatric Hematology/Oncology, vol. 27, no. 3, 2005, pp. 169-72. |
| Poch M, Luks FI, Carr SR, De Paepe ME. "Intratwin arteriovenous fistula of the placenta in a case of twin-to-twin transfusion syndrome." American journal of perinatology, vol. 22, no. 1, 2005, pp. 3-6. |
| Vrochides DV, Sorrells DL Jr, Kurkchubasche AG, Wesselhoeft CW Jr, Tracy TF Jr, Luks FI. "Is there a role for routine preoperative endoscopic retrograde cholangiopancreatography for suspected choledocholithiasis in children?." Archives of surgery (Chicago, Ill. : 1960), vol. 140, no. 4, 2005, pp. 359-61. |
| Lui F, Gormley P, Sorrells DL Jr, Biffl WL, Kurkchubasche AG, Tracy TF Jr, Luks FI. "Pediatric trauma patients with isolated airway compromise or Glasgow Coma Scale less than 8: does immediate attending surgeon's presence upon arrival make a difference?." Journal of Pediatric Surgery, vol. 40, no. 1, 2005, pp. 103-6. |
| Truitt AK, Sorrells DL, Halvorson E, Starring J, Kurkchubasche AG, Tracy TF Jr, Luks FI. "Pulmonary embolism: which pediatric trauma patients are at risk?." Journal of Pediatric Surgery, vol. 40, no. 1, 2005, pp. 124-7. |
| Luks FI, Carr SR, De Paepe ME, Tracy TF Jr. "What--and why--the pediatric surgeon should know about twin-to-twin transfusion syndrome." Journal of Pediatric Surgery, vol. 40, no. 7, 2005, pp. 1063-9. |
| Carr SR, Luks F, Tracy T, Plevyak M. "Antenatal necrotic injury in severe twin-to-twin transfusion syndrome. A case and review." Fetal diagnosis and therapy, vol. 19, no. 4, 2004, pp. 370-2. |
| Sattar AK, McRae R, Mangray S, Hansen K, Luks FI. "Core excision of the foramen cecum for recurrent thyroglossal duct cyst after Sistrunk operation." Journal of Pediatric Surgery, vol. 39, no. 4, 2004, pp. e3-5. |
| De Paepe ME, Mao Q, Luks FI. "Expression of apoptosis-related genes after fetal tracheal occlusion in rabbits." Journal of Pediatric Surgery, vol. 39, no. 11, 2004, pp. 1616-25. |
| De Paepe ME, Mao Q, Embree-Ku M, Rubin LP, Luks FI. "Fas/FasL-mediated apoptosis in perinatal murine lungs." American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 287, no. 4, 2004, pp. L730-42. |
| Luks FI, Carr SR, Plevyak M, Craigo SD, Athanassiou A, Ralston SJ, Tracy TF Jr. "Limited prognostic value of a staging system for twin-to-twin transfusion syndrome." Fetal diagnosis and therapy, vol. 19, no. 3, 2004, pp. 301-4. |
| Bussey JG, Luks F, Carr SR, Plevyak M, Tracy TF Jr. "Minimal-access fetal surgery for twin-to-twin transfusion syndrome." Surgical Endoscopy, vol. 18, no. 1, 2004, pp. 83-6. |
| Oka T, Kurkchubasche AG, Bussey JG, Wesselhoeft CW Jr, Tracy TF Jr, Luks FI. "Open and laparoscopic appendectomy are equally safe and acceptable in children." Surgical Endoscopy, vol. 18, no. 2, 2004, pp. 242-5. |
| Cloutier DR, Baird TB, Gormley P, McCarten KM, Bussey JG, Luks FI. "Pediatric splenic injuries with a contrast blush: successful nonoperative management without angiography and embolization." Journal of Pediatric Surgery, vol. 39, no. 6, 2004, pp. 969-71. |
| De Paepe ME, Friedman RM, Poch M, Hansen K, Carr SR, Luks FI. "Placental findings after laser ablation of communicating vessels in twin-to-twin transfusion syndrome." Pediatric and Developmental Pathology, vol. 7, no. 2, 2004, pp. 159-65. |
| Luks FI, Carr SR, Feit LR, Rubin LP. "Experience with a multidisciplinary antenatal diagnosis and management model in fetal medicine." The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 14, no. 5, 2003, pp. 333-7. |
| Erfanian K, Luks FI, Kurkchubasche AG, Wesselhoeft CW Jr, Tracy TF Jr. "In-line image projection accelerates task performance in laparoscopic appendectomy." Journal of Pediatric Surgery, vol. 38, no. 7, 2003, pp. 1059-62. |
| De Paepe ME, Stopa E, Huang C, Hansen K, Luks FI. "Renal tubular apoptosis in twin-to-twin transfusion syndrome." Pediatric and Developmental Pathology, vol. 6, no. 3, 2003, pp. 215-25. |
| Huang J, Kurkchubasche AG, Carr SR, Wesselhoeft CW Jr, Tracy TF Jr, Luks FL. "Benefits of term delivery in infants with antenatally diagnosed gastroschisis." Obstetrics and gynecology, vol. 100, no. 4, 2002, pp. 695-9. |
| De Paepe ME, Burke S, Luks FI, Pinar H, Singer DB. "Demonstration of placental vascular anatomy in monochorionic twin gestations." Pediatric and Developmental Pathology, vol. 5, no. 1, 2002, pp. 37-44. |
| Tomicic JT, Luks FI, Shalon L, Tracy TF. "Laparoscopic gastrostomy in infants and children." European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, vol. 12, no. 2, 2002, pp. 107-10. |
| Luks FI, Roggin KK, Wild YK, Piasecki GJ, Rubin LP, Lesieur-Brooks AM, De Paepe ME. "Effect of lung fluid composition on type II cellular activity after tracheal occlusion in the fetal lamb." Journal of Pediatric Surgery, vol. 36, no. 1, 2001, pp. 196-201. |
| Luks FI. "Fetal surgery." Medicine and health, Rhode Island, vol. 84, no. 5, 2001, pp. 169-70. |
| Luks FI, Carr SR, Tracy TF Jr. "Intestinal atresia associated with twin-twin transfusion syndrome." Journal of Pediatric Surgery, vol. 36, no. 7, 2001, pp. 1105-6. |
| Luks FI, Carr SR, Ponte B, Rogg JM, Tracy TF Jr. "Preoperative planning with magnetic resonance imaging and computerized volume rendering in twin-to-twin transfusion syndrome." American Journal of Obstetrics and Gynecology, vol. 185, no. 1, 2001, pp. 216-9. |
| De Paepe ME, Rubin LP, Jude C, Lesieur-Brooks AM, Mills DR, Luks FI. "Fas ligand expression coincides with alveolar cell apoptosis in late-gestation fetal lung development." American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 279, no. 5, 2000, pp. L967-76. |
| Liao SL, Luks FI, Piasecki GJ, Wild YK, Papadakis K, De Paepe ME. "Late-gestation tracheal occlusion in the fetal lamb causes rapid lung growth with type II cell preservation." Journal of Surgical Research, vol. 92, no. 1, 2000, pp. 64-70. |
| Luks FI. "Requirements for fetal surgery: the diaphragmatic hernia model." European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 92, no. 1, 2000, pp. 115-8. |
| Luks FI, Wild YK, Piasecki GJ, De Paepe ME. "Short-term tracheal occlusion corrects pulmonary vascular anomalies in the fetal lamb with diaphragmatic hernia." Surgery, vol. 128, no. 2, 2000, pp. 266-72. |
| Wild YK, Piasecki GJ, De Paepe ME, Luks FI. "Short-term tracheal occlusion in fetal lambs with diaphragmatic hernia improves lung function, even in the absence of lung growth." Journal of Pediatric Surgery, vol. 35, no. 5, 2000, pp. 775-9. |
| Roggin KK, Breuer CK, Carr SR, Hansen K, Kurkchubasche AG, Wesselhoeft CW Jr, Tracy TF Jr, Luks FI. "The unpredictable character of congenital cystic lung lesions." Journal of Pediatric Surgery, vol. 35, no. 5, 2000, pp. 801-5. |
| Luks FI, Logan J, Breuer CK, Kurkchubasche AG, Wesselhoeft CW Jr, Tracy TF Jr. "Cost-effectiveness of laparoscopy in children." Archives of Pediatrics & Adolescent Medicine, vol. 153, no. 9, 1999, pp. 965-8. |
| Luks FI, Deprest JA, Peers KH, Steegers EA, van Der Wildt B. "Gelatin sponge plug to seal fetoscopy port sites: technique in ovine and primate models." American Journal of Obstetrics and Gynecology, vol. 181, no. 4, 1999, pp. 995-6. |
| Tackett LD, Breuer CK, Luks FI, Caldamone AA, Breuer JG, DeLuca FG, Caesar RE, Efthemiou E, Wesselhoeft CW Jr. "Incidence of contralateral inguinal hernia: a prospective analysis." Journal of Pediatric Surgery, vol. 34, no. 5, 1999, pp. 684-7; discussion 687-8. |
| De Paepe ME, Johnson BD, Papadakis K, Luks FI. "Lung growth response after tracheal occlusion in fetal rabbits is gestational age-dependent." American Journal of Respiratory Cell and Molecular Biology, vol. 21, no. 1, 1999, pp. 65-76. |
| Deprest JA, Luks FI, Peers KH, D'Olieslager J, Van Ginderdeuren R. "Natural protective mechanisms against endoscopic white-light injury in the fetal lamb eye." Obstetrics and gynecology, vol. 94, no. 1, 1999, pp. 124-7. |
| Lessin MS, Luks FI, Brem AS, Wesselhoeft CW Jr. "Primary laparoscopic placement of peritoneal dialysis catheters in children and young adults." Surgical Endoscopy, vol. 13, no. 11, 1999, pp. 1165-7. |
| Lessin MS, Wesselhoeft CW, Luks FI, DeLuca FG. "Primary repair of long-gap esophageal atresia by mobilization of the distal esophagus." European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, vol. 9, no. 6, 1999, pp. 369-72. |
| Lessin MS, Chan M, Catallozzi M, Gilchrist MF, Richards C, Manera L, Wallach MT, Luks FI. "Selective use of ultrasonography for acute appendicitis in children." The American Journal of Surgery, vol. 177, no. 3, 1999, pp. 193-6. |
| Papadakis K, Chen EA, Luks FI, Lessin MS, Wesselhoeft CW Jr, DeLuca FG. "The changing presentation of pyloric stenosis." The American Journal of Emergency Medicine, vol. 17, no. 1, 1999, pp. 67-9. |
| De Paepe ME, Sardesai MP, Johnson BD, Lesieur-Brooks AM, Papadakis K, Luks FI. "The role of apoptosis in normal and accelerated lung development in fetal rabbits." Journal of Pediatric Surgery, vol. 34, no. 5, 1999, pp. 863-70; discussion 870-1. |
| De Paepe ME, Papadakis K, Johnson BD, Luks FI. "Fate of the type II pneumocyte following tracheal occlusion in utero: a time-course study in fetal sheep." Virchows Archiv, vol. 432, no. 1, 1998, pp. 7-16. |
| Lessin MS, Luks FI. "Laparoscopic appendectomy and duodenocolonic dissociation (LADD) procedure for malrotation." Pediatric surgery international, vol. 13, no. 2-3, 1998, pp. 184-5. |
| Lessin MS, Luks FI, Wesselhoeft CW Jr, Gilchrist BF, Iannitti D, DeLuca FG. "Peritoneal drainage as definitive treatment for intestinal perforation in infants with extremely low birth weight (<750 g)." Journal of Pediatric Surgery, vol. 33, no. 2, 1998, pp. 370-2. |
| Luks FI, Johnson BD, Papadakis K, Traore M, Piasecki GJ. "Predictive value of monitoring parameters in fetal surgery." Journal of Pediatric Surgery, vol. 33, no. 8, 1998, pp. 1297-301. |
| Papadakis K, Luks FI, Deprest JA, Evrard VE, Flageole H, Miserez M, Lerut TE. "Single-port tracheoscopic surgery in the fetal lamb." Journal of Pediatric Surgery, vol. 33, no. 6, 1998, pp. 918-20. |
| De Paepe ME, Johnson BD, Papadakis K, Sueishi K, Luks FI. "Temporal pattern of accelerated lung growth after tracheal occlusion in the fetal rabbit." The American Journal of Pathology, vol. 152, no. 1, 1998, pp. 179-90. |
| Papadakis K, De Paepe ME, Tackett LD, Piasecki GJ, Luks FI. "Temporary tracheal occlusion causes catch-up lung maturation in a fetal model of diaphragmatic hernia." Journal of Pediatric Surgery, vol. 33, no. 7, 1998, pp. 1030-7. |
| Gilchrist BF, Luks FI, DeLuca FG, Wesselhoeft CW Jr. "A modified feeding Roux-en-Y jejunostomy in the neurologically damaged child." Journal of Pediatric Surgery, vol. 32, no. 4, 1997, pp. 588-9. |
| Luks FI, Deprest JA, Gilchrist BF, Peers KH, van der Wildt B, Steegers EA, Vandenberghe K. "Access techniques in endoscopic fetal surgery." European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, vol. 7, no. 3, 1997, pp. 131-4. |
| Evrard VA, Verbeke K, Peers KH, Luks FI, Lerut AE, Vandenberghe K, Deprest JA. "Amnioinfusion with Hartmann's solution: a safe distention medium for endoscopic fetal surgery in the ovine model." Fetal diagnosis and therapy, vol. 12, no. 3, 1997, pp. 188-92. |
| Papadakis K, Luks FI, De Paepe ME, Piasecki GJ, Wesselhoeft CW Jr. "Fetal lung growth after tracheal ligation is not solely a pressure phenomenon." Journal of Pediatric Surgery, vol. 32, no. 2, 1997, pp. 347-51. |
| Ng T, Lessin MS, Luks FI, Wallach MT, Wesselhoeft CW Jr. "Wandering spleen presenting as duodenal obstruction after repair of congenital diaphragmatic hernia." Journal of Pediatric Surgery, vol. 32, no. 12, 1997, pp. 1790-2. |
| Guleserian KJ, Gilchrist BF, Luks FI, Wesselhoeft CW, DeLuca FG. "Child abuse as a cause of traumatic chylothorax." Journal of Pediatric Surgery, vol. 31, no. 12, 1996, pp. 1696-7. |
| Luks FI, Gilchrist BF, Jackson BT, Piasecki GJ. "Endoscopic tracheal obstruction with an expanding device in a fetal lamb model: preliminary considerations." Fetal diagnosis and therapy, vol. 11, no. 1, 1996, pp. 67-71. |
| DeLuca FG, Gilchrist BF, Paquette E, Wesselhoeft CW, Luks FI. "External compression as initial management of giant omphaloceles." Journal of Pediatric Surgery, vol. 31, no. 7, 1996, pp. 965-7. |
| Chen EA, Luks FI, Gilchrist BF, Wesselhoeft CW Jr, DeLuca FG. "Pyloric stenosis in the age of ultrasonography: fading skills, better patients?." Journal of Pediatric Surgery, vol. 31, no. 6, 1996, pp. 829-30. |
| Pricolo VE, Potenti FM, Luks FI. "Selective preservation of the anal transition zone in ileoanal pouch procedures." Diseases of the Colon & Rectum, vol. 39, no. 8, 1996, pp. 871-7. |
| Luks FI, Peers KH, Deprest JA, Lerut TE, Vandenberghe K. "The effect of open and endoscopic fetal surgery on uteroplacental oxygen delivery in the sheep." Journal of Pediatric Surgery, vol. 31, no. 2, 1996, pp. 310-4. |
| van der Wildt B, Luks FI, Steegers EA, Deprest JA, Peers KH. "Absence of electrical uterine activity after endoscopic access for fetal surgery in the rhesus monkey." European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 58, no. 2, 1995, pp. 213-4. |
| Luks FI. "Fetal surgery." Bailliere's clinical obstetrics and gynaecology, vol. 9, no. 3, 1995, pp. 571-7. |
| Luks FI. "Fetal surgery." BMJ, vol. 311, no. 7018, 1995, pp. 1449-50. |
| Luks FI, Peers KH, Deprest JA, Lerut TE. "Gasless laparoscopy in infants: the rabbit model." Journal of Pediatric Surgery, vol. 30, no. 8, 1995, pp. 1206-8. |
| Deprest JA, Luks FI, Peers KH, Vandenberghe K, Lerut TE, Brosens IA, Van Assche FA. "Intrauterine endoscopic creation of urinary tract obstruction in the fetal lamb: a model for fetal surgery." American Journal of Obstetrics and Gynecology, vol. 172, no. 5, 1995, pp. 1422-6. |
| Luks FI, Deprest JA, Vandenberghe K, Brosens IA, Lerut T. "A model for fetal surgery through intrauterine endoscopy." Journal of Pediatric Surgery, vol. 29, no. 8, 1994, pp. 1007-9. |
| Luks FI, Deprest J, Marcus M, Vandenberghe K, Vertommen JD, Lerut T, Brosens I. "Carbon dioxide pneumoamnios causes acidosis in fetal lamb." Fetal diagnosis and therapy, vol. 9, no. 2, 1994, pp. 105-9. |
| Luks FI, Deprest J, Brosens I, Lerut T. "Extracorporeal surgical knot." Journal of the American College of Surgeons, vol. 179, no. 2, 1994, pp. 220-2. |
| Luks FI, Deprest JA, Vandenberghe K, Laermans I, De Simpelaere L, Brosens IA, Lerut T. "Fetoscopy-guided fetal endoscopy in a sheep model." Journal of the American College of Surgeons, vol. 178, no. 6, 1994, pp. 609-12. |
| Luks FI, Deprest JA, Peers KH, Desimpelaere L, Vandenberghe K. "Infrared fetoscopy in the sheep." Fetal diagnosis and therapy, vol. 9, no. 5, 1994, pp. 327-30. |
| Brandt ML, Luks FI, Lacroix J, Guay J, Collin PP, Dilorenzo M. "The paediatric chest tube." Clinical intensive care : international journal of critical & coronary care medicine, vol. 5, no. 3, 1994, pp. 123-9. |
| Lallier M, St-Vil D, Luks FI, Laberge JM, Bensoussan AL, Blanchard H. "[Biliary complications in pediatric liver transplantation]." Annales de chirurgie, vol. 47, no. 9, 1993, pp. 821-5. |
| Bruneau N, St-Vil D, Luks FI, LaBerge JM, Bensoussan AL, Blanchard H. "[Surgical and metabolic aspects of liver transplantation for tyrosinemia]." Annales de chirurgie, vol. 47, no. 9, 1993, pp. 803-9. |
| Lallier M, St-Vil D, Luks FI, Laberge JM, Bensoussan AL, Guttman FM, Blanchard H. "Biliary tract complications in pediatric orthotopic liver transplantation." Journal of Pediatric Surgery, vol. 28, no. 9, 1993, pp. 1102-5. |
| Luks FI, Lemire A, St-Vil D, Di Lorenzo M, Filiatrault D, Ouimet A. "Blunt abdominal trauma in children: the practical value of ultrasonography." The Journal of trauma, vol. 34, no. 5, 1993, pp. 607-10; discussion 610-1. |
| Luks FI, Deprest JA. "Endoscopic fetal surgery: a new alternative?." European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 52, no. 1, 1993, pp. 1-3. |
| Luks FI, St-Vil D, Hancock BJ, Laberge JM, Bensoussan AL, Russo P, Mitchell G, Lambert M, Blanchard H. "Surgical and metabolic aspects of liver transplantation for tyrosinemia." Transplantation, vol. 56, no. 6, 1993, pp. 1376-80. |
| Luks FI, De Paepe ME, DiLorenzo M, Mercier C, Desjardins JG. "Tailgut remnant--or teratoma?." European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, vol. 3, no. 3, 1993, pp. 182-5. |
| Luks FI, Yazbeck S, Homsy Y, Collin PP. "The abdominoscrotal hydrocele." European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, vol. 3, no. 3, 1993, pp. 176-8. |
| St-Vil D, Luks FI, Derouin M, Bensoussan AL, Blanchard H, Filiatrault D. "[Cysts of the choledochus in children: experience of the Sainte-Justine hospital]." Annales de chirurgie, vol. 46, no. 9, 1992, pp. 821-5. |
| Yazbeck S, Luks FI, St-Vil D. "Anterior perineal approach and three-flap anoplasty for imperforate anus: optimal reconstruction with minimal destruction." Journal of Pediatric Surgery, vol. 27, no. 2, 1992, pp. 190-4; discussion 194-5. |
| Luks FI, Yazbeck S, Perreault G, Desjardins JG. "Changes in the presentation of intussusception." The American Journal of Emergency Medicine, vol. 10, no. 6, 1992, pp. 574-6. |
| St-Vil D, Yazbeck S, Luks FI, Hancock BJ, Filiatrault D, Youssef S. "Cholelithiasis in newborns and infants." Journal of Pediatric Surgery, vol. 27, no. 10, 1992, pp. 1305-7. |
| Hancock BJ, St-Vil D, Luks FI, Di Lorenzo M, Blanchard H. "Complications of lymphangiomas in children." Journal of Pediatric Surgery, vol. 27, no. 2, 1992, pp. 220-4; discussion 224-6. |
| St-Vil D, Luks FI, Hancock BJ, Garel L, Brochu P, Blanchard H, Bensoussan AL. "Diaphragm of the gallbladder: a case report." Journal of Pediatric Surgery, vol. 27, no. 10, 1992, pp. 1301-3. |
| Brandt ML, Luks FI, Spigland NA, DiLorenzo M, Laberge JM, Ouimet A. "Diaphragmatic injury in children." The Journal of trauma, vol. 32, no. 3, 1992, pp. 298-301. |
| Luks FI, St-Vil D, Angaté H, Farrell CA, Chartrand C. "Inadvertent pericardiacophrenic vein catheterization." Chest, vol. 102, no. 5, 1992, pp. 1635. |
| St-Vil D, LeBouthillier G, Luks FI, Bensoussan AL, Blanchard H, Youssef S. "Neonatal gastrointestinal perforations." Journal of Pediatric Surgery, vol. 27, no. 10, 1992, pp. 1340-2. |
| Andzé GO, Luks FI, Bensoussan AL, Blanchard H. "[Role of surgical treatment of gastro-esophageal reflux in children with severe asthma]." Pediatrie, vol. 46, no. 5, 1991, pp. 451-4. |
| Luks FI, Yazbeck S, Brandt ML, Bensoussan AL, Brochu P, Blanchard H. "Benign liver tumors in children: a 25-year experience." Journal of Pediatric Surgery, vol. 26, no. 11, 1991, pp. 1326-30. |
| Saint-Vil D, Luks FI, Lebel P, Brandt ML, Paradis K, Weber A, Guay J, Guttman FM, Bensoussan AL, Laberge JM. "Infectious complications of pediatric liver transplantation." Journal of Pediatric Surgery, vol. 26, no. 8, 1991, pp. 908-13. |
| Luks FI, Chung MA, Brandt ML, Hertecant J, Roy CC, Blanchard H, Bensoussan AL. "Pneumatosis and pneumoperitoneum in chronic idiopathic intestinal pseudoobstruction." Journal of Pediatric Surgery, vol. 26, no. 12, 1991, pp. 1384-6. |
| Brandt ML, Luks FI, Filiatrault D, Garel L, Desjardins JG, Youssef S. "Surgical indications in antenatally diagnosed ovarian cysts." Journal of Pediatric Surgery, vol. 26, no. 3, 1991, pp. 276-81; discussion 281-2. |
| Brandt ML, Luks FI, St Vil D, Laberge JM, Caouette-Laberge L, Blanchard H. "The use of Glisson's capsule flap in reduced orthotopic hepatic transplantation." Surgery, gynecology & obstetrics, vol. 172, no. 4, 1991, pp. 321-2. |
| Luks FI, Yazbeck S, Brandt ML, Desjardins JG. "[Transient fever associated with a reduction of intestinal invagination]." Chirurgie pediatrique, vol. 31, no. 3, 1990, pp. 157-9. |
| Lee HS, LaMaute HR, Pizzi WF, Picard DL, Luks FI. "Acute gastroduodenal perforations associated with use of crack." Annals of Surgery, vol. 211, no. 1, 1990, pp. 15-7. |
| Luks FI, Shah MN, Bulauitan MC, LoPresti PA, Pizzi WF. "Adult foregut duplication." Surgery, vol. 108, no. 1, 1990, pp. 101-4. |
| Luks FI, Picard DL, Pizzi WF. "Electrocardiographic guidance for percutaneous placement of central venous catheters." Surgery, gynecology & obstetrics, vol. 169, no. 2, 1989, pp. 157-8. |
| Luks FI, Huntley HN, Tula JC, Pizzi WF. "Small-bowel obstruction by an inflatable penile prosthesis reservoir." Surgery, vol. 106, no. 1, 1989, pp. 101-4. |
| Luks FI. "An easy approach to the slit catheter technique in intracompartmental pressure measurement." Surgery, gynecology & obstetrics, vol. 167, no. 6, 1988, pp. 518-20. |
| Luks FI, Hansbrough F, Klotz DH Jr, Kottmeier PK, Tolete-Velcek F. "Early gender assignment in true hermaphroditism." Journal of Pediatric Surgery, vol. 23, no. 12, 1988, pp. 1122-6. |
Our laboratory work, starting 25 years ago, had centered around fetal lung development and the feasibility of endoscopic fetal surgery. More recently, this research experience has been translated into a clinical application, with the creation of the Fetal Treatment Program at Brown ( www.fetal-program.org ).
The Fetal Treatment Program offers the possibility of fetal surgical intervention for selected conditions, particularly severe Twin-to-twin Transfusion Syndrome. This surgical procedure is available in only a few centers nation-wide, and Brown is the only such center in New England. In 2004, the New England Journal of Medicine published the results of a multicenter, randomized trial (www.eurofoetus.org), which included Brown, showing a significant survival advantages for fetuses undergoing this procedure.
We are pursuing clinical research in that field, as well as in other aspects of fetal medicine and surgery. In 2008, we obtained an Investigational Device Exemption (IDE) from the FDA - one of only two such studies approved in the U.S. - to treat severe congenital diaphragmatic hernia by endoscopic fetal surgery.
Ongoing and future research projects include a laboratory model of twin-to-twin transfusion syndrome, the search for prognostic indicators in TTTS and the application of newer monitoring technology in endoscopic fetal surgery (the latter in conjunction with the Division of Engineering)
A recent focus of clinical research centers on the non-operative treatment of acute appendicitis in children. While the gold standard remains appendectomy, an increasing number of pilot studies and case reports have indicated that, as in adults, early, uncomplicated appendicitis can be treated with antibiotics alone, with relatively good success. We have obtained a U34 planning grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) for a multicenter 5-year randomized controlled study to evaluate the feasiblity and safety of non-operative treatment of early appendicitis in children.
1994-1995
Belgian National Fund for Scientific Research grant # 3.0122.94
("Fetal surgery through intra-uterine endoscopy")
Principal Researcher
$ 35,000
1995-1996
Rhode Island Foundation Grant # 5477
("Tracheal obstruction to promote lung growth in the fetal lamb")
Principal Investigator
$ 5,000
1997-1998
American Lung Association Research Grant # RG-159-N
("The tracheal ligation model of accelerated fetal lung growth")
Principal Investigator
$ 24,300
renewed 1998-99
$ 25,000
1998-1999
Lifespan Research Advisory Committee Developmental Grant # DG1142
("Role of the KGF/KGFr axis in normal, hypoplastic and experimentally accelerated
fetal lung development")
Collaborator
(Monique E. De Paepe, M.D. - P.I.)
$ 24,500
2000-2003
Eurofoetus: Endoscopic Access to the Fetoplacental Unit
Biomed 2 Programme of the European Commission-Directorate XII Grant # PL
962383
("Management of Twin-Twin Transfusion Syndrome. An Open multicentre
randomized trial for the evaluation of serial amniodrainage vs endoscopic placental
laser surgery with amniodrainage.")
Center P.I.
(Yves Ville, M.D. P.I.)
250,000
2003-2006
Grant # P20-RR018728 NIH NCRR COBRE
("Biological basis for perinatal transition", James F. Padbury, M.D. P.I.)
Collaborator
(Monique E. De Paepe, M.D. P.I. subproject IV :
"Role of Fas-mediated apoptosis in perinatal lung remodeling")
$ 129,000/year for subproject IV
2008-2013
Investigational Device Exemption #G080077
Food and Drug Administration
Detachable balloon for fetal tracheal occlusion
Principal Investigator and Sponsor
2011-2012
Small Business Industrial Research (SBIR) Grant
National Institutes of Health
(Lung nodule detection using 3D "visual palpation" via standard thoracoscopes")
Co-Principal Investigator, with Jason Harry
$171,328 in direct costs
2012-2013
Rhode Island Foundation Grant # 20113467
(“Interactive multi-user display system for laparoscopic surgery”)
Collaborator and Acting Principal Investigator (with Jeremy T. Aidlen)
$15,000
2017-2018
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Application # 1U34DK112584-01
(“Non-Operative Management of Pediatric Appendicitis: A Randomized Controlled Study”)
Co-Principal Investigator
$305,000 in direct costs
2019
Arnold F. Gold Foundation Grant #GH-19-006
(“Beyond words: the role of medical comics in expressing medical education experiences among students”)
Faculty Mentor (student: Sheyla Medina, MS IV)
$1,500
2021– 2024
Eunice Kennedy Shriver National Institute for Child Health & Human Development Grant # R01HD104607
(“Gastroschisis Outcomes of Delivery (GOOD)”)
Site Principal Investigator
$785,552 in direct costs
2020 – 21
Brown Biomedical Innovations to Impact Development Grants
(“Driver-Actived VIDeoscopic system (DA-VID)”)
Principal Investigator
$75,000 in direct costs
CORPORATE AUTHORSHIP OR MULTICENTER TRIALS
Senat MV, Deprest J, Noulvain M, Paupe A, Winner, Ville Y. Endoscopic laser surgery versus serial amnioreduction for severe twin-to-twin transfusion syndrome. N Engl J Med 351:136-144, 2004. (Center P.I.)
PATENTS
US Patent 9,693,728 Systems and Methods for Measuring Mechanical Properties of Deformable Materials (granted 7/4/2017)
(Harry JD, Ackerson DS, Luks FI)
US Patent 10,499,994 Interactive Display for Surgery
(Luks FI, Merck D)
US Patent 11,051,890 Interactive Display for Surgery
(Luks FI, Merck D)
TEDx URI talk: “Spark’s the limit: The visual abstract." April 1, 2023.
| Year | Degree | Institution |
|---|---|---|
| 1998 | PhD | KU Leuven |
| 1983 | MD | University of Antwerp |
| 1979 | BMS | University of Antwerp |
1993 - 1994 Doctoral Scholarship, Research Council of the Catholic University of Leuven
1992 - 1993 Research Scholarship, Faculty of Medicine, Catholic University of Leuven
1998 Master of Arts ad eundem, Brown University
Faculty Teaching Award, Department of Surgery, Brown Medical School (1999-2000, 2007-2008, 2010-2011)
2011 - Alumni of the Year (with Monique E. De Paepe, MD), University of Antwerp, Belgium
2007 Faculty election to Alpha Omega Alpha Honor Medical Society, Brown University Chapter
2022 - Lifetime Achievement Award, North American Fetal Therapy Network (NAFTNet)
| Name | Title |
|---|---|
| Ahle, Samantha | Assistant Professor of Pediatrics, Clinician Educator, Assistant Professor of Surgery, Clinician Educator |
| Carr, Stephen | Professor of Obstetrics and Gynecology |
| Chernoguz, Artur | Assistant Professor of Pediatrics, Assistant Professor of Surgery |
| Chun, Thomas | Professor of Pediatrics, Professor of Emergency Medicine |
| De Paepe, Monique | Professor of Pathology and Laboratory Medicine |
| Jackson, Carl-Christian | Associate Professor of Surgery, Clinician Educator |
| Monteagudo, Julie | Assistant Professor of Pediatrics, Assistant Professor of Surgery |
| Renaud, Elizabeth | Professor of Pediatrics, Clinician Educator, Professor of Surgery, Clinician Educator |
American Surgical Association
Association of Medical Illustrators
International Fetal Medicine & Surgery Society (President 2013-14)
American College of Surgeons (Fellow since 1997)
Trauma Association of Canada
Société Française de Chirurgie Pédiatrique
Canadian Association of Paediatric Surgeons (member, Committee on laparoscopy and Publications Committee)
Belgian Association of Pediatric Surgery
Providence Surgical Society/R.I. Chapter, A.C.S.
American Academy of Pediatrics (Specialty Fellow, Surgical Section)
Pediatric Oncology Group/Children's Oncology Group
Pediatric Surgery Biology Club
International Pediatric Endosurgery Group (member, Standards/Ethics Committee)
American Pediatric Surgical Association (member, Publications Committee; Chair, Fetal Diagnosis and Treatment Committee)
New England Surgical Society
Society of University Surgeons (member, Membership Committee)
Birth Defects Surveillance Advisory Committee, R.I. Department of Health
National Institutes of Health Workshop: Fetal Treatment: Needs Assessment And Future (invited participant)
North-American Fetal Therapy Network (Chair, Steering Committee; Chair, Web site Committee; member, Executive Committee)
| Pediatric Surgeon-in-Chief. 2016- |
| Chief, Division of Pediatric Surgery. Hasbro Children's Hospital, 2016- |
In addition to my involvement in the teaching of pediatric surgery to medical students, surgical residents and a dedicated fellow (pediatric surgery residency, one of only 30 positions in North-America), I am involved in several courses and classes at the undergraduate and medical school level.
"The Physician as Medical Illustrator" (BIOL 6527) is a preclinical elective that offers 1st and 2nd year medical students the opportunity to learn to draw (better). Many physicians draw. We are not all artists, but we often use pictures instead of thousands of words – whether to explain medical concepts to students or procedures to patients. Cultural, language and educational barriers may hinder verbal communication, and the use of simplified diagrams can enhance patients’ understanding of their medical condition. Of course, not all sketches are created equal; but just like medical students can be taught how to communicate better with patients and colleagues, so too can the rudiments of sketching be an acquired, rather than an innate talent. Rather than teaching detailed artistic illustration to a few “talented” individuals, the course aims at inculcating basic graphic rules to a large group of medical students. This preclinical elective is a formalization of a one-day workshop given to first-year medical students over the last five years, as part of an arts-and-humanities-based curriculum.
A more extensive version of this initiative is a full semester course offered to PLME and other Brown undergraduate students, as well as selected students from the Rhode Island School of Design (RISD). The PLME 0400 - Introduction to Medical Illustration course is offered in collaboration with faculty and TAs from RISD, and introduces students to the various aspects of professional medical illustration. While an arts degree is not a prerequisite, the course caters to individuals who have some graphic design background or interest. More advanced graphic instruction is combined with lectures on the history of medical illustration, art and medicine, and the course includes several "field trips" to the RISD Nature Lab, research laboratories at Rhode Island Hospital and Women & Infants Hospital, and the operating room at Rhode Island Hospital.
I am involved in the Fetal Medicine Program at Brown, the first program of its kind to teach fetal medicine at the Medical School level. A multidisciplinary course seminar is offered to 1st and 2nd year medical students and undergraduate PLME students (BIOL 6505).
From 2008 to 2017, I taught a session on image displays in medicine for the Topics in Emerging and Breakthrough Technologies course (ENGN 2910 G291).
| PLME 0400 - Introduction to Medical Illustration |
